Therapeutic effects of < em > Bombax ceiba < /em > flower aqueous extracts against loperamide-induced constipation in mice
CONCLUSIONS: This study suggested that BCE is a promising agent for the treatment of constipation.PMID:36582187 | PMC:PMC9809371 | DOI:10.1080/13880209.2022.2157841 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - December 30, 2022 Category: Drugs & Pharmacology Authors: Liuping Wang Shiyuan Xie Xuan Jiang Caini Xu Youqiong Wang Jianfang Feng Bin Yang Source Type: research
Molecules, Vol. 27, Pages 8880: The Detailed Pharmacodynamics of the Gut Relaxant Effect and GC-MS Analysis of the Grewia tenax Fruit Extract: In Vivo and Ex Vivo Approach
hd Amir
The study was performed to assess and rationalize the traditional utilization of the fruit part of Grewia tenax (G. tenax). The phytoconstituents present in the methanolic extract were analyzed using Gas-Chromatography-Mass Spectroscopy (GC-MS), while the anti-diarrheal activity was investigated in the Swiss albino mice against castor oil-provoked diarrhea in vivo. The antispasmodic effect and the possible pharmacodynamics of the observed antispasmodic effect were determined in an isolated rat ileum using the organ bath setup as an ex vivo model. GC-MS findings indicate that G. tenax is rich in alcohol (6,6-did...
Source: Molecules - December 14, 2022 Category: Chemistry Authors: Najeeb Ur Rehman Mohd Nazam Ansari Wasim Ahmad Mohd Amir Tags: Article Source Type: research
Cannabis sativa L. alleviates loperamide-induced constipation by modulating the composition of gut microbiota in mice
This study was designed to investigate the laxative effect and underlying mechanism of the water extract of Cannabis sativa L. (WECSL) using a loperamide-induced constipation mouse model. We found that WECSL treatment significantly improved intestinal motility and water-electrolyte metabolism, decreased inflammatory responses, prevented gut barrier damage, and relieved anxiety and depression in constipated mice. WECSL also structurally remodeled the composition of the gut microbiota and altered the abundance of bacteria related to inflammation, specifically Butyricicoccus and Parasutterella. Moreover, WECSL failed to relie...
Source: Frontiers in Pharmacology - December 2, 2022 Category: Drugs & Pharmacology Source Type: research
Whipple's disease - A typical endoscopic finding of a rare disease
Rev Esp Enferm Dig. 2022 Dec 1;116. doi: 10.17235/reed.2022.9338/2022. Online ahead of print.ABSTRACTA 49-year-old female presented with a 5-month course of diarrhoea, nocturn abdominal pain, asthenia, and weight loss of 30% of her body mass in three months. The patient had also a four-year medical history of bilateral mechanic gonalgy and arthralgias of the metacarpophalangeal and interphalangeal joints, despite treatment with prednisolone. On examination the patient had hyperpigmentation of the face and thorax, low-grade fever, and a BMI of 15,8 Kg/m2. Diarrhoea was documented with watery stools seven times per day despi...
Source: Revista Espanola de Enfermedades Digestivas - December 1, 2022 Category: Gastroenterology Authors: Ana Valadas Narcisa Fatela Tiago Sep úlveda Santos Maria Leonor Carvalho Source Type: research
Anti-Diarrheal Activities of Hydromethanolic Crude Extract and Solvent Fractions of < em > Acacia seyal < /em > (Fabaceae) Roots in Mice
CONCLUSION: According to this study, the hydromethanolic crude extract and solvent fractions of Acacia seyal roots have promising antidiarrheal effects.PMID:36411816 | PMC:PMC9675325 | DOI:10.2147/CPAA.S383896 (Source: Clinical Pharmacology: Advances and Applications)
Source: Clinical Pharmacology: Advances and Applications - November 22, 2022 Category: Allergy & Immunology Authors: Assefa Kebad Mengesha Eshetie Melese Birru Meaza Adugna Source Type: research
