lincRNA00907 promotes NASH progression by targeting miRNA-942-5p/TAOK1

CONCLUSIONS: Our research suggests that linc00907 functions as a competitive endogenous RNA (ceRNA) by sequestering miRNA-942-5p, thus increasing the expression of TAOK1 and encouraging lipid accumulation in hepatocytes, leading to the aggravation of NASH development. Targeting the linc00907/miRNA-942-5p/TAOK1 axis may hold therapeutic potential for the treatment of NASH.PMID:38613803 | DOI:10.18632/aging.205730

Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Gang Du Zhaochen Jiang Tong Xia Mingkun Liu Zeyang Liu Huaxin Zhou Hao Zhang Xiangyu Zhai Bin Jin Source Type: research