< em > Lycium barbarum < /em > polysaccharide ameliorates the accumulation of lipid droplets in adipose tissue via an ATF6/SIRT1-dependent mechanism
In this study, we hypothesize that LBP alleviates LD accumulation in adipose tissue (AT) by inhibiting fat-specific protein 27 (Fsp27) through an activating transcription factor-6 (ATF6)/small-molecule sirtuin 1 (SIRT1)-dependent mechanism. LD accumulation in AT is induced in high-fat diet (HFD)-fed mice, and differentiation of 3T3-L1 preadipocytes (PAs) is induced. The ability of LBP to alleviate LD accumulation and the possible underlying mechanism are then investigated both in vivo and in vitro. The influences of LBP on the expressions of LD-associated genes ( ATF6 and Fsp27) are also detected. The results show that HFD...
Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Rui Zhou Yajing Liu Weiqian Hu Jing Yang Bing Lin Zhentian Zhang Mingyan Chen Jingwen Yi Cuifeng Zhu Source Type: research
Resolvin D2 prevents vascular remodeling, hypercontractility and endothelial dysfunction in obese hypertensive mice through modulation of vascular and proinflammatory factors
Biomed Pharmacother. 2024 Apr 11;174:116564. doi: 10.1016/j.biopha.2024.116564. Online ahead of print.ABSTRACTDuring resolution of inflammation, specialized proresolving mediators (SPMs), including resolvins, are produced to restore tissue homeostasis. We hypothesized that there might be a dysregulation of SPMs pathways in pathological vascular remodeling and that resolvin D2 (RvD2) might prevent vascular remodeling and contractile and endothelial dysfunction in a model of obesity and hypertension. In aortic samples of patients with or without abdominal aortic aneurysms (AAA), we evaluated gene expression of enzymes involv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2024 Category: Drugs & Pharmacology Authors: Raquel Rodrigues-Diez Constanza Ballesteros-Martinez Rosa Mar ía Moreno-Carriles Francisco Nistal Luc ía S Díaz Del Campo Victoria Cachofeiro Jesmond Dalli Ana B Garc ía-Redondo Juan M Redondo Mercedes Salaices Ana M Briones Source Type: research
< em > Lycium barbarum < /em > polysaccharide ameliorates the accumulation of lipid droplets in adipose tissue via an ATF6/SIRT1-dependent mechanism
In this study, we hypothesize that LBP alleviates LD accumulation in adipose tissue (AT) by inhibiting fat-specific protein 27 (Fsp27) through an activating transcription factor-6 (ATF6)/small-molecule sirtuin 1 (SIRT1)-dependent mechanism. LD accumulation in AT is induced in high-fat diet (HFD)-fed mice, and differentiation of 3T3-L1 preadipocytes (PAs) is induced. The ability of LBP to alleviate LD accumulation and the possible underlying mechanism are then investigated both in vivo and in vitro. The influences of LBP on the expressions of LD-associated genes ( ATF6 and Fsp27) are also detected. The results show that HFD...
Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Rui Zhou Yajing Liu Weiqian Hu Jing Yang Bing Lin Zhentian Zhang Mingyan Chen Jingwen Yi Cuifeng Zhu Source Type: research
< em > Lycium barbarum < /em > polysaccharide ameliorates the accumulation of lipid droplets in adipose tissue via an ATF6/SIRT1-dependent mechanism
In this study, we hypothesize that LBP alleviates LD accumulation in adipose tissue (AT) by inhibiting fat-specific protein 27 (Fsp27) through an activating transcription factor-6 (ATF6)/small-molecule sirtuin 1 (SIRT1)-dependent mechanism. LD accumulation in AT is induced in high-fat diet (HFD)-fed mice, and differentiation of 3T3-L1 preadipocytes (PAs) is induced. The ability of LBP to alleviate LD accumulation and the possible underlying mechanism are then investigated both in vivo and in vitro. The influences of LBP on the expressions of LD-associated genes ( ATF6 and Fsp27) are also detected. The results show that HFD...
Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Rui Zhou Yajing Liu Weiqian Hu Jing Yang Bing Lin Zhentian Zhang Mingyan Chen Jingwen Yi Cuifeng Zhu Source Type: research
Would Combination Be Better: Swimming Exercise and Intermittent Fasting Improve High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Obese Rats via the miR-122-5p/SREBP-1c/CPT1A Pathway
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - April 11, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
A cross talk study on sitagliptin mediated reclamation on TGF β signalling, DPP 4, miR-29a and miR-24 expression in PCOS rats fed with high fat-high fructose diet
In conclusion, current results reflect the potential impact of STG against dyslipidaemia, inflammation and fibrosis in PCOS rats via regulating dyslipidaemia and fibrosis via DPP 4 mediated miR-29a expression.PMID:38604038 | DOI:10.1016/j.tice.2024.102375 (Source: Tissue and Cell)
Source: Tissue and Cell - April 11, 2024 Category: Cytology Authors: Dipti Nanda Anuradha Carani Venkatraman Kalpana Kalaivanan Source Type: research
High-fat diet consumption promotes adolescent neurobehavioral abnormalities and hippocampal structural alterations via microglial overactivation accompanied by an elevated serum free fatty acid concentration
In conclusion, our studies demonstrate that the adverse influence of early-life HFD consumption on behavior and hippocampal structure is attributed at least in part to microglial overaction that is accompanied by an elevated serum FFA concentration and microglial aberrations represent a potential preventive and therapeutic target for HFD-related emotional disorders.PMID:38604269 | DOI:10.1016/j.bbi.2024.04.005 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 11, 2024 Category: Neurology Authors: Xiuting Yao Chenxi Yang Xirui Jia Zhehao Yu Conghui Wang Jingyi Zhao Yuxi Chen Bingjie Xie Hong Zhuang Congli Sun Qian Li Xiaomin Kang Yu Xiao Lijie Liu Source Type: research
Association between dietary pattern and Helicobacter Pylori infection at Queen Elizabeth Hospital, Kota Kinabalu: A case-control study
CONCLUSION: To conclude, "high fiber pattern" lowers the risk of H. pylori infection while "high salt pattern" increases the infection risk. Our study also highlighted the importance of nutrient intake within daily allowances.PMID:38604869 | DOI:10.1016/j.asjsur.2024.03.177 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 11, 2024 Category: Surgery Authors: Vanessa Urie Kasum Firdaus Hayati Syed Sharizman Syed Abdul Rahim Nik Amin Sahid Nik Lah Serene En Hui Tung Source Type: research
Curcuma wenyujin rhizomes extract ameliorates lipid accumulation
In conclusion, CWP rich in sesquiterpenes reduces the accumulation of lipids in vivo and in vitro by improving lipid metabolism and activating autophagy.PMID:38604260 | DOI:10.1016/j.fitote.2024.105957 (Source: Fitoterapia)
Source: Fitoterapia - April 11, 2024 Category: Biochemistry Authors: Hong Wang Lijia Chen Ruiyu Zhang Guanying Zhang Jingwen Liu Fujiang Guo Source Type: research
Feeding dogs a high-fat diet induces metabolic changes similar to natural aging, including dyslipidemia, hyperinsulinemia, and peripheral insulin resistance
Am J Vet Res. 2024 Apr 15:1-11. doi: 10.2460/ajvr.23.11.0253. Online ahead of print.ABSTRACTOBJECTIVE: The goal of this study was to characterize changes induced by a high-fat diet in body composition, insulin levels and sensitivity, blood lipids, and other key biomarkers also associated with the metabolic dysfunction that occurs with natural aging.ANIMALS: 24 male Beagle dogs, 3 to 7 years of age, of mixed castration status.METHODS: Dogs were randomly assigned to continue twice daily feeding of the commercial adult maintenance diet (n = 12, including 2 intact) that they were previously fed or to a high-fat diet (12, inclu...
