A comparative analysis of depressive-like behavior: Exploring sex-related differences and insights
This study compares circulating plasma corticosterone levels [CORT] and behavioral alterations in mice exposed to sucrose preference, forced swimming, and tail suspension tests (SPT, FST, and TST, respectively). While SPT exposure did not significantly alter [CORT], FST and TST showed notable changes. Mice in the TST exhibited increased movement and decreased immobility time compared to FST, suggesting a lower likelihood of depressive-like behavior in male mice. Not ably, during the proestrus phase, female mice displayed the highest tendency for depressive-like behavior and elevated [CORT], but similar response to antidepr...
Source: PLoS One - November 29, 2023 Category: Biomedical Science Authors: Ana Carolina Cavalcante Rodrigues Source Type: research
Pharmacological treatments in panic disorder in adults: a network meta-analysis
CONCLUSIONS: In terms of efficacy, SSRIs, SNRIs (venlafaxine), TCAs, MAOIs and BDZs may be effective, with little difference between classes. However, it is important to note that the reliability of these findings may be limited due to the overall low quality of the studies, with all having unclear or high risk of bias across multiple domains. Within classes, some differences emerged. For example, amongst the SSRIs paroxetine and fluoxetine seem to have stronger evidence of efficacy than sertraline. Benzodiazepines appear to have a small but significant advantage in terms of tolerability (incidence of dropouts) over other ...
Source: Cochrane Database of Systematic Reviews - November 28, 2023 Category: General Medicine Authors: Giuseppe Guaiana Nicholas Meader Corrado Barbui Simon Jc Davies Toshi A Furukawa Hissei Imai Sofia Dias Deborah M Caldwell Markus Koesters Aran Tajika Irene Bighelli Alessandro Pompoli Andrea Cipriani Sarah Dawson Lindsay Robertson Source Type: research
Pharmacological treatments in panic disorder in adults: a network meta-analysis
CONCLUSIONS: In terms of efficacy, SSRIs, SNRIs (venlafaxine), TCAs, MAOIs and BDZs may be effective, with little difference between classes. However, it is important to note that the reliability of these findings may be limited due to the overall low quality of the studies, with all having unclear or high risk of bias across multiple domains. Within classes, some differences emerged. For example, amongst the SSRIs paroxetine and fluoxetine seem to have stronger evidence of efficacy than sertraline. Benzodiazepines appear to have a small but significant advantage in terms of tolerability (incidence of dropouts) over other ...
Source: Cochrane Database of Systematic Reviews - November 28, 2023 Category: General Medicine Authors: Giuseppe Guaiana Nicholas Meader Corrado Barbui Simon Jc Davies Toshi A Furukawa Hissei Imai Sofia Dias Deborah M Caldwell Markus Koesters Aran Tajika Irene Bighelli Alessandro Pompoli Andrea Cipriani Sarah Dawson Lindsay Robertson Source Type: research
Lysosomal membrane stabilization by imipramine attenuates gentamicin-induced renal injury: Enhanced LAMP2 expression, down-regulation of cytoplasmic cathepsin D and tBid/cytochrome c/cleaved caspase-3 apoptotic signaling
This study was designed to evaluate the prospective defensive effect of lysosomal membrane stabilization by imipramine (IMP) against GTM nephrotoxicity in rats. GTM (30 mg/kg/h) was intraperitoneally administered over 4 h daily (120 mg/kg/day) for 7 days. IMP (30 mg/kg/day) was orally administered for 14 days; starting 7 days before and then concurrently with GTM. On 15th day, samples (urine, blood, kidney) were collected to estimate biomarkers of kidney function, lysosomal stability, apoptosis, and inflammation. IMP administration to GTM-treated rats ameliorated the disruption in lysosomal membrane stability induced by GT...
