Loperamide ingestions and cardiotoxicity reported to Texas poison centers, 2004-2021 - Baillio M, Tarkenton T, Stuteville H, Varney SM.
BACKGROUND: Loperamide is an over-the-counter anti-diarrheal mu-opioid analogue that has appeared more frequently in emergency department patients in excessive doses to mitigate opioid cravings and withdrawal symptoms. Given the concern for its abuse poten... (Source: SafetyLit)
Source: SafetyLit - April 4, 2024 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Loperamide cases reported to United States poison centers, 2010-2022 - Patel A, Rine NI, Spiller HA, Hays H, Badeti J, Zhu M, Ding K, Smith GA.
The objective of this study is to investigate the characteristics and trends of loperamide cases reported to United States (US) poison centers and to evalu... (Source: SafetyLit)
Source: SafetyLit - November 27, 2023 Category: International Medicine & Public Health Tags: Poisoning Source Type: news
The potential mechanisms behind loperamide-induced cardiac arrhythmias associated with human abuse and extreme overdose - Lu HR, Damiano BP, Kreir M, Rohrbacher J, van der Linde H, Saidov T, Teisman A, Gallacher DJ.
Loperamide has been a safe and effective treatment for diarrhea for many years. However, many cases of cardiotoxicity with intentional abuse of loperamide ingestion have recently been reported. We evaluated loperamide in in vitro and in vivo cardiac safety... (Source: SafetyLit)
Source: SafetyLit - October 2, 2023 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
La FDA advierte de problemas cardiacos graves con dosis altas del medicamento antidiarreico loperamida (Imodium), incluyendo por su consumo excesivo e indebido
La Administraci ón de Alimentos y Medicamentos de los Estados Unidos (FDA, por sus siglas en inglés) advierte que tomar dosis más altas que las recomendadas del medicamento común de venta con o sin receta médica para la diarrea, loperamida (Imodium), incluso por un uso excesivo o indebido del product (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - August 25, 2023 Category: Drugs & Pharmacology Authors: FDA Source Type: news
Perspectives of and experience toward the abuse of antidiarrheal drug (loperamide) among community pharmacists: a cross-sectional study - Barakat M, Akour A, Malaeb D, Cherri S, Al Safadi W, Al Safadi A, Wazaify M.
This study aimed to assess the ability of community pharmacists to recognize cases of loperamide abuse at the point of sale, their perspective of and experience toward potential abuse cases. METHODS: A cross-sectional study was conducted in Jordan,... (Source: SafetyLit)
Source: SafetyLit - July 31, 2023 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Ventricular arrhythmias associated with over-the-counter and recreational opioids - Krantz MJ, Rudo TJ, Haigney MCP, Stockbridge N, Kleiman RB, Klein M, Kao DP.
BACKGROUND: Epidemic increases in opioid deaths prompted policies limiting access to prescription opioids in North America. Consequently, the over-the-counter opioids loperamide (Imodium A-D) and mitragynine, the herbal ingredient in kratom, are increasing... (Source: SafetyLit)
Source: SafetyLit - June 9, 2023 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Johnson & Johnson Reports Q1 2023 Results
New Brunswick, N.J. (April 18, 2023) – Johnson & Johnson (NYSE: JNJ) today announced results for first-quarter 2023. “Our first quarter results demonstrate strong performance across all three segments of our business and reflect the dedication of Johnson & Johnson colleagues around the world,” said Joaquin Duato, Chairman of the Board and Chief Executive Officer. “With this momentum, I look forward to the remainder of the year, one filled with exciting catalysts that will create both near- and long-term value for patients and all of our stakeholders.”OVERALL FINANCIAL RESULTSQ1($ in Millions, except EPS)2...
