Single Agent Treats Two Cancers With Same Genetic Cause
Pembrolizumab treated colon cancer, intrahepatic cholangiocarcinoma in patient with Lynch syndrome (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - September 27, 2018 Category: Cancer & Oncology Tags: Gastroenterology, Oncology, Pathology, Pharmacy, Journal, Source Type: news

My IVF life: the science experiment to make a baby – from a partner's view
E, Jean Hannah Edelstein ’s husband, explains his side of IVF treatment, from the sperm analysis to the importance of patienceWhat ’s it like to be the partner of someone going through IVF treatment? This week, I sat down to discuss the experience with my husband, E. Like me, E is in his mid-30s and has never had kids before. Here’s what he told me.We discussed IVF very early in our relationship – it’s been with us basically from the beginning. On our first date we talked about cancer in our families – I lost my mom about a year before you lost your dad, you told me about Lynch syndrome ...
Source: Guardian Unlimited Science - August 6, 2018 Category: Science Authors: Jean Hannah Edelstein Tags: Family Pregnancy Life and style Sex Parents and parenting Health & wellbeing Source Type: news

Evaluating the role of public health in implementation of genomics-related recommendations: a case study of hereditary cancers using the CDC Science Impact Framework
Study used the CDC Science Impact Framework to trace the impact of public health activities and partnerships on the implementation of the 2009 Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Lynch Syndrome screening recommendation and the 2005 and 2013 USPSTF BRCA1 and BRCA2 testing recommendations. (Source: PHPartners.org)
Source: PHPartners.org - July 26, 2018 Category: International Medicine & Public Health Source Type: news

More Cancers Seem to Harbor Lynch Syndrome
(MedPage Today) -- Broader testing implied by " practice-changing " study (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - June 3, 2018 Category: Gastroenterology Source Type: news

Test All Patients With MSI Tumors for Lynch Syndrome Test All Patients With MSI Tumors for Lynch Syndrome
Tumors that have high microsatellite instability are more likely to be linked to Lynch syndrome; this includes tumors that have not been previously associated with the syndrome.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 2, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Lynch Syndrome Common in MSI-High Tumors
Leah LawrenceJun 2, 2018The presence of MSI-high was predictive of Lynch syndrome, which was found to be associated with a much wider spectrum of cancers than previously thought. (Source: CancerNetwork)
Source: CancerNetwork - June 2, 2018 Category: Cancer & Oncology Authors: A Source Type: news

Gene sequencing study finds new cancers linked with Lynch syndrome
CHICAGO (Reuters) - Lynch syndrome, a rare hereditary disease typically associated with an increased risk of colorectal and endometrial cancers, appears to be linked with several additional types of cancer than previously thought, U.S. researchers said on Saturday. (Source: Reuters: Health)
Source: Reuters: Health - June 2, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Potential Role for Vaccines, Checkpoint Inhibitors in Chemoprevention of Lynch Syndrome
Researchers from MD Anderson say their study results " open the field of immunoprevention in LS to checkpoint inhibitors as an immune interception strategy. " (Source: CancerNetwork)
Source: CancerNetwork - May 11, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Colorectal Cancer Gastrointestinal Cancer News Source Type: news

Screening for Lynch syndrome cost  effective in CRC
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - May 1, 2018 Category: Drugs & Pharmacology Source Type: news

Precancerous colon polyps in patients with Lynch syndrome exhibit immune activation
(University of Texas M. D. Anderson Cancer Center) Colon polyps from patients with Lynch syndrome, a hereditary condition that raises colorectal cancer risk, display immune system activation well before cancer development, according to research from The University of Texas MD Anderson Cancer Center. The preclinical research challenges traditional models of cancer immune activation and suggests immunotherapy may be useful for colorectal cancer prevention in certain high-risk groups. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 16, 2018 Category: Cancer & Oncology Source Type: news

Tumor Sequencing Useful for Lynch-syndrome Screening Tumor Sequencing Useful for Lynch-syndrome Screening
Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - April 10, 2018 Category: Surgery Tags: Hematology-Oncology News Source Type: news

Mayo Clinic Q and A: Lynch syndrome and genetic testing
DEAR MAYO CLINIC: I am considering undergoing genetic testing to see if I have the gene mutation that causes Lynch syndrome. Because of my family history, I already have regular colonoscopies even though I?m only 41. What would knowing I have the mutation change as far as how I?m monitored for colon cancer? ANSWER: Knowing [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - April 10, 2018 Category: Databases & Libraries Source Type: news

Hospitals 'failing' on genetic bowel cancer test
A charity says that more than 80% are failing to test for the genetic condition Lynch syndrome. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - March 27, 2018 Category: Consumer Health News Source Type: news

