Genetic Prediction of Micronutrient Levels and the Risk of Colorectal Polyps: A Mendelian Randomization Study
Previous epidemiological and experimental studies have yielded conflicting results regarding the influence of human micronutrient levels on the risk of colorectal polyps (CP). In our study, we conducted a two-sample Mendelian randomization (MR) investigation to probe the link between 13 human micronutrients (calcium, selenium, magnesium, phosphorus, folate, vitamins B-6, B-12, C, D, beta-carotene, iron, zinc, and copper) and the genetic susceptibility to CP. (Source: Clinical Nutrition)
Source: Clinical Nutrition - April 25, 2024 Category: Nutrition Authors: Siyao Lv, Yunyi Ding, Junli Huang, Yixin He, Ruijie Xie, Xiaohong Shi, Wei Ye Source Type: research
Isolated Langerhans cell histiocytosis in the stomach of adults: four-case series and literature review
We examined four cases (one female, three males) of gastric LCH. The affected patients were between 33 and 70 years of age. Endoscopically, three patients presented with a solitary polyp or elevated lesions, whereas one patient showed no abnormalities. Under a microscope, all cases showed abnormal proliferation of histiocytoid cells infiltrating in a nested or sheet-like fashion. The tumor cells were medium-sized, with a slightly eosinophilic cytoplasm, irregular or renal-shaped nuclei, folded nuclear membranes, visible nuclear grooves, and the infiltration of inflammatory cells in the background. Immunohistochemically, al...
Source: Journal of Hematopathology - April 23, 2024 Category: Pathology Source Type: research
Audit of hemostatic clip use after colorectal polyp resection in an academic endoscopy unit
Conclusions Audits of clip use in an endoscopy practice can reveal surprising findings, including high and variable rates of unnecessary use after cold resection. Audit can potentially reduce unnecessary costs, carbon emissions, and plastic waste. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - April 23, 2024 Category: Gastroenterology Authors: Stark, Easton M. Lahr, Rachel E. Shultz, Jeremiah Vemulapalli, Krishna C. Guardiola, John J. Rex, Douglas K. Tags: Original article Source Type: research
Response
We appreciate the letter from Pasam et al1 in response to our article2 in Gastrointestinal Endoscopy. The authors included only randomized controlled trials, as opposed to our analysis,2 where we included both observational studies and randomized controlled trials to provide a more comprehensive review. Our analysis did not include the trials by Rex et al3 and Rodríguez Sánchez et al4 because they were published after our search period until January 12, 2023. Because our study inclusion criteria for polyps were size ≥1.5 cm, we also did not include the 2019 study by Yamashina et al. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 21, 2024 Category: Gastroenterology Authors: Dhruvil Radadiya, Madhav Desai, Prateek Sharma Tags: Letter to the Editor Source Type: research
Endoscopic techniques to reduce recurrence after EMR of large nonpedunculated colorectal polyps
We congratulate Radadiya et al1 on their recent study comparing various EMR techniques for large nonpedunculated colorectal polyps by using indirect pairwise comparison. However, their study included observational studies and randomized control trials (RCTs), which limits the ability to draw conclusions. In support of this t opic, we performed a network meta-analysis of RCTs comparing various margin ablation techniques after EMR—snare tip soft coagulation (STSC) and argon plasma coagulation (APC)—with conventional EMR (CEMR) and underwater EMR (UEMR) to treat large nonpedunculated colorectal polyps. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 21, 2024 Category: Gastroenterology Authors: Ravi Teja Pasam, Saurabh Chandan, Babu P. Mohan Tags: Letter to the Editor Source Type: research
Early detection of gastrointestinal polyps and neoplasia following radiation for childhood-onset cancer
A massive and rapidly increasing burden of care exists for all physicians caring for the 80–90% of childhood cancer survivors. All paediatricians and general practitioners (GPs) seeing these adolescents must attain a sound knowledge of the risks, current and future, faced by these young people. Provision of improved care and appropriate surveillance during adolescence, with information for adult services at time of transition, will also empower patients and their families to advocate for and act upon the essential requirements for long-term surveillance. Not all these risks are yet commonly recognised. Exposure to ab...
Source: Archives of Disease in Childhood - April 18, 2024 Category: Pediatrics Authors: Atlas, G., Zacharin, M. R. Tags: PostScript Source Type: research
Twenty First Century Technological Toolbox Innovation for Transanal Minimally Invasive Surgery (TAMIS)
Surg Technol Int. 2024 Apr 16;44:sti44/1760. Online ahead of print.ABSTRACTTransanal minimally invasive surgery (TAMIS) is an effective procedure that plays an important role in the care of patients with significant rectal neoplasia and polyps including early-stage cancers. However, it is perhaps underutilised and under threat from both advanced flexible endoscopic procedures and proceduralists (who often act as gatekeepers for referral to colorectal surgeons), as well as from robotic surgery proponents. TAMIS advocates can learn and adopt practice insights from both these fields and incorporate available technological inn...
