Dana-Farber Opens First Center Devoted to Lynch Syndrome Dana-Farber Opens First Center Devoted to Lynch Syndrome
The new center will provide genetic testing, coordinated care, and research for individuals with Lynch syndrome.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - April 1, 2019 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Colorectal cancer vaccine could prevent tumors in people at genetic risk
People with Lynch Syndrome have genes that give them an 80 percent higher risk of the cancer. A vaccine developed by Weill Cornell Medicine researchers prevented the cancer in some mice. (Source: the Mail online | Health)
Source: the Mail online | Health - April 1, 2019 Category: Consumer Health News Source Type: news

Cancer preventive vaccine showed promising results in preclinical model of Lynch syndrome
(American Association for Cancer Research) Vaccination with as few as four tumor antigens generated antigen-specific responses, reduced intestinal tumors, and improved survival in a mouse model of Lynch syndrome, suggesting that it may be possible to develop a cancer preventive vaccine for patients with Lynch syndrome, according to data presented at the AACR Annual Meeting 2019, March 29-April 3. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 1, 2019 Category: Cancer & Oncology Source Type: news

I Had Lynch Syndrome For 30 Hours
As a genetic counselor, I have been taking the popular home DNA tests on the market. My raw data showed that I have Lynch syndrome, a hereditary cancer syndrome that increases the risk of colorectal, uterine, ovary, and other cancers. Further testing proved that this result was a false positive. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - February 12, 2019 Category: Pharmaceuticals Authors: Ellen Matloff, Contributor Source Type: news

A Man On A Mission: How One Patient Journey Can Change The Course Of A Hereditary Cancer
Lynch syndrome is a hereditary cancer estimated to affect 1 in every 279 Americans – meaning it isn’t rare. But the staggering number of those who may be carriers and not know it is what sets Lynch syndrome apart. Carriers are often diagnosed at younger ages, and develop multiple cancers over time. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - February 8, 2019 Category: Pharmaceuticals Authors: Nicole Fisher, Contributor Source Type: news

23andMe Has a New Genetic Cancer Test. But the Results Don ’t Tell You the Whole Story
Consumer genetics company 23andMe is diving deeper into the medical space. On Jan. 22, the company announced that the Food and Drug Administration (FDA) approved its newest report, which can flag whether people have genetic variants that may raise their risk of developing colorectal cancer. The new test looks for two gene variants associated with MUTYH-associated polyposis, an inherited colorectal cancer syndrome. “If left unchecked, carrying both of these variants or having two copies of one increases the risk of developing colorectal cancer to between 43 and 100 percent,” according to 23andMe. The test will b...
Source: TIME: Health - January 23, 2019 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Cancer healthytime Source Type: news

23andMe Just Got FDA Approval for a DNA Cancer Test
(Bloomberg) — DNA testing company 23andMe Inc. said it has gotten the green light from the U.S. Food and Drug Administration to offer consumers a test for a hereditary colorectal cancer syndrome. 23andMe said it will now be able to tell customers whether they have two genetic variants that influence MUTYH-associated polyposis, a rare condition associated with an increased risk of colorectal cancer. The FDA didn’t immediately respond to a request for comment. Key Insights It’s the second test associated with cancer risk for which 23andMe has received FDA clearance. Last March, the Mountain View, Califo...
Source: TIME: Health - January 22, 2019 Category: Consumer Health News Authors: Kristen V. Brown / Bloomberg Tags: Uncategorized DNA Testing onetime Source Type: news

Researchers develop personalized medicine tool for inherited colorectal cancer syndrome
(Huntsman Cancer Institute) An international team of researchers led by Huntsman Cancer Institute (HCI) at the University of Utah (U of U) has developed, calibrated, and validated a novel tool for identifying the genetic changes in Lynch syndrome genes that are likely to be responsible for causing symptoms of the disease. The results were published this week in the journal Genetics in Medicine. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 10, 2018 Category: Cancer & Oncology Source Type: news

Lynch Syndrome More Prevalent Than Previously Thought
Microsatellite instability and or mismatch repair deficiency found predictive of LS across a broader tumor spectrum than previously thought. (Source: CancerNetwork)
Source: CancerNetwork - November 20, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Single Agent Treats Two Cancers With Same Genetic Cause
Pembrolizumab treated colon cancer, intrahepatic cholangiocarcinoma in patient with Lynch syndrome (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - September 27, 2018 Category: Cancer & Oncology Tags: Gastroenterology, Oncology, Pathology, Pharmacy, Journal, Source Type: news