Four in five hospitals won't carry out 'life saving' bowel cancer test
Bowel Cancer UK found that 83% of hospital trusts do not provide 'life-saving' £200 test to identify Lynch syndrome - a genetic condition which increases a person's risk of Bowel Cancer (Source: the Mail online | Health)
Source: the Mail online | Health - March 26, 2018 Category: Consumer Health News Source Type: news

Researchers find link between breast cancer and two gene mutations
(Springer) Individuals with Lynch syndrome, a genetic condition that has long been known to carry dramatically increased risk of colorectal cancer and uterine cancer, now also have an increased risk of breast cancer. This is the conclusion of a study in the journal Genetics in Medicine which is published by Springer Nature. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 19, 2018 Category: Cancer & Oncology Source Type: news

Two new breast cancer genes emerge from lynch syndrome gene study
(Columbia University Medical Center) Columbia University researchers have identified two new breast cancer genes that also cause Lynch syndrome. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 18, 2018 Category: Cancer & Oncology Source Type: news

GP missed woman's bowel cancer as she was 'too young'
Cara Hoofe, from west London, is speaking out to raise awareness that bowel cancer can affect younger people. She has Lynch syndrome, an inherited condition raising risks of certain  cancers. (Source: the Mail online | Health)
Source: the Mail online | Health - November 10, 2017 Category: Consumer Health News Source Type: news

ACG Wrap-up: Fecal Transplant; Lynch Syndrome Screening; Probiotics for Pain
(MedPage Today) -- Additional highlights from this year's meeting (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - October 19, 2017 Category: Gastroenterology Source Type: news

Lynch Syndrome Studies Highlight Screening, Surveillance Opportunities
Two studies on Lynch syndrome highlight cancer screening and surveillance opportunities. (Source: CancerNetwork)
Source: CancerNetwork - August 13, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Colorectal Cancer Endometrial Cancer Gastrointestinal Cancer Gynecologic Cancers News Ovarian Cancer Source Type: news

Cancer Risk Patterns in Lynch Syndrome Differ by Path_MMR Variants Cancer Risk Patterns in Lynch Syndrome Differ by Path_MMR Variants
Carriers of different path_MMR variants (Lynch syndrome) show different patterns of cancer risk and survival, according to findings from the Prospective Lynch Syndrome Database (PSLD).Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - August 11, 2017 Category: Pathology Tags: Hematology-Oncology News Source Type: news

Even Distant Relatives of Lynch Syndrome Patients Face Higher Cancer Risks Even Distant Relatives of Lynch Syndrome Patients Face Higher Cancer Risks
Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 8, 2017 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Do YOU have Lynch syndrome? Genetic condition is common cause of killer bowel cancer
LYNCH syndrome is a genetic condition which is the most common cause of hereditary bowel cancer. (Source: Daily Express - Health)
Source: Daily Express - Health - June 27, 2017 Category: Consumer Health News Source Type: news

Lynch Syndrome Mutations and Risk of Breast and Ovarian Cancer Lynch Syndrome Mutations and Risk of Breast and Ovarian Cancer
Although Lynch syndrome is thought to increase the risk of colorectal and/or uterine cancer, certain mutations may confer an increased risk of breast or ovarian cancer, researchers say.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 2, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Increasing the age limit for Lynch syndrome genetic testing may save lives
(European Society of Human Genetics) Raising the age limit for routine genetic testing in colorectal cancer could identify more cases of families affected by Lynch syndrome, a condition that accounts for around 5 percent of all colon cancers. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 29, 2017 Category: Cancer & Oncology Source Type: news

NICE recommends wider use of tests to detect cancer-causing genetic condition
NICE has published diagnostics guidance recommending that everyone who is diagnosed with colorectal cancer should be tested for an inherited genetic condition called Lynch syndrome (LS). (Source: NHS Networks)
Source: NHS Networks - February 22, 2017 Category: UK Health Source Type: news

Understanding GP attitudes to cancer preventing drugs
A report from Cancer Research explores how much GPs know about two drugs that can reduce the risk of cancer – tamoxifen for women at high risk of breast cancer, and aspirin for people with Lynch Syndrome, a condition that increases the risk of several types of cancer. (Source: NHS Networks)
Source: NHS Networks - February 16, 2017 Category: UK Health Source Type: news

Lynch Syndrome –Associated Ovarian Cancer Presents Early, Has Good Prognosis
An analysis of Lynch syndrome –associated ovarian cancer found that the malignancy tends to present at an early stage and has a generally good prognosis. (Source: CancerNetwork)
Source: CancerNetwork - January 25, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Gynecologic Cancers News Ovarian Cancer Source Type: news

