Diagnostic precision of Truenat ® technique and co-relation of ALT levels with HBV-DNA viral load among HBsAg positive patients at a tertiary care hospital in Eastern Uttar Pradesh
CONCLUSION: Truenat®-PCR technique is a highly sensitive and can be performed with low resources for effective control of HBV infection. Evaluation of HBV-DNA levels and serum ALT levels showed a significant proportion of patient harbored ongoing viral replication and disease progression.PMID:38682056 | PMC:PMC11055448 | DOI:10.18502/ijm.v16i1.14882 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Sarita Kumari Bechan Kumar Gautam Amresh Kumar Singh Vivek Gaur Ankur Kumar Source Type: research
Current status of liver transplantation for human immunodeficiency virus-infected patients in mainland China
This study provides an overview of the current landscape of HIV-positive patients receiving liver transplantation (LT) in mainland China. To date, our transplant center has conducted LT for eight end-stage liver disease patients co-infected with HIV, and all but one, who died two months postoperatively due to sepsis and progressive multi-organ failure, have survived. Comparative analysis with hepatitis B virus-infected patients during the same period revealed no statistically significant differences in acute rejection reactions, cytomegalovirus infection, bacteremia, pulmonary infections, acute kidney injury, new-onset can...
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Jian-Xin Tang Dong Zhao Source Type: research
Diagnostic precision of Truenat ® technique and co-relation of ALT levels with HBV-DNA viral load among HBsAg positive patients at a tertiary care hospital in Eastern Uttar Pradesh
CONCLUSION: Truenat®-PCR technique is a highly sensitive and can be performed with low resources for effective control of HBV infection. Evaluation of HBV-DNA levels and serum ALT levels showed a significant proportion of patient harbored ongoing viral replication and disease progression.PMID:38682056 | PMC:PMC11055448 | DOI:10.18502/ijm.v16i1.14882 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Sarita Kumari Bechan Kumar Gautam Amresh Kumar Singh Vivek Gaur Ankur Kumar Source Type: research
Viruses, Vol. 16, Pages 707: The Adaptive Immune Response in Hepatitis B Virus-Associated Hepatocellular Carcinoma Is Characterized by Dysfunctional and Exhausted HBV-Specific T Cells
na Weis
This systematic review investigates the immunosuppressive environment in HBV-associated hepatocellular carcinoma (HCC), characterized by dysfunctional and exhausted HBV-specific T cells alongside an increased infiltration of HBV-specific CD4+ T cells, particularly regulatory T cells (Tregs). Heightened expression of checkpoint inhibitors, notably PD-1, is linked with disease progression and recurrence, indicating its potential as both a prognostic indicator and a target for immunotherapy. Nevertheless, using PD-1 inhibitors has shown limited effectiveness. In a future perspective, understanding the intricate in...
Source: Viruses - April 29, 2024 Category: Virology Authors: Malene Broholm Anne-Sofie Mathiasen Ása Didriksen Apol Nina Weis Tags: Review Source Type: research
The lack of HBsAg secretion does neither facilitate induction of antiviral T cell responses nor Hepatitis B Virus clearance in mice
Antiviral Res. 2024 Apr 26:105896. doi: 10.1016/j.antiviral.2024.105896. Online ahead of print.ABSTRACTImmune tolerance to the hepatitis B virus (HBV) is crucial for developing chronic hepatitis, and the HBV surface antigen (HBsAg) produced and secreted in high amounts is regarded as a key contributor. HBsAg is expressed in HBV-infected hepatocytes and those carrying an HBV integration. Whether either HBsAg secretion or the high antigen amount expressed in the liver determines its immunomodulatory properties, however, remains unclear. We, therefore, developed a novel HBV animal model that allowed us to study the role of se...
