Decreased Ubiquitination and Acetylation of Histones 3 and 4 Are Associated with Obesity-Induced Disorders of Spermatogenesis in Mice
CONCLUSION: These results suggest that low levels of histone ubiquitination and acetylation are linked with obesity-induced disorders during spermatogenesis, contributing to a better understanding of obesity-induced damage to male reproduction.PMID:38668519 | DOI:10.3390/toxics12040296 (Source: Cancer Control)
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Mahamadou Fofana Zhenyang Li Han Li Wenqi Li Lu Wu Lu Lu Qizhan Liu Source Type: research
Osthole ameliorates early diabetic kidney damage by suppressing oxidative stress, inflammation and inhibiting TGF- β1/Smads signaling pathway
CONCLUSION: Our findings indicate that osthole exhibits potential preventive and therapeutic effects on DKD. It deserves further investigation as a promising drug for preventing and treating DKD.PMID:38669945 | DOI:10.1016/j.intimp.2024.112131 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 26, 2024 Category: Allergy & Immunology Authors: Qiangsheng Li Yifei Wang Jia Yan Ruyan Yuan Jiamin Zhang Xinhao Guo Mingming Zhao Fenfen Li Xiaotian Li Source Type: research
Intermittent energy restriction inhibits tumor growth and enhances paclitaxel response in a transgenic mouse model of endometrial cancer
CONCLUSION: In Lkb1fl/flp53fl/fl mice, IER is generally more effective than LFD in promoting weight loss, inhibiting obesity-related endometrial tumor growth (particularly in combination with paclitaxel), and reversing detrimental obesity-related metabolic effects. These findings lay the foundation for further investigations of IER as an EC prevention and treatment strategies in overweight/obesity women.PMID:38669767 | DOI:10.1016/j.ygyno.2024.04.012 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Ziyi Zhao Jiandong Wang Weimin Kong Ziwei Fang Michael F Coleman Ginger L Milne Wesley C Burkett Meredith A Newton Olivia Lara Douglas Lee Boer Deng Xiaochang Shen Hongyan Suo Wenchuan Sun Stephen D Hursting Chunxiao Zhou Victoria L Bae-Jump Source Type: research
Low-Fat Cheese Ameliorates Glucose Intolerance and Normalizes Insulin Secretion in a Rat Model of Type 2 Diabetes by Promoting β-cell Recovery
In conclusion, LOW but not REG cheese enhanced β-cell recovery from HFD/STZ treatment that led to amelioration of glucose tolerance within 5 weeks.PMID:38669698 | DOI:10.1139/cjpp-2023-0447 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - April 26, 2024 Category: Drugs & Pharmacology Authors: Anik R Z Hanning Mortaza Fatehi Hassanabad Zohre Hashemi Xiaofeng Wang Catherine Chan Source Type: research
Diet-induced metabolic and immune impairments are sex-specifically modulated by soluble TNF signaling in the 5xFAD mouse model of Alzheimer's disease
Neurobiol Dis. 2024 Apr 24:106511. doi: 10.1016/j.nbd.2024.106511. Online ahead of print.ABSTRACTEmerging evidence indicates that high-fat, high carbohydrate diet (HFHC) impacts central pathological features of Alzheimer's disease (AD) across both human incidences and animal models. However, the mechanisms underlying this association are poorly understood. Here, we identify compartment-specific metabolic and inflammatory dysregulations that are induced by HFHC diet in the 5xFAD mouse model of AD pathology. We observe that both male and female 5xFAD mice display exacerbated adiposity, cholesterolemia, and dysregulated insul...
Source: Neurobiology of Disease - April 26, 2024 Category: Neurology Authors: Maria Elizabeth De Sousa Rodrigues MacKenzie L Bolen Lisa Blackmer-Raynolds Noah Schwartz Jianjun Chang Mal ú Gámez Tansey Timothy Robert Sampson Source Type: research
Osthole ameliorates early diabetic kidney damage by suppressing oxidative stress, inflammation and inhibiting TGF- β1/Smads signaling pathway
CONCLUSION: Our findings indicate that osthole exhibits potential preventive and therapeutic effects on DKD. It deserves further investigation as a promising drug for preventing and treating DKD.PMID:38669945 | DOI:10.1016/j.intimp.2024.112131 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 26, 2024 Category: Allergy & Immunology Authors: Qiangsheng Li Yifei Wang Jia Yan Ruyan Yuan Jiamin Zhang Xinhao Guo Mingming Zhao Fenfen Li Xiaotian Li Source Type: research
Intermittent energy restriction inhibits tumor growth and enhances paclitaxel response in a transgenic mouse model of endometrial cancer
CONCLUSION: In Lkb1fl/flp53fl/fl mice, IER is generally more effective than LFD in promoting weight loss, inhibiting obesity-related endometrial tumor growth (particularly in combination with paclitaxel), and reversing detrimental obesity-related metabolic effects. These findings lay the foundation for further investigations of IER as an EC prevention and treatment strategies in overweight/obesity women.PMID:38669767 | DOI:10.1016/j.ygyno.2024.04.012 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Ziyi Zhao Jiandong Wang Weimin Kong Ziwei Fang Michael F Coleman Ginger L Milne Wesley C Burkett Meredith A Newton Olivia Lara Douglas Lee Boer Deng Xiaochang Shen Hongyan Suo Wenchuan Sun Stephen D Hursting Chunxiao Zhou Victoria L Bae-Jump Source Type: research
