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Intentional misuse and abuse of loperamide: a new look at a drug with "low abuse potential" - Borron SW, Watts SH, Tull J, Baeza S, Diebold S, Barrow A.
BACKGROUND: Despite its opioid properties, loperamide has long been thought to have low abuse potential due to its poor absorption from the gastrointestinal tract and limited potential to cross the blood-brain barrier. A recent patient reportedly taking lo... (Source: SafetyLit)
Source: SafetyLit - May 19, 2017 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Loperamide, the "poor man's methadone": brief review - Stanciu CN, Gnanasegaram SA.
Loperamide is widely available as an inexpensive, over-the-counter remedy commonly used for management of diarrhea. Although an opioid, at therapeutic doses it acts primarily on the gastrointestinal tissues; however, larger than recommended amounts facilit... (Source: SafetyLit)
Source: SafetyLit - May 19, 2017 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Mommy And The Beast: Growing Up Under The Lingering Shadow Of Breast Cancer
Tomorrow she will graduate from kindergarten. I will be thankful that I was there, present in my mortal body, for at least one graduation of hers, be it from Montessori school. There will be no gowns or hats neither will she know what it means to me, but that is just fine. She is excited about wearing her pretty beaded dress and singing a “Good Bye Song”. I am planning not to wear mascara and to use a waterproof eyeliner. I will drag myself to get dressed and go as I am still exhausted from chemotherapy. I will take some Imodium so I can last through the 90 minutes without rushing to the restroom. She has been ...
Source: Healthy Living - The Huffington Post - May 13, 2017 Category: Consumer Health News Source Type: news

Loperamide misuse and abuse - Miller H, Panahi L, Tapia D, Tran A, Bowman JD.
OBJECTIVE: The epidemic of opioid prescription deaths in recent years resulted in the recent rescheduling of hydrocodone-containing products to restrict access to them. Opioid users have recognized that loperamide can ameliorate withdrawal symptoms and als... (Source: SafetyLit)
Source: SafetyLit - February 16, 2017 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Cardiac Dysrhythmias After Loperamide Abuse -- NY, 2008-2016 Cardiac Dysrhythmias After Loperamide Abuse -- NY, 2008-2016
This report indicates that abuse of loperamide, an over-the-counter antidiarrheal with opioid-receptor agonist properties, is on the rise--and high doses can result in serious cardiac toxicity.Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 9, 2016 Category: Consumer Health News Tags: Emergency Medicine Journal Article Source Type: news

Loperamide abuse and cardiac dysrhythmia
3.5 out of 5 stars Cardiac Dysrhythmias After Loperamide Abuse — New York, 2008-2016. Eggleston W et al. MMWR 2016 Nov 18;65:1276-1277. Full Text Last week we reviewed a new paper showing that the number of cases of loperamide abuse reported to the National Poison Data System increased by 91% from the years 2000 to 2015. For reasons detailed in that review and in my recent Emergency Medicine News article on the topic, massive doses of loperamide can alleviate opioid withdrawal symptoms and also produce opioid-like effects. This very brief report has some interesting clinical and epidemiological nu...
Source: The Poison Review - November 25, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical cardiotoxicity ecg ekg electrocardiogram imodium loperamide Source Type: news

Notes from the field: Cardiac dysrhythmias after loperamide abuse - New York, 2008-2016 - Eggleston W, Marraffa JM, Stork CM, Mercurio-Zappala M, Su MK, Wightman RS, Cummings KR, Schier JG.
Loperamide is an over-the-counter antidiarrheal with opioid-receptor agonist properties. Recommended over-the-counter doses (range  = 2-8 mg daily) do not produce opioid effects in the central nervous system because of poor oral bioavailability and P-glyc... (Source: SafetyLit)
Source: SafetyLit - November 19, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Notes from the Field: Cardiac Dysrhythmias After Loperamide Abuse — New York, 2008–2016
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - November 17, 2016 Category: American Health Source Type: news

