GSE229796 Effect of electroacupuncture on gene expression of adipose tissue in HFD-induced obese mice
Contributors : Hongyan Gao ; Yanhui LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate whether electroacupuncture (EA) promotes adipose tissue browning by regulating the expression of angiogenesis genes through EA, we sequenced the adipose tissue of mice fed high fat diet with and without electroacupuncture, as well as those fed normally.We then performed gene expression profiling analysis using data obtained from RNA-seq of 9 mice in three groups. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 14, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence
Nutrients. 2024 Mar 26;16(7):952. doi: 10.3390/nu16070952.ABSTRACTHigh-fat diets (HFDs) have pervaded modern dietary habits, characterized by their excessive saturated fat content and low nutritional value. Epidemiological studies have compellingly linked HFD consumption to obesity and the development of type 2 diabetes mellitus. Moreover, the synergistic interplay of HFD, obesity, and diabetes expedites the aging process and prematurely fosters age-related diseases. However, the underlying mechanisms driving these associations remain enigmatic. One of the most conspicuous hallmarks of aging is the accumulation of highly i...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Priya Balasubramanian Tamas Kiss Rafal Gulej Adam Nyul Toth Stefano Tarantini Andriy Yabluchanskiy Zoltan Ungvari Anna Csiszar Source Type: research
lincRNA00907 promotes NASH progression by targeting miRNA-942-5p/TAOK1
CONCLUSIONS: Our research suggests that linc00907 functions as a competitive endogenous RNA (ceRNA) by sequestering miRNA-942-5p, thus increasing the expression of TAOK1 and encouraging lipid accumulation in hepatocytes, leading to the aggravation of NASH development. Targeting the linc00907/miRNA-942-5p/TAOK1 axis may hold therapeutic potential for the treatment of NASH.PMID:38613803 | DOI:10.18632/aging.205730 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Gang Du Zhaochen Jiang Tong Xia Mingkun Liu Zeyang Liu Huaxin Zhou Hao Zhang Xiangyu Zhai Bin Jin Source Type: research
lincRNA00907 promotes NASH progression by targeting miRNA-942-5p/TAOK1
CONCLUSIONS: Our research suggests that linc00907 functions as a competitive endogenous RNA (ceRNA) by sequestering miRNA-942-5p, thus increasing the expression of TAOK1 and encouraging lipid accumulation in hepatocytes, leading to the aggravation of NASH development. Targeting the linc00907/miRNA-942-5p/TAOK1 axis may hold therapeutic potential for the treatment of NASH.PMID:38613803 | DOI:10.18632/aging.205730 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Gang Du Zhaochen Jiang Tong Xia Mingkun Liu Zeyang Liu Huaxin Zhou Hao Zhang Xiangyu Zhai Bin Jin Source Type: research
Geniposide ameliorates atherosclerosis by restoring lipophagy via suppressing PARP1/PI3K/AKT signaling pathway
CONCLUSION: Geniposide alleviated AS by restoring PARP1/PI3K/AKT signaling pathway-suppressed lipophagy. This study is the first to present the lipophagy-inducing effect of Geniposide and the binding of ABCG1 and PLIN1 inhibited by PARP1.PMID:38614041 | DOI:10.1016/j.phymed.2024.155617 (Source: Atherosclerosis)
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Jinhai Lin Xiaolong Wang Mingyang Gu Yuanyuan Chen Jiongbo Xu Nhi Van Chau Junlong Li Xiaodong Ji Qingmin Chu Lijin Qing Wei Wu Source Type: research
lincRNA00907 promotes NASH progression by targeting miRNA-942-5p/TAOK1
CONCLUSIONS: Our research suggests that linc00907 functions as a competitive endogenous RNA (ceRNA) by sequestering miRNA-942-5p, thus increasing the expression of TAOK1 and encouraging lipid accumulation in hepatocytes, leading to the aggravation of NASH development. Targeting the linc00907/miRNA-942-5p/TAOK1 axis may hold therapeutic potential for the treatment of NASH.PMID:38613803 | DOI:10.18632/aging.205730 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Gang Du Zhaochen Jiang Tong Xia Mingkun Liu Zeyang Liu Huaxin Zhou Hao Zhang Xiangyu Zhai Bin Jin Source Type: research