My IVF life: the science experiment to make a baby – from a partner's view
E, Jean Hannah Edelstein ’s husband, explains his side of IVF treatment, from the sperm analysis to the importance of patienceWhat ’s it like to be the partner of someone going through IVF treatment? This week, I sat down to discuss the experience with my husband, E. Like me, E is in his mid-30s and has never had kids before. Here’s what he told me.We discussed IVF very early in our relationship – it’s been with us basically from the beginning. On our first date we talked about cancer in our families – I lost my mom about a year before you lost your dad, you told me about Lynch syndrome ...
Source: Guardian Unlimited Science - August 6, 2018 Category: Science Authors: Jean Hannah Edelstein Tags: Family Pregnancy Life and style Sex Parents and parenting Health & wellbeing Source Type: news

Evaluating the role of public health in implementation of genomics-related recommendations: a case study of hereditary cancers using the CDC Science Impact Framework
Study used the CDC Science Impact Framework to trace the impact of public health activities and partnerships on the implementation of the 2009 Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Lynch Syndrome screening recommendation and the 2005 and 2013 USPSTF BRCA1 and BRCA2 testing recommendations. (Source: PHPartners.org)
Source: PHPartners.org - July 26, 2018 Category: International Medicine & Public Health Source Type: news

More Cancers Seem to Harbor Lynch Syndrome
(MedPage Today) -- Broader testing implied by " practice-changing " study (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - June 4, 2018 Category: Gastroenterology Source Type: news

Test All Patients With MSI Tumors for Lynch Syndrome Test All Patients With MSI Tumors for Lynch Syndrome
Tumors that have high microsatellite instability are more likely to be linked to Lynch syndrome; this includes tumors that have not been previously associated with the syndrome.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 3, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Lynch Syndrome Common in MSI-High Tumors
Leah LawrenceJun 2, 2018The presence of MSI-high was predictive of Lynch syndrome, which was found to be associated with a much wider spectrum of cancers than previously thought. (Source: CancerNetwork)
Source: CancerNetwork - June 2, 2018 Category: Cancer & Oncology Authors: A Source Type: news

Gene sequencing study finds new cancers linked with Lynch syndrome
CHICAGO (Reuters) - Lynch syndrome, a rare hereditary disease typically associated with an increased risk of colorectal and endometrial cancers, appears to be linked with several additional types of cancer than previously thought, U.S. researchers said on Saturday. (Source: Reuters: Health)
Source: Reuters: Health - June 2, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Potential Role for Vaccines, Checkpoint Inhibitors in Chemoprevention of Lynch Syndrome
Researchers from MD Anderson say their study results " open the field of immunoprevention in LS to checkpoint inhibitors as an immune interception strategy. " (Source: CancerNetwork)
Source: CancerNetwork - May 11, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Colorectal Cancer Gastrointestinal Cancer News Source Type: news

Screening for Lynch syndrome cost  effective in CRC
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - May 1, 2018 Category: Drugs & Pharmacology Source Type: news

Precancerous colon polyps in patients with Lynch syndrome exhibit immune activation
(University of Texas M. D. Anderson Cancer Center) Colon polyps from patients with Lynch syndrome, a hereditary condition that raises colorectal cancer risk, display immune system activation well before cancer development, according to research from The University of Texas MD Anderson Cancer Center. The preclinical research challenges traditional models of cancer immune activation and suggests immunotherapy may be useful for colorectal cancer prevention in certain high-risk groups. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 16, 2018 Category: Cancer & Oncology Source Type: news

Tumor Sequencing Useful for Lynch-syndrome Screening Tumor Sequencing Useful for Lynch-syndrome Screening
Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - April 10, 2018 Category: Surgery Tags: Hematology-Oncology News Source Type: news

Mayo Clinic Q and A: Lynch syndrome and genetic testing
DEAR MAYO CLINIC: I am considering undergoing genetic testing to see if I have the gene mutation that causes Lynch syndrome. Because of my family history, I already have regular colonoscopies even though I?m only 41. What would knowing I have the mutation change as far as how I?m monitored for colon cancer? ANSWER: Knowing [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - April 10, 2018 Category: Databases & Libraries Source Type: news

Hospitals 'failing' on genetic bowel cancer test
A charity says that more than 80% are failing to test for the genetic condition Lynch syndrome. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - March 27, 2018 Category: Consumer Health News Source Type: news

Four in five hospitals won't carry out 'life saving' bowel cancer test
Bowel Cancer UK found that 83% of hospital trusts do not provide 'life-saving' £200 test to identify Lynch syndrome - a genetic condition which increases a person's risk of Bowel Cancer (Source: the Mail online | Health)
Source: the Mail online | Health - March 27, 2018 Category: Consumer Health News Source Type: news

Researchers find link between breast cancer and two gene mutations
(Springer) Individuals with Lynch syndrome, a genetic condition that has long been known to carry dramatically increased risk of colorectal cancer and uterine cancer, now also have an increased risk of breast cancer. This is the conclusion of a study in the journal Genetics in Medicine which is published by Springer Nature. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 19, 2018 Category: Cancer & Oncology Source Type: news

