Genomic Landscape of Lynch Syndrome Colorectal Neoplasia Identifies Shared Mutated Neoantigens for Immunoprevention

We report a focused somatic mutation and frameshift-neoAg landscape of microsatellite loci from colorectal polyps without malignant potential (PWOMPs), pre-cancers and early-stage cancers in LS carriers.

Source: Gastroenterology - January 18, 2024 Category: Gastroenterology Authors: Ana M. Bolivar, Fahriye Duzagac, Nan Deng, Laura Reyes-Uribe, Kyle Chang, Wenhui Wu, Charles M. Bowen, Melissa W. Taggart, Selvi Thirumurthi, Patrick M. Lynch, Y. Nancy You, Jesus Rodriguez-Pascual, Steven M. Lipkin, Scott Kopetz, Paul Scheet, Gregory A. Tags: Basic and Translational - Alimentary Tract Source Type: research