High-fat diet enhances cell proliferation and compromises intestinal permeability in a translational canine intestinal organoid model
Emerging evidence underscores the responsiveness of the mammalian intestine to dietary cues, notably through the involvement of LGR5 + intestinal stem cells in orchestrating responses to diet-driven signals. H... (Source: BMC Cell Biology)
Source: BMC Cell Biology - April 30, 2024 Category: Cytology Authors: Itsuma Nagao and Yoko M. Ambrosini Tags: Research Source Type: research
Adipose Tissue-Brain Interactions Modulate an Anorexia-Related Phenotype in Mice
Anorexia nervosa (AN) is characterized by hypophagia, low body weight, and compulsive exercise. The activity-based anorexia (ABA) paradigm induces aspects of AN in rodents. We tested whether transplanting adipose tissue from high fat diet-fed obese mice into normal weight recipient mice would attenuate ABA in recipients. We also assessed whether the effects of transplanted obese fat depend upon hypothalamic AgRP neurons. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Dongmin Yoon, Zhang Jie, Rizaldy Zapata, Imran Kyeso, Eeshi Uppalapati, Stephanie Dulawa Tags: SYMPOSIUM Source Type: research
Ameliorative effects of < em > Myrtus communis < /em > L. extract involving the inhibition of oxidative stress on high fat diet-induced testis damage in rats
In conclusion, HFD caused alterations in sperm parameters and testicular morphology by increasing oxidative damage and apoptosis. MC extract may have potential protective effects by inhibiting oxidative damage.PMID:38682543 | DOI:10.1080/10520295.2024.2344491 (Source: Biotechnic and Histochemistry)
Source: Biotechnic and Histochemistry - April 29, 2024 Category: Research Authors: Busra Coskunlu M Kutay Koroglu Irem Hersek Busra Ertas Ali Sen Goksel Sener Feriha Ercan Source Type: research
Ameliorative effects of < em > Myrtus communis < /em > L. extract involving the inhibition of oxidative stress on high fat diet-induced testis damage in rats
In conclusion, HFD caused alterations in sperm parameters and testicular morphology by increasing oxidative damage and apoptosis. MC extract may have potential protective effects by inhibiting oxidative damage.PMID:38682543 | DOI:10.1080/10520295.2024.2344491 (Source: Biotechnic and Histochemistry)
Source: Biotechnic and Histochemistry - April 29, 2024 Category: Research Authors: Busra Coskunlu M Kutay Koroglu Irem Hersek Busra Ertas Ali Sen Goksel Sener Feriha Ercan Source Type: research
Ameliorative effects of < em > Myrtus communis < /em > L. extract involving the inhibition of oxidative stress on high fat diet-induced testis damage in rats
In conclusion, HFD caused alterations in sperm parameters and testicular morphology by increasing oxidative damage and apoptosis. MC extract may have potential protective effects by inhibiting oxidative damage.PMID:38682543 | DOI:10.1080/10520295.2024.2344491 (Source: Biotechnic and Histochemistry)
Source: Biotechnic and Histochemistry - April 29, 2024 Category: Research Authors: Busra Coskunlu M Kutay Koroglu Irem Hersek Busra Ertas Ali Sen Goksel Sener Feriha Ercan Source Type: research
Ameliorative effects of < em > Myrtus communis < /em > L. extract involving the inhibition of oxidative stress on high fat diet-induced testis damage in rats
In conclusion, HFD caused alterations in sperm parameters and testicular morphology by increasing oxidative damage and apoptosis. MC extract may have potential protective effects by inhibiting oxidative damage.PMID:38682543 | DOI:10.1080/10520295.2024.2344491 (Source: Biotechnic and Histochemistry)
Source: Biotechnic and Histochemistry - April 29, 2024 Category: Research Authors: Busra Coskunlu M Kutay Koroglu Irem Hersek Busra Ertas Ali Sen Goksel Sener Feriha Ercan Source Type: research
Oncheong-eum alleviated hepatic lipid accumulation and intestinal barrier disruption in nonalcoholic steatohepatitis in vivo model
ConclusionOCE reduces body weight, increases the weight of organs when fed a high-fat diet, and improves the lipid composition of the serum and liver. Therefore, OCE has shown great application potential as a material for obesity-related medicines and health-functional food. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 29, 2024 Category: Cytology Source Type: research
Influence of Gadoxetate disodium to the hepatic proton density fat fraction quantified with the Dixon sequences in a rabbit model
Conclusion2E- and 6E-VIBE Dixon can obtain accurate PDFFs in the hepatobiliary specific phase from 13 to 17th min after Gx enhancement. On 2E-VIBE Dixon (FA = 10°), effective minimization of T1 Bias by the Gx administration markedly improved the accuracy of the hepatic PDFF quantification.Graphical abstract (Source: Abdominal Imaging)
Source: Abdominal Imaging - April 29, 2024 Category: Radiology Source Type: research
Bone-derived PDGF-BB enhances hippocampal non-specific transcytosis through microglia-endothelial crosstalk in HFD-induced metabolic syndrome
It is well known that high-fat diet (HFD)-induced metabolic syndrome plays a crucial role in cognitive decline and brain-blood barrier (BBB) breakdown. However, whether the bone-brain axis participates in this... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 29, 2024 Category: Neurology Authors: Guanqiao Liu, Wen Shu, Yingqi Chen, Yong Fu, Shuai Fang, Haonan Zheng, Weike Cheng, Qingrong Lin, Yanjun Hu, Nan Jiang and Bin Yu Tags: Research Source Type: research
Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction
Obesity increases the morbidity and mortality of traumatic brain injury (TBI). Detailed analyses of transcriptomic changes in the brain and adipose tissue were performed to elucidate the interactive effects be... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 29, 2024 Category: Neurology Authors: Rebecca J. Henry, James P. Barrett, Maria Vaida, Niaz Z. Khan, Oleg Makarevich, Rodney M. Ritzel, Alan I. Faden and Bogdan A. Stoica Tags: Research Source Type: research
Transcriptomic analysis reveals the critical role of Chemokine signaling in the anti-atherosclerosis effect of Xuefu Zhuyu Decoction
CONCLUSION: Xuefu Zhuyu decoction demonstrates effective regulation of plaque components, retarding plaque progression and preserving plaque stability by modulating lipid metabolism and inflammatory responses. Subsequent transcriptome analysis identified the cytokine-cytokine receptor interaction and chemokine signaling pathway as potential key pathways for the therapeutic effects of Xuefu Zhuyu decoction. This insight not only provides crucial avenues for further exploration into the mechanisms underlying Xuefu Zhuyu decoction but also offers valuable perspectives and hypotheses for enhancing disease prevention and treatm...
