Eye antibiotics may ease pain caused by endometriosis
Researchers in Japan have found that a type of bacteria called fusobacterium may be involved in triggering the extremely painful symptoms of endometriosis. (Source: the Mail online | Health)
Source: the Mail online | Health - September 25, 2023 Category: Consumer Health News Source Type: news

Metabolomic profiles of obesity and subgingival microbiome in periodontally healthy individuals: A cross-sectional study
Conclusions: Obesity-related perturbations in circulating blood metabolites are associated with the development of periodontopathic bacterial colonization in the subgingival microbiome and consequently may increase the risk for periodontal disease in obese individuals.  (Source: Dental Technology Blog)
Source: Dental Technology Blog - August 28, 2023 Category: Dentistry Source Type: news

Endometriosis, affecting six million US women, could be caused by bacteria, study suggests
An early study from Japan showed that the majority of women with the painful reproductive condition endometriosis had the bacterial genus Fusobacterium in their uterine lining. (Source: the Mail online | Health)
Source: the Mail online | Health - June 15, 2023 Category: Consumer Health News Source Type: news

Antibiotic may reduce endometriosis lesions, Japanese researchers say
Japanese researchers said in a new study that an antibiotic used for Fusobacterium can be taken to reduce lesions associated with endometriosis. (Source: Health News - UPI.com)
Source: Health News - UPI.com - June 14, 2023 Category: Consumer Health News Source Type: news

Hypochlorous acid inactivates oral pathogens and a SARS-CoV-2-surrogate
ConclusionsHOCl solution (45 –60 ppm) is still effective against oral pathogens and SAR-CoV-2 surrogate viruses even in the presence of saliva and after passing through the dental unit water line. This study indicates that the HOCl solution can be used as therapeutic water or mouthwash and may ultimately reduce the risk of airborne infection in dental practice. (Source: Dental Technology Blog)
Source: Dental Technology Blog - March 7, 2023 Category: Dentistry Source Type: news

Fusobacterium nucleatum induces proliferation and migration in pancreatic cancer cells through host autocrine and paracrine signaling | Science Signaling
The host cell response to Fusobacterium infection promotes aggressive pancreatic cancer cell behavior. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 18, 2022 Category: Science Source Type: news

Evidence Grows for Vaping ’s Role in Gum Disease
 Feb. 22, 2022Washington, DC – February 22, 2022 – A series of new studies by researchers at New York University ' s College of Dentistry highlights how e-cigarettes alter oral health and may be contributing to gum disease. The latest, published in mBio, an open-access journal of the American Society for Microbiology, finds that e-cigarette users have a unique oral microbiome —the community of bacteria and other microorganisms—that is less healthy than nonsmokers but potentially healthier than cigarette smokers and measures worsening gum disease over time. “To our knowledge, this is ...
Source: Dental Technology Blog - March 10, 2022 Category: Dentistry Source Type: news

The Common Mouth Microbe That Keeps Popping Up in Tumors
Lab studies link the oral bacteria Fusobacterium nucleatum to cancers from the gut to the head and neck. Could targeting the microbe tackle tumors? (Source: The Scientist)
Source: The Scientist - December 15, 2021 Category: Science Tags: News & Opinion Source Type: news

What is the Difference Between a Paronychia and a Felon?
Discussion The hands are one of the most important parts of the body for interacting with the world. They are remarkably adapted having sensitive sensory receptors as well as feedback receptors for grasping, holding, and manipulating objects. Hands, especially with an opposable thumb, multiple joints within the hand, along with the wrist and elbow, allow the hand to move in multiple positions to manipulate the world. Hands also symbolize an emotional caring and sharing between individuals as hands are used to provide a true “human touch” in personal and social situations. Due to their important interactions in ...
Source: PediatricEducation.org - December 6, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

