A shift to a standard diet after exposure to a high-fat, high-sucrose diet from gestation to weaning restores brain metabolism and behavioral flexibility in adult rats
In conclusion, switching from an HFS diet to a balanced diet after weaning would have beneficial effects on behavioral flexibility and brain metabolism, without significant sex differences.PMID:38679144 | DOI:10.1016/j.bbr.2024.115020 (Source: Brain Research)
Source: Brain Research - April 28, 2024 Category: Neurology Authors: Sa úl Sal-Sarria Isabel L ópez-Taboada H éctor González-Pardo N élida M Conejo Source Type: research
A shift to a standard diet after exposure to a high-fat, high-sucrose diet from gestation to weaning restores brain metabolism and behavioral flexibility in adult rats
In conclusion, switching from an HFS diet to a balanced diet after weaning would have beneficial effects on behavioral flexibility and brain metabolism, without significant sex differences.PMID:38679144 | DOI:10.1016/j.bbr.2024.115020 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - April 28, 2024 Category: Neurology Authors: Sa úl Sal-Sarria Isabel L ópez-Taboada H éctor González-Pardo N élida M Conejo Source Type: research
Oscillatory shear stress promotes endothelial senescence and atherosclerosis via STING activation
Biochem Biophys Res Commun. 2024 Apr 23;715:149979. doi: 10.1016/j.bbrc.2024.149979. Online ahead of print.ABSTRACTEndothelial dysfunction is an initiating factor in atherosclerosis. Endothelial cells (ECs) are constantly subject to blood flow shear stress, and atherosclerotic plaques tend to occur in aortic bends or bifurcations impaired by low oscillatory shear stress (OSS). However, the mechanism that how OSS affects the initiation and progression of atherosclerosis remains to be explored. Here, we first reported that OSS can promote endothelial dysfunction and atherogenesis in vivo and in vitro by activating STING path...
Source: Biochemical and Biophysical Research communications - April 28, 2024 Category: Biochemistry Authors: Mengdie Dong Minghong Chen Yunjia Zhang Xian He Jiao Min Yongkang Tan Huiyuan Wei Xinyu Li Xiang Chen Longbin Zheng Quanwen Yin Xuesong Li Hongshan Chen Hong Jiang Source Type: research
Sesamin ameliorates nonalcoholic hepatic steatosis by inhibiting CD36-mediated hepatocyte lipid accumulation in vitro and in vivo
In this study, we observed the anti-hepatic steatosis effects of Ses in palmitate/oleate (PA/OA)-incubated primary mouse hepatocytes, AML12 hepatocytes, and HepG2 cells, as well as in high-fat, high-cholesterol diet-induced NASH mice. RNA sequencing analysis revealed that cluster of differentiation 36 (CD36), a free fatty acid (FA) transport protein, was involved in the Ses-mediated inhibition of hepatic fat accumulation. Moreover, the overexpression of CD36 significantly increased hepatic steatosis in both Ses-treated PA/OA-incubated HepG2 cells and NASH mice. Furthermore, Ses treatment suppressed insulin-induced de novo ...
Source: Biochemical Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Ya-Ping Bai Teng Zhang Zheng-Yan Hu Yan Zhang De-Guo Wang Meng-Yun Zhou Ying Zhang Fang Zhang Xiang Kong Source Type: research
A shift to a standard diet after exposure to a high-fat, high-sucrose diet from gestation to weaning restores brain metabolism and behavioral flexibility in adult rats
In conclusion, switching from an HFS diet to a balanced diet after weaning would have beneficial effects on behavioral flexibility and brain metabolism, without significant sex differences.PMID:38679144 | DOI:10.1016/j.bbr.2024.115020 (Source: Brain Research)
Source: Brain Research - April 28, 2024 Category: Neurology Authors: Sa úl Sal-Sarria Isabel L ópez-Taboada H éctor González-Pardo N élida M Conejo Source Type: research
A shift to a standard diet after exposure to a high-fat, high-sucrose diet from gestation to weaning restores brain metabolism and behavioral flexibility in adult rats
In conclusion, switching from an HFS diet to a balanced diet after weaning would have beneficial effects on behavioral flexibility and brain metabolism, without significant sex differences.PMID:38679144 | DOI:10.1016/j.bbr.2024.115020 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - April 28, 2024 Category: Neurology Authors: Sa úl Sal-Sarria Isabel L ópez-Taboada H éctor González-Pardo N élida M Conejo Source Type: research
