Science Saturday: Could population genetic screening improve public health?
Hereditary BRCA-related breast and ovarian cancer, Lynch syndrome and familial hypercholesterolemia are estimated to be relatively prevalent in the general population but poorly found using traditional risk screening. In a typical medical practice, genetic testing for these conditions is based on personal or family history, ethnic background or other demographic characteristics, that may not always be easily or accurately gathered by a physician. [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - September 5, 2020 Category: Databases & Libraries Source Type: news

Aspirin Tied to Lasting Reduction in CRC Risk in Lynch Syndrome
MONDAY, June 15, 2020 -- For patients with Lynch syndrome, aspirin is associated with a reduced risk for colorectal cancer during long-term follow-up, according to a study published in the June 13 issue of The Lancet. John Burn, M.D., from... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 15, 2020 Category: Pharmaceuticals Source Type: news

Genetic Counseling, Testing Not Common in People at Risk for Lynch Syndrome Genetic Counseling, Testing Not Common in People at Risk for Lynch Syndrome
Only a minority of people with risk factors for Lynch syndrome undergo genetic counseling and testing, although the rate has increased over time, according to new findings.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - December 19, 2019 Category: Pathology Tags: Gastroenterology News Source Type: news

Medical News Today: What is Lynch syndrome?
Lynch syndrome is a genetic condition that increases a person ’s risk of developing colorectal cancer. Learn more about its symptoms, diagnosis, and treatment here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 28, 2019 Category: Consumer Health News Tags: Colorectal Cancer Source Type: news

Aspirin may reduce the risk of colorectal cancer
Aspirin taken daily for two years or more could reduce the risk of colorectal cancer in people with Lynch syndrome, says NICE in new draft updated guidance. (Source: NHS Networks)
Source: NHS Networks - August 7, 2019 Category: UK Health Source Type: news

People with genetic condition should be given aspirin daily to slash their risk of colorectal cancer
An estimated 200,000 people in the UK are born with Lynch syndrome. A study showed taking aspirin daily for two years could prevent a diagnosis of the killer disease. (Source: the Mail online | Health)
Source: the Mail online | Health - August 2, 2019 Category: Consumer Health News Source Type: news

Lynch Syndrome and Urologic Malignancies Lynch Syndrome and Urologic Malignancies
Get up-to-date on the most recent developments regarding lynch syndrome-associated urologic malignancies.Current Opinion in Urology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 15, 2019 Category: Consumer Health News Tags: Urology Journal Article Source Type: news

Dr Henry Lynch obituary
Geneticist who unlocked the secrets of hereditary cancersIn 1962 a medical intern sat with a man recovering from alcohol poisoning in a veterans ’ hospital in the US state of Nebraska. Henry Lynch, who has died aged 91, listened as the young farm worker told him that he liked to drown his sorrows because, as with everyone else in his family, he was pretty much guaranteed to die young of cancer.Lynch, with a background in genetics and psychology, wanted to know more about this family and its high prevalence of cancer. His investigations intothis and other such families led to the discovery of hereditary non-polyposis ...
Source: Guardian Unlimited Science - June 20, 2019 Category: Science Authors: Penny Warren Tags: Genetics Biology People in science Cancer research Medical research Medicine Education Source Type: news

Colorectal-Tumor Screening for Lynch Syndrome Has Low Yield in Elderly Colorectal-Tumor Screening for Lynch Syndrome Has Low Yield in Elderly
The diagnostic yield of universal screening of colorectal tumors for Lynch syndrome decreases substantially after ages 70 to 75, a retrospective study suggests.Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - June 14, 2019 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news

Diagnostic Yield of Lynch Syndrome Screening Drops With Age
Incremental diagnostic yield decreases substantially after 70 to 75 years; LS is rare after 80 years (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - June 11, 2019 Category: Cancer & Oncology Tags: Gastroenterology, Internal Medicine, Oncology, Pathology, Geriatrics, Journal, Source Type: news

Diagnostic Yield of Lynch Syndrome Screening Drops With Age
TUESDAY, June 11, 2019 -- The incremental diagnostic yield of Lynch syndrome (LS) screening decreases substantially after age 70 to 75 years, according to a study published online June 11 in the Annals of Internal Medicine. Dan Li, M.D., from Kaiser... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 11, 2019 Category: Pharmaceuticals Source Type: news