Source: International Immunopharmacology - November 23, 2023 Category: Allergy & Immunology Authors: Dina A Hanna Basim A S Messiha Ali A Abo-Saif Fares E M Ali Amany A Azouz Source Type: research
Lysosomal membrane stabilization by imipramine attenuates gentamicin-induced renal injury: Enhanced LAMP2 expression, down-regulation of cytoplasmic cathepsin D and tBid/cytochrome c/cleaved caspase-3 apoptotic signaling
This study was designed to evaluate the prospective defensive effect of lysosomal membrane stabilization by imipramine (IMP) against GTM nephrotoxicity in rats. GTM (30 mg/kg/h) was intraperitoneally administered over 4 h daily (120 mg/kg/day) for 7 days. IMP (30 mg/kg/day) was orally administered for 14 days; starting 7 days before and then concurrently with GTM. On 15th day, samples (urine, blood, kidney) were collected to estimate biomarkers of kidney function, lysosomal stability, apoptosis, and inflammation. IMP administration to GTM-treated rats ameliorated the disruption in lysosomal membrane stability induced by GT...
Source: International Immunopharmacology - November 23, 2023 Category: Allergy & Immunology Authors: Dina A Hanna Basim A S Messiha Ali A Abo-Saif Fares E M Ali Amany A Azouz Source Type: research
Investigation of mechanisms of action involved in the antidepressant-like effect of Trans,trans-farnesol in mice antidepressant-like effect of Trans,trans-farnesol in mice
This study aimed to investigate, through in vivo and biochemical methodologies, the effect of trans,trans-farnesol (12.5, 25, 50 or 100 mg/kg, p.o.) acute administration, adopting different behavioral and neurochemical parameters associated with an acute induced-depression model in mice. The initial results showed that, the oral treatment with trans,trans-farnesol, at the dose of 100 mg/kg induced a possible antidepressant-like effect in animals subjected to forced swim test (FST) and reserpine-induced akinesia. In addition, it was observed that the compound in question has an effect size and properties similar to imiprami...
Source: Chemico-Biological Interactions - November 3, 2023 Category: Molecular Biology Authors: Gyllyandeson de Ara újo Delmondes Maria Janice Pereira Lopes Alex de Sousa Borges Daniel Souza Bezerra Jairo Pessoa da Silva Bruna Silva Souto Jadson Galdino da Silva Costa Paula Elo íse de Sousa Campos Temistocles Italo de Santana Henrique Douglas Melo Source Type: research
A new MAS-related G protein-coupled receptor X2 cell membrane chromatography analysis model based on HALO-tag technology and its applications
Talanta. 2023 Oct 18;268(Pt 1):125317. doi: 10.1016/j.talanta.2023.125317. Online ahead of print.ABSTRACTCell membrane chromatography (CMC) is an effective method for studying receptors with multiple transmembrane structure such as MAS-related G protein-coupled receptor X2 (MrgX2). CMC relies on the maintenance of the complete biological structure of a membrane receptor; however, it needs to be further improved to obtain a more convenient and stable CMC model. In the present study, the haloalkane dehalogenase protein tag (HALO-tag) technology was used to construct a new MrgX2/CMC model. The fusion receptors of MrgX2 with H...
Source: Talanta - October 25, 2023 Category: Chemistry Authors: Qianqian Jia Yanni Lv Chenyang Miao Jingting Feng Yifan Ding Tongpei Zhou Shengli Han Langchong He Source Type: research
A new MAS-related G protein-coupled receptor X2 cell membrane chromatography analysis model based on HALO-tag technology and its applications
Talanta. 2023 Oct 18;268(Pt 1):125317. doi: 10.1016/j.talanta.2023.125317. Online ahead of print.ABSTRACTCell membrane chromatography (CMC) is an effective method for studying receptors with multiple transmembrane structure such as MAS-related G protein-coupled receptor X2 (MrgX2). CMC relies on the maintenance of the complete biological structure of a membrane receptor; however, it needs to be further improved to obtain a more convenient and stable CMC model. In the present study, the haloalkane dehalogenase protein tag (HALO-tag) technology was used to construct a new MrgX2/CMC model. The fusion receptors of MrgX2 with H...
Source: Talanta - October 25, 2023 Category: Chemistry Authors: Qianqian Jia Yanni Lv Chenyang Miao Jingting Feng Yifan Ding Tongpei Zhou Shengli Han Langchong He Source Type: research
A new MAS-related G protein-coupled receptor X2 cell membrane chromatography analysis model based on HALO-tag technology and its applications
Talanta. 2023 Oct 18;268(Pt 1):125317. doi: 10.1016/j.talanta.2023.125317. Online ahead of print.ABSTRACTCell membrane chromatography (CMC) is an effective method for studying receptors with multiple transmembrane structure such as MAS-related G protein-coupled receptor X2 (MrgX2). CMC relies on the maintenance of the complete biological structure of a membrane receptor; however, it needs to be further improved to obtain a more convenient and stable CMC model. In the present study, the haloalkane dehalogenase protein tag (HALO-tag) technology was used to construct a new MrgX2/CMC model. The fusion receptors of MrgX2 with H...