Multigene Testing a'Must' for Young Patients With CRC Multigene Testing a'Must' for Young Patients With CRC
Genetic testing for patients with colorectal cancer diagnosed at age younger than 50 years needs to go beyond Lynch syndrome.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - December 15, 2016 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Family History and Genomics as Tools for Cancer Prevention Family History and Genomics as Tools for Cancer Prevention
This brief examines the role of public health initiatives for cancer genomics at the federal, state, and community level, with a focus on hereditary breast and ovarian cancers and Lynch syndrome.Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 14, 2016 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

NICE recommends wider use of tests to detect cancer-causing genetic condition
In draft guidance published for consultation NICE has recommended that everyone who is diagnosed with colorectal cancer should be tested for an inherited genetic condition called Lynch syndrome (LS). (Source: NHS Networks)
Source: NHS Networks - October 30, 2016 Category: UK Health Source Type: news

Patients With Bowel Cancer'Not Being Tested for Lynch Syndrome'Patients With Bowel Cancer'Not Being Tested for Lynch Syndrome '
Almost one third of UK hospitals do not routinely test patients with bowel cancer younger than age 50 years for Lynch syndrome, despite it increasing the risk for cancer recurrence, survey results suggest.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 10, 2016 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Nearly a third of hospitals failing bowel cancer patients
Pathologists says hospitals must offer younger patients screening for Lynch syndrome Related items fromOnMedica Gene found to be linked to increased risk of recurrence in bowel cancer More than half of new bowel cancer screen test invitees fail to take up offer Meeting cancer promises and more – a new model for NHS diagnostics? New test prompts rise in bowel screening uptake Early stage bowel cancer more likely to be picked up by screening (Source: OnMedica Latest News)
Source: OnMedica Latest News - August 7, 2016 Category: UK Health Source Type: news

Target screening for Lynch syndrome saves costs
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - June 30, 2016 Category: Drugs & Pharmacology Source Type: news

Methylated DNA markers hold promise for Lynch syndrome
SAN DIEGO – It has been challenging to identify reliable biomarkers for Lynch syndrome colorectal neoplasms, but that may be about to change. Researchers have identified 10 discriminant methylated... (Source: Family Practice News)
Source: Family Practice News - May 23, 2016 Category: Primary Care Source Type: news

CRC Risk in African American Families With Lynch SyndromeCRC Risk in African American Families With Lynch Syndrome
Are African American families with Lynch syndrome at an increased risk for developing colorectal cancer and, if so, what exactly is the pathophysiology of disease in this group? Gastroenterology (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - May 18, 2016 Category: Pathology Tags: Gastroenterology Journal Article Source Type: news

Screening for Lynch Syndrome: An Audit and Cost AnalysisScreening for Lynch Syndrome: An Audit and Cost Analysis
This report assessed the potential financial impact of routinely screening colorectal cancer patients for Lynch syndrome. Could it save money in the long run? Journal of Clinical Pathology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 21, 2016 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news

Six Ways to Lower Your Risk for Colon Cancer
By Stacy Simon Colon cancer is one of the more common cancers in the US. About 1 in 20 Americans will develop colon cancer at some point during their lifetime. But there are things you can do to help lower your colon cancer risk. Here are 6 ways to help protect your colon health. Get screened for colon cancer. Screenings are tests that look for cancer before signs and symptoms develop. Colon screenings can often find growths called polyps that can be removed before they turn into cancer. These tests also can find colon cancer earlier, when treatments are more likely to be successful. The American Cancer Society recommend...
Source: American Cancer Society :: News and Features - March 7, 2016 Category: Cancer & Oncology Tags: Colon/Rectum Cancer Source Type: news

Signs and Symptoms of Colon Cancer
By Stacy Simon Many of the symptoms of colon cancer can also be caused by something that isn’t cancer, such as infection, hemorrhoids, irritable bowel syndrome, or inflammatory bowel disease. In most cases, people who have these symptoms do not have cancer. Still, if you have any of these problems, it is a sign that you should go to the doctor so the cause can be found and treated, if needed:A change in bowel habits, such as diarrhea, constipation, or narrowing of the stool, that lasts for more than a few daysA feeling that you need to have a bowel movement that is not relieved by doing soRectal bleedingDark stools, ...
Source: American Cancer Society :: News and Features - February 29, 2016 Category: Cancer & Oncology Tags: Colon/Rectum Cancer Prevention/Early Detection Source Type: news