Missing loperamide (Imodium) abuse can be a fatal mistake
3 out of 5 stars Epidemiologic Trends in Loperamide Abuse and Misuse. Vakkalanka JP et al. Ann Emerg Med 2016 Nov 4 [Epub ahead of print] Abstract This paper reviews loperamide exposures reported to the National Poison Data System  over the 6-year period from 2010 through 2015. Because of the well-recognized limitations involved in retrospective analysis of poison center data, there is not much clinically useful information revealed by their study. The authors did find — unsurprisingly — that reported exposures to loperamide went up from 2010 to 2015, increasing by 91%. As we’ve discus...
Source: The Poison Review - November 15, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical cardiotoxicity fatality imodium loperamide overdose prolonged QT syndrome Source Type: news

Epidemiologic trends in loperamide abuse  and misuse - Vakkalanka JP, Charlton NP, Holstege CP.
STUDY OBJECTIVE: Loperamide abuse has been increasing in the United States as a potential alternative to manage opioid withdrawal symptoms or to achieve euphoric effects of opioid use. In June 2016, the Food and Drug Administration warned health care provi... (Source: SafetyLit)
Source: SafetyLit - November 11, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Imodium (Loperamide Hcl) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - October 18, 2016 Category: Drugs & Pharmacology Source Type: news

Loperamide-related deaths in North Carolina - Bishop-Freeman SC, Feaster MS, Beal J, Miller A, Hargrove RL, Brower JO, Winecker RE.
Loperamide (Imodium ®) has been accepted as a safe, effective, over-the-counter anti-diarrheal drug with low potential for abuse. It is a synthetic opioid that lacks central nervous system activity at prescribed doses, rendering it ineffective for abuse. S... (Source: SafetyLit)
Source: SafetyLit - August 7, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Loperamide (Imodium) overdose can cause fatal cardiac toxicity
A recent paper described two fatalities associated with overdose of the anti-diarrhea drug loperamide (Imodium.) This drug, once available by prescription only, had been thought so safe that in 1988 it was approved for purchase over-the-counter. Here are some important questions regarding this medication: Why is it sometimes called the “poor man’s methadone”? Why, despite having typical opiate μ-receptor activity, does it generally not cause respiratory or mental status depression? Why is P-glycoprotein (P-gp) important for understanding the pharmacokinetics of loperamide, and what does that have to d...
Source: The Poison Review - July 4, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical cardiotoxicity imodium loperamide opiate P-glycoprotein Source Type: news

Toxicology Rounds: Opioid Abusers Using Loperamide to Get High or Alleviate Withdrawal, with Fatal Consequences
No abstract available (Source: Emergency Medicine News)
Source: Emergency Medicine News - July 1, 2016 Category: Emergency Medicine Tags: Toxicology Rounds Source Type: news

This month ’s toughest USMLE Step 2 question to master
Getting ready for the United States Medical Licensing Examination ® (USMLE®) Step 2 is no easy feat, but we’re sharing expert insights to help give you a leg up. Take a look at the exclusive scoop on this month’s most-missed USMLE Step 2 test prep question. Think you have what it takes to rise above your peers? Test your USMLE knowledge, and view an expert v ideo explanation of the answer from Kaplan Medical. Once you ’ve got this question under your belt, be sure to test your knowledge with  other posts in this series . Ready. Set. Go. This month ’s question that stumped most st...
Source: AMA Wire - June 28, 2016 Category: Journals (General) Authors: Troy Parks Source Type: news

This month’s toughest USMLE Step 2 question to master
Getting ready for the United States Medical Licensing Examination® (USMLE®) Step 2 is no easy feat, but we’re sharing expert insights to help give you a leg up. Take a look at the exclusive scoop on this month’s most-missed USMLE Step 2 test prep question. Think you have what it takes to rise above your peers? Test your USMLE knowledge, and view an expert video explanation of the answer from Kaplan Medical. Once you’ve got this question under your belt, be sure to test your knowledge with other posts in this series. Ready. Set. Go. This month’s question that stumped most students:...
Source: AMA Wire - June 28, 2016 Category: Journals (General) Authors: Troy Parks Source Type: news

