Imipramine Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Diabetic Peripheral Neuropathy: Prevention and Treatment
Am Fam Physician. 2024 Mar;109(3):226-232.ABSTRACTDiabetic peripheral neuropathy occurs in up to 50% of patients with diabetes mellitus and increases the risk of diabetic foot ulcers and infections. Consistent screening and clear communication are essential to decrease disparities in assessment of neuropathic symptoms and diagnosis. Physicians should address underlying risk factors such as poor glycemic control, vitamin B12 deficiency, elevated blood pressure, and obesity to reduce the likelihood of developing neuropathy. First-line drug therapy for painful diabetic peripheral neuropathy includes duloxetine, gabapentin, am...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Scott Bragg Sarah Tucker Marrison Sean Haley Source Type: research

Evidence that keratinocyte microvesicle particles carrying Platelet-activating factor mediate the widespread multi-organ damage associated with intoxicated thermal burn injury
J Leukoc Biol. 2024 Mar 26:qiae078. doi: 10.1093/jleuko/qiae078. Online ahead of print.ABSTRACTThermal burn injuries can result in significant morbidity and mortality. The combination of ethanol intoxication with thermal burn injury results in increased morbidity through an exaggerated inflammatory response involving many organs. Recent studies have linked involvement of the lipid mediator Platelet-activating factor (PAF) in the pathology associated with intoxicated thermal burn injury (ITBI). The present studies tested the roles of PAF and the elevated levels of subcellular microvesicle particles (MVP) generated in respon...
Source: Journal of Leukocyte Biology - March 26, 2024 Category: Hematology Authors: Rushabh P Lohade Chad Brewer Christine M Rapp Karen M Henkels Wenfeng Zhang Anita Thyagarajan Shikshita Singh Pranali Manjrekar Taskin Sabit Ravi P Sahu Jeffrey B Travers Source Type: research

Sustainable beeswax modified cellulose paper for the determination of tricyclic antidepressants in biofluids
This article describes the synthesis of sorptive phases for bioanalysis based on the modification of cellulose paper with natural beeswax as sorbent, resulting in a substrate completely renewable and sustainable. The preparation of the sorptive phases consisted of the dissolution of beeswax in hexane, followed by its drop-casting on cellulose paper and subsequent evaporation of the solvent. The beeswax modification of paper renders it hydrophobic, enabling the extraction of the target analytes, i.e., imipramine, desipramine, amitriptyline and trimipramine, via hydrophobic interactions. The main variables affecting the extr...
Source: Talanta - March 13, 2024 Category: Chemistry Authors: Marisol Gonz ález-Bermúdez Ángela I López-Lorente Rafael Lucena Soledad C árdenas Source Type: research

Elucidation of escitalopram oxalate and related antidepressants as putative inhibitors of PTP4A3/PRL-3 protein in hepatocellular carcinoma: A multi-computational investigation
Comput Biol Chem. 2024 Feb 29;110:108039. doi: 10.1016/j.compbiolchem.2024.108039. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) persists to be one of the most devastating and deadliest malignancies globally. Recent research into the molecular signaling networks entailed in many malignancies has given some prominent insights that can be leveraged to create molecular therapeutics for combating HCC. Therefore, in the current communication, an in-silico drug repurposing approach has been employed to target the function of PTP4A3/PRL-3 protein in HCC using antidepressants: Fluoxetine hydrochloride, Citalopram, A...
Source: Computational Biology and Chemistry - March 12, 2024 Category: Bioinformatics Authors: Ishfaq Hassan Mir Kankipati Teja Shyam Susmida Seni Balakrishnan Muthuvel Suresh Kumar Thiyagarajan Ramesh Chinnasamy Thirunavukkarasu Source Type: research

