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A mutual regulatory loop between transcription factor Yin Yang 1 and hepatitis B virus replication influences chronic hepatitis B 1 
In conclusion, our study demonstrates that YY1 plays an important role in HBV replication and gene expression, providing a potential target for the treatment of CHB.PMID:38631661 | DOI:10.1016/j.antiviral.2024.105889 (Source: Antiviral Research)
Source: Antiviral Research - April 17, 2024 Category: Virology Authors: Jie Zhou Yunhao Hua Yuwei Liu Tong Wu Hongqin Xu Zhongfeng Wang Xiaomei Wang Junqi Niu Source Type: research

Global prevalence of MAFLD-related hepatocellular carcinoma: A systematic review and meta-analysis
CONCLUSION: MAFLD is common as a sole aetiology, but more so and as a co-factor in mixed-aetiology HCC, supporting the use of a positive diagnostic criteria.PMID:38623613 | DOI:10.3350/cmh.2024.0109 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 16, 2024 Category: Gastroenterology Authors: Harry Crane Guy D Eslick Cameron Gofton Anjiya Shaikh George Cholankeril Mark Cheah Jian-Hong Zhong Gianluca Svegliati-Baroni Alessandro Vitale Beom Kyung Kim Sang Hoon Ahn Mi Na Kim Simone Strasser Jacob George Source Type: research

The orientation of CpG conjugation on aluminum oxyhydroxide nanoparticles determines the immunostimulatory effects of combination adjuvants
Biomaterials. 2024 Apr 11;308:122569. doi: 10.1016/j.biomaterials.2024.122569. Online ahead of print.ABSTRACTIn subunit vaccines, aluminum salts (Alum) are commonly used as adjuvants, but with limited cellular immune responses. To overcome this limitation, CpG oligodeoxynucleotides (ODNs) have been used in combination with Alum. However, current combined usage of Alum and CpG is limited to linear mixtures, and the underlying interaction mechanism between CpG and Alum is not well understood. Thus, we propose to chemically conjugate Alum nanoparticles and CpG (with 5' or 3' end exposed) to design combination adjuvants. Our s...
Source: Biomaterials - April 16, 2024 Category: Materials Science Authors: Zhihui Liang Hang Bao Zhiying Yao Min Li Chen Chen Lei Zhang Huiyang Wang Yiyang Guo Yubin Ma Xuecheng Yang Ge Yu Jiancheng Zhang Changying Xue Bingbing Sun Chuanbin Mao Source Type: research

Viruses, Vol. 16, Pages 615: Co-Transcriptional Regulation of HBV Replication: RNA Quality Also Matters
Testoni Chronic hepatitis B (CHB) virus infection is a major public health burden and the leading cause of hepatocellular carcinoma. Despite the efficacy of current treatments, hepatitis B virus (HBV) cannot be fully eradicated due to the persistence of its minichromosome, or covalently closed circular DNA (cccDNA). The HBV community is investing large human and financial resources to develop new therapeutic strategies that either silence or ideally degrade cccDNA, to cure HBV completely or functionally. cccDNA transcription is considered to be the key step for HBV replication. Transcription not only influences the lev...
Source: Viruses - April 16, 2024 Category: Virology Authors: Guillaume Giraud Khadija El Achi Fabien Zoulim Barbara Testoni Tags: Review Source Type: research

Cancers, Vol. 16, Pages 1513: Time-Restricted Feeding Attenuates Metabolic Dysfunction-Associated Steatohepatitis and Hepatocellular Carcinoma in Obese Male Mice
In this study, we tested a time-restricted feeding (TRF) nutritional intervention in mouse models of MASH and HCC. We show that TRF abrogated metabolic dysregulation induced by a Western diet without any calorie restriction or weight loss. TRF improved insulin sensitivity and reduced hyperinsulinemia, liver steatosis, inflammation, and fibrosis. Importantly, TRF inhibited liver tumors in two mouse models of obesity-driven HCC. Our data suggest that TRF is likely to be effective in abrogating MASH and HCC and warrant further studies of time-restricted eating in humans with MASH who are at higher risk of developing HCC. (Source: Cancers)
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Manasi Das Deepak Kumar Consuelo Sauceda Alexis Oberg Lesley G. Ellies Liping Zeng Lily J. Jih Isabel G. Newton Nicholas J. G. Webster Tags: Article Source Type: research