lincRNA00907 promotes NASH progression by targeting miRNA-942-5p/TAOK1
CONCLUSIONS: Our research suggests that linc00907 functions as a competitive endogenous RNA (ceRNA) by sequestering miRNA-942-5p, thus increasing the expression of TAOK1 and encouraging lipid accumulation in hepatocytes, leading to the aggravation of NASH development. Targeting the linc00907/miRNA-942-5p/TAOK1 axis may hold therapeutic potential for the treatment of NASH.PMID:38613803 | DOI:10.18632/aging.205730 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Gang Du Zhaochen Jiang Tong Xia Mingkun Liu Zeyang Liu Huaxin Zhou Hao Zhang Xiangyu Zhai Bin Jin Source Type: research
Oxidized low-density lipoproteins impair the pro-atherosclerotic effect of granulocyte-macrophage-colony-stimulating factor-producing T helper cells on macrophages
This study aims to characterize the phenotype and function of ThGM cells in experimental atherosclerosis. Atherosclerosis was induced by feeding apolipoprotein E knockout (ApoE-/-) mice with a high-fat diet. Aortic ThGM cells were detected and sorted by flow cytometry. The effect of oxidized low-density lipoprotein (oxLDL) on ThGM cells and the impact of ThGM cells on macrophages were evaluated by flow cytometry, quantitative RT-PCR, oxLDL binding/uptake assay, immunoblotting and foam cell formation assay. We found that GM-CSF+IFN-γ- ThGM cells existed in atherosclerotic aortas. Live ThGM cells were enriched in aortic CD4...
Source: Atherosclerosis - April 12, 2024 Category: Cardiology Authors: Xiaofang Xiong Zheng Yan Long Yan Xuexue Yang Dongsheng Li Guizhen Lin Source Type: research
< em > Lycium barbarum < /em > polysaccharide ameliorates the accumulation of lipid droplets in adipose tissue via an ATF6/SIRT1-dependent mechanism
In this study, we hypothesize that LBP alleviates LD accumulation in adipose tissue (AT) by inhibiting fat-specific protein 27 (Fsp27) through an activating transcription factor-6 (ATF6)/small-molecule sirtuin 1 (SIRT1)-dependent mechanism. LD accumulation in AT is induced in high-fat diet (HFD)-fed mice, and differentiation of 3T3-L1 preadipocytes (PAs) is induced. The ability of LBP to alleviate LD accumulation and the possible underlying mechanism are then investigated both in vivo and in vitro. The influences of LBP on the expressions of LD-associated genes ( ATF6 and Fsp27) are also detected. The results show that HFD...
Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Rui Zhou Yajing Liu Weiqian Hu Jing Yang Bing Lin Zhentian Zhang Mingyan Chen Jingwen Yi Cuifeng Zhu Source Type: research
Long-term exposure to dietary emulsifier Tween 80 promotes liver lipid accumulation and induces different-grade inflammation in young and aged mice
In conclusion, our study provides compelling evidence that Tween 80 could contribute to a low-grade inflammation and liver lipid accumulation. These findings underscore the need for increasing attention regarding the consumption of UPFs with Tween 80 as the emulsifier, particularly in the elderly consumers.PMID:38609253 | DOI:10.1016/j.foodres.2024.114205 (Source: Cell Research)
Source: Cell Research - April 12, 2024 Category: Cytology Authors: Enjun Xie Yunmei Chen Wanbao Yang Quan Pan James Zheng Shen Fenghua Zhou Jie Shen Tao Li Qili Li Xiaopeng Li Source Type: research
Oxidized low-density lipoproteins impair the pro-atherosclerotic effect of granulocyte-macrophage-colony-stimulating factor-producing T helper cells on macrophages
This study aims to characterize the phenotype and function of ThGM cells in experimental atherosclerosis. Atherosclerosis was induced by feeding apolipoprotein E knockout (ApoE-/-) mice with a high-fat diet. Aortic ThGM cells were detected and sorted by flow cytometry. The effect of oxidized low-density lipoprotein (oxLDL) on ThGM cells and the impact of ThGM cells on macrophages were evaluated by flow cytometry, quantitative RT-PCR, oxLDL binding/uptake assay, immunoblotting and foam cell formation assay. We found that GM-CSF+IFN-γ- ThGM cells existed in atherosclerotic aortas. Live ThGM cells were enriched in aortic CD4...
