Effectiveness and safety of thin vs. thick cold snare polypectomy of small colorectal polyps: Systematic review and meta-analysis
Conclusions We found no differences in CR rates for CSP between thin-wire and thick-wire snares. CSP, regardless of snare type, is safe and effective for resection of small colorectal polyps. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - January 19, 2024 Category: Gastroenterology Authors: Khan, Rishad Samnani, Sunil Vaska, Marcus Grover, Samir C Walsh, Catharine M Mosko, Jeffrey Bourke, Michael Heitman, Steven J Forbes, Nauzer Tags: Review Source Type: research
Genomic Landscape of Lynch Syndrome Colorectal Neoplasia Identifies Shared Mutated Neoantigens for Immunoprevention
We report a focused somatic mutation and frameshift-neoAg landscape of microsatellite loci from colorectal polyps without malignant potential (PWOMPs), pre-cancers and early-stage cancers in LS carriers. (Source: Gastroenterology)
Source: Gastroenterology - January 18, 2024 Category: Gastroenterology Authors: Ana M. Bolivar, Fahriye Duzagac, Nan Deng, Laura Reyes-Uribe, Kyle Chang, Wenhui Wu, Charles M. Bowen, Melissa W. Taggart, Selvi Thirumurthi, Patrick M. Lynch, Y. Nancy You, Jesus Rodriguez-Pascual, Steven M. Lipkin, Scott Kopetz, Paul Scheet, Gregory A. Tags: Basic and Translational - Alimentary Tract Source Type: research
Geometry of cold snare polypectomy and risk of incomplete resection
Conclusion RER is more important with p-CSP than with HSP. The number of resections, n, and consequently RIR increases with increasing polyp size. Given the overwhelming safety of CSP, specific techniques to minimize the RER should be studied and developed. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Endoscopy)
Source: Endoscopy - January 17, 2024 Category: Gastroenterology Authors: Cronin, Oliver Kirszenblat, David Forbes, Nauzer Gupta, Sunil Whitfield, Anthony O'Sullivan, Timothy Gauci, Julia Abuarisha, Muhammad Wang, Hunter Burgess, Nicholas G. Lee, Eric Y.T. Williams, Stephen J. Bourke, Michael J. Tags: Innovations and brief communications Source Type: research
The effect of nurse assisted colonoscopy on adenoma detection rates: A meta-analysis of randomized controlled trials
ConclusionEndoscopy nurses ’ participation in colonoscopy can improve the detection rate of polyps and adenomas, However, more research is needed to confirm the results. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - January 16, 2024 Category: Gastroenterology Source Type: research
Significance of SDC2 and NDRG4 methylation in stool for colorectal cancer diagnosis
CONCLUSIONS: This research confirmed the significance of detection of SDC2 and NDRG4 methylation by using noninvasive samples of stool. More importantly, attributing to their high level and frequency of methylation in stool, SDC2 and NDRG4 could be promising biomarkers for stool-based method for screening and early diagnosis of CRC, especially when combined.PMID:38224931 | DOI:10.1016/j.clinbiochem.2024.110717 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - January 15, 2024 Category: Biochemistry Authors: Lu Long Qian Sun Fang Yang Hui Zhou Yu Wang Changhe Xiao Qing He Bin Yi Source Type: research
Colon Polyp Surveillance – Separating the Wheat from the Chaff
One goal of colorectal cancer (CRC) screening is to prevent CRC incidence by removing precancerous colonic polyps, which are detected in up to 50% of screening exams. Yet, the lifetime risk of CRC is 3.9-4.3%, so it is clear that most of these individuals with polyps would not develop CRC in their lifetime. It is therefore a challenge to determine which individuals with polyps will benefit from follow up, and at what intervals. There is some evidence that individuals with advanced polyps, based on size and histology, benefit from intensive surveillance. (Source: Gastroenterology)
Source: Gastroenterology - January 13, 2024 Category: Gastroenterology Authors: Brian A. Sullivan, David A. Lieberman Tags: Reviews in Basic and Clinical Gastroenterology and Hepatology Source Type: research
Impact of Texture and Color Enhancement Imaging on Adenoma and Sessile Serrated Lesion Detection: Much More to Explore
We read with great interest the article by Young et al1 regarding a randomized trial on texture and color enhancement imaging (TXI) vs white-light imaging (WLI) for colorectal adenoma detection. Their study demonstrated that compared with WLI, TXI improves both the adenoma detection rate (ADR) and number of adenomas found per colonoscopy. The effec t is most significant for flat and right-sided polyps, which are frequently missed at colonoscopy.2 We congratulate the authors for their promising findings. (Source: Gastroenterology)
Source: Gastroenterology - January 13, 2024 Category: Gastroenterology Authors: Jiahui Wei, Shengbing Zhao, Bai Yu Tags: Correspondence Source Type: research
Colon Polyp Surveillance: Separating the Wheat From the Chaff
One goal of colorectal cancer (CRC) screening is to prevent CRC incidence by removing precancerous colonic polyps, which are detected in up to 50% of screening examinations. Yet, the lifetime risk of CRC is 3.9% –4.3%, so it is clear that most of these individuals with polyps would not develop CRC in their lifetime. It is, therefore, a challenge to determine which individuals with polyps will benefit from follow-up, and at what intervals. There is some evidence that individuals with advanced polyps, based on size and histology, benefit from intensive surveillance. (Source: Gastroenterology)
Source: Gastroenterology - January 13, 2024 Category: Gastroenterology Authors: Brian A. Sullivan, David A. Lieberman Tags: Reviews in Basic and Clinical Gastroenterology and Hepatology Source Type: research
Assessment of Circulating Tumor Cells in Colorectal Cancer as an Adjunctive Non-invasive Diagnostic Method
CONCLUSION: This study assessed the diagnostic potential of CTC examination in CRC as an adjunctive diagnostic method using the subjective manual identification method and laser capture microdissection at 40x magnification. Despite the limitations associated with subjective cell counting, the results showed 50% sensitivity and 88.89% specificity in diagnosing CRC. Further studies are needed to optimize the manual identification process and validate the clinical utility of CTC analysis in CRC patients.PMID:38213054 (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - January 12, 2024 Category: Internal Medicine Authors: Saskia Aziza Nursyirwan Murdani Abdullah Andri Sanityoso Sulaiman Ikhwan Rinaldi Dadang Makmun Marcellus Simadibrata Dimas Ramadhian Noor Agustinus Wiraatmadja Wifanto Saditya Jeo Nur Rahadiani Diah Rini Handjari Hamzah Shatri Source Type: research