La FDA advierte de problemas cardiacos graves con dosis altas del medicamento antidiarreico loperamida (Imodium), incluyendo por su consumo excesivo e indebido
La Administración de Alimentos y Medicamentos de los Estados Unidos (FDA, por sus siglas en inglés) advierte que tomar dosis más altas que las recomendadas del medicamento común de venta con o sin receta médica para la diarrea, loperamida (Imodium), incluso por un uso excesivo o indebido del producto, puede causar problemas cardiacos graves que pueden conducir a la muerte. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - June 14, 2016 Category: Drugs & Pharmacology Source Type: news

Why FDA is warning people about Imodium overdoses
Higher-than-recommended doses of the antidiarrheal medicine loperamide, sold under the brand name Imodium, can lead to serious heart problems and even death, the U.S. Food and Drug Administration warned this week. The warning applies to both over-the-counter and prescription strength medications, which are also sold under other generic names. (Source: CNN.com - Health)
Source: CNN.com - Health - June 9, 2016 Category: Consumer Health News Source Type: news

High Doses of Imodium Linked to Cardiac Problems and Death (FREE)
By Kelly Young Edited by David G. Fairchild, MD, MPH, and Lorenzo Di Francesco, MD, FACP, FHM The FDA is cautioning that higher-than-recommended doses of the antidiarrheal drug loperamide (Imodium) are associated with potentially fatal … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - June 7, 2016 Category: Primary Care Source Type: news

Abuse, Misuse of Antidiarrheal Linked to Serious Heart ProblemsAbuse, Misuse of Antidiarrheal Linked to Serious Heart Problems
Abuse and misuse of the commonly available antidiarrheal medication loperamide has been linked to life-threatening cardiac events, according to a warning issued by the US Food and Drug Administration. News Alerts (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 7, 2016 Category: Consumer Health News Tags: Psychiatry News Alert Source Type: news

FDA Warns of Heart Risk with Loperamide Overdose
(MedPage Today) -- Permanent and fatal arrhythmias tied to misuse of loperamide (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - June 7, 2016 Category: American Health Source Type: news

FDA Warns of Heart Risk with Imodium
(MedPage Today) -- Permanent and fatal arrhythmias tied to misuse of loperamide (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - June 7, 2016 Category: Gastroenterology Source Type: news

FDA Drug Safety Communication: FDA warns about serious heart problems with high doses of the antidiarrheal medicine loperamide (Imodium), including from abuse and misuse
[06-07-2016] The U.S. Food and Drug Administration (FDA) is warning that taking higher than recommended doses of the common over-the-counter (OTC) and prescription diarrhea medicine loperamide (Imodium), including through abuse or misuse of the product, can cause serious heart problems that can lead to death. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - June 6, 2016 Category: Drugs & Pharmacology Source Type: news

The Highs and Lows of Loperamide AbuseThe Highs and Lows of Loperamide Abuse
How an over-the-counter medication for diarrhea has become a worrying and potentially lethal drug of abuse. Medscape Emergency Medicine (Source: Medscape Emergency Medicine Headlines)
Source: Medscape Emergency Medicine Headlines - May 23, 2016 Category: Emergency Medicine Tags: Emergency Medicine Expert Interview Source Type: news

May 13 Cardiology NewsMay 13 Cardiology News
Weight loss and AF, rotor mapping in AF ablation, repeat AF ablation as a routine strategy, stroke in patients in AF on anticoagulants, and loperamide cardiotoxicity are discussed this week. theheart.org on Medscape (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 13, 2016 Category: Consumer Health News Tags: Cardiology News Source Type: news

