Precision Medicine in the Era of Genetic Testing: Microsatellite Instability Evolved
Clin Colon Rectal Surg. 2023 Jul 25;37(3):157-171. doi: 10.1055/s-0043-1770385. eCollection 2024 May.ABSTRACTThe recognized importance of microsatellite instability (MSI) in cancer has evolved considerably in the past 30 years. From its beginnings as a molecular predictor for Lynch syndrome, MSI first transitioned to a universal screening test in all colorectal and endometrial cancers, substantially increasing the identification of patients with Lynch syndrome among cancer patients. More recently, MSI has been shown to be a powerful biomarker of response to immune checkpoint blockade therapy across a diversity of tumor typ...
Source: Clinical Colorectal Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Dina Ioffe Michelle McSweeny Michael J Hall Source Type: research
Familial syndromes associated with testicular and paratesticular neoplasms: a comprehensive review
AbstractA syndromic association between a subset of testicular/paratesticular neoplasms is well established. Such examples include Carney complex and large cell calcifying Sertoli cell tumor, Peutz-Jeghers syndrome and intratubular large cell hyalinizing Sertoli cell neoplasia, and VHL syndrome and clear cell papillary cystadenoma of the epididymis.However, recent studies proposed potential novel links between some testicular and paratesticular neoplasms with certain tumor syndromes. While more studies are still needed to solidify these associations, recent research suggests that a subset of Leydig cell tumors may arise in...
Source: Virchows Archiv - April 15, 2024 Category: Pathology Source Type: research
Incidence and molecular characteristics of deficient mismatch repair conditions across nine different tumors and identification of germline variants involved in Lynch-like syndrome
CONCLUSIONS: Our data regarding the LS to LLS ratio would be useful for genetic counseling in patients who are suspected to have LS, though the genetic backgrounds for the pathogenesis of LLS need further investigation.PMID:38615286 | DOI:10.1007/s10147-024-02518-y (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 14, 2024 Category: Cancer & Oncology Authors: Tetsuya Ito Tatsuro Yamaguchi Kensuke Kumamoto Okihide Suzuki Noriyasu Chika Satoru Kawakami Tomonori Nagai Tsukasa Igawa Kenji Fujiyoshi Yoshito Akagi Tomio Arai Kiwamu Akagi Hidetaka Eguchi Yasushi Okazaki Hideyuki Ishida Source Type: research
Incidence and molecular characteristics of deficient mismatch repair conditions across nine different tumors and identification of germline variants involved in Lynch-like syndrome
CONCLUSIONS: Our data regarding the LS to LLS ratio would be useful for genetic counseling in patients who are suspected to have LS, though the genetic backgrounds for the pathogenesis of LLS need further investigation.PMID:38615286 | DOI:10.1007/s10147-024-02518-y (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 14, 2024 Category: Cancer & Oncology Authors: Tetsuya Ito Tatsuro Yamaguchi Kensuke Kumamoto Okihide Suzuki Noriyasu Chika Satoru Kawakami Tomonori Nagai Tsukasa Igawa Kenji Fujiyoshi Yoshito Akagi Tomio Arai Kiwamu Akagi Hidetaka Eguchi Yasushi Okazaki Hideyuki Ishida Source Type: research
Incidence and molecular characteristics of deficient mismatch repair conditions across nine different tumors and identification of germline variants involved in Lynch-like syndrome
ConclusionsOur data regarding the LS to LLS ratio would be useful for genetic counseling in patients who are suspected to have LS, though the genetic backgrounds for the pathogenesis of LLS need further investigation. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 14, 2024 Category: Cancer & Oncology Source Type: research
The Evolution of Genetic Testing from Focused Testing to Panel Testing and from Patient Focused to Population Testing: Are We There Yet?
Clin Colon Rectal Surg. 2023 Jul 19;37(3):133-139. doi: 10.1055/s-0043-1770381. eCollection 2024 May.ABSTRACTThe field of cancer genetics has evolved significantly over the past 30 years. Genetic testing has become less expensive and more comprehensive which has changed practice patterns. It is no longer necessary to restrict testing to those with the highest likelihood of testing positive. In addition, we have learned that the criteria developed to determine who has the highest likelihood of testing positive are neither sensitive nor specific. As a result, the field is moving from testing only the highest risk patients id...
Source: Clinical Breast Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Lauren Gima Ilana Solomon Heather Hampel Source Type: research
The Evolution of Genetic Testing from Focused Testing to Panel Testing and from Patient Focused to Population Testing: Are We There Yet?
Clin Colon Rectal Surg. 2023 Jul 19;37(3):133-139. doi: 10.1055/s-0043-1770381. eCollection 2024 May.ABSTRACTThe field of cancer genetics has evolved significantly over the past 30 years. Genetic testing has become less expensive and more comprehensive which has changed practice patterns. It is no longer necessary to restrict testing to those with the highest likelihood of testing positive. In addition, we have learned that the criteria developed to determine who has the highest likelihood of testing positive are neither sensitive nor specific. As a result, the field is moving from testing only the highest risk patients id...
Source: Clinical Genitourinary Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Lauren Gima Ilana Solomon Heather Hampel Source Type: research
Management of Rectal Cancer in Lynch Syndrome: Balancing Risk Reduction and Quality of Life
Clin Colon Rectal Surg. 2023 Aug 10;37(3):180-184. doi: 10.1055/s-0043-1770730. eCollection 2024 May.ABSTRACTPatients with Lynch syndrome are predisposed to developing colorectal cancer and a variety of extracolonic malignancies, at a young age. The management of rectal cancer in the setting of Lynch syndrome is a complex clinical scenario that requires the expertise of a multidisciplinary management team. In this review, we delve into the approach for rectal cancer in these patients, and specifically focus on several key aspects of treatment. Some unique aspects of rectal cancer in Lynch syndrome include the decision betw...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Bradley A Krasnick Matthew F Kalady Source Type: research
The Evolution of Genetic Testing from Focused Testing to Panel Testing and from Patient Focused to Population Testing: Are We There Yet?
