Intermittent energy restriction inhibits tumor growth and enhances paclitaxel response in a transgenic mouse model of endometrial cancer

CONCLUSION: In Lkb1fl/flp53fl/fl mice, IER is generally more effective than LFD in promoting weight loss, inhibiting obesity-related endometrial tumor growth (particularly in combination with paclitaxel), and reversing detrimental obesity-related metabolic effects. These findings lay the foundation for further investigations of IER as an EC prevention and treatment strategies in overweight/obesity women.PMID:38669767 | DOI:10.1016/j.ygyno.2024.04.012

Source: Gynecologic Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Ziyi Zhao Jiandong Wang Weimin Kong Ziwei Fang Michael F Coleman Ginger L Milne Wesley C Burkett Meredith A Newton Olivia Lara Douglas Lee Boer Deng Xiaochang Shen Hongyan Suo Wenchuan Sun Stephen D Hursting Chunxiao Zhou Victoria L Bae-Jump Source Type: research