Hypochlorous acid inactivates oral pathogens and a SARS-CoV-2-surrogate
ConclusionsHOCl solution (45 –60 ppm) is still effective against oral pathogens and SAR-CoV-2 surrogate viruses even in the presence of saliva and after passing through the dental unit water line. This study indicates that the HOCl solution can be used as therapeutic water or mouthwash and may ultimately reduce the risk of airborne infection in dental practice. (Source: Dental Technology Blog)
Source: Dental Technology Blog - March 7, 2023 Category: Dentistry Source Type: news
Fusobacterium nucleatum induces proliferation and migration in pancreatic cancer cells through host autocrine and paracrine signaling | Science Signaling
The host cell response to Fusobacterium infection promotes aggressive pancreatic cancer cell behavior. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 18, 2022 Category: Science Source Type: news
Evidence Grows for Vaping ’s Role in Gum Disease
Feb. 22, 2022Washington, DC – February 22, 2022 – A series of new studies by researchers at New York University ' s College of Dentistry highlights how e-cigarettes alter oral health and may be contributing to gum disease. The latest, published in mBio, an open-access journal of the American Society for Microbiology, finds that e-cigarette users have a unique oral microbiome —the community of bacteria and other microorganisms—that is less healthy than nonsmokers but potentially healthier than cigarette smokers and measures worsening gum disease over time. “To our knowledge, this is ...
Source: Dental Technology Blog - March 10, 2022 Category: Dentistry Source Type: news
The Common Mouth Microbe That Keeps Popping Up in Tumors
Lab studies link the oral bacteria Fusobacterium nucleatum to cancers from the gut to the head and neck. Could targeting the microbe tackle tumors? (Source: The Scientist)
Source: The Scientist - December 15, 2021 Category: Science Tags: News & Opinion Source Type: news
What is the Difference Between a Paronychia and a Felon?
Discussion
The hands are one of the most important parts of the body for interacting with the world. They are remarkably adapted having sensitive sensory receptors as well as feedback receptors for grasping, holding, and manipulating objects. Hands, especially with an opposable thumb, multiple joints within the hand, along with the wrist and elbow, allow the hand to move in multiple positions to manipulate the world. Hands also symbolize an emotional caring and sharing between individuals as hands are used to provide a true “human touch” in personal and social situations.
Due to their important interactions in ...
Source: PediatricEducation.org - December 6, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
How Common are Co-infections with Trichomonas and Bacterial Vaginosis?
Discussion
Vulvovaginitis is a common gynecological complaint for females of all ages. It is specifically the inflammation of the vulva and vagina but is used as a general term often to mean vulvar irritation, itching, and burning that can occur with or without vaginal discharge. In prepubertal females there is lack of estrogenization, and less lactobacillus species which creates a more neutral pH (normal vaginal pH is < 4.5), lack of pubic hair and fat pad which provide trauma protection, location of anus close to the vagina and tendency of poor hygiene in young children. With puberty, estrogen thickens the vaginal tis...
Source: PediatricEducation.org - May 24, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Bacterial invaders drive CRC progression
The oral bacterium Fusobacterium nucleatum is often found in colorectal cancer (CRC). In the 21 July 2020 issue of Science Signaling, Casasanta et al. show that CRC cell–resident F. nucleatum promotes cytokine secretion that may potentiate tumor growth and metastatic progression in patients. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - August 10, 2020 Category: Science Authors: Meyerson, M. Tags: STKE Focus Source Type: news
Fusobacterium nucleatum host-cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration
Fusobacterium nucleatum is implicated in accelerating colorectal cancer (CRC) and is found within metastatic CRC cells in patient biopsies. Here, we found that bacterial invasion of CRC cells and cocultured immune cells induced a differential cytokine secretion that may contribute to CRC metastasis. We used a modified galactose kinase markerless gene deletion approach and found that F. nucleatum invaded cultured HCT116 CRC cells through the bacterial surface adhesin Fap2. In turn, Fap2-dependent invasion induced the secretion of the proinflammatory cytokines IL-8 and CXCL1, which are associated with CRC progression and pro...
