Viruses, Vol. 16, Pages 628: Dismantling Barriers to Hepatitis B and Delta Screening, Prevention, and Linkage to Care among the PWUD Community in Philadelphia
This study found high rates of current and past HBV infection, and a 10% HBV/HDV co-infection rate. Despite availability of vaccine, one quarter of participants remained vulnerable to infection. Findings demonstrate the need to improve low-threshold HBV/HDV screening, vaccination, and linkage to care among PWUD. The study also identified gaps in the HBV/HDV care cascade, including lack of point-of-care diagnostics and lack of support for HROs to provide HBV services. (Source: Viruses)
Source: Viruses - April 18, 2024 Category: Virology Authors: Beatrice Zovich Catherine Freeland Holly Moore Kara Sapp Anousha Qureshi Rachel Holbert Jason Zambrano Daljinder Bhangoo Chari Cohen Richard W. Hass Amy Jessop Tags: Article Source Type: research
Characterization of mutations in hepatitis B virus DNA isolated from Japanese HBsAg-positive blood donors in 2021 and 2022
In this study, we isolated hepatitis B virus (HBV) DNA from 58 of 169 hepatitis B surface antigen (HBsAg)-positive blood samples from Japanese blood donors and determined the nucleotide sequence encoding the small envelope protein. DNA from six (10%) of the samples had VEMs, but no missense mutations, such as G145R, were detected. Complete HBV genome sequences were obtained from 29 of the 58 samples; the viral genotype was A1 in one (3%), A2 in three (10%), B1 in nine (31%), B2 in five (17%), B4 in one (3%), and C2 in 10 (34%) samples. Tenofovir-resistance mutations were detected in two (7%) samples. In addition, several c...
Source: Archives of Virology - April 18, 2024 Category: Virology Source Type: research
Monitoring hepatocellular carcinoma using tumor content in circulating cell-free DNA
CONCLUSIONS: The tumor content in ccfDNA is correlated with tumor burden and may help in monitoring HCC one year earlier than clinical diagnosis and in predicting patient prognosis.PMID:38630548 | DOI:10.1158/1078-0432.CCR-23-3449 (Source: Cell Research)
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Shifeng Lian Chenyu Lu Fugui Li Xia Yu Limei Ai Biao-Hua Wu Xueyi Gong Wenjing Zhou Xuejun Liang Jiyun Zhan Yong Yuan Fang Fang Zhiwei Liu Mingfang Ji Zongli Zheng Source Type: research
Monitoring hepatocellular carcinoma using tumor content in circulating cell-free DNA
CONCLUSIONS: The tumor content in ccfDNA is correlated with tumor burden and may help in monitoring HCC one year earlier than clinical diagnosis and in predicting patient prognosis.PMID:38630548 | DOI:10.1158/1078-0432.CCR-23-3449 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 17, 2024 Category: Cancer & Oncology Authors: Shifeng Lian Chenyu Lu Fugui Li Xia Yu Limei Ai Biao-Hua Wu Xueyi Gong Wenjing Zhou Xuejun Liang Jiyun Zhan Yong Yuan Fang Fang Zhiwei Liu Mingfang Ji Zongli Zheng Source Type: research
A mutual regulatory loop between transcription factor Yin Yang 1 and hepatitis B virus replication influences chronic hepatitis B < sup > 1 < /sup >
In conclusion, our study demonstrates that YY1 plays an important role in HBV replication and gene expression, providing a potential target for the treatment of CHB.PMID:38631661 | DOI:10.1016/j.antiviral.2024.105889 (Source: Antiviral Research)