Viruses, Vol. 16, Pages 618: Burden, Outcome, and Comorbidities of Extrahepatic Manifestations in Hepatitis B Virus Infections
Nugent Hepatitis B virus (HBV) infections affect approximately 296 million people around the world, and the prevalence of any past or present HBV infection during the years 2015&ndash;2018 was as high as 4.3%. Acute HBV infection often presents with nonspecific symptoms and is usually self-limited, but 5% of patients can have persistent infections leading to chronic HBV infection and the risk of turning into chronic HBV infection is significantly higher in babies with vertical transmission (95%). Patients with chronic HBV infection are usually asymptomatic, but 15 to 40% of chronic HBV carriers develop cirrhosi...
Source: Viruses - April 16, 2024 Category: Virology Authors: Busara Songtanin Nattanicha Chaisrimaneepan Roberto Mend óza Kenneth Nugent Tags: Review Source Type: research

Cancers, Vol. 16, Pages 1521: Hepatitis-C-Related Hepatocellular Carcinoma, Still a Relevant Etiology beyond a Hepatitis C Infection Cure
Conclusions: Whereas accessibility to antiviral therapy is granted, HCV infection remains as one of the main HCC etiologies. MASLD-related HCC, although growing globally, is not as relevant in our area. Strong public policies need to be implemented to prevent alcohol consumption, the main etiology of liver disease and liver cancer. (Source: Cancers)
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Elena Vargas-Accarino M ónica Higuera Mar ía Buti Beatriz M ínguez Tags: Article Source Type: research

Assessing recent recurrence after hepatectomy for hepatitis B-related hepatocellular carcinoma by a predictive model based on sarcopenia
CONCLUSION: Sarcopenia is associated with recent recurrence after hepatectomy for hepatitis B-related HCC. A nutritional status-based prediction model is first established for postoperative recurrence of hepatitis B-related HCC, which is superior to other models and contributes to prognosis prediction.PMID:38617742 | PMC:PMC11008376 | DOI:10.3748/wjg.v30.i12.1727 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Hong Peng Si-Yi Lei Wei Fan Yu Dai Yi Zhang Gen Chen Ting-Ting Xiong Tian-Zhao Liu Yue Huang Xiao-Feng Wang Jin-Hui Xu Xin-Hua Luo Source Type: research

Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis
CONCLUSION: LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota, improving liver function, and reducing inflammatory factor levels.PMID:38617455 | PMC:PMC11008409 | DOI:10.3748/wjg.v30.i11.1556 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Yan-Chao Hu Xiang-Chun Ding Hui-Juan Liu Wan-Long Ma Xue-Yan Feng Li-Na Ma Source Type: research

Assessing recent recurrence after hepatectomy for hepatitis B-related hepatocellular carcinoma by a predictive model based on sarcopenia
CONCLUSION: Sarcopenia is associated with recent recurrence after hepatectomy for hepatitis B-related HCC. A nutritional status-based prediction model is first established for postoperative recurrence of hepatitis B-related HCC, which is superior to other models and contributes to prognosis prediction.PMID:38617742 | PMC:PMC11008376 | DOI:10.3748/wjg.v30.i12.1727 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Hong Peng Si-Yi Lei Wei Fan Yu Dai Yi Zhang Gen Chen Ting-Ting Xiong Tian-Zhao Liu Yue Huang Xiao-Feng Wang Jin-Hui Xu Xin-Hua Luo Source Type: research

Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis
CONCLUSION: LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota, improving liver function, and reducing inflammatory factor levels.PMID:38617455 | PMC:PMC11008409 | DOI:10.3748/wjg.v30.i11.1556 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Yan-Chao Hu Xiang-Chun Ding Hui-Juan Liu Wan-Long Ma Xue-Yan Feng Li-Na Ma Source Type: research