Source: Signal Transduction Knowledge Environment - July 20, 2020 Category: Science Authors: Casasanta, M. A., Yoo, C. C., Udayasuryan, B., Sanders, B. E., Umana, A., Zhang, Y., Peng, H., Duncan, A. J., Wang, Y., Li, L., Verbridge, S. S., Slade, D. J. Tags: STKE Research Articles Source Type: news
Gut bacteria may be one culprit for increase of colorectal cancer in younger people
(Georgetown University Medical Center) A bacteria typically linked to periodontal disease, Fusobacterium nucleatum (F. nuc), could play an important role in the rising incidence of colorectal cancer in people under the age of 45. Another type of bacteria, Moraxella osloensis, has been found in colorectal cancer tumors at a nearly four-fold higher rate in people over 75 than in those under 45 years of age. These are the preliminary findings of an ongoing study that will be presented at ASCO GI 2020. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 21, 2020 Category: Cancer & Oncology Source Type: news
The Association between Inflammatory Bowel Disease and Periodontal Conditions: Is There a Common Bacterial Etiology?
CONCLUSION:A number of studies have showed an association between PD and IBD. Both diseases share genetic and environmental etiological factors. The precise role of intestinal bacteria remains vague. The periodontal microbiota that might be involved in the association of these diseases are Fusobacterium nucleatum, Campylobacter rectus and Campylobacter concisus. Fungal and viral microbiota dysbiosis should also be evaluated as common pathogenic pathways in IBD and periodontal disease. (Source: Dental Technology Blog)
Source: Dental Technology Blog - September 23, 2019 Category: Dentistry Source Type: news
Researchers discover cellular messengers communicate with bacteria in the mouth
This study establishes that there is a clear channel of communication between RNA messengers and bacteria in our mouth,” said Wong, who holds the Felix and Mildred Yip Endowed Chair in Dentistry. “Furthermore, we have shown that these messengers may play an important role in mediating interac tions between bacteria and their host.”Another significant study finding was the majority of tRNA bacteria sequences that show high sequence similarity with salivary tsRNAs came from antibiotic-resistant Gram-negative bacteria. This observation could lead to a better understanding of the mechanisms behind the growth of oral bact...
Source: UCLA Newsroom: Health Sciences - May 9, 2018 Category: Universities & Medical Training Source Type: news
UCLA researchers discover cellular messengers communicate with bacteria in the mouth
This study establishes that there is a clear channel of communication between RNA messengers and bacteria in our mouth,” said Wong, who holds the Felix and Mildred Yip Endowed Chair in Dentistry. “Furthermore, we have shown that these messengers may play an important role in mediating interac tions between bacteria and their host.”Another significant study finding was the majority of tRNA bacteria sequences that show high sequence similarity with salivary tsRNAs came from antibiotic-resistant Gram-negative bacteria. This observation could lead to a better understanding of the mechanisms behind the growth of oral bact...
Source: UCLA Newsroom: Health Sciences - May 7, 2018 Category: Universities & Medical Training Source Type: news
Inhibition of Oral Pathogens Adhesion to Human Gingival Fibroblasts by Wine Polyphenols Alone and in Combination with an Oral Probiotic
Lots of you will enjoy this research! MJ J. Agric. Food Chem., Article ASAPDOI:10.1021/acs.jafc.7b05466Publication Date (Web): February 21, 2018 AbstractSeveral benefits have been described for red wine polyphenols and probiotic strains in the promotion of colonic metabolism and health. On the contrary, knowledge about their role in the management of oral health is still scarce. In this work, the antiadhesive capacity of selected red wine polyphenols and oenological extracts against the oral pathogensPorphyromonas gingivalis,Fusobacterium nucleatum, andStreptococcus mutans in an in vitro model of human gingival f...
Source: Dental Technology Blog - February 27, 2018 Category: Dentistry Source Type: news
Influence of the oscillation frequency of different side-to-side toothbrushes on noncontact biofilm removal
ConclusionsThe oscillation frequency of the tested side-to-side toothbrushes affected the biofilm reduction in an interdental space model.Clinical relevanceWithin a toothbrush, higher oscillation frequencies may lead to beneficial effects on interdental biofilm removal by noncontact brushing. (Source: Dental Technology Blog)
Source: Dental Technology Blog - February 5, 2018 Category: Dentistry Source Type: news