The Effect of Broccoli Glucoraphanin Supplementation on Ameliorating High ‐Fat‐Diet‐Induced Obesity through the Gut Microbiome and Metabolome Interface
ConclusionThese results indicate that beneficial effects of broccoli GRN on reversing HFD-induced adverse metabolic parameters may be attributed to its impacts on reprogramming microbial community and metabolites. Identification of the mechanistic functions of GRN further warrants it as a dietary candidate for obesity prevention. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 28, 2024 Category: Food Science Authors: Taiwo Bankole,
Tianzhou Ma,
Itika Arora,
Zhentian Lei,
Murugesan Raju,
Zhenhai Li,
Yuanyuan Li Tags: Research Article Source Type: research
LXR Agonist T0901317's Hepatic Impact Overrules Its Atheroprotective Action in Macrophages, Driving Early Atherogenesis in Chow-Diet-Fed Male Apolipoprotein E Knockout Mice
In conclusion, these findings highlight that the pro-atherogenic hepatic effects of LXR agonism are dominant over the anti-atherogenic effects in macrophages in determining the overall atherosclerosis outcome under low-fat diet feeding conditions. A low-fat diet experimental setting, as compared to the commonly used high-fat-diet-based preclinical setup, thus appears more sensitive in uncovering the potential relevance of the off-target liver effects of novel anti-atherogenic therapeutic approaches that target macrophage LXR.PMID:38672446 | DOI:10.3390/biom14040429 (Source: Atherosclerosis)
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Menno Hoekstra Laura M de Jong Rick van der Geest Lidewij R de Leeuw Rani Krisnamurthi Janine J Geerling Miranda Van Eck Source Type: research
IL-33 Reduces Saturated Fatty Acid Accumulation in Mouse Atherosclerotic Foci
This study aimed to elucidate the pathogenesis of atherosclerosis development using atherosclerosis model mice (ApoE KO mice) and mice deficient in IL-33 receptor ST2 (ApoEST2 DKO mice). Sixteen-week-old male ApoE KO and ApoEST2 DKO mice were subjected to an 8-week regimen of a high-fat, high-sucrose diet. Atherosclerotic foci were assessed histologically at the aortic valve ring. Chronic inflammation was assessed using flow cytometry and real-time polymerase chain reaction. In addition, saturated fatty acids (palmitic acid) and IL-33 were administered to human aortic endothelial cells (HAECs) to assess fatty acid metaboli...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Yukako Hosomi Takuro Okamura Kimiko Sakai Hiroki Yuge Takashi Yoshimura Saori Majima Hiroshi Okada Takafumi Senmaru Emi Ushigome Naoko Nakanishi Takashi Satoh Shizuo Akira Masahide Hamaguchi Michiaki Fukui Source Type: research
Ginseng polysaccharide components attenuate obesity and liver lipid accumulation by regulating fecal microbiota and hepatic lysine degradation
In this study, we found that PGP inhibited the high-fat diet (HFD)-induced weight gain, fat ratio and fat tissue weight after 8-week administration. Serum and liver lipid analysis showed that PGP decreased the levels of triglyceride and total cholesterol, which was mediated by the inhibition of key genes for fatty acid and cholesterol metabolisms. Metabolomics studies showed that the inhibitory effect of PGP on liver lipid accumulation was significantly correlated with its regulation of citric acid cycle and lysine degradation. PGP regulated the expression of genes related to lysine degradation in both liver tissue and hep...
Source: International Journal of Biological Macromolecules - April 27, 2024 Category: Biochemistry Authors: Qing Liu Zepeng Zhang Peng Ji Jiaqi Liu Boxue Chen E Mingyao Hongyu Qi Tong Hou Qingxia Huang Lu Ding Chen Guo Daqing Zhao Wenzhi Yang Zeyu Wang Xiangyan Li Source Type: research
Prolyl isomerase Pin1 in skeletal muscles contributes to systemic energy metabolism and exercise capacity through regulating SERCA activity
Biochem Biophys Res Commun. 2024 Apr 24;715:150001. doi: 10.1016/j.bbrc.2024.150001. Online ahead of print.ABSTRACTThe skeletal muscle is a pivotal organ involved in the regulation of both energy metabolism and exercise capacity. There is no doubt that exercise contributes to a healthy life through the consumption of excessive energy or the release of myokines. Skeletal muscles exhibit insulin sensitivity and can rapidly uptake blood glucose. In addition, they can undergo non-shivering thermogenesis through actions of both the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) and small peptide, sarcolipin, resulting i...