Source: Antiviral Research - April 28, 2024 Category: Virology Authors: Thomas Michler Jakob Zillinger Philipp Hagen Fuwang Cheng Julia Festag Anna Kosinska Ulrike Protzer Source Type: research
Current and future use of antibody-based passive immunity to prevent or control HBV/HDV infections
Antiviral Res. 2024 Apr 26:105893. doi: 10.1016/j.antiviral.2024.105893. Online ahead of print.ABSTRACTWith the increasing momentum and success of monoclonal antibody therapy in conventional medical practices, there is a revived emphasis on the development of monoclonal antibodies targeting the hepatitis B surface antigen (anti-HBs) for the treatment of chronic hepatitis B (HBV) and hepatitis D (HDV). Combination therapies of anti-HBs monoclonal antibodies, and novel anti-HBV compounds and immunomodulatory drugs presenting a promising avenue to enhanced therapeutic outcomes in HBV/HDV cure regimens. In this review, we will...
Source: Antiviral Research - April 28, 2024 Category: Virology Authors: Adam J Gehring Loghman Salimzadeh Source Type: research
The lack of HBsAg secretion does neither facilitate induction of antiviral T cell responses nor Hepatitis B Virus clearance in mice
Antiviral Res. 2024 Apr 26:105896. doi: 10.1016/j.antiviral.2024.105896. Online ahead of print.ABSTRACTImmune tolerance to the hepatitis B virus (HBV) is crucial for developing chronic hepatitis, and the HBV surface antigen (HBsAg) produced and secreted in high amounts is regarded as a key contributor. HBsAg is expressed in HBV-infected hepatocytes and those carrying an HBV integration. Whether either HBsAg secretion or the high antigen amount expressed in the liver determines its immunomodulatory properties, however, remains unclear. We, therefore, developed a novel HBV animal model that allowed us to study the role of se...
Source: Cell Research - April 28, 2024 Category: Cytology Authors: Thomas Michler Jakob Zillinger Philipp Hagen Fuwang Cheng Julia Festag Anna Kosinska Ulrike Protzer Source Type: research
The lack of HBsAg secretion does neither facilitate induction of antiviral T cell responses nor Hepatitis B Virus clearance in mice
Antiviral Res. 2024 Apr 26:105896. doi: 10.1016/j.antiviral.2024.105896. Online ahead of print.ABSTRACTImmune tolerance to the hepatitis B virus (HBV) is crucial for developing chronic hepatitis, and the HBV surface antigen (HBsAg) produced and secreted in high amounts is regarded as a key contributor. HBsAg is expressed in HBV-infected hepatocytes and those carrying an HBV integration. Whether either HBsAg secretion or the high antigen amount expressed in the liver determines its immunomodulatory properties, however, remains unclear. We, therefore, developed a novel HBV animal model that allowed us to study the role of se...
Source: Antiviral Research - April 28, 2024 Category: Virology Authors: Thomas Michler Jakob Zillinger Philipp Hagen Fuwang Cheng Julia Festag Anna Kosinska Ulrike Protzer Source Type: research
Current and future use of antibody-based passive immunity to prevent or control HBV/HDV infections
Antiviral Res. 2024 Apr 26:105893. doi: 10.1016/j.antiviral.2024.105893. Online ahead of print.ABSTRACTWith the increasing momentum and success of monoclonal antibody therapy in conventional medical practices, there is a revived emphasis on the development of monoclonal antibodies targeting the hepatitis B surface antigen (anti-HBs) for the treatment of chronic hepatitis B (HBV) and hepatitis D (HDV). Combination therapies of anti-HBs monoclonal antibodies, and novel anti-HBV compounds and immunomodulatory drugs presenting a promising avenue to enhanced therapeutic outcomes in HBV/HDV cure regimens. In this review, we will...
