Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: J Physiol Pharmacol - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: Journal of Physiology and Pharmacology - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: J Physiol Pharmacol - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: Journal of Physiology and Pharmacology - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: J Physiol Pharmacol - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: Journal of Physiology and Pharmacology - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: J Physiol Pharmacol - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: Journal of Physiology and Pharmacology - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: J Physiol Pharmacol - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: Journal of Physiology and Pharmacology - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: J Physiol Pharmacol - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: Journal of Physiology and Pharmacology - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: J Physiol Pharmacol - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Decreased sensitivity to antidepressant drugs in Wistar Hannover rats submitted to two animal models of depression
In this study, we aimed to characterise the behavioural responses of WHR to acute and repeated antidepressant treatments upon exposure to the Forced Swim (FST) or Learned Helplessness (LH) tests. WHR were subjected to forced swimming pre-test and test with antidepressant administration (imipramine, fluoxetine, or escitalopram) at 0, 5h, and 23h after pre-test. WHR displayed high immobility in the test compared to unstressed controls (no pre-swim) and failed to respond to the antidepressants tested. The effect of acute and repeated treatment (imipramine, fluoxetine, escitalopram or s-ketamine) was then tested in animals not...
Source: Acta Neuropsychiatrica - September 14, 2022 Category: Psychiatry Authors: Kennia M Silveira Ariandra G Sartim Let ícia Vieira Sabrina F Lisboa Gregers Wegener S âmia R L Joca Source Type: research
