Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: Journal of Physiology and Pharmacology - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: J Physiol Pharmacol - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: Journal of Physiology and Pharmacology - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: J Physiol Pharmacol - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: Journal of Physiology and Pharmacology - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: J Physiol Pharmacol - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: Journal of Physiology and Pharmacology - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: J Physiol Pharmacol - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: Journal of Physiology and Pharmacology - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: J Physiol Pharmacol - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: Journal of Physiology and Pharmacology - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: J Physiol Pharmacol - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: Journal of Physiology and Pharmacology - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: J Physiol Pharmacol - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5
J Physiol Pharmacol. 2022 Apr;73(2). doi: 10.26402/jpp.2022.2.15. Epub 2022 Sep 29.ABSTRACTSince we previously discovered that simultaneous inhibition of cyclooxygenase-2 (COX-2; a highly inducible enzyme, crucial for the conversion of arachidonic acid to prostaglandin G2, which plays a predominant role in the CNS) by NS398 and metabotropic glutamate receptor 5 (mGluR5) through the use of its antagonist [3-((2-methyl-4-thiazolyl)ethyl)pyridine; MTEP] alters mouse behavior (e.g., affects spatial learning, and induces/intensifies the antidepressant effect), our aim was to discover the mechanism responsible for these changes....
Source: Journal of Physiology and Pharmacology - October 4, 2022 Category: Drugs & Pharmacology Authors: K Stachowicz P Panczyszyn-Trzewik S Rzezniczek X M Sowa-Kucma Source Type: research