Two new breast cancer genes emerge from lynch syndrome gene study
(Columbia University Medical Center) Columbia University researchers have identified two new breast cancer genes that also cause Lynch syndrome. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 18, 2018 Category: Cancer & Oncology Source Type: news

GP missed woman's bowel cancer as she was 'too young'
Cara Hoofe, from west London, is speaking out to raise awareness that bowel cancer can affect younger people. She has Lynch syndrome, an inherited condition raising risks of certain  cancers. (Source: the Mail online | Health)
Source: the Mail online | Health - November 10, 2017 Category: Consumer Health News Source Type: news

ACG Wrap-up: Fecal Transplant; Lynch Syndrome Screening; Probiotics for Pain
(MedPage Today) -- Additional highlights from this year's meeting (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - October 19, 2017 Category: Gastroenterology Source Type: news

Lynch Syndrome Studies Highlight Screening, Surveillance Opportunities
Two studies on Lynch syndrome highlight cancer screening and surveillance opportunities. (Source: CancerNetwork)
Source: CancerNetwork - August 13, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Colorectal Cancer Endometrial Cancer Gastrointestinal Cancer Gynecologic Cancers News Ovarian Cancer Source Type: news

Cancer Risk Patterns in Lynch Syndrome Differ by Path_MMR Variants Cancer Risk Patterns in Lynch Syndrome Differ by Path_MMR Variants
Carriers of different path_MMR variants (Lynch syndrome) show different patterns of cancer risk and survival, according to findings from the Prospective Lynch Syndrome Database (PSLD).Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - August 11, 2017 Category: Pathology Tags: Hematology-Oncology News Source Type: news

Even Distant Relatives of Lynch Syndrome Patients Face Higher Cancer Risks Even Distant Relatives of Lynch Syndrome Patients Face Higher Cancer Risks
Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 8, 2017 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Do YOU have Lynch syndrome? Genetic condition is common cause of killer bowel cancer
LYNCH syndrome is a genetic condition which is the most common cause of hereditary bowel cancer. (Source: Daily Express - Health)
Source: Daily Express - Health - June 27, 2017 Category: Consumer Health News Source Type: news

Lynch Syndrome Mutations and Risk of Breast and Ovarian Cancer Lynch Syndrome Mutations and Risk of Breast and Ovarian Cancer
Although Lynch syndrome is thought to increase the risk of colorectal and/or uterine cancer, certain mutations may confer an increased risk of breast or ovarian cancer, researchers say.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 2, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Increasing the age limit for Lynch syndrome genetic testing may save lives
(European Society of Human Genetics) Raising the age limit for routine genetic testing in colorectal cancer could identify more cases of families affected by Lynch syndrome, a condition that accounts for around 5 percent of all colon cancers. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 29, 2017 Category: Cancer & Oncology Source Type: news

NICE recommends wider use of tests to detect cancer-causing genetic condition
NICE has published diagnostics guidance recommending that everyone who is diagnosed with colorectal cancer should be tested for an inherited genetic condition called Lynch syndrome (LS). (Source: NHS Networks)
Source: NHS Networks - February 23, 2017 Category: UK Health Source Type: news

Understanding GP attitudes to cancer preventing drugs
A report from Cancer Research explores how much GPs know about two drugs that can reduce the risk of cancer – tamoxifen for women at high risk of breast cancer, and aspirin for people with Lynch Syndrome, a condition that increases the risk of several types of cancer. (Source: NHS Networks)
Source: NHS Networks - February 17, 2017 Category: UK Health Source Type: news

Lynch Syndrome –Associated Ovarian Cancer Presents Early, Has Good Prognosis
An analysis of Lynch syndrome –associated ovarian cancer found that the malignancy tends to present at an early stage and has a generally good prognosis. (Source: CancerNetwork)
Source: CancerNetwork - January 25, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Gynecologic Cancers News Ovarian Cancer Source Type: news

Multigene Testing a'Must' for Young Patients With CRC Multigene Testing a'Must' for Young Patients With CRC
Genetic testing for patients with colorectal cancer diagnosed at age younger than 50 years needs to go beyond Lynch syndrome.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - December 15, 2016 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Family History and Genomics as Tools for Cancer Prevention Family History and Genomics as Tools for Cancer Prevention
This brief examines the role of public health initiatives for cancer genomics at the federal, state, and community level, with a focus on hereditary breast and ovarian cancers and Lynch syndrome.Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 14, 2016 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

