Inhibitory Effects of Tricyclic Antidepressants on Human Liver Microsomal Morphine Glucuronidation: Application of IVIVE to Predict Potential Drug-Drug Interactions in Humans
CONCLUSION: The results suggest that the likelihood of potential clinical DDIs arising from tricyclic antidepressant inhibition on morphine glucuronidation is low.PMID:38270153 | DOI:10.2174/0113892002270594231212090958 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 25, 2024 Category: Drugs & Pharmacology Authors: Verawan Uchaipichat Source Type: research
Inhibitory Effects of Tricyclic Antidepressants on Human Liver Microsomal Morphine Glucuronidation: Application of IVIVE to Predict Potential Drug-Drug Interactions in Humans
CONCLUSION: The results suggest that the likelihood of potential clinical DDIs arising from tricyclic antidepressant inhibition on morphine glucuronidation is low.PMID:38270153 | DOI:10.2174/0113892002270594231212090958 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 25, 2024 Category: Drugs & Pharmacology Authors: Verawan Uchaipichat Source Type: research
Inhibitory Effects of Tricyclic Antidepressants on Human Liver Microsomal Morphine Glucuronidation: Application of IVIVE to Predict Potential Drug-Drug Interactions in Humans
CONCLUSION: The results suggest that the likelihood of potential clinical DDIs arising from tricyclic antidepressant inhibition on morphine glucuronidation is low.PMID:38270153 | DOI:10.2174/0113892002270594231212090958 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 25, 2024 Category: Drugs & Pharmacology Authors: Verawan Uchaipichat Source Type: research
Inhibitory Effects of Tricyclic Antidepressants on Human Liver Microsomal Morphine Glucuronidation: Application of IVIVE to Predict Potential Drug-Drug Interactions in Humans
CONCLUSION: The results suggest that the likelihood of potential clinical DDIs arising from tricyclic antidepressant inhibition on morphine glucuronidation is low.PMID:38270153 | DOI:10.2174/0113892002270594231212090958 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 25, 2024 Category: Drugs & Pharmacology Authors: Verawan Uchaipichat Source Type: research
Inhibitory Effects of Tricyclic Antidepressants on Human Liver Microsomal Morphine Glucuronidation: Application of IVIVE to Predict Potential Drug-Drug Interactions in Humans
CONCLUSION: The results suggest that the likelihood of potential clinical DDIs arising from tricyclic antidepressant inhibition on morphine glucuronidation is low.PMID:38270153 | DOI:10.2174/0113892002270594231212090958 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 25, 2024 Category: Drugs & Pharmacology Authors: Verawan Uchaipichat Source Type: research
Inhibitory Effects of Tricyclic Antidepressants on Human Liver Microsomal Morphine Glucuronidation: Application of IVIVE to Predict Potential Drug-Drug Interactions in Humans
CONCLUSION: The results suggest that the likelihood of potential clinical DDIs arising from tricyclic antidepressant inhibition on morphine glucuronidation is low.PMID:38270153 | DOI:10.2174/0113892002270594231212090958 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 25, 2024 Category: Drugs & Pharmacology Authors: Verawan Uchaipichat Source Type: research
The Practice of Prescribing Antidepressants During Pregnancy and Breastfeeding Among Mental Health Practitioners in Tertiary Care Centers in Oman
CONCLUSIONS: There was inconsistency among mental health practitioners in making prescription decisions and in their prescribing patterns.PMID:38264515 | PMC:PMC10801695 | DOI:10.5001/omj.2023.123 (Source: Oman Medical Journal)
Source: Oman Medical Journal - January 24, 2024 Category: Middle East Health Authors: Salim Al Kasbi Yousif Obaid Samir Al Adawi Sanjay Jaju Source Type: research
Is cognitive behavioral therapy more effective than pharmacotherapy for binge spectrum disorders? A systematic review and meta-analysis
CONCLUSIONS: Data are scarce, comparisons underpowered and, considering the inherent methodological limitations of psychotherapy trials, questions arise regarding the presumed superiority of cognitive behavioral therapy. Further research is needed.PMID:38179705 | DOI:10.1177/00048674231219593 (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - January 5, 2024 Category: Psychiatry Authors: Myrto T Samara Niki Michou Andreas S Lappas Aikaterini Argyrou Elissavet Mathioudaki Dimitra Rafailia Bakaloudi Eirini Tsekitsidi Zoi A Polyzopoulou Nikos Christodoulou Georgios Papazisis Michail Chourdakis Source Type: research
Is cognitive behavioral therapy more effective than pharmacotherapy for binge spectrum disorders? A systematic review and meta-analysis
CONCLUSIONS: Data are scarce, comparisons underpowered and, considering the inherent methodological limitations of psychotherapy trials, questions arise regarding the presumed superiority of cognitive behavioral therapy. Further research is needed.PMID:38179705 | DOI:10.1177/00048674231219593 (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - January 5, 2024 Category: Psychiatry Authors: Myrto T Samara Niki Michou Andreas S Lappas Aikaterini Argyrou Elissavet Mathioudaki Dimitra Rafailia Bakaloudi Eirini Tsekitsidi Zoi A Polyzopoulou Nikos Christodoulou Georgios Papazisis Michail Chourdakis Source Type: research
