Fusobacterium nucleatum induces oxaliplatin resistance by inhibiting ferroptosis through E-cadherin/ β-catenin/GPX4 axis in colorectal cancer
Free Radic Biol Med. 2024 Apr 22:S0891-5849(24)00405-2. doi: 10.1016/j.freeradbiomed.2024.04.226. Online ahead of print.ABSTRACTFusobacterium (F.) nucleatum is a carcinogenesis microbiota in colorectal cancer (CRC). Growing evidence shows that F. nucleatum contributes to chemoresistance. Ferroptosis is reported to restore the susceptibility of resistant cells to chemotherapy. However, the role of gut microbiota affecting ferroptosis in chemoresistance remains unclear. Here, we examined the CRC tissues of patients using 16S rRNA sequencing to investigate the possible connection between gut microbiota dysbiosis and the relap...
Source: Free Radical Biology and Medicine - April 24, 2024 Category: Biology Authors: Bowen Li Zixian Wei Zhiyue Wang Fangqi Xu Jinhua Yang Baiqiang Lin Yu Chen Hubin Wenren Lingli Wu Xiao Guo Yang Liu Yunwei Wei Source Type: research
< em > Fretibacterium < /em > Species to < em > Fusobacterium periodonticum < /em > Ratio as a Potential Biomarker of Periodontitis Based on Salivary Microbiome Profiling
Ann Lab Med. 2024 Apr 22. doi: 10.3343/alm.2024.0043. Online ahead of print.NO ABSTRACTPMID:38644360 | DOI:10.3343/alm.2024.0043 (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - April 21, 2024 Category: Laboratory Medicine Authors: Eun Ji Oh Hyun Hee Jang Sangwon Park Hyun-Pil Lim Kwi-Dug Yun Woohyung Jang Ok-Su Kim Chan Park Eun Jeong Won Source Type: research
Fusobacterium nucleatum carcinogenesis and drug delivery interventions
This article presents a comprehensive review of microbial communities especially F. nucleatum in tumor tissue, exploring their roles and underlying mechanisms in tumor development, treatment, and prevention. When the tumor-associated F. nucleatum is killed, the host immune response is activated to recognize tumor cells. Bacteria epitopes restricted by the host antigens, can be identified for future anti-bacteria/tumor vaccine development.PMID:38643839 | DOI:10.1016/j.addr.2024.115319 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - April 21, 2024 Category: Drugs & Pharmacology Authors: Zhenzhen Chen Leaf Huang Source Type: research
< em > Fretibacterium < /em > Species to < em > Fusobacterium periodonticum < /em > Ratio as a Potential Biomarker of Periodontitis Based on Salivary Microbiome Profiling
Ann Lab Med. 2024 Apr 22. doi: 10.3343/alm.2024.0043. Online ahead of print.NO ABSTRACTPMID:38644360 | DOI:10.3343/alm.2024.0043 (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - April 21, 2024 Category: Laboratory Medicine Authors: Eun Ji Oh Hyun Hee Jang Sangwon Park Hyun-Pil Lim Kwi-Dug Yun Woohyung Jang Ok-Su Kim Chan Park Eun Jeong Won Source Type: research
Fusobacterium nucleatum carcinogenesis and drug delivery interventions
This article presents a comprehensive review of microbial communities especially F. nucleatum in tumor tissue, exploring their roles and underlying mechanisms in tumor development, treatment, and prevention. When the tumor-associated F. nucleatum is killed, the host immune response is activated to recognize tumor cells. Bacteria epitopes restricted by the host antigens, can be identified for future anti-bacteria/tumor vaccine development.PMID:38643839 | DOI:10.1016/j.addr.2024.115319 (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - April 21, 2024 Category: Drugs & Pharmacology Authors: Zhenzhen Chen Leaf Huang Source Type: research
< em > Fretibacterium < /em > Species to < em > Fusobacterium periodonticum < /em > Ratio as a Potential Biomarker of Periodontitis Based on Salivary Microbiome Profiling
Ann Lab Med. 2024 Apr 22. doi: 10.3343/alm.2024.0043. Online ahead of print.NO ABSTRACTPMID:38644360 | DOI:10.3343/alm.2024.0043 (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - April 21, 2024 Category: Laboratory Medicine Authors: Eun Ji Oh Hyun Hee Jang Sangwon Park Hyun-Pil Lim Kwi-Dug Yun Woohyung Jang Ok-Su Kim Chan Park Eun Jeong Won Source Type: research
GSE172334 Fusobacterium nucleatum Induces PD-L1 Expression by Tumor-Associated Macrophages and Inhibits Anti-Tumor Immunity in Colorectal Cancer.
Contributors : Yz Yang ; Yl MaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFusobacterium nucleatum (Fn) infection has been linked to the initiation and development of colorectal cancer (CRC). However, the underlying mechanisms remains unexplored. Tissues from Fn-infected mice were first collected for single-cell RNA sequencing. we investigated the correlation between Fn infection and accumulations of tumor associated macrophages (TAMs) in tissues from human CRC or AOM/DSS treated mice. The impact of Fn on biological function of TAMs were interrogated. We deciphered the mechanis...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Bacterial Subspecies Linked With Aggressive Colorectal Cancer Tumors
Previous research has tied the presence of Fusobacterium nucleatum, a bacterium normally found in the mouth, with colorectal cancer tumors. High amounts of F nucleatum in the tumor are linked with worse prognosis. A recent study clarified that risk, showing that what was thought to be a single bacterial subspecies, F nucleatum animalis, is actually 2 clades: C1 and C2. Based on an analysis of human tissue and animal models, F nucleatum animalis C1 is found mostly in the mouth while C2 is the bacterium driving tumor growth, the researchers reported in Nature. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 19, 2024 Category: General Medicine Source Type: research
The role of CXCL2-mediated crosstalk between tumor cells and macrophages in Fusobacterium nucleatum-promoted oral squamous cell carcinoma progression
Cell Death & Disease, Published online: 18 April 2024; doi:10.1038/s41419-024-06640-7The role of CXCL2-mediated crosstalk between tumor cells and macrophages in Fusobacterium nucleatum-promoted oral squamous cell carcinoma progression (Source: Cell death and disease)
Source: Cell death and disease - April 18, 2024 Category: Internal Medicine Authors: Fujiao Nie Jie Zhang Haoyang Tian Jingjing Zhao Pizhang Gong Huiru Wang Suli Wang Pishan Yang Chengzhe Yang Source Type: research
A crucial Fusobacterium nucleatum clade in colorectal cancer
Nature Reviews Gastroenterology & Hepatology, Published online: 16 April 2024; doi:10.1038/s41575-024-00930-3A crucial Fusobacterium nucleatum clade in colorectal cancer (Source: Nature Reviews Gastroenterology and Hepatology)
Source: Nature Reviews Gastroenterology and Hepatology - April 16, 2024 Category: Gastroenterology Authors: Katrina Ray Source Type: research