Source: Johnson and Johnson - April 18, 2023 Category: Pharmaceuticals Tags: Financial Source Type: news
What Clinicians Need to Know About Loperamide Misuse
(MedPage Today) -- Loperamide, the active ingredient in Imodium, is readily available in over-the-counter (OTC) anti-diarrheal agents that are safe when used as directed. Sources have reported cases of people misusing extreme high doses of loperamide... (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - February 23, 2023 Category: Psychiatry Source Type: news
Coping With the Side Effects of Kidney-Cancer Treatment
Not long ago, the treatment options available to people with metastatic kidney cancer were few and feeble. Surgical removal of the affected tissue was an effective and often durable fix for people with cancer that was confined to the kidneys. But for the roughly 30% to 40% of people with kidney cancer that spreads to other parts of the body, the prognosis was dispiritingly grim.
Fortunately, things are much different today. “Since the early 2000s, we’ve had a class of drugs called blood-vessel inhibitors, and these made an immediate impact,” says Dr. Primo Lara, a professor, clinician, and director of the...
Source: TIME: Health - October 27, 2022 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized Cancer healthscienceclimate Source Type: news
Johnson & Johnson Reports Q2 2022 Results
New Brunswick, N.J. (July 19, 2022) – Johnson & Johnson (NYSE: JNJ) today announced results for second-quarter 2022. “Our solid second quarter results across Johnson & Johnson reflect the strength and resilience of our Company’s market leadership in the midst of macroeconomic challenges,” said Joaquin Duato, Chief Executive Officer. “I am continually energized by the focus and passion of my Johnson & Johnson colleagues and their dedication toward delivering transformative healthcare solutions to patients and consumers around the world.”OVERALL FINANCIAL RESULTS
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Source: Johnson and Johnson - July 19, 2022 Category: Pharmaceuticals Tags: Financial Source Type: news
Johnson & Johnson Reports Q1 2022 Results
New Brunswick, N.J. (April 19, 2022) – Johnson & Johnson (NYSE: JNJ) today announced results for first-quarter 2022. “Our first quarter results demonstrate strong performance across the enterprise, despite macro-economic headwinds. I am incredibly proud of Johnson & Johnson’s 144,000 employees for their relentless passion and Credo-based commitment to delivering transformative healthcare solutions to patients and customers around the world,” said Joaquin Duato, Chief Executive Officer. “Looking ahead, I remain confident in the future of Johnson & Johnson as we continue advancing our portfolio and inno...
Source: Johnson and Johnson - April 19, 2022 Category: Pharmaceuticals Tags: Financial Source Type: news
DR PHILLIPA KAY: How to save money on over-the-counter medication
DR PHILLIPA KAY: I also warn patients not to get fooled into shelling out for expensive branded products, such as Imodium or Nurofen, when you can get generic versions for a fraction of the price. (Source: the Mail online | Health)
Source: the Mail online | Health - February 5, 2022 Category: Consumer Health News Source Type: news
FDA Drug Safety Communication: FDA warns about serious heart problems with high doses of the antidiarrheal medicine loperamide (Imodium), including from abuse and misuse
[06-07-2016] The U.S. Food and Drug Administration (FDA) is warning that taking higher than recommended doses of the common over-the-counter (OTC) and prescription diarrhea medicine loperamide (Imodium), including through abuse or misuse of the product, can cause serious heart problems that can lead to death. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - June 29, 2021 Category: Drugs & Pharmacology Authors: FDA Source Type: news
Pharmacological aspects of over-the-counter opioid drugs misuse - Sobczak, Gory ński K.
Several over-the-counter (OTC) drugs are known to be misused. Among them are opioids such as codeine, dihydrocodeine, and loperamide. This work elucidates their pharmacology, interactions, safety profiles, and how pharmacology is being manipulated to misus... (Source: SafetyLit)
Source: SafetyLit - September 5, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Loperamide abuse and its sequelae - Strzyzewski L, Key P, Jones P, Prahlow JA.
INTRODUCTION: Loperamide is an opioid available over the counter and in prescription form. Loperamide functions as a μ-agonist within the enteric nervous system to slow intestinal motility. Its antidiarrheal properties and primarily peripheral activity ma... (Source: SafetyLit)
Source: SafetyLit - August 18, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