Source: Talanta - October 25, 2023 Category: Chemistry Authors: Qianqian Jia Yanni Lv Chenyang Miao Jingting Feng Yifan Ding Tongpei Zhou Shengli Han Langchong He Source Type: research
Clinical values of serum neuropeptide changes in patients with chronic urticaria complicated with allergic rhinitis
ConclusionsOur data indicates that substance P, VIP, and neuropeptide Y levels before treatment correlate strongly with the treatment outcomes of the patients, which could potentially serve as a decision support tool in clinical management of chronic urticaria complicated with allergic rhinitis. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - October 24, 2023 Category: General Medicine Source Type: research
Design, Docking, Characterisation, and Synthesis of Pyrimidine Derivatives for Antidepressant Activity
CONCLUSION: Compound 24 showed the highest MolDock score as well as found to be the most potent antidepressant agent.PMID:37859311 | DOI:10.2174/0115701638243835230925161546 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 20, 2023 Category: Drugs & Pharmacology Authors: Ashwini Jadhav Sunil G Shingade Prachita Gauns Dessai Bheemanagouda S Biradar Shivalingrao MamleDesai Source Type: research
Ginsenoside Rg1 ameliorates depressive-like behavior by inhibiting NLRP3 inflammasome activation in mice exposed to chronic stress
Eur J Pharmacol. 2023 Oct 18:176120. doi: 10.1016/j.ejphar.2023.176120. Online ahead of print.ABSTRACTMicroglia-mediated inflammatory process is recognized as a target in the treatment of depression. Ginsenoside Rg1 (GRg1), the active ingredient of traditional ginseng, regulates microglial phenotypes to resist stress-induced inflammatory responses. Here we used a mouse model of stress-induced depression to investigate the involvement of microglial Nod-like receptor protein 3 (NLRP3) in the antidepressant effects of GRg1. Male C57BL/6J mice were exposed to chronic mild stress (CMS) for three weeks, followed by intraperitone...
Source: European Journal of Pharmacology - October 20, 2023 Category: Drugs & Pharmacology Authors: Hui He Xiaofang Xie Xixi Kang Jinqiang Zhang Lu Wang Nan Hu Lei Xie Cheng Peng Zili You Source Type: research
Design, Docking, Characterisation, and Synthesis of Pyrimidine Derivatives for Antidepressant Activity
CONCLUSION: Compound 24 showed the highest MolDock score as well as found to be the most potent antidepressant agent.PMID:37859311 | DOI:10.2174/0115701638243835230925161546 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 20, 2023 Category: Drugs & Pharmacology Authors: Ashwini Jadhav Sunil G Shingade Prachita Gauns Dessai Bheemanagouda S Biradar Shivalingrao MamleDesai Source Type: research
Ginsenoside Rg1 ameliorates depressive-like behavior by inhibiting NLRP3 inflammasome activation in mice exposed to chronic stress
Eur J Pharmacol. 2023 Oct 18:176120. doi: 10.1016/j.ejphar.2023.176120. Online ahead of print.ABSTRACTMicroglia-mediated inflammatory process is recognized as a target in the treatment of depression. Ginsenoside Rg1 (GRg1), the active ingredient of traditional ginseng, regulates microglial phenotypes to resist stress-induced inflammatory responses. Here we used a mouse model of stress-induced depression to investigate the involvement of microglial Nod-like receptor protein 3 (NLRP3) in the antidepressant effects of GRg1. Male C57BL/6J mice were exposed to chronic mild stress (CMS) for three weeks, followed by intraperitone...
Source: European Journal of Pharmacology - October 20, 2023 Category: Drugs & Pharmacology Authors: Hui He Xiaofang Xie Xixi Kang Jinqiang Zhang Lu Wang Nan Hu Lei Xie Cheng Peng Zili You Source Type: research
