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Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer
Colorectal cancers comprise a complex mixture of malignant cells, nontransformed cells, and microorganisms. Fusobacterium nucleatum is among the most prevalent bacterial species in colorectal cancer tissues. Here we show that colonization of human colorectal cancers with Fusobacterium and its associated microbiome—including Bacteroides, Selenomonas, and Prevotella species—is maintained in distal metastases, demonstrating microbiome stability between paired primary and metastatic tumors. In situ hybridization analysis revealed that Fusobacterium is predominantly associated with cancer cells in the metastatic les...
Source: ScienceNOW - December 14, 2017 Category: Science Authors: Bullman, S., Pedamallu, C. S., Sicinska, E., Clancy, T. E., Zhang, X., Cai, D., Neuberg, D., Huang, K., Guevara, F., Nelson, T., Chipashvili, O., Hagan, T., Walker, M., Ramachandran, A., Diosdado, B., Serna, G., Mulet, N., Landolfi, S., Ramon y Cajal, S., Tags: Medicine, Diseases reports Source Type: news

Why Is This Bacterium Hiding in Human Tumors?
Whether Fusobacterium nucleatum causes colon tumors is unknown. But a new study hints that it may be ‘ an integral part of the cancer. ’ (Source: NYT Health)
Source: NYT Health - November 24, 2017 Category: Consumer Health News Authors: GINA KOLATA Tags: Colon and Colorectal Cancer Bacteria Tumors Dana-Farber Cancer Institute Source Type: news

Cancer-death button gets jammed by gut bacterium
(Michigan Medicine - University of Michigan) Researchers at Michigan Medicine and in China showed that a type of bacterium is associated with the recurrence of colorectal cancer and poor outcomes. They found that Fusobacterium nucleatum in the gut can stop chemotherapy from causing a type of cancer cell death called apoptosis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 27, 2017 Category: Cancer & Oncology Source Type: news

Study suggests link between imbalanced gut microbiome and systemic sclerosis
This study is the first to examine gastrointestinal bacterial composition in two independent groups of people with systemic sclerosis. Systemic sclerosis, also known as scleroderma, is an autoimmune disease affecting the body ’s connective tissue. It is characterized by a hardening and scarring of skin and can progress to inflammation and scarring in the organs such as kidneys, heart, lungs and gastrointestinal tract. Previous UCLA-led research  detailed a link between the disease and the imbalance in the gut microbiome and suggested that this imbalance contributed to scleroderma’s symptoms.METHODThe ...
Source: UCLA Newsroom: Health Sciences - May 12, 2017 Category: Universities & Medical Training Source Type: news

Oral bacterium related esophageal cancer prognosis in Japanese patients
(Kumamoto University) A type of bacterium usually found in the human mouth, Fusobacterium nucleatum (F. nucleatum), has been found to be related to the prognosis of esophageal cancer in Japanese patients by researchers from Kumamoto University, Japan. The bacteria are a causative agent of periodontal disease and though it can be found among the intestinal flora, it hasn't been the focus of much research until now. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 8, 2016 Category: Global & Universal Source Type: news

Vaccine may help diseases in animals, people meet their match
(Kansas State University) Kansas State University researchers have patented a vaccine that provides effective, antibiotic-free prevention and treatment of Fusobacterium necrophorum infection, which affects animals and people. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 4, 2016 Category: Global & Universal Source Type: news

Consider Fusobacterium in culture-negative pharyngitis
BOSTON – An underappreciated cause of bacterial pharyngitis had a similar clinical presentation to group A Streptococcus (GAS), although prevalence was low in the population of 300 pediatric... (Source: Pediatric News)
Source: Pediatric News - June 21, 2016 Category: Journals (General) Source Type: news

Your NEJM Group Today: Contagious Ecthyma Images, Fusobacterium & Pharyngitis Blog, Indiana Internal Medicine Opportunities (FREE)
By The Editors NEJM Group offers so many valuable resources for practicing clinicians. Here's what we chose for you today: … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - February 23, 2015 Category: Primary Care Source Type: news

When strep throat is something else: Forgotten bacterium is cause of many severe sore throats in young adults
New research suggests that Fusobacterium necrophorum more often causes severe sore throats in young adults than streptococcus — the cause of the much better known strep throat. The findings, suggest physicians should consider F. necrophorum when treating severe sore throat in young adults and adolescents that worsens. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 17, 2015 Category: Science Source Type: news