Sildenafil, alone and in combination with imipramine or escitalopram, display antidepressant-like effects in an adrenocorticotropic hormone-induced (ACTH) rodent model of treatment-resistant depression
CONCLUSION: This study suggests that sildenafil shows promise as a treatment for TRD, either as a stand-alone therapy or in combination with a traditional antidepressant. The neurobiological mechanism underlying the antidepressant-like effects of the different sildenafil mono- and combination therapies reflects a multimodal action and cannot be explained in full by changes in the individually measured biomarker levels.PMID:38458412 | DOI:10.1016/j.ejphar.2024.176434 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 8, 2024 Category: Drugs & Pharmacology Authors: Juandr é Lambertus Bernardus Saayman Brian Herbert Harvey Gregers Wegener Christiaan Beyers Brink Source Type: research

The acid sphingomyelinase inhibitor imipramine enhances the release of UV photoproduct ‐containing DNA in small extracellular vesicles in UVB‐irradiated human skin
Using cultured HaCaT cells in vitro, discarded human surgical skin ex vivo, and skin biopsies from human subjects in vivo, the association of UV photoproduct-containing DNA with small extracellular vesicles is shown to be increased by treatment with the acid sphingomyelinase inhibitor imipramine. These results indicate that a pharmacological inhibitor of large extracellular vesicle release is associated with elevated release of DNA damaged by UV radiation. AbstractNucleic acids, lipids, and other cell components can be found within different types of extracellular vesicles (EVs), which include apoptotic bodies (ABs), l...
Source: Photochemistry and Photobiology - March 4, 2024 Category: Science Authors: M. Alexandra Carpenter, Anita Thyagarajan, Madison Owens, Risha Annamraju, Christina B. Borchers, Jeffrey B. Travers, Michael G. Kemp Tags: RESEARCH ARTICLE Source Type: research

Common changes in rat cortical gene expression after antidepressant drug treatment: impacts on metabolism of polyamines, mRNA splicing, regulation of RAS by GAPs, neddylation and GPCR ligand binding
CONCLUSIONS: Our study shows there are common, correlated, changes in coding and non-coding RNA in the rat cortex after treatment with fluoxetine or imipramine; we propose the pathways affected by these changes are involved in the therapeutic mechanisms of action of antidepressant drugs.PMID:38349617 | DOI:10.1080/15622975.2024.2312475 (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - February 13, 2024 Category: Psychiatry Authors: Brian Dean Elizabeth Scarr Source Type: research

Evidence for the involvement of keratinocyte ‐derived microvesicle particles in the photosensitivity associated with xeroderma pigmentosum type A deficiency
Hypothetical model by which UVR generates PAFR agonists via ROS which then result in skin inflammation. In this model, ROS generated by UVB result in MVP release via PAFR. XPA deficiency results in increased ROS and augmented responses. This process can be blocked by antioxidants, PAFR inhibitors and aSMase inhibitors. AbstractPhotosensitivity can be due to numerous causes. The photosensitivity associated with deficiency of xeroderma pigmentosum type A (XPA) has been previously shown to be associated with excess levels of the lipid mediator platelet-activating factor (PAF) generated by the keratinocyte. As PAF has been rep...
Source: Photochemistry and Photobiology - January 30, 2024 Category: Science Authors: Lea Christian, Pranali Manjrekar, Karen M. Henkels, Christine M. Rapp, Risha Annamraju, Rushabh P. Lohade, Shikshita Singh, M. Alexandra Carpenter, Saman Khan, Michael G. Kemp, Yanfang Chen, Ravi P. Sahu, Jeffrey B. Travers Tags: RESEARCH ARTICLE Source Type: research

Inhibitory Effects of Tricyclic Antidepressants on Human Liver Microsomal Morphine Glucuronidation: Application of IVIVE to Predict Potential Drug-Drug Interactions in Humans
CONCLUSION: The results suggest that the likelihood of potential clinical DDIs arising from tricyclic antidepressant inhibition on morphine glucuronidation is low.PMID:38270153 | DOI:10.2174/0113892002270594231212090958 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 25, 2024 Category: Drugs & Pharmacology Authors: Verawan Uchaipichat Source Type: research