P2Y1 receptor in the colonic submucosa of rats and its association with opioid ‑induced constipation
Exp Ther Med. 2022 Dec 13;25(1):67. doi: 10.3892/etm.2022.11766. eCollection 2023 Jan.ABSTRACTThe aim of the present study was to explore the expression changes of P2Y purinergic receptor 1 (P2Y1) in the distal colonic submucosa of opioid-induced constipation (OIC) rats and its association with the occurrence of OIC, an OIC rat model was generated by intraperitoneal injection of loperamide hydrochloride, a selective agonist of µ-opioid receptors (MORs). At 7 days post-treatment, the model was assessed by analyzing stool scores and calculating the gastrointestinal (GI) transit ratio of rats. The distribution of P2Y1-expres...
Source: Experimental and Therapeutic Medicine - January 6, 2023 Category: General Medicine Authors: Yuqiong Zhao Xiaojie Ren Fan Li Binghan Jia Dengke Wang Hua Jia Xuwen Jiao Lixin Wang Junping Li Source Type: research
Analgesic effect of structured anal skin care for perianal dermatitis after low anterior resection in the rectal cancer patients: prospective, single-center, open-label, therapeutic confirmatory, randomized clinical trial
CONCLUSION: Structured anal skin care has a significant analgesic effect in reducing anal pain and improving anal skin conditions in patients with LARS after rectal cancer surgery.PMID:36601338 | PMC:PMC9763779 | DOI:10.4174/astr.2022.103.6.360 (Source: Annals of Surgical Treatment and Research)
Source: Annals of Surgical Treatment and Research - January 5, 2023 Category: Surgery Authors: Gyung Mo Son In Young Lee Mi Sook Yun Jung-Hea Youn Hong Min An Kyung Hee Kim Seung Mi Yeo Bokyung Ku Myeong Suk Kwon Kun Hyung Kim Source Type: research