Source: American Journal of Veterinary Research - April 11, 2024 Category: Veterinary Research Authors: Brennen McKenzie Matthew Peloquin Ashley Tovar Jessica L Graves Ellen Ratcliff Katya Tucker Kenny Vo Karen Greenwood Celine-Lea Halioua-Haubold Dina Juarez-Salinas Source Type: research
A cross talk study on sitagliptin mediated reclamation on TGF β signalling, DPP 4, miR-29a and miR-24 expression in PCOS rats fed with high fat-high fructose diet
In conclusion, current results reflect the potential impact of STG against dyslipidaemia, inflammation and fibrosis in PCOS rats via regulating dyslipidaemia and fibrosis via DPP 4 mediated miR-29a expression.PMID:38604038 | DOI:10.1016/j.tice.2024.102375 (Source: Tissue and Cell)
Source: Tissue and Cell - April 11, 2024 Category: Cytology Authors: Dipti Nanda Anuradha Carani Venkatraman Kalpana Kalaivanan Source Type: research
High-fat diet consumption promotes adolescent neurobehavioral abnormalities and hippocampal structural alterations via microglial overactivation accompanied by an elevated serum free fatty acid concentration
In conclusion, our studies demonstrate that the adverse influence of early-life HFD consumption on behavior and hippocampal structure is attributed at least in part to microglial overactivation that is accompanied by an elevated serum FFA concentration and microglial aberrations represent a potential preventive and therapeutic target for HFD-related emotional disorders.PMID:38604269 | DOI:10.1016/j.bbi.2024.04.005 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 11, 2024 Category: Neurology Authors: Xiuting Yao Chenxi Yang Xirui Jia Zhehao Yu Conghui Wang Jingyi Zhao Yuxi Chen Bingjie Xie Hong Zhuang Congli Sun Qian Li Xiaomin Kang Yu Xiao Lijie Liu Source Type: research
Curcuma wenyujin rhizomes extract ameliorates lipid accumulation
In conclusion, CWP rich in sesquiterpenes reduces the accumulation of lipids in vivo and in vitro by improving lipid metabolism and activating autophagy.PMID:38604260 | DOI:10.1016/j.fitote.2024.105957 (Source: Fitoterapia)
Source: Fitoterapia - April 11, 2024 Category: Biochemistry Authors: Hong Wang Lijia Chen Ruiyu Zhang Guanying Zhang Jingwen Liu Fujiang Guo Source Type: research
Feeding dogs a high-fat diet induces metabolic changes similar to natural aging, including dyslipidemia, hyperinsulinemia, and peripheral insulin resistance
Am J Vet Res. 2024 Apr 15:1-11. doi: 10.2460/ajvr.23.11.0253. Online ahead of print.ABSTRACTOBJECTIVE: The goal of this study was to characterize changes induced by a high-fat diet in body composition, insulin levels and sensitivity, blood lipids, and other key biomarkers also associated with the metabolic dysfunction that occurs with natural aging.ANIMALS: 24 male Beagle dogs, 3 to 7 years of age, of mixed castration status.METHODS: Dogs were randomly assigned to continue twice daily feeding of the commercial adult maintenance diet (n = 12, including 2 intact) that they were previously fed or to a high-fat diet (12, inclu...
Source: American Journal of Veterinary Research - April 11, 2024 Category: Veterinary Research Authors: Brennen McKenzie Matthew Peloquin Ashley Tovar Jessica L Graves Ellen Ratcliff Katya Tucker Kenny Vo Karen Greenwood Celine-Lea Halioua-Haubold Dina Juarez-Salinas Source Type: research
Association between dietary pattern and Helicobacter Pylori infection at Queen Elizabeth Hospital, Kota Kinabalu: A case-control study
CONCLUSION: To conclude, "high fiber pattern" lowers the risk of H. pylori infection while "high salt pattern" increases the infection risk. Our study also highlighted the importance of nutrient intake within daily allowances.PMID:38604869 | DOI:10.1016/j.asjsur.2024.03.177 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 11, 2024 Category: Surgery Authors: Vanessa Urie Kasum Firdaus Hayati Syed Sharizman Syed Abdul Rahim Nik Amin Sahid Nik Lah Serene En Hui Tung Source Type: research
