HIV-Leishmania Co-infection Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

GSE244972 The different impact of drug-resistant Leishmania on the transcription programs activated in neutrophils.
Contributors : M íriam Díaz-Varela ; Andrea Sánchez-Hidalgo ; Sandra Calderon-Copete ; Virginie Tacchini ; Tobias Shipley ; LadyGiovanna Ramírez ; Julien Marquis ; OlgaLucía Fernández ; Nancy Gore Saravia ; Fabienne Tacchini-CottierSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDrug resistance threatens the effective control of infections, including parasitic diseases such as leishmaniases. Neutrophils are essential players in antimicrobial control, but their role in drug-resistant infections is poorly understood. Here, we evaluated human neutrophil response to clinic...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Genetic diversity in Leishmania infantum and Leishmania tropica isolates from human and canine hosts in northern Morocco
This study investigated nine provinces in northern Morocco and collected 275 skin scraping, 22 bone marrow aspirates, and 89 fine needle aspirations from suspected cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL) patients and potentially infected dogs. Molecular analysis using ITS1 RFLP PCR and RT-PCR revealed a higher prevalence of L. infantum (66.18 %; χ2 = 28.804; df = 1; P-value = 8.01e-08) than L. tropica in skin scraping, with L. infantum being the sole causative agent for both VL and canine leishmaniasis. L. infantum was predominantly found in most provinces, while L. tropica was relatively more dominan...
Source: Gene - April 20, 2024 Category: Genetics & Stem Cells Authors: Maryam Hakkour Bouabid Badaoui Sarah El Hamiani Khatat Hamid Sahibi Hajiba Fellah Abderrahim Sadak Faiza Sebti Source Type: research

Molecules, Vol. 29, Pages 1876: Promising Antileishmanial Activity of Micromeria nervosa Essential Oil: In Vitro and In Silico Studies
bbene Ferid Limam The present study aimed to evaluate the leishmanicidal potential of the essential oil (EO) of Micromeria (M.) nervosa and to investigate its molecular mechanism of action by qPCR. Furthermore, in silicointeraction study of the major M. nervosa EO compounds with the enzyme cytochrome P450 sterol 14&alpha;-demethylase (CYP51) was also performed. M. nervosa EO was analyzed by gas chromatography-mass spectrometry (GC-MS). Results showed that &alpha;-pinene (26.44%), t-cadinol (26.27%), caryophyllene Oxide (7.73 &plusmn; 1.04%), and &alpha;-Cadinene (3.79 &plusmn; ...
Source: Molecules - April 19, 2024 Category: Chemistry Authors: Rym Essid Sarra Kefi Bilel Damergi Ghassen Abid Nadia Fares Selim Jallouli Islem Abid Dina Hussein Olfa Tabbene Ferid Limam Tags: Article Source Type: research

< i > Leishmania < /i > blood parasite dynamics during and after treatment of visceral leishmaniasis in Eastern Africa: A pharmacokinetic-pharmacodynamic model
ConclusionThis semi-mechanistic pharmacokinetic-pharmacodynamic model adequately captured the blood parasite dynamics during and after treatment, and revealed that high blood parasite loads on Day 28 and Day 56 after start of treatment are an early indication for VL relapse, which could be a useful biomarker to assess treatment efficacy of a treatment regimen in a clinical trial setting. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 19, 2024 Category: Tropical Medicine Authors: Luka Verrest Source Type: research

Molecules, Vol. 29, Pages 1819: The Synthesis of 2 & prime;-Hydroxychalcones under Ball Mill Conditions and Their Biological Activities
Molecules, Vol. 29, Pages 1819: The Synthesis of 2′-Hydroxychalcones under Ball Mill Conditions and Their Biological Activities Molecules doi: 10.3390/molecules29081819 Authors: Imen Abid Wassim Moslah Sandrine Cojean Nicolas Imbert Philippe M. Loiseau Alain Chamayou Najet Srairi-Abid Rachel Calvet Michel Baltas Chalcones are polyphenols that belong to the flavonoids family, known for their broad pharmacological properties. They have thus attracted the attention of chemists for their obtention and potential activities. In our study, a library of compounds from 2&prime;-hydroxychalc...
Source: Molecules - April 17, 2024 Category: Chemistry Authors: Imen Abid Wassim Moslah Sandrine Cojean Nicolas Imbert Philippe M. Loiseau Alain Chamayou Najet Srairi-Abid Rachel Calvet Michel Baltas Tags: Article Source Type: research

A case report of acute claudication due to vena cava thromboembolism in a dog naturally infected with Leishmania Infantum
AbstractCanine leishmaniosis is a vector-borne disease caused byLeishmania infantum, and clinical manifestations of infection range from absent or severe to fatal and result from immune-mediated mechanisms. In dogs, the most common clinical signs of leishmaniosis include skin lesions and lymphadenomegaly. However, the presence of other nontypical signs has been described, and diagnosing these cases can be challenging. The aim of the present short communication was to describe the impact of the formation of circulating immunocomplexes due toL. infantum in a dog with leishmaniosis affected by a massive venous thrombus of the...
Source: Veterinary Research Communications - April 17, 2024 Category: Veterinary Research Source Type: research