Source: Antiviral Research - April 17, 2024 Category: Virology Authors: Jie Zhou Yunhao Hua Yuwei Liu Tong Wu Hongqin Xu Zhongfeng Wang Xiaomei Wang Junqi Niu Source Type: research
Monitoring hepatocellular carcinoma using tumor content in circulating cell-free DNA
CONCLUSIONS: The tumor content in ccfDNA is correlated with tumor burden and may help in monitoring HCC one year earlier than clinical diagnosis and in predicting patient prognosis.PMID:38630548 | DOI:10.1158/1078-0432.CCR-23-3449 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 17, 2024 Category: Cancer & Oncology Authors: Shifeng Lian Chenyu Lu Fugui Li Xia Yu Limei Ai Biao-Hua Wu Xueyi Gong Wenjing Zhou Xuejun Liang Jiyun Zhan Yong Yuan Fang Fang Zhiwei Liu Mingfang Ji Zongli Zheng Source Type: research
Liver transplantation for hepatitis B virus-related cirrhosis with acute-on-chronic liver failure and grade 3-4 hepatic encephalopathy: Survival and quality of life
Chin Med J (Engl). 2024 Apr 17. doi: 10.1097/CM9.0000000000003037. Online ahead of print.NO ABSTRACTPMID:38630917 | DOI:10.1097/CM9.0000000000003037 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 17, 2024 Category: General Medicine Authors: Shaohua Shi Minghui Zhang Xuliang Chen Zhuoyi Wang Songming Ding Zhitao Chen Yu Yang Shusen Zheng Source Type: research
A mutual regulatory loop between transcription factor Yin Yang 1 and hepatitis B virus replication influences chronic hepatitis B < sup > 1 < /sup >
In conclusion, our study demonstrates that YY1 plays an important role in HBV replication and gene expression, providing a potential target for the treatment of CHB.PMID:38631661 | DOI:10.1016/j.antiviral.2024.105889 (Source: Antiviral Research)
Source: Antiviral Research - April 17, 2024 Category: Virology Authors: Jie Zhou Yunhao Hua Yuwei Liu Tong Wu Hongqin Xu Zhongfeng Wang Xiaomei Wang Junqi Niu Source Type: research
Global prevalence of MAFLD-related hepatocellular carcinoma: A systematic review and meta-analysis
CONCLUSION: MAFLD is common as a sole aetiology, but more so and as a co-factor in mixed-aetiology HCC, supporting the use of a positive diagnostic criteria.PMID:38623613 | DOI:10.3350/cmh.2024.0109 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 16, 2024 Category: Gastroenterology Authors: Harry Crane Guy D Eslick Cameron Gofton Anjiya Shaikh George Cholankeril Mark Cheah Jian-Hong Zhong Gianluca Svegliati-Baroni Alessandro Vitale Beom Kyung Kim Sang Hoon Ahn Mi Na Kim Simone Strasser Jacob George Source Type: research
The orientation of CpG conjugation on aluminum oxyhydroxide nanoparticles determines the immunostimulatory effects of combination adjuvants
Biomaterials. 2024 Apr 11;308:122569. doi: 10.1016/j.biomaterials.2024.122569. Online ahead of print.ABSTRACTIn subunit vaccines, aluminum salts (Alum) are commonly used as adjuvants, but with limited cellular immune responses. To overcome this limitation, CpG oligodeoxynucleotides (ODNs) have been used in combination with Alum. However, current combined usage of Alum and CpG is limited to linear mixtures, and the underlying interaction mechanism between CpG and Alum is not well understood. Thus, we propose to chemically conjugate Alum nanoparticles and CpG (with 5' or 3' end exposed) to design combination adjuvants. Our s...