Is cognitive behavioral therapy more effective than pharmacotherapy for binge spectrum disorders? A systematic review and meta-analysis
CONCLUSIONS: Data are scarce, comparisons underpowered and, considering the inherent methodological limitations of psychotherapy trials, questions arise regarding the presumed superiority of cognitive behavioral therapy. Further research is needed.PMID:38179705 | DOI:10.1177/00048674231219593 (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - January 5, 2024 Category: Psychiatry Authors: Myrto T Samara Niki Michou Andreas S Lappas Aikaterini Argyrou Elissavet Mathioudaki Dimitra Rafailia Bakaloudi Eirini Tsekitsidi Zoi A Polyzopoulou Nikos Christodoulou Georgios Papazisis Michail Chourdakis Source Type: research
Is cognitive behavioral therapy more effective than pharmacotherapy for binge spectrum disorders? A systematic review and meta-analysis
CONCLUSIONS: Data are scarce, comparisons underpowered and, considering the inherent methodological limitations of psychotherapy trials, questions arise regarding the presumed superiority of cognitive behavioral therapy. Further research is needed.PMID:38179705 | DOI:10.1177/00048674231219593 (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - January 5, 2024 Category: Psychiatry Authors: Myrto T Samara Niki Michou Andreas S Lappas Aikaterini Argyrou Elissavet Mathioudaki Dimitra Rafailia Bakaloudi Eirini Tsekitsidi Zoi A Polyzopoulou Nikos Christodoulou Georgios Papazisis Michail Chourdakis Source Type: research
Evaluation of the passive permeability of antidepressants through pore-suspended lipid bilayer
Colloids Surf B Biointerfaces. 2023 Dec 7;234:113688. doi: 10.1016/j.colsurfb.2023.113688. Online ahead of print.ABSTRACTHYPOTHESIS: The antidepressant drug imipramine, and its metabolite desipramine show different extents of interaction with, and passive permeation through, cellular membrane models, with the effects depending on the membrane composition. Through multimodal interrogation, we can observe that the drugs have a direct impact on the physicochemical properties of the membrane, that may play a role in their pharmacokinetics.EXPERIMENTS: Microcavity pore-suspended lipid bilayers (MSLBs) of four different composit...
Source: Colloids and Surfaces - December 21, 2023 Category: Biotechnology Authors: Nirod Kumar Sarangi Amrutha Prabhakaran Mark Roantree Tia E Keyes Source Type: research
Evaluation of the passive permeability of antidepressants through pore-suspended lipid bilayer
Colloids Surf B Biointerfaces. 2023 Dec 7;234:113688. doi: 10.1016/j.colsurfb.2023.113688. Online ahead of print.ABSTRACTHYPOTHESIS: The antidepressant drug imipramine, and its metabolite desipramine show different extents of interaction with, and passive permeation through, cellular membrane models, with the effects depending on the membrane composition. Through multimodal interrogation, we can observe that the drugs have a direct impact on the physicochemical properties of the membrane, that may play a role in their pharmacokinetics.EXPERIMENTS: Microcavity pore-suspended lipid bilayers (MSLBs) of four different composit...
Source: Colloids and Surfaces - December 21, 2023 Category: Biotechnology Authors: Nirod Kumar Sarangi Amrutha Prabhakaran Mark Roantree Tia E Keyes Source Type: research
Efficacy of pharmacotherapies for bulimia nervosa: a systematic review and meta-analysis
CONCLUSIONS: This meta-analysis indicates that most pharmacotherapies decreased the frequency of binge-eating and vomiting episodes, body weight, and depressive symptoms in BN patients, but the efficacy was not significant. In each drug the efficacy is different, treating different aspects, different symptoms to improve the clinical performance of bulimia nervosa.PMID:38042827 | DOI:10.1186/s40360-023-00713-7 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - December 2, 2023 Category: Drugs & Pharmacology Authors: Sijie Yu Yuhan Zhang Chongkai Shen Fei Shao Source Type: research
Efficacy of pharmacotherapies for bulimia nervosa: a systematic review and meta-analysis
CONCLUSIONS: This meta-analysis indicates that most pharmacotherapies decreased the frequency of binge-eating and vomiting episodes, body weight, and depressive symptoms in BN patients, but the efficacy was not significant. In each drug the efficacy is different, treating different aspects, different symptoms to improve the clinical performance of bulimia nervosa.PMID:38042827 | PMC:PMC10693702 | DOI:10.1186/s40360-023-00713-7 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - December 2, 2023 Category: Drugs & Pharmacology Authors: Sijie Yu Yuhan Zhang Chongkai Shen Fei Shao Source Type: research
