Symptoms predictive of Fusobacterium necrophorum pharyngotonsillitis – an observational study of cases presenting to hospitals in Southern Sweden
ConclusionOur results suggest thatF. necrophorum cases presenting to hospitals might be better distinguished from other pharyngotonsillitis cases by a simple scoring system presented, with age 13 –30 being the strongest predictor forF. necrophorum. Prospective studies, involving primary care settings, are needed to evaluate generalisability of findings beyond cases presenting to hospitals. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 12, 2024 Category: Microbiology Source Type: research

Periodontitis increases the risk of gastrointestinal dysfunction: an update on the plausible pathogenic molecuar mechanisms
Crit Rev Microbiol. 2024 Apr 11:1-31. doi: 10.1080/1040841X.2024.2339260. Online ahead of print.ABSTRACTPeriodontitis is an immuno-inflammatory disease of the soft tissues surrounding the teeth. Periodontitis is linked to many communicable and non-communicable diseases such as diabetes, cardiovascular disease, rheumatoid arthritis, and cancers. The oral-systemic link between periodontal disease and systemic diseases is attributed to the spread of inflammation, microbial products and microbes to distant organ systems. Oral bacteria reach the gut via swallowed saliva, whereby they induce gut dysbiosis and gastrointestinal dy...
Source: Critical Reviews in Microbiology - April 11, 2024 Category: Microbiology Authors: Sayantan Mukherjee Aditi Chopra Shaswata Karmakar Subraya Giliyar Bhat Source Type: research

Fusobacterium nucleatum subsp. animalis comes to the spotlight in oral diseases
Cell Host Microbe. 2024 Apr 10;32(4):443-444. doi: 10.1016/j.chom.2024.03.009.ABSTRACTKrieger et al.'s study in this issue of Cell Host & Microbe reveals that Fusobacterium nucleatum subsp. animalis strains, previously underestimated, are significant in disease-affected oral areas. This challenges the long-held notion of the dominance of Fusobacterium nucleatum subsp. nucleatum, reshaping our understanding of Fusobacterium distribution in the oral microbiome.PMID:38604121 | DOI:10.1016/j.chom.2024.03.009 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - April 11, 2024 Category: Microbiology Authors: Bibek G C Peng Zhou Chenggang Wu Source Type: research

Periodontitis increases the risk of gastrointestinal dysfunction: an update on the plausible pathogenic molecuar mechanisms
Crit Rev Microbiol. 2024 Apr 11:1-31. doi: 10.1080/1040841X.2024.2339260. Online ahead of print.ABSTRACTPeriodontitis is an immuno-inflammatory disease of the soft tissues surrounding the teeth. Periodontitis is linked to many communicable and non-communicable diseases such as diabetes, cardiovascular disease, rheumatoid arthritis, and cancers. The oral-systemic link between periodontal disease and systemic diseases is attributed to the spread of inflammation, microbial products and microbes to distant organ systems. Oral bacteria reach the gut via swallowed saliva, whereby they induce gut dysbiosis and gastrointestinal dy...
Source: Critical Reviews in Microbiology - April 11, 2024 Category: Microbiology Authors: Sayantan Mukherjee Aditi Chopra Shaswata Karmakar Subraya Giliyar Bhat Source Type: research

Characteristics of the oral microbiota in patients with primary Sj ögren’s syndrome
ConclusionsThe oral microbial ecology of patients with pSS is dysregulated, resulting in a decrease in overall diversity.Prevotella andVeillonella may be related to pSS, whileFusobacterium,Actinomyces, andLeptotrichia may be related to dental caries in pSS patients.Key Points•This study revealed differences in the oral microbial composition of patients with pSS compared to healthy controls.•We included a plaque group of pSS patients to identify the microbiota related to pSS and dental caries.•Prevotella and Veillonella may contribute to pSS, and Fusobacterium,Actinomyces, and Leptotrichia are associated with dental c...
Source: Clinical Rheumatology - April 11, 2024 Category: Rheumatology Source Type: research

