HIV-Leishmania Co-infection Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Molecular Regulation of NLRP3 Inflammasome Activation During Parasitic Infection
Biosci Rep. 2024 Apr 16:BSR20231918. doi: 10.1042/BSR20231918. Online ahead of print.ABSTRACTParasitic diseases are a serious global health concern, causing many common and severe infections, including Chagas disease, leishmaniasis,and schistosomiasis. The NLRP3 inflammasome belongs to the NLR (nucleotide-binding domain leucine-rich-repeat-containing proteins) family, which are cytosolic proteins playing key roles in the detection of pathogens. NLRP3 inflammasomes are activated in immune responses to Plasmodium,Leishmania, Toxoplasma gondii, Entamoeba histolytica,Trypanosoma cruzi and other parasites. The role of NLRP3 is ...
Source: Bioscience Reports - April 16, 2024 Category: Biomedical Science Authors: Rasha Alonaizan Source Type: research

Pathogen-associated molecular patterns (PAMPs) derived from Leishmania and bacteria increase gene expression of antimicrobial peptides and gut surface proteins in sand flies
Int J Parasitol. 2024 Apr 14:S0020-7519(24)00075-4. doi: 10.1016/j.ijpara.2024.04.005. Online ahead of print.ABSTRACTThe interaction between pathogens and vectors' physiology can impact parasite transmission. Studying this interaction at the molecular level can help in developing control strategies. We study leishmaniases, diseases caused by Leishmania parasites transmitted by sand fly vectors, posing a significant global public health concern. Lipophosphoglycan (LPG), the major surface glycoconjugate of Leishmania, has been described to have several roles throughout the parasite's life cycle, both in the insect and verteb...
Source: International Journal for Parasitology - April 16, 2024 Category: Parasitology Authors: Barbora Vom áčková Kykalová Fabiana Sass ù Felipe Dutra R êgo Rodrigo Pedro Soares Petr Volf Erich Loza Telleria Source Type: research

Modulation and Determination of the Status of Inflammasomes in Leishmania-Infected Macrophages
Methods Mol Biol. 2024;2782:137-146. doi: 10.1007/978-1-0716-3754-8_10.ABSTRACTLeishmania, an intra-macrophage kinetoplastid parasite, modulates a vast array of defensive mechanisms of the host macrophages to create a comfortable environment for their survival. When the host encounters intracellular pathogens, a multimeric protein complex called NLRP3 inflammasome gets turned on, leading to caspase-1 activation-mediated maturation of IL-1β from its pro-form. However, Leishmania often manages to neutralize inflammasome activation by manipulating negative regulatory molecules of the host itself. Exhaustion of NLRP3 and pro-...
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Arunima Biswas Anindita Bhattacharjee Pijush K Das Source Type: research

Modulation and Determination of the Status of Inflammasomes in Leishmania-Infected Macrophages
Methods Mol Biol. 2024;2782:137-146. doi: 10.1007/978-1-0716-3754-8_10.ABSTRACTLeishmania, an intra-macrophage kinetoplastid parasite, modulates a vast array of defensive mechanisms of the host macrophages to create a comfortable environment for their survival. When the host encounters intracellular pathogens, a multimeric protein complex called NLRP3 inflammasome gets turned on, leading to caspase-1 activation-mediated maturation of IL-1β from its pro-form. However, Leishmania often manages to neutralize inflammasome activation by manipulating negative regulatory molecules of the host itself. Exhaustion of NLRP3 and pro-...
Source: Mol Biol Cell - April 15, 2024 Category: Molecular Biology Authors: Arunima Biswas Anindita Bhattacharjee Pijush K Das Source Type: research

Detection of Leishmania infantum Antibodies in Stray Dogs from Nonendemic Areas in Bulgaria
Vector-Borne and Zoonotic Diseases, Ahead of Print. (Source: Vector-Borne and Zoonotic Diseases)
Source: Vector-Borne and Zoonotic Diseases - April 15, 2024 Category: Infectious Diseases Authors: Georgi M. Stoimenov Simona Tchakarova Source Type: research

The apo-acyl coenzyme A binding protein of Leishmania major forms a unique 'AXXA' motif mediated dimer
Biochim Biophys Acta Proteins Proteom. 2024 Apr 12:141016. doi: 10.1016/j.bbapap.2024.141016. Online ahead of print.ABSTRACTAcyl-Coenzyme A binding domain containing proteins (ACBDs) are ubiquitous in nearly all eukaryotes. They can exist as a free protein, or a domain of a large, multidomain, multifunctional protein. Besides modularity, ACBDs also display multiplicity. The same organism may have multiple ACBDs, differing in sequence and organization. By virtue of this diversity, ACBDs perform functions ranging from transport, synthesis, trafficking, signal transduction, transcription, and gene regulation. In plants and so...
Source: Biochimica et Biophysica Acta - April 14, 2024 Category: Biochemistry Authors: Shalini Verma Rohit Singh Dangi Manoj Kumar Rajak Ravi Kant Pal Monica Sundd Source Type: research

Distribution and Seasonal Variation of Phlebotomus and Sergentomyia Sand Fly Populations in Bhutan
Am J Trop Med Hyg. 2024 Apr 9:tpmd230125. doi: 10.4269/ajtmh.23-0125. Online ahead of print.ABSTRACTLeishmaniasis is considered one of the neglected tropical diseases in the world. Although Bhutan is a member of the visceral leishmaniasis elimination consortium in South Asia, not much attention has been accorded to the disease because of its low incidence. The vector that transmits Leishmania remains poorly understood. In this backdrop, sand-fly surveys were regularly conducted at multiple sites where leishmaniasis cases have been reported in Bhutan. Collections were made using CDC light traps and cattle-baited net traps i...
Source: The American Journal of Tropical Medicine and Hygiene - April 9, 2024 Category: Tropical Medicine Authors: Tenzin Wangdi Sanath Senanayake Sithar Dorjee Tashi Tobgay Guofa Zhou Sachee B Piyasiri W M Lakshika I Weerasinghe Nadira Karunaweera Source Type: research

Distribution and Seasonal Variation of Phlebotomus and Sergentomyia Sand Fly Populations in Bhutan
Am J Trop Med Hyg. 2024 Apr 9:tpmd230125. doi: 10.4269/ajtmh.23-0125. Online ahead of print.ABSTRACTLeishmaniasis is considered one of the neglected tropical diseases in the world. Although Bhutan is a member of the visceral leishmaniasis elimination consortium in South Asia, not much attention has been accorded to the disease because of its low incidence. The vector that transmits Leishmania remains poorly understood. In this backdrop, sand-fly surveys were regularly conducted at multiple sites where leishmaniasis cases have been reported in Bhutan. Collections were made using CDC light traps and cattle-baited net traps i...
Source: Am J Trop Med Hyg - April 9, 2024 Category: Infectious Diseases Authors: Tenzin Wangdi Sanath Senanayake Sithar Dorjee Tashi Tobgay Guofa Zhou Sachee B Piyasiri W M Lakshika I Weerasinghe Nadira Karunaweera Source Type: research