OTC Diarrhea Drug Increasingly Being Misused for Opioid Effects
By Amy Orciari Herman Edited by Susan Sadoughi, MD, and Richard Saitz, MD, MPH, FACP, FASAM The over-the-counter antidiarrheal loperamide (sold as Imodium and others) can lead to central nervous system and respiratory depression, dysrhythmias, and … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - May 11, 2016 Category: Primary Care Source Type: news

Addicts Who Can’t Find Painkillers Turn to Anti-Diarrhea Drugs
The opioid epidemic has led to a form of drug abuse that few experts saw coming: the use of Imodium and other anti-diarrhea medications to get high. (Source: NYT Health)
Source: NYT Health - May 11, 2016 Category: Consumer Health News Authors: CATHERINE SAINT LOUIS Tags: Addiction (Psychology) Pain-Relieving Drugs Drug Abuse and Traffic imodium Annals of Emergency Medicine Eggleston, William Source Type: news

Ingredient in anti-diarrhea medication used to self-treat opioid addiction with dangerous results, Upstate Poison Center study shows
Loperamide's abuse has has fatal consequences, says Poison Center expert (Source: SUNY Upstate Medical)
Source: SUNY Upstate Medical - May 7, 2016 Category: Universities & Medical Training Source Type: news

Addicts turning to anti-diarrhea medication to get high
Experts say some desperate addicts are taking dangerously high doses of Imodium A-D (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - May 6, 2016 Category: Consumer Health News Source Type: news

Addicts Using Diarrhea Drug Imodium to Get High
Trend is increasing among those who can't get opioid prescription painkillers, experts say (Source: WebMD Health)
Source: WebMD Health - May 5, 2016 Category: Consumer Health News Source Type: news

Addicts Using Diarrhea Drug Imodium to Get High
Trend is increasing among those who can't get opioid prescription painkillers, experts saySource: HealthDay Related MedlinePlus Pages: Drug Abuse, Prescription Drug Abuse (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - May 5, 2016 Category: Consumer Health News Source Type: news

Addicts Using Diarrhea Drug Imodium to Get High
THURSDAY, May 5, 2016 -- Searching for an alternative to opioid painkillers such as Oxycontin and Vicodin, some addicts are now turning to the diarrhea drug Imodium for a high, researchers say. This abuse of Imodium -- with its key ingredient,... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - May 5, 2016 Category: Journals (General) Source Type: news

Doctors warn against deadly trend of using anti-diarrhoea drugs like Imodium to get high
Two case studies outlining the disturbing phenomenon have been published online by the journal Annals of Emergency Medicine. The key ingredient loperamide is to blame, doctors say. (Source: the Mail online | Health)
Source: the Mail online | Health - May 4, 2016 Category: Consumer Health News Source Type: news

Getting High From This Drug For Diarrhea Can Be Fatal
An increasing number of opioid abusers are taking huge doses of Imodium to ease withdrawal symptoms or get high. But at those high doses, toxicologists warn, the normally safe drug can stop the heart. (Source: NPR Health and Science)
Source: NPR Health and Science - May 3, 2016 Category: Consumer Health News Authors: Alison Kodjak Source Type: news

Getting high on Imodium dangerous, growing in popularity
Stephen FellerWASHINGTON, May 3 (UPI) -- People are using large doses of Imodium for self-treatment of opioid addiction, or just to get high, which researchers say poses a significant danger to health. (Source: Health News - UPI.com)
Source: Health News - UPI.com - May 3, 2016 Category: Consumer Health News Source Type: news

Imodium abuse: Anti-diarrhea medication containing loperamide dangerous for self-treatment of opiod addiction
The over-the-counter anti-diarrhea medication Imodium, or its key ingredient loperamide, is increasingly being abused by people attempting to self-treat their opioid addiction, with sometime fatal results. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 3, 2016 Category: Science Source Type: news

Imodium for a legal high is as dumb and dangerous as it sounds
(American College of Emergency Physicians) WASHINGTON -- The over-the-counter anti-diarrhea medication Imodium®, or its key ingredient loperamide, is increasingly being abused by people attempting to self-treat their opioid addiction, with sometime fatal results. Two case studies outlining the phenomenon were published online Friday in Annals of Emergency Medicine ('Loperamide Abuse Associated with Cardiac Dysrhythmia and Death'). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 3, 2016 Category: Global & Universal Source Type: news

