An allosteric inhibitor of sirtuin 2 blocks hepatitis B virus covalently closed circular DNA establishment and its transcriptional activity
In this study, we investigated the antiviral properties of a newly described allosteric modulator, FLS-359, that targets sirtuin 2 (SIRT2), an NAD+-dependent deacylase. Our results demonstrate that SIRT2 modulation by FLS-359 and by other tool compounds inhibits cccDNA synthesis following de novo infection of primary human hepatocytes and HepG2 (C3A)-NTCP cells, and FLS-359 substantially reduces cccDNA recycling in HepAD38 cells. While pre-existing cccDNA is not eradicated by short-term treatment with FLS-359, its transcriptional activity is substantially impaired, likely through inhibition of viral promoter activities. Co...
Source: Antiviral Research - April 19, 2024 Category: Virology Authors: Liudi Tang Stacy Remiszewski Andrew Snedeker Lillian W Chiang Thomas Shenk Source Type: research
Quantitative HBeAg is a strong predictor of HBeAg loss among patients receiving pegylated interferon
CONCLUSIONS: Baseline and on-treatment qHBeAg is a useful biomarker that can identify participants on NA therapy who may benefit from adding or switching to pegylated interferon.PMID:38641023 | DOI:10.1016/j.antiviral.2024.105876 (Source: Antiviral Research)
Source: Antiviral Research - April 19, 2024 Category: Virology Authors: Daniel Q Huang Liang Shen Wah Wah Phyo Gavin Cloherty Emily K Butler Mary C Kuhns Anne L McNamara Vera Holzmayer None Jeffrey Gersch Mark Anderson Wei Lyn Yang Jing Hieng Ngu Jason Chang Jessica Tan Taufique Ahmed Yock Young Dan Yin Mei Lee Guan Huei Lee Source Type: research
Trends in Mortality Related to Hepatitis B and C from 1990 to 2019 in the Western Pacific Region
CONCLUSIONS: : Although the mortality rate from hepatitis B and C decreased from 1990 to 2019, notable variation was observed among 27 Western Pacific countries. Efforts targeting hepatitis B and C prevention and treatment are still required in this region, especially for the pandemic countries.PMID:38638100 | DOI:10.5009/gnl230023 (Source: Gut and Liver)
Source: Gut and Liver - April 19, 2024 Category: Gastroenterology Authors: Hua Zhou Mengxia Yan Datian Che Bin Wu Source Type: research
Fonction de l'ARNnc exosomal HEIH dans le carcinome h épatocellulaire associé au virus de l'hépatite B
This study aimed to investigate the expression of exosomal lncRNA-HEIH in B-HCC patients and explore its clinical significance. We collected blood samples from 60 B-HCC patients, 60 non-hepatitis virus-associated HCC (N-HCC) patients, and 50 healthy volunteers. Exosomal lncRNA-HEIH levels were measured by real-time PCR and analyzed for their correlation with patient prognosis using Kaplan-Meier analysis. Multivariate COX regression analysis was conducted to identify factors affecting patient outcomes. The effects of lncRNA-HEIH on carcinogenesis were also investigated by constructing a Huh7 cell line stably expressing the ...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Tao Yu Huiming Li Guijia Shen Qifang Wu Source Type: research
Trends in Mortality Related to Hepatitis B and C from 1990 to 2019 in the Western Pacific Region
CONCLUSIONS: : Although the mortality rate from hepatitis B and C decreased from 1990 to 2019, notable variation was observed among 27 Western Pacific countries. Efforts targeting hepatitis B and C prevention and treatment are still required in this region, especially for the pandemic countries.PMID:38638100 | DOI:10.5009/gnl230023 (Source: Gut and Liver)
Source: Gut and Liver - April 19, 2024 Category: Gastroenterology Authors: Hua Zhou Mengxia Yan Datian Che Bin Wu Source Type: research
Fonction de l'ARNnc exosomal HEIH dans le carcinome h épatocellulaire associé au virus de l'hépatite B
This study aimed to investigate the expression of exosomal lncRNA-HEIH in B-HCC patients and explore its clinical significance. We collected blood samples from 60 B-HCC patients, 60 non-hepatitis virus-associated HCC (N-HCC) patients, and 50 healthy volunteers. Exosomal lncRNA-HEIH levels were measured by real-time PCR and analyzed for their correlation with patient prognosis using Kaplan-Meier analysis. Multivariate COX regression analysis was conducted to identify factors affecting patient outcomes. The effects of lncRNA-HEIH on carcinogenesis were also investigated by constructing a Huh7 cell line stably expressing the ...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Tao Yu Huiming Li Guijia Shen Qifang Wu Source Type: research
Trends in Mortality Related to Hepatitis B and C from 1990 to 2019 in the Western Pacific Region
CONCLUSIONS: : Although the mortality rate from hepatitis B and C decreased from 1990 to 2019, notable variation was observed among 27 Western Pacific countries. Efforts targeting hepatitis B and C prevention and treatment are still required in this region, especially for the pandemic countries.PMID:38638100 | DOI:10.5009/gnl230023 (Source: Gut and Liver)
Source: Gut and Liver - April 19, 2024 Category: Gastroenterology Authors: Hua Zhou Mengxia Yan Datian Che Bin Wu Source Type: research
Fonction de l'ARNnc exosomal HEIH dans le carcinome h épatocellulaire associé au virus de l'hépatite B