How Common are Co-infections with Trichomonas and Bacterial Vaginosis?
Discussion Vulvovaginitis is a common gynecological complaint for females of all ages. It is specifically the inflammation of the vulva and vagina but is used as a general term often to mean vulvar irritation, itching, and burning that can occur with or without vaginal discharge. In prepubertal females there is lack of estrogenization, and less lactobacillus species which creates a more neutral pH (normal vaginal pH is < 4.5), lack of pubic hair and fat pad which provide trauma protection, location of anus close to the vagina and tendency of poor hygiene in young children. With puberty, estrogen thickens the vaginal tis...
Source: PediatricEducation.org - May 24, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Bacterial invaders drive CRC progression
The oral bacterium Fusobacterium nucleatum is often found in colorectal cancer (CRC). In the 21 July 2020 issue of Science Signaling, Casasanta et al. show that CRC cell–resident F. nucleatum promotes cytokine secretion that may potentiate tumor growth and metastatic progression in patients. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 10, 2020 Category: Science Authors: Meyerson, M. Tags: STKE Focus Source Type: news

Fusobacterium nucleatum host-cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration
Fusobacterium nucleatum is implicated in accelerating colorectal cancer (CRC) and is found within metastatic CRC cells in patient biopsies. Here, we found that bacterial invasion of CRC cells and cocultured immune cells induced a differential cytokine secretion that may contribute to CRC metastasis. We used a modified galactose kinase markerless gene deletion approach and found that F. nucleatum invaded cultured HCT116 CRC cells through the bacterial surface adhesin Fap2. In turn, Fap2-dependent invasion induced the secretion of the proinflammatory cytokines IL-8 and CXCL1, which are associated with CRC progression and pro...
Source: Signal Transduction Knowledge Environment - July 20, 2020 Category: Science Authors: Casasanta, M. A., Yoo, C. C., Udayasuryan, B., Sanders, B. E., Umana, A., Zhang, Y., Peng, H., Duncan, A. J., Wang, Y., Li, L., Verbridge, S. S., Slade, D. J. Tags: STKE Research Articles Source Type: news

Gut bacteria may be one culprit for increase of colorectal cancer in younger people
(Georgetown University Medical Center) A bacteria typically linked to periodontal disease, Fusobacterium nucleatum (F. nuc), could play an important role in the rising incidence of colorectal cancer in people under the age of 45. Another type of bacteria, Moraxella osloensis, has been found in colorectal cancer tumors at a nearly four-fold higher rate in people over 75 than in those under 45 years of age. These are the preliminary findings of an ongoing study that will be presented at ASCO GI 2020. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 21, 2020 Category: Cancer & Oncology Source Type: news

The Association between Inflammatory Bowel Disease and Periodontal Conditions: Is There a Common Bacterial Etiology?
CONCLUSION:A number of studies have showed an association between PD and IBD. Both diseases share genetic and environmental etiological factors. The precise role of intestinal bacteria remains vague. The periodontal microbiota that might be involved in the association of these diseases are Fusobacterium nucleatum, Campylobacter rectus and Campylobacter concisus. Fungal and viral microbiota dysbiosis should also be evaluated as common pathogenic pathways in IBD and periodontal disease. (Source: Dental Technology Blog)
Source: Dental Technology Blog - September 23, 2019 Category: Dentistry Source Type: news

Researchers discover cellular messengers communicate with bacteria in the mouth
This study establishes that there is a clear channel of communication between RNA messengers and bacteria in our mouth,” said Wong, who holds the Felix and Mildred Yip Endowed Chair in Dentistry. “Furthermore, we have shown that these messengers may play an important role in mediating interac tions between bacteria and their host.”Another significant study finding was the majority of tRNA bacteria sequences that show high sequence similarity with salivary tsRNAs came from antibiotic-resistant Gram-negative bacteria. This observation could lead to a better understanding of the mechanisms behind the growth of oral bact...
Source: UCLA Newsroom: Health Sciences - May 9, 2018 Category: Universities & Medical Training Source Type: news