Molecules, Vol. 29, Pages 1835: Identification of Leishmania donovani PEX5-PTS1 Interaction Inhibitors through Fluorescence Polarization-Based High-Throughput Screening
In this study, we focused on identifying small molecule inhibitors which prevents the interaction between peroxin 5 (PEX5) and peroxisomal targeting signal 1 (PTS1), pivotal for kinetoplastid parasite survival. The Leishmania donovani PEX5, containing a C-terminal tetratricopeptide repeat (TPR) domain, was expressed and purified, followed by the quantification of kinetic parameters of PEX5-PTS1 interactions. A fluorescence polarization-based high-throughput screening assay was developed and small molecules inhibiting the LdPEX5-PTS1 interaction were discovered through the screening of a library of 51,406 compounds. Based o...
Source: Molecules - April 17, 2024 Category: Chemistry Authors: Trong-Nhat Phan Kyu-Ho Paul Park David Shum Joo Hwan No Tags: Article Source Type: research

Alternative hosts of Leishmania infantum: a neglected parasite in Europe
AbstractMulti-host pathogens that infect various animal species and humans are considered of great importance for public and animal health.Leishmania spp. parasites are a characteristic example of such pathogens. Although leishmaniosis in humans is endemic for about 100 countries around the world it is classified as a neglected tropical disease. There are three main forms of leishmaniosis in humans: cutaneous (CL), visceral (VL) and mucocutaneous leishmaniosis (MCL). Each year, about 30,000 new cases of VL and more than 1 million new cases of CL are recorded. In EuropeL. infantum is the dominant species with dogs being r...
Source: Tropical Animal Health and Production - April 17, 2024 Category: Veterinary Research Source Type: research

Molecular Regulation of NLRP3 Inflammasome Activation During Parasitic Infection
Biosci Rep. 2024 Apr 16:BSR20231918. doi: 10.1042/BSR20231918. Online ahead of print.ABSTRACTParasitic diseases are a serious global health concern, causing many common and severe infections, including Chagas disease, leishmaniasis,and schistosomiasis. The NLRP3 inflammasome belongs to the NLR (nucleotide-binding domain leucine-rich-repeat-containing proteins) family, which are cytosolic proteins playing key roles in the detection of pathogens. NLRP3 inflammasomes are activated in immune responses to Plasmodium,Leishmania, Toxoplasma gondii, Entamoeba histolytica,Trypanosoma cruzi and other parasites. The role of NLRP3 is ...
Source: Bioscience Reports - April 16, 2024 Category: Biomedical Science Authors: Rasha Alonaizan Source Type: research

Pathogen-associated molecular patterns (PAMPs) derived from Leishmania and bacteria increase gene expression of antimicrobial peptides and gut surface proteins in sand flies
Int J Parasitol. 2024 Apr 14:S0020-7519(24)00075-4. doi: 10.1016/j.ijpara.2024.04.005. Online ahead of print.ABSTRACTThe interaction between pathogens and vectors' physiology can impact parasite transmission. Studying this interaction at the molecular level can help in developing control strategies. We study leishmaniases, diseases caused by Leishmania parasites transmitted by sand fly vectors, posing a significant global public health concern. Lipophosphoglycan (LPG), the major surface glycoconjugate of Leishmania, has been described to have several roles throughout the parasite's life cycle, both in the insect and verteb...
Source: International Journal for Parasitology - April 16, 2024 Category: Parasitology Authors: Barbora Vom áčková Kykalová Fabiana Sass ù Felipe Dutra R êgo Rodrigo Pedro Soares Petr Volf Erich Loza Telleria Source Type: research

Modulation and Determination of the Status of Inflammasomes in Leishmania-Infected Macrophages
Methods Mol Biol. 2024;2782:137-146. doi: 10.1007/978-1-0716-3754-8_10.ABSTRACTLeishmania, an intra-macrophage kinetoplastid parasite, modulates a vast array of defensive mechanisms of the host macrophages to create a comfortable environment for their survival. When the host encounters intracellular pathogens, a multimeric protein complex called NLRP3 inflammasome gets turned on, leading to caspase-1 activation-mediated maturation of IL-1β from its pro-form. However, Leishmania often manages to neutralize inflammasome activation by manipulating negative regulatory molecules of the host itself. Exhaustion of NLRP3 and pro-...
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Arunima Biswas Anindita Bhattacharjee Pijush K Das Source Type: research

Modulation and Determination of the Status of Inflammasomes in Leishmania-Infected Macrophages
Methods Mol Biol. 2024;2782:137-146. doi: 10.1007/978-1-0716-3754-8_10.ABSTRACTLeishmania, an intra-macrophage kinetoplastid parasite, modulates a vast array of defensive mechanisms of the host macrophages to create a comfortable environment for their survival. When the host encounters intracellular pathogens, a multimeric protein complex called NLRP3 inflammasome gets turned on, leading to caspase-1 activation-mediated maturation of IL-1β from its pro-form. However, Leishmania often manages to neutralize inflammasome activation by manipulating negative regulatory molecules of the host itself. Exhaustion of NLRP3 and pro-...
Source: Mol Biol Cell - April 15, 2024 Category: Molecular Biology Authors: Arunima Biswas Anindita Bhattacharjee Pijush K Das Source Type: research