Characterization of the oral microbiota and the relationship of the oral microbiota with the dental and periodontal status in children and adolescents with nonsyndromic cleft lip and palate. Systematic literature review and meta-analysis
ConclusionIn the microbiota, there was a great diversity of microorganisms that can vary according to the type of fissure and surgical interventions predisposing patients to a greater probability of dental caries, it is important to take into account the technique used to describe the oral microbiota in order to be able to compare the different studies.Clinical relevanceStudying the microbiota and the relationship of dental caries and periodontal status in children and adolescents with cleft lip and palate can facilitate the comprehensive care of patients with these conditions. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 8, 2024 Category: Dentistry Source Type: research

Characterization of biliary and duodenal microbiota in patients with primary and recurrent choledocholithiasis
ConclusionsThe duodenal microbiota was in an imbalance in CDL. The duodenal microbiota was probably the main source of the biliary microbiota and was closely related to CDL formation and recurrence.Enterococcus,Fusobacterium,Escherichia andKlebsiella might contribute to CDL recurrence.Clinical trialsThe study was registered at the Chinese Clinical Trial Registry (https://www.chictr.org.cn/index.html,  ChiCTR2000033940). (Source: Health Information Science and Systems)
Source: Health Information Science and Systems - April 4, 2024 Category: Information Technology Source Type: research

Changes in the Urinary Microbiome After Transurethral Resection of Non-muscle-Invasive Bladder Cancer: Insights from a Prospective Observational Study
CONCLUSIONS: In patients with low-grade NMIBC, the urine microbiome undergoes changes over time after removal of the tumor. The microbiome detected in tumor tissues is more phylogenetically diverse than in paired urine samples collected at TURBT. The interplay between bladder microbiome, tumor microbiome, and their alterations requires further studies to elucidate their predictive value and perhaps therapeutic implications.PMID:38570378 | DOI:10.1245/s10434-024-15198-9 (Source: Ann Oncol)
Source: Ann Oncol - April 3, 2024 Category: Cancer & Oncology Authors: Aleksander Ślusarczyk Hamza Ismail Łukasz Zapała Tomasz Piecha Piotr Zapa ła Piotr Radziszewski Source Type: research

Changes in the Urinary Microbiome After Transurethral Resection of Non-muscle-Invasive Bladder Cancer: Insights from a Prospective Observational Study
ConclusionsIn patients with low-grade NMIBC, the urine microbiome undergoes changes over time after removal of the tumor. The microbiome detected in tumor tissues is more phylogenetically diverse than in paired urine samples collected at TURBT. The interplay between bladder microbiome, tumor microbiome, and their alterations requires further studies to elucidate their predictive value and perhaps therapeutic implications. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research

Indoxyl sulfate contributes to colorectal cancer cell proliferation and increased EGFR expression by activating AhR and Akt
This study found that indoxyl sulfate induced the proliferation of CRC-derived HCT-116 cells by activating the aryl hydrocarbon receptor (AhR) and the proto-oncogene Akt. The AhR antagonist CH223191 and Akt inhibitor MK2206 suppressed indoxyl sulfate-induced proliferation of HCT-116 cells. We also found that indoxyl sulfate upregulated epidermal growth factor receptor (EGFR) expression, which is associated with poor prognosis of CRC, whereas CH223191 and MK2206 repressed EGFR expression. Furthermore, indoxyl sulfate increased the sensitivity of CRC cells to EGF by upregulating EGFR expression. These findings suggest that i...
Source: Biomed Res - March 31, 2024 Category: Research Authors: Yu Ichisaka Shozo Yano Kohji Nishimura Toshimitsu Niwa Hidehisa Shimizu Source Type: research