Source: Surgical Technology International - April 17, 2024 Category: Surgery Authors: Alice Moynihan Patrick Boland Ronan A Cahill Source Type: research
Rectal gastric heterotopia with fundic gland polyps, mimicking a high-risk primary anorectal neoplasm: histological evidence of the effects of gastric acid-suppressing medication in a rectal ‘outlet patch’
Gastric heterotopia can occur in any part of the gastrointestinal tract but is rare in the rectum. This case of rectal gastric heterotopia is novel as the heterotopic mucosa contained fundic gland polyps, and there were histological changes in the gastric glands characteristic of proton pump inhibitor-related changes. These changes included apocrine-like luminal cytoplasmic protrusions in cystically dilated oxyntic gland parietal cells. These are well described in the native stomachs of PPI treated patients, but this is the first report of these changes in heterotopic gastric mucosa to our knowledge. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - April 17, 2024 Category: Pathology Authors: Ethan Clarke, Khine Thu, Tim Bracey Tags: Short case Source Type: research
Endoscopic treatment of scarred polyps with a non-thermal device (Endorotor): A review of the literature
World J Gastroenterol. 2024 Mar 28;30(12):1706-1713. doi: 10.3748/wjg.v30.i12.1706.ABSTRACTEndoscopic resection (ER) of colorectal polyps has become a daily practice in most endoscopic units providing a colorectal cancer screening program and requires the availability of local experts and high-end endoscopic devices. ER procedures have evolved over the past few years from endoscopic mucosal resection (EMR) to more advanced techniques, such as endoscopic submucosal dissection and endo-scopic full-thickness resection. Complete resection and disease eradication are the ultimate goals of ER-based techniques, and novel devices ...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Mariam Zaghloul Hameed Rehman Stefano Sansone Konstantinos Argyriou Adolfo Parra-Blanco Source Type: research
Endoscopic treatment of scarred polyps with a non-thermal device (Endorotor): A review of the literature
World J Gastroenterol. 2024 Mar 28;30(12):1706-1713. doi: 10.3748/wjg.v30.i12.1706.ABSTRACTEndoscopic resection (ER) of colorectal polyps has become a daily practice in most endoscopic units providing a colorectal cancer screening program and requires the availability of local experts and high-end endoscopic devices. ER procedures have evolved over the past few years from endoscopic mucosal resection (EMR) to more advanced techniques, such as endoscopic submucosal dissection and endo-scopic full-thickness resection. Complete resection and disease eradication are the ultimate goals of ER-based techniques, and novel devices ...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Mariam Zaghloul Hameed Rehman Stefano Sansone Konstantinos Argyriou Adolfo Parra-Blanco Source Type: research
Surgical Decision-Making in Familial Adenomatous Polyposis
Clin Colon Rectal Surg. 2023 Aug 10;37(3):191-197. doi: 10.1055/s-0043-1770732. eCollection 2024 May.ABSTRACTFamilial adenomatous polyposis (FAP) is an autosomal dominant disorder affecting patients with germline mutations of the adenomatous polyposis coli (APC) tumor suppressor gene. The surgical treatment of colorectal disease in FAP, which has the goal of colorectal cancer prevention, varies based on both patient and disease factors but can include the following: total colectomy with ileorectal anastomosis, proctocolectomy with stapled or hand-sewn ileal pouch-anal anastomosis, or total proctocolectomy with end ileostom...
Source: Hand Surgery - April 15, 2024 Category: Surgery Authors: Allie E Steinberger Maggie L Westfal Paul E Wise Source Type: research
Gastroenterology/Hepatology: What You May Have Missed in 2023
This article summarizes clinically important gastroenterology developments from 2023 for internal medicine specialists. In colorectal cancer screening, a new RNA fecal screening test is on the horizon, as well as a new analysis on the benefits of using artificial intelligence in screening colonoscopy to detect more polyps. There is new evidence for management of gastrointestinal bleeding, a new drug for treatment of recurrent small-intestinal angiodysplasia, and a new endoscopic treatment method in patients with gastrointestinal tumor bleeding. The authors feature a randomized trial about amitriptyline as treatment for pat...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Sama Anvari Kayla Dadgar Ciar án Galts Michael Bretthauer Source Type: research
GI genius endoscopy module: a clinical profile
Expert Rev Med Devices. 2024 Apr 15. doi: 10.1080/17434440.2024.2342508. Online ahead of print.ABSTRACTINTRODUCTION: The identification of early-stage colorectal cancers (CRC) and the resection of pre-cancerous neoplastic lesions through colonoscopy allows to decrease both CRC incidence and mortality. However, colonoscopy miss rates up to 26% for adenomas and 9% for advanced adenomas have been reported. In recent years, artificial intelligence (AI) systems have been emerging as easy-to-use tools, potentially lowering the risk of missing lesions.AREAS COVERED: This review paper focuses on GI Genius device (Medtronic Co. Min...
Source: Expert Review of Medical Devices - April 15, 2024 Category: Medical Devices Authors: Alberto Savino Emanuele Rondonotti Simone Rocchetto Alessandra Piagnani Niccol ò Bina Pasquale Di Domenico Francesco Segatta Franco Radaelli Source Type: research
Surgical Decision-Making in Familial Adenomatous Polyposis
Clin Colon Rectal Surg. 2023 Aug 10;37(3):191-197. doi: 10.1055/s-0043-1770732. eCollection 2024 May.ABSTRACTFamilial adenomatous polyposis (FAP) is an autosomal dominant disorder affecting patients with germline mutations of the adenomatous polyposis coli (APC) tumor suppressor gene. The surgical treatment of colorectal disease in FAP, which has the goal of colorectal cancer prevention, varies based on both patient and disease factors but can include the following: total colectomy with ileorectal anastomosis, proctocolectomy with stapled or hand-sewn ileal pouch-anal anastomosis, or total proctocolectomy with end ileostom...
Source: Clinical Colorectal Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Allie E Steinberger Maggie L Westfal Paul E Wise Source Type: research