Low-Fat Cheese Ameliorates Glucose Intolerance and Normalizes Insulin Secretion in a Rat Model of Type 2 Diabetes by Promoting β-cell Recovery
In conclusion, LOW but not REG cheese enhanced β-cell recovery from HFD/STZ treatment that led to amelioration of glucose tolerance within 5 weeks.PMID:38669698 | DOI:10.1139/cjpp-2023-0447 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - April 26, 2024 Category: Drugs & Pharmacology Authors: Anik R Z Hanning Mortaza Fatehi Hassanabad Zohre Hashemi Xiaofeng Wang Catherine Chan Source Type: research
Low-Fat Cheese Ameliorates Glucose Intolerance and Normalizes Insulin Secretion in a Rat Model of Type 2 Diabetes by Promoting β-cell Recovery
In conclusion, LOW but not REG cheese enhanced β-cell recovery from HFD/STZ treatment that led to amelioration of glucose tolerance within 5 weeks.PMID:38669698 | DOI:10.1139/cjpp-2023-0447 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - April 26, 2024 Category: Drugs & Pharmacology Authors: Anik R Z Hanning Mortaza Fatehi Hassanabad Zohre Hashemi Xiaofeng Wang Catherine Chan Source Type: research
Low-Fat Cheese Ameliorates Glucose Intolerance and Normalizes Insulin Secretion in a Rat Model of Type 2 Diabetes by Promoting β-cell Recovery
In conclusion, LOW but not REG cheese enhanced β-cell recovery from HFD/STZ treatment that led to amelioration of glucose tolerance within 5 weeks.PMID:38669698 | DOI:10.1139/cjpp-2023-0447 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - April 26, 2024 Category: Drugs & Pharmacology Authors: Anik R Z Hanning Mortaza Fatehi Hassanabad Zohre Hashemi Xiaofeng Wang Catherine Chan Source Type: research
Low-Fat Cheese Ameliorates Glucose Intolerance and Normalizes Insulin Secretion in a Rat Model of Type 2 Diabetes by Promoting β-cell Recovery
In conclusion, LOW but not REG cheese enhanced β-cell recovery from HFD/STZ treatment that led to amelioration of glucose tolerance within 5 weeks.PMID:38669698 | DOI:10.1139/cjpp-2023-0447 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - April 26, 2024 Category: Drugs & Pharmacology Authors: Anik R Z Hanning Mortaza Fatehi Hassanabad Zohre Hashemi Xiaofeng Wang Catherine Chan Source Type: research
A short-term rodent model for non-alcoholic steatohepatitis induced by a high-fat diet and carbon tetrachloride
This study aimed to evaluate the joint action of a high-fat diet and CCl4 in developing a short-term non-alcoholic steatohepatitis model. C57BL6/J mice were divided into two groups: standard diet-fed (SD), the high-fat diet-fed (HFD) and HFD + fructose-fed and carbon tetrachloride (HFD+CCl4). Animals fed with HFD+CCl4 presented increased lipid deposition compared with both SD and HFD mice. Plasma cholesterol was increased in animals from the HFD+CCl4 group compared to the SD and HFD groups, without significant differences between the SD and HFD groups. Plasma triglycerides showed no significant difference between the group...
Source: Bioscience Reports - April 25, 2024 Category: Biomedical Science Authors: Layanne C C Araujo Carolina C B Dias Felipe G Sucupira Leandra N Z Ramalho Joao Paulo Camporez Source Type: research
Safety, tolerability, and pharmacokinetics of the novel RdRp inhibitor SHEN26 against SARS-CoV-2: a randomized, placebo-controlled, double-blind phase I study in healthy subjects
CONCLUSION: SHEN26 demonstrated satisfactory safety and tolerability in healthy subjects, which supports the continued study of SHEN26 against SARS-CoV-2.TRIAL REGISTRATION: The trial is registered in ClinicalTrials.gov (CT. gov identifier: NCT05504746).PMID:38662639 | DOI:10.1080/13543784.2024.2347302 (Source: Expert Opinion on Investigational Drugs)
Source: Expert Opinion on Investigational Drugs - April 25, 2024 Category: Drugs & Pharmacology Authors: Cheng Sun Hao Liu Ziwei Ouyang Jie Ding Qin Zhang Hongjie Ma Dandan Xu Qian Zhang Renpeng Zhou Mingming Yang Wei Hu Source Type: research
The effects of Atractylodes macrocephala extract BZEP self-microemulsion based on gut-liver axis HDL/LPS signaling pathway to ameliorate metabolic dysfunction-associated fatty liver disease in rats
CONCLUSION: BZEPWR and BZEP exert restorative and reversal effects on the pathophysiological damage to the gut-liver axis in MAFLD rats, and the therapeutic mechanism may be related to the regulation of the intestinal flora and the HDL/LPS signaling pathway.PMID:38663104 | DOI:10.1016/j.biopha.2024.116519 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 25, 2024 Category: Drugs & Pharmacology Authors: Bo Li Xiao-Feng Jiang Ying-Jie Dong Yi-Piao Zhang Xing-Li-Shang He Cheng-Liang Zhou Yan-Yan Ding Ning Wang Yi-Bin Wang Wan-Qi Cheng Ning-Hua Jiang Jie Su Gui-Yuan Lv Su-Hong Chen Source Type: research
The LEPIS-HuR-TMOD4 axis regulates hepatic cholesterol homeostasis and accelerates atherosclerosis
CONCLUSIONS: These results suggest that the LEPIS-HuR-TMOD4 axis is a potential intervention target for dysregulated hepatic cholesterol homeostasis and AS and may provide the basis for further reductions in the circulating LDL-C concentration and arterial plaque burden.PMID:38663275 | DOI:10.1016/j.atherosclerosis.2024.117554 (Source: Atherosclerosis)
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Ping LYu Hangyu Pan Kexin Hu Yazhi Xue Qinxian Li Rongzhan Lin Shaoyi Zheng Zhigang Guo Kai Guo Source Type: research