Source: Atherosclerosis - April 28, 2024 Category: Cardiology Authors: Dongdong Jia Mengzhu Zhao Xinyue Zhang Xu Cheng Qiong Wei Lixia Lou Yizhou Zhao Qiushuo Jin Meng Chen Dongmei Zhang Source Type: research
Oscillatory shear stress promotes endothelial senescence and atherosclerosis via STING activation
Biochem Biophys Res Commun. 2024 Apr 23;715:149979. doi: 10.1016/j.bbrc.2024.149979. Online ahead of print.ABSTRACTEndothelial dysfunction is an initiating factor in atherosclerosis. Endothelial cells (ECs) are constantly subject to blood flow shear stress, and atherosclerotic plaques tend to occur in aortic bends or bifurcations impaired by low oscillatory shear stress (OSS). However, the mechanism that how OSS affects the initiation and progression of atherosclerosis remains to be explored. Here, we first reported that OSS can promote endothelial dysfunction and atherogenesis in vivo and in vitro by activating STING path...
Source: Atherosclerosis - April 28, 2024 Category: Cardiology Authors: Mengdie Dong Minghong Chen Yunjia Zhang Xian He Jiao Min Yongkang Tan Huiyuan Wei Xinyu Li Xiang Chen Longbin Zheng Quanwen Yin Xuesong Li Hongshan Chen Hong Jiang Source Type: research
Inhibition of vascular calcification by Compound Danshen Dripping Pill through multiple mechanisms
CONCLUSIONS: Our study suggests that CDDP reduces vascular calcification by regulating the DKK1/LRP6/β-catenin signaling pathway in ECs/SMCs and interactions with the crosstalk of ECs and SMCs. It also reduces the senescence of ECs/SMCs, contributing to the Sirt1 activation, indicating CDDP's novel role in ameliorating vascular calcification.PMID:38678949 | DOI:10.1016/j.phymed.2024.155618 (Source: Atherosclerosis)
Source: Atherosclerosis - April 28, 2024 Category: Cardiology Authors: Yanfang Yang Liying Yuan Hui Xiong Kaimin Guo Mengying Zhang Tengteng Yan Wenjia Wang Shuiping Zhou He Sun Shuang Zhang Yajun Duan Yunhui Hu Source Type: research
Sesamin ameliorates nonalcoholic hepatic steatosis by inhibiting CD36-mediated hepatocyte lipid accumulation in vitro and in vivo
In this study, we observed the anti-hepatic steatosis effects of Ses in palmitate/oleate (PA/OA)-incubated primary mouse hepatocytes, AML12 hepatocytes, and HepG2 cells, as well as in high-fat, high-cholesterol diet-induced NASH mice. RNA sequencing analysis revealed that cluster of differentiation 36 (CD36), a free fatty acid (FA) transport protein, was involved in the Ses-mediated inhibition of hepatic fat accumulation. Moreover, the overexpression of CD36 significantly increased hepatic steatosis in both Ses-treated PA/OA-incubated HepG2 cells and NASH mice. Furthermore, Ses treatment suppressed insulin-induced de novo ...
Source: Biochemical Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Ya-Ping Bai Teng Zhang Zheng-Yan Hu Yan Zhang De-Guo Wang Meng-Yun Zhou Ying Zhang Fang Zhang Xiang Kong Source Type: research
A shift to a standard diet after exposure to a high-fat, high-sucrose diet from gestation to weaning restores brain metabolism and behavioral flexibility in adult rats
In conclusion, switching from an HFS diet to a balanced diet after weaning would have beneficial effects on behavioral flexibility and brain metabolism, without significant sex differences.PMID:38679144 | DOI:10.1016/j.bbr.2024.115020 (Source: Brain Research)
Source: Brain Research - April 28, 2024 Category: Neurology Authors: Sa úl Sal-Sarria Isabel L ópez-Taboada H éctor González-Pardo N élida M Conejo Source Type: research