Source: Biomaterials - April 16, 2024 Category: Materials Science Authors: Zhihui Liang Hang Bao Zhiying Yao Min Li Chen Chen Lei Zhang Huiyang Wang Yiyang Guo Yubin Ma Xuecheng Yang Ge Yu Jiancheng Zhang Changying Xue Bingbing Sun Chuanbin Mao Source Type: research
Global prevalence of MAFLD-related hepatocellular carcinoma: A systematic review and meta-analysis
CONCLUSION: MAFLD is common as a sole aetiology, but more so and as a co-factor in mixed-aetiology HCC, supporting the use of a positive diagnostic criteria.PMID:38623613 | DOI:10.3350/cmh.2024.0109 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 16, 2024 Category: Gastroenterology Authors: Harry Crane Guy D Eslick Cameron Gofton Anjiya Shaikh George Cholankeril Mark Cheah Jian-Hong Zhong Gianluca Svegliati-Baroni Alessandro Vitale Beom Kyung Kim Sang Hoon Ahn Mi Na Kim Simone Strasser Jacob George Source Type: research
The orientation of CpG conjugation on aluminum oxyhydroxide nanoparticles determines the immunostimulatory effects of combination adjuvants
Biomaterials. 2024 Apr 11;308:122569. doi: 10.1016/j.biomaterials.2024.122569. Online ahead of print.ABSTRACTIn subunit vaccines, aluminum salts (Alum) are commonly used as adjuvants, but with limited cellular immune responses. To overcome this limitation, CpG oligodeoxynucleotides (ODNs) have been used in combination with Alum. However, current combined usage of Alum and CpG is limited to linear mixtures, and the underlying interaction mechanism between CpG and Alum is not well understood. Thus, we propose to chemically conjugate Alum nanoparticles and CpG (with 5' or 3' end exposed) to design combination adjuvants. Our s...
Source: Biomaterials - April 16, 2024 Category: Materials Science Authors: Zhihui Liang Hang Bao Zhiying Yao Min Li Chen Chen Lei Zhang Huiyang Wang Yiyang Guo Yubin Ma Xuecheng Yang Ge Yu Jiancheng Zhang Changying Xue Bingbing Sun Chuanbin Mao Source Type: research
Global prevalence of MAFLD-related hepatocellular carcinoma: A systematic review and meta-analysis
CONCLUSION: MAFLD is common as a sole aetiology, but more so and as a co-factor in mixed-aetiology HCC, supporting the use of a positive diagnostic criteria.PMID:38623613 | DOI:10.3350/cmh.2024.0109 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 16, 2024 Category: Gastroenterology Authors: Harry Crane Guy D Eslick Cameron Gofton Anjiya Shaikh George Cholankeril Mark Cheah Jian-Hong Zhong Gianluca Svegliati-Baroni Alessandro Vitale Beom Kyung Kim Sang Hoon Ahn Mi Na Kim Simone Strasser Jacob George Source Type: research
Viruses, Vol. 16, Pages 615: Co-Transcriptional Regulation of HBV Replication: RNA Quality Also Matters
Testoni
Chronic hepatitis B (CHB) virus infection is a major public health burden and the leading cause of hepatocellular carcinoma. Despite the efficacy of current treatments, hepatitis B virus (HBV) cannot be fully eradicated due to the persistence of its minichromosome, or covalently closed circular DNA (cccDNA). The HBV community is investing large human and financial resources to develop new therapeutic strategies that either silence or ideally degrade cccDNA, to cure HBV completely or functionally. cccDNA transcription is considered to be the key step for HBV replication. Transcription not only influences the lev...
Source: Viruses - April 16, 2024 Category: Virology Authors: Guillaume Giraud Khadija El Achi Fabien Zoulim Barbara Testoni Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1513: Time-Restricted Feeding Attenuates Metabolic Dysfunction-Associated Steatohepatitis and Hepatocellular Carcinoma in Obese Male Mice
In this study, we tested a time-restricted feeding (TRF) nutritional intervention in mouse models of MASH and HCC. We show that TRF abrogated metabolic dysregulation induced by a Western diet without any calorie restriction or weight loss. TRF improved insulin sensitivity and reduced hyperinsulinemia, liver steatosis, inflammation, and fibrosis. Importantly, TRF inhibited liver tumors in two mouse models of obesity-driven HCC. Our data suggest that TRF is likely to be effective in abrogating MASH and HCC and warrant further studies of time-restricted eating in humans with MASH who are at higher risk of developing HCC. (Source: Cancers)
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Manasi Das Deepak Kumar Consuelo Sauceda Alexis Oberg Lesley G. Ellies Liping Zeng Lily J. Jih Isabel G. Newton Nicholas J. G. Webster Tags: Article Source Type: research
