Short communication: The miR-155a-5p is correlated with increased ROS and impaired apoptosis in macrophages infected by < i > Leishmania braziliensis < /i >

by Tain ã Lago, Thyago Marconi Cardoso, Alan Rocha, Edgar M. Carvalho, Léa Cristina Castellucci Cutaneous leishmaniasis (CL) caused byLeishmania braziliensis, is a disease characterized by well-limited ulcerated lesions with raised borders in exposed parts of the body. miRNAs are recognized for their role in the complex and plastic interaction between host and pathogens, either as part of the host ’s strategy to neutralize infection or as a molecular mechanism employed by the pathogen to modulate host inflammatory pathways to remain undetected. The mir155 targets a broad range of inflammatory mediators, following toll-like receptors (TLRs) signaling. In this work, we evaluated the effects o f the expression of miR155a-5p in human macrophages infected with L. braziliensis. Our results show that miR155a-5p is inversely correlated with early apoptosis and conversely, seems to influence an increment in the oxidative burst in these cells. Altogether, we spotted a functional role of the miR1 55a-5p in CL pathogenesis, raising the hypothesis that an increased miR-155 expression by TLR ligands influences cellular mechanisms settled to promote both killing and control of parasite density after infection.
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research