F. necrophorum More Common Than Group A Strep in Young Adults with Pharyngitis (FREE)
By Amy Orciari Herman Edited by David G. Fairchild, MD, MPH, and Jaye Elizabeth Hefner, MD In young adults presenting with pharyngitis, Fusobacterium necrophorum is twice as common as group A streptococcus, according to a single-center study in … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - February 17, 2015 Category: Primary Care Source Type: news

Bacteria protect intestinal tumor model from being killed by immune cells
(Cell Press) Bacteria that are commonly found in the mouth are often abundant in patients with colon cancer, but the potential role these microbes play in tumor development has not been clear. A study published by Cell Press Feb. 18 in the journal Immunity reveals that the oral pathogen Fusobacterium nucleatum protects a variety of tumor cells from being killed by immune cells. The findings could open new avenues for the treatment of cancer in human patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 11, 2015 Category: Cancer & Oncology Source Type: news

A Case of Lemierre's Syndrome Caused by Initially Identified as Group C Streptococcus
We report a rare case of Lemierre's syndrome in a previously healthy 21-year-old male caused by Streptococcus anginosus, initially identified as a group C Streptococcus. The only other case of Lemierre's syndrome caused by group C Streptococcus may have been misidentified (1). (Source: Clinical Microbiology Newsletter)
Source: Clinical Microbiology Newsletter - January 14, 2015 Category: Microbiology Authors: Diana Otero, Martin Gnoni, James W. Snyder, Forest W. Arnold Tags: Case Report Source Type: news

Multiplex Fluorescence In Situ Hybridization (M-FISH) and Confocal Laser Scanning Microscopy (CLSM) to Analyze Multispecies Oral Biofilms
Multiplex fluorescence in situ hybridization (M-FISH) constitutes a favorable microbiological method for the analysis of spatial distribution of highly variable phenotypes found in multispecies oral biofilms. The combined use of confocal laser scanning microscopy (CLSM) produces high-resolution three-dimensional (3D) images of individual bacteria in their natural environment. Here, we describe the application of M-FISH on early (Streptococcus spp., Actinomyces naeslundii) and late colonizers (Fusobacterium nucleatum, Veillonella spp.) of in situ-formed oral biofilms, the acquisition of CLSM images, as well as the qualitati...
Source: Springer protocols feed by Microbiology - March 27, 2014 Category: Microbiology Source Type: news

Key role for Fusobacterium adhesin in non-orthodontic periodontal inflammation
Researchers from China have found that patients with gingivitis and periodontitis are more likely to have Fusobacterium nucleatum carrying the novel Fusobacterium adhesin A than periodontally healthy people. (Source: MedWire News - Infectious Diseases)
Source: MedWire News - Infectious Diseases - January 31, 2014 Category: Infectious Diseases Source Type: news

Incidence, and Outcomes of Fusobacterium Species BacteremiaIncidence, and Outcomes of Fusobacterium Species Bacteremia
Fusobacterium are a rare cause of serious infection. What are the risk factors, incidence and outcomes of infection? BMC Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 18, 2013 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

A rare case of Lemierre's syndrome caused by methicillin-resistant Staphylococcus aureus in a facial abscess
Lemierre's syndrome, also known as postanginal sepsis, is characterized by unilateral jugular vein thrombosis; bacteremia, most often due to Fusobacterium necrophorum; and septic pulmonary emboli. Clinically, patients present with a severe sore throat, followed by fever and anterior cervical neck pain over the jugular vein. Most cases involve young healthy adults, but persons of any age may be affected. (Source: Clinical Microbiology Newsletter)
Source: Clinical Microbiology Newsletter - August 29, 2013 Category: Microbiology Authors: Joshua Rein, Sikhminder Sahansra, Anita Jose, Burke A. Cunha Source Type: news

What Are the Potential Complications of a Retropharyngeal Abscess?
Discussion Retropharyngeal abscesses (RPA) occur in the potential space bound anterior to the prevertebral fascia, posterior to the pharyngeal constrictor muscles and their fascia and laterally by the carotid sheaths and parapharyngeal space (another potential space lying laterally to the pharynx). The retropharyngeal potential space runs superiorally from the base of the skull to the mediastinum distally. It is the most common deep neck infection. In children under 4 years of age, retropharyngeal lymph nodes are present which regress after this age. RPA is most common in young children when these lymph nodes are present, ...
Source: PediatricEducation.org - May 27, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news