Source: Atherosclerosis - April 12, 2024 Category: Cardiology Authors: Xiaofang Xiong Zheng Yan Long Yan Xuexue Yang Dongsheng Li Guizhen Lin Source Type: research
Resolvin D2 prevents vascular remodeling, hypercontractility and endothelial dysfunction in obese hypertensive mice through modulation of vascular and proinflammatory factors
Biomed Pharmacother. 2024 Apr 11;174:116564. doi: 10.1016/j.biopha.2024.116564. Online ahead of print.ABSTRACTDuring resolution of inflammation, specialized proresolving mediators (SPMs), including resolvins, are produced to restore tissue homeostasis. We hypothesized that there might be a dysregulation of SPMs pathways in pathological vascular remodeling and that resolvin D2 (RvD2) might prevent vascular remodeling and contractile and endothelial dysfunction in a model of obesity and hypertension. In aortic samples of patients with or without abdominal aortic aneurysms (AAA), we evaluated gene expression of enzymes involv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2024 Category: Drugs & Pharmacology Authors: Raquel Rodrigues-Diez Constanza Ballesteros-Martinez Rosa Mar ía Moreno-Carriles Francisco Nistal Luc ía S Díaz Del Campo Victoria Cachofeiro Jesmond Dalli Ana B Garc ía-Redondo Juan M Redondo Mercedes Salaices Ana M Briones Source Type: research
Sea cucumber plasmalogen enhance lipophagy to alleviate abnormal lipid accumulation induced by high-fat diet
Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Apr 10:159495. doi: 10.1016/j.bbalip.2024.159495. Online ahead of print.ABSTRACTSea cucumber phospholipids, including the plasmalogen (PlsEtn) and plasmanylcholine (PakCho), have been shown to play a regulatory role in lipid metabolism disorders, but their mechanism of action remains unclear. Therefore, high-fat diet (HFD) and palmitic acid were used to establish lipid accumulation models in mice and HepG2 cells, respectively. Results showed that PlsEtn can reduce lipid deposition both in vivo and in vitro. HFD stimulation abnormally activated lipophagy through the phosphoryl...
Source: Mol Biol Cell - April 12, 2024 Category: Molecular Biology Authors: Zhigao Wang Yanjun Liu Xiaoxu Wang Xincen Wang Yuan Wu Yu Song Jie Xu Changhu Xue Source Type: research
< em > Lycium barbarum < /em > polysaccharide ameliorates the accumulation of lipid droplets in adipose tissue via an ATF6/SIRT1-dependent mechanism
In this study, we hypothesize that LBP alleviates LD accumulation in adipose tissue (AT) by inhibiting fat-specific protein 27 (Fsp27) through an activating transcription factor-6 (ATF6)/small-molecule sirtuin 1 (SIRT1)-dependent mechanism. LD accumulation in AT is induced in high-fat diet (HFD)-fed mice, and differentiation of 3T3-L1 preadipocytes (PAs) is induced. The ability of LBP to alleviate LD accumulation and the possible underlying mechanism are then investigated both in vivo and in vitro. The influences of LBP on the expressions of LD-associated genes ( ATF6 and Fsp27) are also detected. The results show that HFD...
Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Rui Zhou Yajing Liu Weiqian Hu Jing Yang Bing Lin Zhentian Zhang Mingyan Chen Jingwen Yi Cuifeng Zhu Source Type: research
Sea cucumber plasmalogen enhance lipophagy to alleviate abnormal lipid accumulation induced by high-fat diet
Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Apr 10;1869(5):159495. doi: 10.1016/j.bbalip.2024.159495. Online ahead of print.ABSTRACTSea cucumber phospholipids, including the plasmalogen (PlsEtn) and plasmanylcholine (PakCho), have been shown to play a regulatory role in lipid metabolism disorders, but their mechanism of action remains unclear. Therefore, high-fat diet (HFD) and palmitic acid were used to establish lipid accumulation models in mice and HepG2 cells, respectively. Results showed that PlsEtn can reduce lipid deposition both in vivo and in vitro. HFD stimulation abnormally activated lipophagy through the ph...
Source: Biochimica et Biophysica Acta - April 12, 2024 Category: Biochemistry Authors: Zhigao Wang Yanjun Liu Xiaoxu Wang Xincen Wang Yuan Wu Yu Song Jie Xu Changhu Xue Source Type: research
