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Physiologically Based Pharmacokinetic Model of Brain Delivery of Plasma Protein Bound Drugs
ConclusionsIn vitro measurement of free drug concentration in plasma under-estimates the free drug in brainin vivo if PMUin vivo from either the albumin and/or the AGP pools in plasma takes place at the BBB surface. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - February 24, 2023 Category: Drugs & Pharmacology Source Type: research