Father of Cancer Genetics, Dr Henry Lynch, Has Died Aged 91 Father of Cancer Genetics, Dr Henry Lynch, Has Died Aged 91
A pioneer in the study of cancer and genetics, Lynch discovered the most common form of hereditary colorectal cancer, now known as Lynch syndrome.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - June 6, 2019 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Dana-Farber Opens First Center Devoted to Lynch Syndrome Dana-Farber Opens First Center Devoted to Lynch Syndrome
The new center will provide genetic testing, coordinated care, and research for individuals with Lynch syndrome.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - April 1, 2019 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Colorectal cancer vaccine could prevent tumors in people at genetic risk
People with Lynch Syndrome have genes that give them an 80 percent higher risk of the cancer. A vaccine developed by Weill Cornell Medicine researchers prevented the cancer in some mice. (Source: the Mail online | Health)
Source: the Mail online | Health - April 1, 2019 Category: Consumer Health News Source Type: news

Cancer preventive vaccine showed promising results in preclinical model of Lynch syndrome
(American Association for Cancer Research) Vaccination with as few as four tumor antigens generated antigen-specific responses, reduced intestinal tumors, and improved survival in a mouse model of Lynch syndrome, suggesting that it may be possible to develop a cancer preventive vaccine for patients with Lynch syndrome, according to data presented at the AACR Annual Meeting 2019, March 29-April 3. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 1, 2019 Category: Cancer & Oncology Source Type: news

I Had Lynch Syndrome For 30 Hours
As a genetic counselor, I have been taking the popular home DNA tests on the market. My raw data showed that I have Lynch syndrome, a hereditary cancer syndrome that increases the risk of colorectal, uterine, ovary, and other cancers. Further testing proved that this result was a false positive. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - February 12, 2019 Category: Pharmaceuticals Authors: Ellen Matloff, Contributor Source Type: news

A Man On A Mission: How One Patient Journey Can Change The Course Of A Hereditary Cancer
Lynch syndrome is a hereditary cancer estimated to affect 1 in every 279 Americans – meaning it isn’t rare. But the staggering number of those who may be carriers and not know it is what sets Lynch syndrome apart. Carriers are often diagnosed at younger ages, and develop multiple cancers over time. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - February 8, 2019 Category: Pharmaceuticals Authors: Nicole Fisher, Contributor Source Type: news

23andMe Has a New Genetic Cancer Test. But the Results Don ’t Tell You the Whole Story
Consumer genetics company 23andMe is diving deeper into the medical space. On Jan. 22, the company announced that the Food and Drug Administration (FDA) approved its newest report, which can flag whether people have genetic variants that may raise their risk of developing colorectal cancer. The new test looks for two gene variants associated with MUTYH-associated polyposis, an inherited colorectal cancer syndrome. “If left unchecked, carrying both of these variants or having two copies of one increases the risk of developing colorectal cancer to between 43 and 100 percent,” according to 23andMe. The test will b...
Source: TIME: Health - January 23, 2019 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Cancer healthytime Source Type: news

23andMe Just Got FDA Approval for a DNA Cancer Test
(Bloomberg) — DNA testing company 23andMe Inc. said it has gotten the green light from the U.S. Food and Drug Administration to offer consumers a test for a hereditary colorectal cancer syndrome. 23andMe said it will now be able to tell customers whether they have two genetic variants that influence MUTYH-associated polyposis, a rare condition associated with an increased risk of colorectal cancer. The FDA didn’t immediately respond to a request for comment. Key Insights It’s the second test associated with cancer risk for which 23andMe has received FDA clearance. Last March, the Mountain View, Califo...
Source: TIME: Health - January 22, 2019 Category: Consumer Health News Authors: Kristen V. Brown / Bloomberg Tags: Uncategorized DNA Testing onetime Source Type: news

Researchers develop personalized medicine tool for inherited colorectal cancer syndrome
(Huntsman Cancer Institute) An international team of researchers led by Huntsman Cancer Institute (HCI) at the University of Utah (U of U) has developed, calibrated, and validated a novel tool for identifying the genetic changes in Lynch syndrome genes that are likely to be responsible for causing symptoms of the disease. The results were published this week in the journal Genetics in Medicine. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 10, 2018 Category: Cancer & Oncology Source Type: news

Lynch Syndrome More Prevalent Than Previously Thought
Microsatellite instability and or mismatch repair deficiency found predictive of LS across a broader tumor spectrum than previously thought. (Source: CancerNetwork)
Source: CancerNetwork - November 20, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Single Agent Treats Two Cancers With Same Genetic Cause
Pembrolizumab treated colon cancer, intrahepatic cholangiocarcinoma in patient with Lynch syndrome (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - September 27, 2018 Category: Cancer & Oncology Tags: Gastroenterology, Oncology, Pathology, Pharmacy, Journal, Source Type: news

