HIV-Leishmania Co-infection Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Molecules, Vol. 29, Pages 943: Efficient Expression in Leishmania tarentolae (LEXSY) of the Receptor-Binding Domain of the SARS-CoV-2 S-Protein and the Acetylcholine-Binding Protein from Lymnaea stagnalis
n Igor Kasheverov Leishmania tarentolae (LEXSY) system is an inexpensive and effective expression approach for various research and medical purposes. The stated advantages of this system are the possibility of obtaining the soluble product in the cytoplasm, a high probability of correct protein folding with a full range of post-translational modifications (including uniform glycosylation), and the possibility of expressing multi-subunit proteins. In this paper, a LEXSY expression system has been employed for obtaining the receptor binding domain (RBD) of the spike-protein of the SARS-CoV-2 virus and the homopentameri...
Source: Molecules - February 21, 2024 Category: Chemistry Authors: Lina Son Vladimir Kost Valery Maiorov Dmitry Sukhov Polina Arkhangelskaya Igor Ivanov Denis Kudryavtsev Andrei Siniavin Yuri Utkin Igor Kasheverov Tags: Article Source Type: research

Parasites and microorganisms associated with the snakes collected for the “ < i > festa Dei serpari < /i > ” in Cocullo, Italy
by Jairo Alfonso Mendoza-Roldan, Livia Perles, Ernesto Filippi, Nicole Szafranski, Gianpaolo Montinaro, Mariaelisa Carbonara, Riccardo Scalera, Pedro Paulo de Abreu Teles, Julia Walochnik, Domenico Otranto While in much of the Western world snakes are feared, in the small, rural, mountainous town of Cocullo, in the middle of central Italy, snakes are annually collected and celebrated in a sacro-profane ritual. Every 1st of May,Serpari (snake catchers) capture and showcase dozens of non-venomous snakes to celebrate the ritual ofSan Domenico. In order to detect potential zoonotic pathogens within this unique epidemiological...
Source: PLoS Neglected Tropical Diseases - February 21, 2024 Category: Tropical Medicine Authors: Jairo Alfonso Mendoza-Roldan Source Type: research

Short communication: The miR-155a-5p is correlated with increased ROS and impaired apoptosis in macrophages infected by < i > Leishmania braziliensis < /i >
by Tain ã Lago, Thyago Marconi Cardoso, Alan Rocha, Edgar M. Carvalho, Léa Cristina Castellucci Cutaneous leishmaniasis (CL) caused byLeishmania braziliensis, is a disease characterized by well-limited ulcerated lesions with raised borders in exposed parts of the body. miRNAs are recognized for their role in the complex and plastic interaction between host and pathogens, either as part of the host ’s strategy to neutralize infection or as a molecular mechanism employed by the pathogen to modulate host inflammatory pathways to remain undetected. The mir155 targets a broad range of inflammatory mediators, following toll...
Source: PLoS One - February 21, 2024 Category: Biomedical Science Authors: Tain ã Lago Source Type: research

New synthetic molecules incorporated into polymeric micelles used for treatment against visceral leishmaniasis
In conclusion, preliminary data suggest that 3 s/M and 3 t/M could be considered for future studies as therapeutic agents against VL.PMID:38373365 | DOI:10.1016/j.cyto.2024.156543 (Source: Cytokine)
Source: Cytokine - February 19, 2024 Category: Molecular Biology Authors: Camila S Freitas Isabela A G Pereira Daniela P Lage Danniele L Vale Breno L Pimenta N ícia P Soares Samira S Santiago V ívian T Martins Raquel S B C âmara Marcelo M Jesus Grasiele S V Tavares Fernanda F Ramos Fernanda Ludolf L ícia N D Magalhães Fabr Source Type: research

Unveiling of the antileishmanial activities of Linalool loaded zinc oxide nanocomposite through its potent antioxidant and immunomodulatory effects
This study aimed to produce linalool loaded zinc oxide nanocomposite (LZNPs) and assess its in vitro and in vivo antileishmanial effects against Leishmania major. LZNPs was produced through the synthesis of an ethanolic solution containing polyvinyl alcohol. The average size of LZNPs was determined to be 105 nm. The findings indicated that LZNPs displayed significant (p<0.01) antileishmanial effects on promastigotes and amastigotes. Following exposure of promastigotes to LZNPs, there was a notable rise in the percentage of early and late apoptotic cells from 9.0-57.2%. The gene expression levels of iNOS, IFN-γ, and TNF...
Source: Acta Tropica - February 19, 2024 Category: Infectious Diseases Authors: Aishah E Albalaw Abdullah F Shater Abdullah D Alanazi Hamdan I Almohammed Source Type: research