Source: Biochemical and Biophysical Research communications - April 27, 2024 Category: Biochemistry Authors: Yusuke Nakatsu Yasuka Matsunaga Mikako Nakanishi Takeshi Yamamotoya Tomomi Sano Takashi Kanematsu Tomoichiro Asano Source Type: research
LXR Agonist T0901317's Hepatic Impact Overrules Its Atheroprotective Action in Macrophages, Driving Early Atherogenesis in Chow-Diet-Fed Male Apolipoprotein E Knockout Mice
In conclusion, these findings highlight that the pro-atherogenic hepatic effects of LXR agonism are dominant over the anti-atherogenic effects in macrophages in determining the overall atherosclerosis outcome under low-fat diet feeding conditions. A low-fat diet experimental setting, as compared to the commonly used high-fat-diet-based preclinical setup, thus appears more sensitive in uncovering the potential relevance of the off-target liver effects of novel anti-atherogenic therapeutic approaches that target macrophage LXR.PMID:38672446 | PMC:PMC11047872 | DOI:10.3390/biom14040429 (Source: Atherosclerosis)
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Menno Hoekstra Laura M de Jong Rick van der Geest Lidewij R de Leeuw Rani Krisnamurthi Janine J Geerling Miranda Van Eck Source Type: research
IL-33 Reduces Saturated Fatty Acid Accumulation in Mouse Atherosclerotic Foci
This study aimed to elucidate the pathogenesis of atherosclerosis development using atherosclerosis model mice (ApoE KO mice) and mice deficient in IL-33 receptor ST2 (ApoEST2 DKO mice). Sixteen-week-old male ApoE KO and ApoEST2 DKO mice were subjected to an 8-week regimen of a high-fat, high-sucrose diet. Atherosclerotic foci were assessed histologically at the aortic valve ring. Chronic inflammation was assessed using flow cytometry and real-time polymerase chain reaction. In addition, saturated fatty acids (palmitic acid) and IL-33 were administered to human aortic endothelial cells (HAECs) to assess fatty acid metaboli...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Yukako Hosomi Takuro Okamura Kimiko Sakai Hiroki Yuge Takashi Yoshimura Saori Majima Hiroshi Okada Takafumi Senmaru Emi Ushigome Naoko Nakanishi Takashi Satoh Shizuo Akira Masahide Hamaguchi Michiaki Fukui Source Type: research
Ginseng polysaccharide components attenuate obesity and liver lipid accumulation by regulating fecal microbiota and hepatic lysine degradation
In this study, we found that PGP inhibited the high-fat diet (HFD)-induced weight gain, fat ratio and fat tissue weight after 8-week administration. Serum and liver lipid analysis showed that PGP decreased the levels of triglyceride and total cholesterol, which was mediated by the inhibition of key genes for fatty acid and cholesterol metabolisms. Metabolomics studies showed that the inhibitory effect of PGP on liver lipid accumulation was significantly correlated with its regulation of citric acid cycle and lysine degradation. PGP regulated the expression of genes related to lysine degradation in both liver tissue and hep...
Source: International Journal of Biological Macromolecules - April 27, 2024 Category: Biochemistry Authors: Qing Liu Zepeng Zhang Peng Ji Jiaqi Liu Boxue Chen E Mingyao Hongyu Qi Tong Hou Qingxia Huang Lu Ding Chen Guo Daqing Zhao Wenzhi Yang Zeyu Wang Xiangyan Li Source Type: research
Prolyl isomerase Pin1 in skeletal muscles contributes to systemic energy metabolism and exercise capacity through regulating SERCA activity
Biochem Biophys Res Commun. 2024 Apr 24;715:150001. doi: 10.1016/j.bbrc.2024.150001. Online ahead of print.ABSTRACTThe skeletal muscle is a pivotal organ involved in the regulation of both energy metabolism and exercise capacity. There is no doubt that exercise contributes to a healthy life through the consumption of excessive energy or the release of myokines. Skeletal muscles exhibit insulin sensitivity and can rapidly uptake blood glucose. In addition, they can undergo non-shivering thermogenesis through actions of both the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) and small peptide, sarcolipin, resulting i...
Source: Biochemical and Biophysical Research communications - April 27, 2024 Category: Biochemistry Authors: Yusuke Nakatsu Yasuka Matsunaga Mikako Nakanishi Takeshi Yamamotoya Tomomi Sano Takashi Kanematsu Tomoichiro Asano Source Type: research