My IVF life: the science experiment to make a baby – from a partner's view
E, Jean Hannah Edelstein ’s husband, explains his side of IVF treatment, from the sperm analysis to the importance of patienceWhat ’s it like to be the partner of someone going through IVF treatment? This week, I sat down to discuss the experience with my husband, E. Like me, E is in his mid-30s and has never had kids before. Here’s what he told me.We discussed IVF very early in our relationship – it’s been with us basically from the beginning. On our first date we talked about cancer in our families – I lost my mom about a year before you lost your dad, you told me about Lynch syndrome ...
Source: Guardian Unlimited Science - August 6, 2018 Category: Science Authors: Jean Hannah Edelstein Tags: Family Pregnancy Life and style Sex Parents and parenting Health & wellbeing Source Type: news

Evaluating the role of public health in implementation of genomics-related recommendations: a case study of hereditary cancers using the CDC Science Impact Framework
Study used the CDC Science Impact Framework to trace the impact of public health activities and partnerships on the implementation of the 2009 Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Lynch Syndrome screening recommendation and the 2005 and 2013 USPSTF BRCA1 and BRCA2 testing recommendations. (Source: PHPartners.org)
Source: PHPartners.org - July 26, 2018 Category: International Medicine & Public Health Source Type: news

More Cancers Seem to Harbor Lynch Syndrome
(MedPage Today) -- Broader testing implied by " practice-changing " study (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - June 4, 2018 Category: Gastroenterology Source Type: news

Test All Patients With MSI Tumors for Lynch Syndrome Test All Patients With MSI Tumors for Lynch Syndrome
Tumors that have high microsatellite instability are more likely to be linked to Lynch syndrome; this includes tumors that have not been previously associated with the syndrome.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 3, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Lynch Syndrome Common in MSI-High Tumors
Leah LawrenceJun 2, 2018The presence of MSI-high was predictive of Lynch syndrome, which was found to be associated with a much wider spectrum of cancers than previously thought. (Source: CancerNetwork)
Source: CancerNetwork - June 2, 2018 Category: Cancer & Oncology Authors: A Source Type: news

Gene sequencing study finds new cancers linked with Lynch syndrome
CHICAGO (Reuters) - Lynch syndrome, a rare hereditary disease typically associated with an increased risk of colorectal and endometrial cancers, appears to be linked with several additional types of cancer than previously thought, U.S. researchers said on Saturday. (Source: Reuters: Health)
Source: Reuters: Health - June 2, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Potential Role for Vaccines, Checkpoint Inhibitors in Chemoprevention of Lynch Syndrome
Researchers from MD Anderson say their study results " open the field of immunoprevention in LS to checkpoint inhibitors as an immune interception strategy. " (Source: CancerNetwork)
Source: CancerNetwork - May 11, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Colorectal Cancer Gastrointestinal Cancer News Source Type: news

Screening for Lynch syndrome cost  effective in CRC
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - May 1, 2018 Category: Drugs & Pharmacology Source Type: news

Precancerous colon polyps in patients with Lynch syndrome exhibit immune activation
(University of Texas M. D. Anderson Cancer Center) Colon polyps from patients with Lynch syndrome, a hereditary condition that raises colorectal cancer risk, display immune system activation well before cancer development, according to research from The University of Texas MD Anderson Cancer Center. The preclinical research challenges traditional models of cancer immune activation and suggests immunotherapy may be useful for colorectal cancer prevention in certain high-risk groups. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 16, 2018 Category: Cancer & Oncology Source Type: news

Tumor Sequencing Useful for Lynch-syndrome Screening Tumor Sequencing Useful for Lynch-syndrome Screening
Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - April 10, 2018 Category: Surgery Tags: Hematology-Oncology News Source Type: news

Mayo Clinic Q and A: Lynch syndrome and genetic testing
DEAR MAYO CLINIC: I am considering undergoing genetic testing to see if I have the gene mutation that causes Lynch syndrome. Because of my family history, I already have regular colonoscopies even though I?m only 41. What would knowing I have the mutation change as far as how I?m monitored for colon cancer? ANSWER: Knowing [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - April 10, 2018 Category: Databases & Libraries Source Type: news

Hospitals 'failing' on genetic bowel cancer test
A charity says that more than 80% are failing to test for the genetic condition Lynch syndrome. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - March 27, 2018 Category: Consumer Health News Source Type: news

Four in five hospitals won't carry out 'life saving' bowel cancer test
Bowel Cancer UK found that 83% of hospital trusts do not provide 'life-saving' £200 test to identify Lynch syndrome - a genetic condition which increases a person's risk of Bowel Cancer (Source: the Mail online | Health)
Source: the Mail online | Health - March 27, 2018 Category: Consumer Health News Source Type: news

