HIV-Leishmania Co-infection Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Distribution and Seasonal Variation of Phlebotomus and Sergentomyia Sand Fly Populations in Bhutan
Am J Trop Med Hyg. 2024 Apr 9:tpmd230125. doi: 10.4269/ajtmh.23-0125. Online ahead of print.ABSTRACTLeishmaniasis is considered one of the neglected tropical diseases in the world. Although Bhutan is a member of the visceral leishmaniasis elimination consortium in South Asia, not much attention has been accorded to the disease because of its low incidence. The vector that transmits Leishmania remains poorly understood. In this backdrop, sand-fly surveys were regularly conducted at multiple sites where leishmaniasis cases have been reported in Bhutan. Collections were made using CDC light traps and cattle-baited net traps i...
Source: The American Journal of Tropical Medicine and Hygiene - April 9, 2024 Category: Tropical Medicine Authors: Tenzin Wangdi Sanath Senanayake Sithar Dorjee Tashi Tobgay Guofa Zhou Sachee B Piyasiri W M Lakshika I Weerasinghe Nadira Karunaweera Source Type: research

Distribution and Seasonal Variation of Phlebotomus and Sergentomyia Sand Fly Populations in Bhutan
Am J Trop Med Hyg. 2024 Apr 9:tpmd230125. doi: 10.4269/ajtmh.23-0125. Online ahead of print.ABSTRACTLeishmaniasis is considered one of the neglected tropical diseases in the world. Although Bhutan is a member of the visceral leishmaniasis elimination consortium in South Asia, not much attention has been accorded to the disease because of its low incidence. The vector that transmits Leishmania remains poorly understood. In this backdrop, sand-fly surveys were regularly conducted at multiple sites where leishmaniasis cases have been reported in Bhutan. Collections were made using CDC light traps and cattle-baited net traps i...
Source: Am J Trop Med Hyg - April 9, 2024 Category: Infectious Diseases Authors: Tenzin Wangdi Sanath Senanayake Sithar Dorjee Tashi Tobgay Guofa Zhou Sachee B Piyasiri W M Lakshika I Weerasinghe Nadira Karunaweera Source Type: research

Galactokinase-like protein from Leishmania donovani: Biochemical and structural characterization of a recombinant protein
Biochimie. 2024 Apr 3:S0300-9084(24)00075-0. doi: 10.1016/j.biochi.2024.03.017. Online ahead of print.ABSTRACTLeishmaniasis is a spectrum of conditions caused by infection with the protozoan Leishmania spp. parasites. Leishmaniasis is endemic in 98 countries around the world, and resistance to current anti-leishmanial drugs is rising. Our work has identified and characterised a previously unstudied galactokinase-like protein (GalK) in Leishmania donovani, which catalyses the MgATP-dependent phosphorylation of the C-1 hydroxyl group of d-galactose to galactose-1-phosphate. Here, we report the production of the catalytically...
Source: Biochimie - April 5, 2024 Category: Biochemistry Authors: Hasana Baber Arega Aghajani B Harold Gallimore Cassandra Bethel James G Hyatt Elizabeth F B King Helen P Price Marissa L Maciej-Hulme Suat Sari Anja Winter Source Type: research

Galactokinase-like protein from Leishmania donovani: Biochemical and structural characterization of a recombinant protein
Biochimie. 2024 Apr 4;223:31-40. doi: 10.1016/j.biochi.2024.03.017. Online ahead of print.ABSTRACTLeishmaniasis is a spectrum of conditions caused by infection with the protozoan Leishmania spp. parasites. Leishmaniasis is endemic in 98 countries around the world, and resistance to current anti-leishmanial drugs is rising. Our work has identified and characterised a previously unstudied galactokinase-like protein (GalK) in Leishmania donovani, which catalyses the MgATP-dependent phosphorylation of the C-1 hydroxyl group of d-galactose to galactose-1-phosphate. Here, we report the production of the catalytically active reco...
Source: Biochimie - April 5, 2024 Category: Biochemistry Authors: Hasana Baber Arega Aghajani B Harold Gallimore Cassandra Bethel James G Hyatt Elizabeth F B King Helen P Price Marissa L Maciej-Hulme Suat Sari Anja Winter Source Type: research

Transcriptional signatures in human macrophage-like cells infected by Leishmania infantum , Leishmania major and Leishmania tropica 
by Aurora Diotallevi, Federica Bruno, Germano Castelli, Giuseppe Persico, Gloria Buffi, Marcello Ceccarelli, Daniela Ligi, Ferdinando Mannello, Fabrizio Vitale, Mauro Magnani, Luca Galluzzi BackgroundIn the Mediterranean basin, threeLeishmania species have been identified:L.infantum,L.major andL.tropica, causing zoonotic visceral leishmaniasis (VL), zoonotic cutaneous leishmaniasis (CL) and anthroponotic CL, respectively. Despite animal models and genomic/transcriptomic studies provided important insights, the pathogenic determinants modulating the development of VL and CL are still poorly understood. This work aimed to id...
Source: PLoS Neglected Tropical Diseases - April 5, 2024 Category: Tropical Medicine Authors: Aurora Diotallevi Source Type: research

ABC transporter inhibition by beauvericin partially overcomes drug resistance in Leishmania tropica 
In this study, the ability of beauvericin (BEA) to overcome ABC transporter-mediated resistance of Leishmania tropica to ML was assessed. In addition, the transcription profile of genes involved in resistance acquisition to ML was inspected. Finally, we explored the efflux mechanism of the drug and inhibitor. The efficacy of ML against all developmental stages of L. tropica in the presence or absence of BEA was evaluated using an absolute quantification assay. The expression of resistance genes was evaluated, comparing susceptible and resistant strains. Finally, the mechanisms governing the interaction between the ABC tran...
Source: Antimicrobial Agents and Chemotherapy - April 4, 2024 Category: Microbiology Authors: Charbel Al Khoury Sergio Thoumi Sima Tokajian Aia Sinno Georges Nemer Mark El Beyrouthy Kelven Rahy Source Type: research

Molecules, Vol. 29, Pages 1620: Chemoselective Synthesis and Anti-Kinetoplastidal Properties of 2,6-Diaryl-4H-tetrahydro-thiopyran-4-one S-Oxides: Their Interplay in a Cascade of Redox Reactions from Diarylideneacetones
h Davioud-Charvet 2,6-Diaryl-4H-tetrahydro-thiopyran-4-ones and corresponding sulfoxide and sulfone derivatives were designed to lower the major toxicity of their parent anti-kinetoplatidal diarylideneacetones through a prodrug effect. Novel diastereoselective methodologies were developed and generalized from diarylideneacetones and 2,6-diaryl-4H-tetrahydro-thiopyran-4-ones to allow the introduction of a wide substitution profile and to prepare the related S-oxides. The in vitro biological activity and selectivity of diarylideneacetones, 2,6-diaryl-4H-tetrahydro-thiopyran-4-ones, and their S-sulfoxide and sulfone metab...
Source: Molecules - April 4, 2024 Category: Chemistry Authors: Thibault Gendron Don Antoine Lanfranchi Nicole I. Wenzel Hripsim ée Kessedjian Beate Jannack Louis Maes Sandrine Cojean Thomas J. J. M üller Philippe M. Loiseau Elisabeth Davioud-Charvet Tags: Article Source Type: research