Identification of potential novel proteomic markers of Leishmania spp.-derived exosomes
DiscussionProteomic data indicated potential novel proteic markers of Leishmania-derived exosomes, including proteins involved in endosomal machinery and the ESCRT pathway, as well as the parasitic phosphatase PRL-1. Further investigation is required to determine the specificity and sensitivity of these markers. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - February 19, 2024 Category: Microbiology Source Type: research

Synthesis of halogenated benzimidazolyl-C-nucleosides and their activity against Leishmania major and Leishmania tropica
New J. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4NJ00035H, PaperUmair Ahmed Khan, Muhammad Iqbal Choudhary, Sammer Yousuf Here we report the short synthesis of “reversed” halogenated C-nucleoside (benzimidazole) analogs. Initially, 1,2 ; 3,4 vicinal diols of D-galactose were acetylated with two different ketones, acetone and cyclohexanone, to... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - February 17, 2024 Category: Chemistry Authors: Umair Ahmed Khan Source Type: research

Leishmania amazonensis infection regulates oxidate stress in hyperglycemia and diabetes impairing macrophage's function and immune response
CONCLUSION: Together, these data demonstrate that diabetes and hyperglycemia can impair the cellular immune response, mainly of macrophages, against infection by parasites of the genus Leishmania.PMID:38364941 | DOI:10.1016/j.bbadis.2024.167078 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - February 16, 2024 Category: Biochemistry Authors: Taylon Felipe Silva Mariana Barbosa Detoni Virg ínia Márcia Concato Fernanda Tomiotto-Pellissier Milena Menegazzo Miranda-Sapla Bruna Taciane da Silva Bortoleti Manoela Daiele Gon çalves Ana Carolina Jacob Rodrigues Raquel Arruda Sanfelice Ellen Mayara Source Type: research

Leishmania amazonensis infection regulates oxidate stress in hyperglycemia and diabetes impairing macrophage's function and immune response
CONCLUSION: Together, these data demonstrate that diabetes and hyperglycemia can impair the cellular immune response, mainly of macrophages, against infection by parasites of the genus Leishmania.PMID:38364941 | DOI:10.1016/j.bbadis.2024.167078 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - February 16, 2024 Category: Biochemistry Authors: Taylon Felipe Silva Mariana Barbosa Detoni Virg ínia Márcia Concato-Lopes Fernanda Tomiotto-Pellissier Milena Menegazzo Miranda-Sapla Bruna Taciane da Silva Bortoleti Manoela Daiele Gon çalves Ana Carolina Jacob Rodrigues Raquel Arruda Sanfelice Ellen Source Type: research

Linear motifs regulating protein secretion, sorting and autophagy in Leishmania parasites are diverged with respect to their host equivalents
by Andras Zeke, Toby J. Gibson, Laszlo Dobson The pathogenic, tropicalLeishmania flagellates belong to an early-branching eukaryotic lineage (Kinetoplastida) with several unique features. Unfortunately, they are poorly understood from a molecular biology perspective, making development of mechanistically novel and selective drugs difficult. Here, we explore three functionally critical targeting short linear motif systems as well as their receptors in depth, using a combination of structural modeling, evolutionary sequence divergence and deep learning. Secretory signal peptides, endoplasmic reticulum (ER) retention motifs ...
Source: PLoS Computational Biology - February 16, 2024 Category: Biology Authors: Andras Zeke Source Type: research

Treatment of Cutaneous Leishmaniasis lesion caused by Leishmania major Using Leech Therapy in BALB/c Mice
CONCLUSION: Considering the fact that the standard drugs for the treatment of leishmaniasis have many side effects, alternative therapies such as leech therapy can be effectively used to treat these chronic wounds. There are about 20 active substances in leech saliva. These substances include antistasin, eglins, guamerin, hirudin, saratin, bdellins, complement, and carboxypeptidase inhibitors. Leech saliva is an anticoagulant, anti-inflammation and prevents the platelet. Leech therapy was effective in treating leishmaniasis wounds in BALB/c mice. In this study, there was complete wound healing in 56% of the mice models.PMI...
Source: Journal of Vector Borne Diseases - February 15, 2024 Category: Infectious Diseases Authors: Leila Shirani-Bidabadi Source Type: research