Cardiac effects of loperamide overdose
3 out of 5 stars Not your regular high: cardiac dysrhythmias caused by loperamide. Wightman RS et al. Clin Toxicol 2016 Jun;54:454-458 Abstract Loperamide is an over-the-counter anti-diarrhea medication that is available without prescription under a variety of brand names including Imodium. In therapeutic doses, loperamide acts as a peripheral mu-opioid receptor agonist but doesn’t cross the blood-brain barrier (BBB). However, in massive overdose loperamide can enter the brain and cause central opioid toxicity, including altered mental status and respiratory. Although previously loperamide was thought ...
Source: The Poison Review - April 29, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical cardiac effects cardiogoxicity long QT loperamide overdose QRS interval qt interval Source Type: news

Should Ondansetron Be Used for Acute Gastroenteritis?
Discussion Acute gastroenteritis (AGE) is a common illness worldwide and is “…defined as a decrease in the consistency of stools (loose or liquid) and/or an increase in the frequency of evacuations with or without fever or vomiting….” It is one of the most common reasons for seeking medical care and hospitalizations. In Europe, rotavirus and noroviruses are two of the most frequent viral agents causing AGE and Campylobacter and Salmonella are the most common bacterial AGE causes. For parasitic infections Giardia, and Crytosporidium are most common parasitic infections in Europe. Recommendations f...
Source: PediatricEducation.org - August 24, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

loperamide, Imodium A-D, Anti-Diarrheal, TH Anti-Diarrheal, Diamode, Imodium, Kaopectate II, Imodium
Title: loperamide, Imodium A-D, Anti-Diarrheal, TH Anti-Diarrheal, Diamode, Imodium, Kaopectate II, ImodiumCategory: MedicationsCreated: 7/23/1998 12:00:00 AMLast Editorial Review: 2/24/2015 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - February 24, 2015 Category: Nutrition Source Type: news

'Your Blood Tested Positive for Ebola. I Am Sorry.'
This was originally published on GatesNotes.com Once in a while, you read something that's so compelling, you want to share it with everyone you can. Dr. Ada Igonoh's story had that effect on me. Dr. Igonoh is a physician in Lagos, Nigeria, where she helped care for Patrick Sawyer, the patient who introduced Ebola into Nigeria in July. After coming down with the deadly virus herself, she spent two harrowing weeks getting treatment in isolation wards. When I met her at a conference in New Orleans last week, Dr. Igonoh handed me a written account of her experience. Even knowing she was going to be okay, I couldn't stop re...
Source: Healthy Living - The Huffington Post - November 16, 2014 Category: Consumer Health News Source Type: news

Psyllium as Effective as Loperamide for Fecal IncontinencePsyllium as Effective as Loperamide for Fecal Incontinence
Episodes of fecal incontinence can be nearly halved with either psyllium fiber or loperamide, a crossover placebo-controlled trial has shown. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 20, 2014 Category: Consumer Health News Tags: Internal Medicine News Source Type: news

Summary: International Kidney Cancer Symposium
Conclusions VHL/PBRM1 mutations confirmed 3rd subtype identified and under review but appears to be mis-classified tumors.  Shows value of molecular methods rather than new mechanistic insights. Integration with survival outcome—suggests molecular detailing can be prognostic Full integrative analysis in process Preliminary data can be found at http://tcga-data.nci.hih.gov/tcga/ FoxO Transcription Factors in mTORC1- Activated Renal Tumorigenesis:  Implications for the RCC Treatment Boyi Gan, MD Anderson Cancer Center FoxO Family Transcription Factors:  mammals possess FoxO...
Source: Kidney Cancer Association - December 15, 2011 Category: Urology & Nephrology Source Type: news