Source: Antiviral Research - April 28, 2024 Category: Virology Authors: Adam J Gehring Loghman Salimzadeh Source Type: research
Dismantling Barriers to Hepatitis B and Delta Screening, Prevention, and Linkage to Care among the PWUD Community in Philadelphia
This study found high rates of current and past HBV infection, and a 10% HBV/HDV co-infection rate. Despite availability of vaccine, one quarter of participants remained vulnerable to infection. Findings demonstrate the need to improve low-threshold HBV/HDV screening, vaccination, and linkage to care among PWUD. The study also identified gaps in the HBV/HDV care cascade, including lack of point-of-care diagnostics and lack of support for HROs to provide HBV services.PMID:38675969 | DOI:10.3390/v16040628 (Source: Cancer Control)
Source: Cancer Control - April 27, 2024 Category: Cancer & Oncology Authors: Beatrice Zovich Catherine Freeland Holly Moore Kara Sapp Anousha Qureshi Rachel Holbert Jason Zambrano Daljinder Bhangoo Chari Cohen Richard W Hass Amy Jessop Source Type: research
Treatment patterns, clinical outcomes and gene mutation characteristics of hepatitis B virus-associated mantle cell lymphoma
Hematol Oncol. 2024 May;42(3):e3268. doi: 10.1002/hon.3268.ABSTRACTMantle cell lymphoma (MCL) is an uncommon and incurable B-cell lymphoma subtype that has an aggressive course. Hepatitis B virus (HBV) infection has been associated with an increased risk for B-cell lymphomas, and is characterized by distinct clinical and genetic features. Here, we showed that 9.5% of MCL Chinese patients were hepatitis B surface antigen positive (HBsAg+). Compared to HBsAg-negative (HBsAg-) patients, HBsAg+ MCL patients had a greater incidence of elevated lactate dehydrogenase (LDH), but no difference was observed in the other clinical cha...
Source: Ann Oncol - April 27, 2024 Category: Cancer & Oncology Authors: Jiangfang Feng Yue Fei Meng Gao Xiangrui Meng Dongfeng Zeng Dehui Zou Haige Ye Yun Liang Xiuhua Sun Rong Liang Hui Zhou Xianhuo Wang Huilai Zhang Source Type: research
Treatment patterns, clinical outcomes and gene mutation characteristics of hepatitis B virus-associated mantle cell lymphoma
Hematol Oncol. 2024 May;42(3):e3268. doi: 10.1002/hon.3268.ABSTRACTMantle cell lymphoma (MCL) is an uncommon and incurable B-cell lymphoma subtype that has an aggressive course. Hepatitis B virus (HBV) infection has been associated with an increased risk for B-cell lymphomas, and is characterized by distinct clinical and genetic features. Here, we showed that 9.5% of MCL Chinese patients were hepatitis B surface antigen positive (HBsAg+). Compared to HBsAg-negative (HBsAg-) patients, HBsAg+ MCL patients had a greater incidence of elevated lactate dehydrogenase (LDH), but no difference was observed in the other clinical cha...
Source: Ann Oncol - April 27, 2024 Category: Cancer & Oncology Authors: Jiangfang Feng Yue Fei Meng Gao Xiangrui Meng Dongfeng Zeng Dehui Zou Haige Ye Yun Liang Xiuhua Sun Rong Liang Hui Zhou Xianhuo Wang Huilai Zhang Source Type: research
Changing etiological spectrum of acute liver failure
ConclusionsThe most common cause for ALF was hepatitis A virus, followed by hepatitis B virus, while in ALF mimics it was malaria followed by dengue fever, in our study. Patients of ALF mimics can have similar presentation, but a high index of suspicion and awareness is required to identify the common infectious ALF mimics for early diagnosis.Graphical Abstract (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - April 27, 2024 Category: Gastroenterology Source Type: research
Seroprevalence of anti-SARS-CoV-2 in patients with hepatitis B and C: a pre-vaccination study
This study aims to assess the prevalence of anti-SARS-CoV-2 in hepatitis B and C patients in a pre-vaccination of COVID-19 period. Between March 2020 and January 2021, 199 serum samples from individuals with HBsAg/HBV DNA or anti-HCV/HCV RNA positivity were tested for antibodies (IgM and IgG) against SARS-CoV-2 using Electrochemiluminescent Immunoassay (ECLIA). Among these, 50.3 % (100/199) tested positive for hepatitis C virus infection and 49.7 % (99/199) for hepatitis B virus, confirmed through molecular and serological diagnosis. The anti-SARS-CoV-2 seroprevalence was 24.1 % (48/199) in this population, with 23.23 % (2...
Source: Braz J Infect Dis - April 26, 2024 Category: Infectious Diseases Authors: Lucas Lima da Silva Lia Laura Lewis-Ximenez Monica Magalhaes Figueiredo Vanessa Salete de Paula Livia Melo Villar Source Type: research