Clin Colon Rectal Surg. 2023 Jul 19;37(3):133-139. doi: 10.1055/s-0043-1770381. eCollection 2024 May.ABSTRACTThe field of cancer genetics has evolved significantly over the past 30 years. Genetic testing has become less expensive and more comprehensive which has changed practice patterns. It is no longer necessary to restrict testing to those with the highest likelihood of testing positive. In addition, we have learned that the criteria developed to determine who has the highest likelihood of testing positive are neither sensitive nor specific. As a result, the field is moving from testing only the highest risk patients id...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Lauren Gima Ilana Solomon Heather Hampel Source Type: research
Current Trends in Vaccine Development for Hereditary Colorectal Cancer Syndromes
Clin Colon Rectal Surg. 2023 Jul 31;37(3):146-156. doi: 10.1055/s-0043-1770383. eCollection 2024 May.ABSTRACTThe coming of age for cancer treatment has experienced exponential growth in the last decade with the addition of immunotherapy as the fourth pillar to the fundamentals of cancer treatment-chemotherapy, surgery, and radiation-taking oncology to an astounding new frontier. In this time, rapid developments in computational biology coupled with immunology have led to the exploration of priming the host immune system through vaccination to prevent and treat certain subsets of cancer such as melanoma and hereditary color...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Charles M Bowen Krishna M Sinha Eduardo Vilar Source Type: research
Chemoprevention in Inherited Colorectal Cancer Syndromes
Clin Colon Rectal Surg. 2023 Jul 19;37(3):172-179. doi: 10.1055/s-0043-1770384. eCollection 2024 May.ABSTRACTCancer prevention in hereditary gastrointestinal predisposition syndromes relies primarily on intensive screening (e.g., colonoscopy) or prophylactic surgery (e.g., colectomy). The use of chemopreventive agents as an adjunct to these measures has long been studied both in the general population and in hereditary cancer patients, in whom the risk of malignancy, and therefore the potential risk reduction, is considerably greater. However, to date only few compounds have been found to be effective, safe, and tolerable ...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Ophir Gilad Charles Muller Sonia S Kupfer Source Type: research
The Evolution of Genetic Testing from Focused Testing to Panel Testing and from Patient Focused to Population Testing: Are We There Yet?
Clin Colon Rectal Surg. 2023 Jul 19;37(3):133-139. doi: 10.1055/s-0043-1770381. eCollection 2024 May.ABSTRACTThe field of cancer genetics has evolved significantly over the past 30 years. Genetic testing has become less expensive and more comprehensive which has changed practice patterns. It is no longer necessary to restrict testing to those with the highest likelihood of testing positive. In addition, we have learned that the criteria developed to determine who has the highest likelihood of testing positive are neither sensitive nor specific. As a result, the field is moving from testing only the highest risk patients id...
Source: Cancer Control - April 12, 2024 Category: Cancer & Oncology Authors: Lauren Gima Ilana Solomon Heather Hampel Source Type: research
The Evolution of Genetic Testing from Focused Testing to Panel Testing and from Patient Focused to Population Testing: Are We There Yet?
Clin Colon Rectal Surg. 2023 Jul 19;37(3):133-139. doi: 10.1055/s-0043-1770381. eCollection 2024 May.ABSTRACTThe field of cancer genetics has evolved significantly over the past 30 years. Genetic testing has become less expensive and more comprehensive which has changed practice patterns. It is no longer necessary to restrict testing to those with the highest likelihood of testing positive. In addition, we have learned that the criteria developed to determine who has the highest likelihood of testing positive are neither sensitive nor specific. As a result, the field is moving from testing only the highest risk patients id...
Source: Clinical Breast Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Lauren Gima Ilana Solomon Heather Hampel Source Type: research
The Evolution of Genetic Testing from Focused Testing to Panel Testing and from Patient Focused to Population Testing: Are We There Yet?
Clin Colon Rectal Surg. 2023 Jul 19;37(3):133-139. doi: 10.1055/s-0043-1770381. eCollection 2024 May.ABSTRACTThe field of cancer genetics has evolved significantly over the past 30 years. Genetic testing has become less expensive and more comprehensive which has changed practice patterns. It is no longer necessary to restrict testing to those with the highest likelihood of testing positive. In addition, we have learned that the criteria developed to determine who has the highest likelihood of testing positive are neither sensitive nor specific. As a result, the field is moving from testing only the highest risk patients id...
Source: Clinical Genitourinary Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Lauren Gima Ilana Solomon Heather Hampel Source Type: research
Management of Rectal Cancer in Lynch Syndrome: Balancing Risk Reduction and Quality of Life
Clin Colon Rectal Surg. 2023 Aug 10;37(3):180-184. doi: 10.1055/s-0043-1770730. eCollection 2024 May.ABSTRACTPatients with Lynch syndrome are predisposed to developing colorectal cancer and a variety of extracolonic malignancies, at a young age. The management of rectal cancer in the setting of Lynch syndrome is a complex clinical scenario that requires the expertise of a multidisciplinary management team. In this review, we delve into the approach for rectal cancer in these patients, and specifically focus on several key aspects of treatment. Some unique aspects of rectal cancer in Lynch syndrome include the decision betw...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Bradley A Krasnick Matthew F Kalady Source Type: research