This study aimed to investigate the expression of exosomal lncRNA-HEIH in B-HCC patients and explore its clinical significance. We collected blood samples from 60 B-HCC patients, 60 non-hepatitis virus-associated HCC (N-HCC) patients, and 50 healthy volunteers. Exosomal lncRNA-HEIH levels were measured by real-time PCR and analyzed for their correlation with patient prognosis using Kaplan-Meier analysis. Multivariate COX regression analysis was conducted to identify factors affecting patient outcomes. The effects of lncRNA-HEIH on carcinogenesis were also investigated by constructing a Huh7 cell line stably expressing the ...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Tao Yu Huiming Li Guijia Shen Qifang Wu Source Type: research
Trends in Mortality Related to Hepatitis B and C from 1990 to 2019 in the Western Pacific Region
CONCLUSIONS: : Although the mortality rate from hepatitis B and C decreased from 1990 to 2019, notable variation was observed among 27 Western Pacific countries. Efforts targeting hepatitis B and C prevention and treatment are still required in this region, especially for the pandemic countries.PMID:38638100 | DOI:10.5009/gnl230023 (Source: Gut and Liver)
Source: Gut and Liver - April 19, 2024 Category: Gastroenterology Authors: Hua Zhou Mengxia Yan Datian Che Bin Wu Source Type: research
Fonction de l'ARNnc exosomal HEIH dans le carcinome h épatocellulaire associé au virus de l'hépatite B
This study aimed to investigate the expression of exosomal lncRNA-HEIH in B-HCC patients and explore its clinical significance. We collected blood samples from 60 B-HCC patients, 60 non-hepatitis virus-associated HCC (N-HCC) patients, and 50 healthy volunteers. Exosomal lncRNA-HEIH levels were measured by real-time PCR and analyzed for their correlation with patient prognosis using Kaplan-Meier analysis. Multivariate COX regression analysis was conducted to identify factors affecting patient outcomes. The effects of lncRNA-HEIH on carcinogenesis were also investigated by constructing a Huh7 cell line stably expressing the ...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Tao Yu Huiming Li Guijia Shen Qifang Wu Source Type: research
Fonction de l'ARNnc exosomal HEIH dans le carcinome h épatocellulaire associé au virus de l'hépatite B
This study aimed to investigate the expression of exosomal lncRNA-HEIH in B-HCC patients and explore its clinical significance. We collected blood samples from 60 B-HCC patients, 60 non-hepatitis virus-associated HCC (N-HCC) patients, and 50 healthy volunteers. Exosomal lncRNA-HEIH levels were measured by real-time PCR and analyzed for their correlation with patient prognosis using Kaplan-Meier analysis. Multivariate COX regression analysis was conducted to identify factors affecting patient outcomes. The effects of lncRNA-HEIH on carcinogenesis were also investigated by constructing a Huh7 cell line stably expressing the ...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Tao Yu Huiming Li Guijia Shen Qifang Wu Source Type: research
IJERPH, Vol. 21, Pages 501: Sexually Transmitted Infections in Adolescents and Young Adults: A Cross Section of Public Health
Conclusions. The literature for other countries reports the need for comprehensive, culturally and developmentally sensitive care to address sexuality-related issues in adolescents and young adults, a need that also applies to Italy. These data will be of great importance in adopting evidence-based STI control programs in Marche Region. This study could, indeed, represent a landmark for public health officials and professionals, with the aim of promoting adolescents’ access to sexual health services to receive useful information, strengthening preventive measures in younger age groups, and designing sexual ed...
Source: International Journal of Environmental Research and Public Health - April 19, 2024 Category: Environmental Health Authors: Nunzia Cannovo Elena Bianchini Luciana Gironacci Elisabetta Garbati Filiberto Di Prospero Mariano Cingolani Roberto Scendoni Piergiorgio Fedeli Tags: Article Source Type: research
Hepatitis B virus X protein promotes tumor glycolysis by downregulating lncRNA OIP5-AS1/HKDC1 in HCC
This study aims to investigate the role of HBV in HCC pathogenesis involving glucose metabolism. Long non-coding RNA (lncRNA) OIP5-AS1 was significantly downregulated in HBV-positive HCC patients, and its low expression indicated a poor prognosis. This lncRNA was primarily localized in the cytoplasm, acting as a tumor suppressor. HBV protein X (HBx) repressed OIP5-AS1 expression by inhibiting a ligand-activated transcriptional factor peroxisome proliferator-activated receptor α (PPARα). Furthermore, mechanistic studies revealed that OIP5-AS1 inhibited tumor growth by suppressing Hexokinase domain component 1 (HKDC1)-medi...
Source: Cellular Signalling - April 18, 2024 Category: Cytology Authors: Fan Shi Jingjing Jiang Baohua Wang Liang Hong Yongting Zhang Yuting Meng Xujun Zhang Lan Gong Jianjun Lin Hongyan Diao Source Type: research
MTHFR and MTRR gene polymorphisms in patients with chronic hepatitis B virus infections in Zigong, Sichuan Province
CONCLUSION: The distributions of MTHFR and MRRR genetic polymorphisms in the population with HBV infections in Zigong, Sichuan Province did not differ in age and sex. The MTHFR and MRRR genetic polymorphisms were comparable between the CHB, LC, and PLC groups.PMID:38634541 | DOI:10.1080/03014460.2024.2330926 (Source: Annals of Human Biology)
Source: Annals of Human Biology - April 18, 2024 Category: Biology Authors: Shunhua Qiu Lifen Jin Dan Yang Dewen Zhang Source Type: research