Researchers find link between breast cancer and two gene mutations
(Springer) Individuals with Lynch syndrome, a genetic condition that has long been known to carry dramatically increased risk of colorectal cancer and uterine cancer, now also have an increased risk of breast cancer. This is the conclusion of a study in the journal Genetics in Medicine which is published by Springer Nature. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 19, 2018 Category: Cancer & Oncology Source Type: news

Two new breast cancer genes emerge from lynch syndrome gene study
(Columbia University Medical Center) Columbia University researchers have identified two new breast cancer genes that also cause Lynch syndrome. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 18, 2018 Category: Cancer & Oncology Source Type: news

GP missed woman's bowel cancer as she was 'too young'
Cara Hoofe, from west London, is speaking out to raise awareness that bowel cancer can affect younger people. She has Lynch syndrome, an inherited condition raising risks of certain  cancers. (Source: the Mail online | Health)
Source: the Mail online | Health - November 10, 2017 Category: Consumer Health News Source Type: news

ACG Wrap-up: Fecal Transplant; Lynch Syndrome Screening; Probiotics for Pain
(MedPage Today) -- Additional highlights from this year's meeting (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - October 19, 2017 Category: Gastroenterology Source Type: news

Lynch Syndrome Studies Highlight Screening, Surveillance Opportunities
Two studies on Lynch syndrome highlight cancer screening and surveillance opportunities. (Source: CancerNetwork)
Source: CancerNetwork - August 13, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Colorectal Cancer Endometrial Cancer Gastrointestinal Cancer Gynecologic Cancers News Ovarian Cancer Source Type: news

Cancer Risk Patterns in Lynch Syndrome Differ by Path_MMR Variants Cancer Risk Patterns in Lynch Syndrome Differ by Path_MMR Variants
Carriers of different path_MMR variants (Lynch syndrome) show different patterns of cancer risk and survival, according to findings from the Prospective Lynch Syndrome Database (PSLD).Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - August 11, 2017 Category: Pathology Tags: Hematology-Oncology News Source Type: news

Even Distant Relatives of Lynch Syndrome Patients Face Higher Cancer Risks Even Distant Relatives of Lynch Syndrome Patients Face Higher Cancer Risks
Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 8, 2017 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Do YOU have Lynch syndrome? Genetic condition is common cause of killer bowel cancer
LYNCH syndrome is a genetic condition which is the most common cause of hereditary bowel cancer. (Source: Daily Express - Health)
Source: Daily Express - Health - June 27, 2017 Category: Consumer Health News Source Type: news

Lynch Syndrome Mutations and Risk of Breast and Ovarian Cancer Lynch Syndrome Mutations and Risk of Breast and Ovarian Cancer
Although Lynch syndrome is thought to increase the risk of colorectal and/or uterine cancer, certain mutations may confer an increased risk of breast or ovarian cancer, researchers say.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 2, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Increasing the age limit for Lynch syndrome genetic testing may save lives
(European Society of Human Genetics) Raising the age limit for routine genetic testing in colorectal cancer could identify more cases of families affected by Lynch syndrome, a condition that accounts for around 5 percent of all colon cancers. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 29, 2017 Category: Cancer & Oncology Source Type: news

NICE recommends wider use of tests to detect cancer-causing genetic condition
NICE has published diagnostics guidance recommending that everyone who is diagnosed with colorectal cancer should be tested for an inherited genetic condition called Lynch syndrome (LS). (Source: NHS Networks)
Source: NHS Networks - February 23, 2017 Category: UK Health Source Type: news

Understanding GP attitudes to cancer preventing drugs
A report from Cancer Research explores how much GPs know about two drugs that can reduce the risk of cancer – tamoxifen for women at high risk of breast cancer, and aspirin for people with Lynch Syndrome, a condition that increases the risk of several types of cancer. (Source: NHS Networks)
Source: NHS Networks - February 17, 2017 Category: UK Health Source Type: news

Lynch Syndrome –Associated Ovarian Cancer Presents Early, Has Good Prognosis
An analysis of Lynch syndrome –associated ovarian cancer found that the malignancy tends to present at an early stage and has a generally good prognosis. (Source: CancerNetwork)
Source: CancerNetwork - January 25, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Gynecologic Cancers News Ovarian Cancer Source Type: news

Multigene Testing a'Must' for Young Patients With CRC Multigene Testing a'Must' for Young Patients With CRC
Genetic testing for patients with colorectal cancer diagnosed at age younger than 50 years needs to go beyond Lynch syndrome.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - December 15, 2016 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Family History and Genomics as Tools for Cancer Prevention Family History and Genomics as Tools for Cancer Prevention
This brief examines the role of public health initiatives for cancer genomics at the federal, state, and community level, with a focus on hereditary breast and ovarian cancers and Lynch syndrome.Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 14, 2016 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news