Imipramine Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Design, Docking, Characterisation, and Synthesis of Pyrimidine Derivatives for Antidepressant Activity
CONCLUSION: Compound 24 showed the highest MolDock score as well as found to be the most potent antidepressant agent.PMID:37859311 | DOI:10.2174/0115701638243835230925161546 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 20, 2023 Category: Drugs & Pharmacology Authors: Ashwini Jadhav Sunil G Shingade Prachita Gauns Dessai Bheemanagouda S Biradar Shivalingrao MamleDesai Source Type: research

Evidence-based severity assessment of the forced swim test in the rat
We examined parameters representing the physiological and the affective state, and natural a s well as locomotion-associated behaviors in three separate experiments to reflect as many dimensions as possible of the animal’s condition in the test. Hypothermia was the only effect observed in all animals exposed to the FST when using this standard protocol. Additional adverse effects on body weight, food consumption, and fecal corticosterone metabolite concentrations occurred in response to administration of the antidepressant imipramine, which is frequently used as positive control when testing for antidepressant effects of...
Source: PLoS One - October 12, 2023 Category: Biomedical Science Authors: Laura Becker Source Type: research

Involvement of indoleamine 2, 3-dioxygenase (IDO) and brain-derived neurotrophic factor (BDNF) in the neuroprotective mechanisms of ferulic acid against depressive-like behaviour
Conclusion: The results of this study emphasise that low dose of FA is effective in attenuating depressive-like behaviour by modulating IDO, BDNF and reducing neuroinflammation. (Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - October 1, 2023 Category: Neurology Source Type: research

Differential targeting of lysophosphatidic acid LPA 1 , LPA 2 , and LPA 3 receptor signalling by tricyclic and tetracyclic antidepressants
Eur J Pharmacol. 2023 Sep 25:176064. doi: 10.1016/j.ejphar.2023.176064. Online ahead of print.ABSTRACTWe previously reported that in different cell types antidepressant drugs activate lysophosphatidic acid (LPA) LPA1 receptor to induce proliferative and prosurvival responses. Here, we further characterize this unique action of antidepressants by examining their effects on two additional LPA receptor family members, LPA2 and LPA3. Human LPA1-3 receptors were stably expressed in HEK-293 cells (HEK-LPA1, -LPA2 and -LPA3 cells) and their functional activity was determined by Western blot and immunofluorescence. LPA effectively...
Source: European Journal of Pharmacology - September 27, 2023 Category: Drugs & Pharmacology Authors: Maria C Olianas Simona Dedoni Pierluigi Onali Source Type: research

Involvement of indoleamine 2, 3-dioxygenase (IDO) and brain-derived neurotrophic factor (BDNF) in the neuroprotective mechanisms of ferulic acid against depressive-like behaviour
Conclusion: The results of this study emphasise that low dose of FA is effective in attenuating depressive-like behaviour by modulating IDO, BDNF and reducing neuroinflammation. (Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - September 15, 2023 Category: Neurology Source Type: research

Neuroprotective effects of goji berry (Lycium barbarum L.) polysaccharides on depression-like behavior in ovariectomized rats: behavioral and biochemical evidence
CONCLUSION: This is the first study to show the antidepressant effect of LBP. Although additional research is needed, LBP may be considered a potential new antidepressant.PMID:37654035 (Source: Croatian Medical Journal)
Source: Croatian Medical Journal - September 1, 2023 Category: General Medicine Authors: Hayriye Soyt ürk Bihter G ökçe Bozat Fatma Pehlivan Karakas Hamit Coskun Tulin Firat Source Type: research