NICE recommends wider use of tests to detect cancer-causing genetic condition
In draft guidance published for consultation NICE has recommended that everyone who is diagnosed with colorectal cancer should be tested for an inherited genetic condition called Lynch syndrome (LS). (Source: NHS Networks)
Source: NHS Networks - October 31, 2016 Category: UK Health Source Type: news

Patients With Bowel Cancer'Not Being Tested for Lynch Syndrome'Patients With Bowel Cancer'Not Being Tested for Lynch Syndrome '
Almost one third of UK hospitals do not routinely test patients with bowel cancer younger than age 50 years for Lynch syndrome, despite it increasing the risk for cancer recurrence, survey results suggest.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 10, 2016 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Nearly a third of hospitals failing bowel cancer patients
Pathologists says hospitals must offer younger patients screening for Lynch syndrome Related items fromOnMedica Gene found to be linked to increased risk of recurrence in bowel cancer More than half of new bowel cancer screen test invitees fail to take up offer Meeting cancer promises and more – a new model for NHS diagnostics? New test prompts rise in bowel screening uptake Early stage bowel cancer more likely to be picked up by screening (Source: OnMedica Latest News)
Source: OnMedica Latest News - August 8, 2016 Category: UK Health Source Type: news

Target screening for Lynch syndrome saves costs
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - July 1, 2016 Category: Drugs & Pharmacology Source Type: news

Methylated DNA markers hold promise for Lynch syndrome
SAN DIEGO – It has been challenging to identify reliable biomarkers for Lynch syndrome colorectal neoplasms, but that may be about to change. Researchers have identified 10 discriminant methylated... (Source: Family Practice News)
Source: Family Practice News - May 23, 2016 Category: Primary Care Source Type: news

CRC Risk in African American Families With Lynch SyndromeCRC Risk in African American Families With Lynch Syndrome
Are African American families with Lynch syndrome at an increased risk for developing colorectal cancer and, if so, what exactly is the pathophysiology of disease in this group? Gastroenterology (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - May 18, 2016 Category: Pathology Tags: Gastroenterology Journal Article Source Type: news

Screening for Lynch Syndrome: An Audit and Cost AnalysisScreening for Lynch Syndrome: An Audit and Cost Analysis
This report assessed the potential financial impact of routinely screening colorectal cancer patients for Lynch syndrome. Could it save money in the long run? Journal of Clinical Pathology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 21, 2016 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news

Six Ways to Lower Your Risk for Colon Cancer
By Stacy Simon Colon cancer is one of the more common cancers in the US. About 1 in 20 Americans will develop colon cancer at some point during their lifetime. But there are things you can do to help lower your colon cancer risk. Here are 6 ways to help protect your colon health. Get screened for colon cancer. Screenings are tests that look for cancer before signs and symptoms develop. Colon screenings can often find growths called polyps that can be removed before they turn into cancer. These tests also can find colon cancer earlier, when treatments are more likely to be successful. The American Cancer Society recommend...
Source: American Cancer Society :: News and Features - March 8, 2016 Category: Cancer & Oncology Tags: Colon/Rectum Cancer Source Type: news

Signs and Symptoms of Colon Cancer
By Stacy Simon Many of the symptoms of colon cancer can also be caused by something that isn’t cancer, such as infection, hemorrhoids, irritable bowel syndrome, or inflammatory bowel disease. In most cases, people who have these symptoms do not have cancer. Still, if you have any of these problems, it is a sign that you should go to the doctor so the cause can be found and treated, if needed:A change in bowel habits, such as diarrhea, constipation, or narrowing of the stool, that lasts for more than a few daysA feeling that you need to have a bowel movement that is not relieved by doing soRectal bleedingDark stools, ...
Source: American Cancer Society :: News and Features - February 29, 2016 Category: Cancer & Oncology Tags: Colon/Rectum Cancer Prevention/Early Detection Source Type: news

Lynch Syndrome or Hereditary Nonpolyposis...
Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) increases the risk of developing colon and other cancers. (Source: About.com Colon Cancer)
Source: About.com Colon Cancer - January 20, 2016 Category: Cancer & Oncology Authors: coloncancer.guide at about.com Tags: health Source Type: news

Guidelines Recommend that Patients with Colorectal Cancer Be Tested for Lynch Syndrome (FREE)
By Kelly Young Edited by André Sofair, MD, MPH, and William E. Chavey, MD, MS New guidelines from the American Gastroenterological Association advise physicians to test … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - September 11, 2015 Category: Primary Care Source Type: news

AGA recommends all patients with colorectal cancer get tested for Lynch syndrome
(American Gastroenterological Association) All colorectal cancer patients should undergo tumor testing to see if they carry Lynch syndrome, the most common inherited cause of colorectal cancer, according to a new guideline was published in Gastroenterology, the official journal of the American Gastroenterological Association. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 10, 2015 Category: Cancer & Oncology Source Type: news