Lynch Syndrome or Hereditary Nonpolyposis...
Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) increases the risk of developing colon and other cancers. (Source: About.com Colon Cancer)
Source: About.com Colon Cancer - January 20, 2016 Category: Cancer & Oncology Authors: coloncancer.guide at about.com Tags: health Source Type: news

Guidelines Recommend that Patients with Colorectal Cancer Be Tested for Lynch Syndrome (FREE)
By Kelly Young Edited by André Sofair, MD, MPH, and William E. Chavey, MD, MS New guidelines from the American Gastroenterological Association advise physicians to test … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - September 11, 2015 Category: Primary Care Source Type: news

AGA recommends all patients with colorectal cancer get tested for Lynch syndrome
(American Gastroenterological Association) All colorectal cancer patients should undergo tumor testing to see if they carry Lynch syndrome, the most common inherited cause of colorectal cancer, according to a new guideline was published in Gastroenterology, the official journal of the American Gastroenterological Association. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 10, 2015 Category: Cancer & Oncology Source Type: news

Lynch Syndrome With MLH1 Mutations and Breast Cancer RiskLynch Syndrome With MLH1 Mutations and Breast Cancer Risk
Should breast cancer be included in the spectrum of cancers associated with Lynch syndrome and proven MMR mutations? Journal of Medical Genetics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 28, 2015 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news

New strategy improves detection of genetic mutations in hereditary colorectal cancer
(Elsevier Health Sciences) The role that PMS2 genetic mutations play in Lynch syndrome has been underestimated in part due to technological limitations. A new study in the Journal of Molecular Diagnostics describes a multi-method strategy to overcome existing technological limitations by more accurately identifying PMS2 gene mutations, which will improve diagnosis and support appropriate genetic counseling and medical management. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 27, 2015 Category: Cancer & Oncology Source Type: news

Obesity-Cancer Link in Lynch Syndrome Quashed by AspirinObesity-Cancer Link in Lynch Syndrome Quashed by Aspirin
Obese individuals with Lynch syndrome have an increased risk for colorectal cancer that appears to be eliminated by regular aspirin. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 21, 2015 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

My diagnostic odyssey: The limits of genetic testing
I am on a “diagnostic odyssey.” That term was unfamiliar to me until I spoke with Joy Larsen Haidle, president of the National Society of Genetic Counselors, whose members help patients determine whether genetic testing for diagnostic purposes makes sense for them. I have an epileptic condition, but despite repeated visits with specialists over several years, I haven’t yet identified a root cause. I’ve only been able to treat and moderate symptoms with medication, and I’m pursuing genetic testing to see if we can discover how the condition started in the first place. As Larsen Haidle explained...
Source: Mass Device - August 20, 2015 Category: Medical Equipment Authors: Mark Hollmer Tags: Blog Diagnostics Source Type: news

Aspirin lowers risk of hereditary bowel cancer in obese people
ConclusionThis study followed up on a previous trial that found taking aspirin regularly reduced the risk of bowel cancer in people with the genetic condition Lynch syndrome (or HNPCC), which puts them at an increased risk of developing the disease. The study found being obese appears to further increase bowel cancer risk among people with this condition.It also found that BMI did not appear to have an effect on bowel cancer risk among those taking aspirin. While this might indicate that aspirin removes the effect of BMI, ideally a comparison of aspirin versus placebo in the different BMI groups is needed to further assess...
Source: NHS News Feed - August 18, 2015 Category: Consumer Health News Tags: Cancer Obesity Source Type: news

Aspirin lowers risk of cancer in overweight people: study
The study found that being overweight more than doubled the risk of bowel cancer in people with Lynch Syndrome, an inherited genetic disorder. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - August 18, 2015 Category: Pharmaceuticals Source Type: news

Multigene panel testing for hereditary breast/ovarian cancer risk assessment
(The JAMA Network Journals) Multigene testing of women negative for BRCA1 and BRCA2 found some of them harbored other harmful genetic mutations, most commonly moderate-risk breast and ovarian cancer genes and Lynch syndrome genes, which increase ovarian cancer risk, according to an article published online by JAMA Oncology. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 13, 2015 Category: Cancer & Oncology Source Type: news

Tumor Tissue Screening Helps Spot Lynch SyndromeTumor Tissue Screening Helps Spot Lynch Syndrome
Checking for Lynch syndrome (LS) via germline mutations in mismatch repair (MMR) genes appears to be an effective and cost-saving strategy in patients with colorectal cancer (CRC), researchers say. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 10, 2015 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Medical News Today: Hormonal factors 'lower endometrial cancer risk' for women with Lynch syndrome
New research has identified some hormonal factors linked to reduced risk of endometrial cancer for women with Lynch syndrome - a genetic condition that increases cancer risk. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 8, 2015 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news