Indoxyl sulfate contributes to colorectal cancer cell proliferation and increased EGFR expression by activating AhR and Akt
This study found that indoxyl sulfate induced the proliferation of CRC-derived HCT-116 cells by activating the aryl hydrocarbon receptor (AhR) and the proto-oncogene Akt. The AhR antagonist CH223191 and Akt inhibitor MK2206 suppressed indoxyl sulfate-induced proliferation of HCT-116 cells. We also found that indoxyl sulfate upregulated epidermal growth factor receptor (EGFR) expression, which is associated with poor prognosis of CRC, whereas CH223191 and MK2206 repressed EGFR expression. Furthermore, indoxyl sulfate increased the sensitivity of CRC cells to EGF by upregulating EGFR expression. These findings suggest that i...
Source: Biomed Res - March 31, 2024 Category: Research Authors: Yu Ichisaka Shozo Yano Kohji Nishimura Toshimitsu Niwa Hidehisa Shimizu Source Type: research

Relationship between periodontal diseases and non-specific inflammatory bowel diseases - an  overview. Part I
Ann Agric Environ Med. 2024 Mar 25;31(1):1-7. doi: 10.26444/aaem/185764. Epub 2024 Mar 21.ABSTRACTINTRODUCTION AND OBJECTIVE: An increasing number of studies indicate that the oral cavity and gastrointestinal tract are interconnected and that there is a potential causal link between non-specific inflammatory bowel diseases (IBD) and oral diseases. Therefore, following the example of the brain-gut axis, the concept of the gum-gut axis has now been put forward. The aim of the review is to assess the literature confirming the existence of the recently proposed gum-gut axis and the resulting relationships between non-specific ...
Source: Annals of Agricultural and Environmental Medicine : AAEM - March 29, 2024 Category: Environmental Health Authors: Ma łgorzata Goździewska Aleksandra Łyszczarz Monika Kaczoruk Emilia Kolarzyk Source Type: research

Relationship between periodontal diseases and non-specific inflammatory bowel diseases - an  overview. Part I
Ann Agric Environ Med. 2024 Mar 25;31(1):1-7. doi: 10.26444/aaem/185764. Epub 2024 Mar 21.ABSTRACTINTRODUCTION AND OBJECTIVE: An increasing number of studies indicate that the oral cavity and gastrointestinal tract are interconnected and that there is a potential causal link between non-specific inflammatory bowel diseases (IBD) and oral diseases. Therefore, following the example of the brain-gut axis, the concept of the gum-gut axis has now been put forward. The aim of the review is to assess the literature confirming the existence of the recently proposed gum-gut axis and the resulting relationships between non-specific ...
Source: Annals of Agricultural and Environmental Medicine : AAEM - March 29, 2024 Category: Environmental Health Authors: Ma łgorzata Goździewska Aleksandra Łyszczarz Monika Kaczoruk Emilia Kolarzyk Source Type: research

Relationship between periodontal diseases and non-specific inflammatory bowel diseases - an  overview. Part I
Ann Agric Environ Med. 2024 Mar 25;31(1):1-7. doi: 10.26444/aaem/185764. Epub 2024 Mar 21.ABSTRACTINTRODUCTION AND OBJECTIVE: An increasing number of studies indicate that the oral cavity and gastrointestinal tract are interconnected and that there is a potential causal link between non-specific inflammatory bowel diseases (IBD) and oral diseases. Therefore, following the example of the brain-gut axis, the concept of the gum-gut axis has now been put forward. The aim of the review is to assess the literature confirming the existence of the recently proposed gum-gut axis and the resulting relationships between non-specific ...
Source: Annals of Agricultural and Environmental Medicine : AAEM - March 29, 2024 Category: Environmental Health Authors: Ma łgorzata Goździewska Aleksandra Łyszczarz Monika Kaczoruk Emilia Kolarzyk Source Type: research

Relationship between periodontal diseases and non-specific inflammatory bowel diseases - an  overview. Part I
Ann Agric Environ Med. 2024 Mar 25;31(1):1-7. doi: 10.26444/aaem/185764. Epub 2024 Mar 21.ABSTRACTINTRODUCTION AND OBJECTIVE: An increasing number of studies indicate that the oral cavity and gastrointestinal tract are interconnected and that there is a potential causal link between non-specific inflammatory bowel diseases (IBD) and oral diseases. Therefore, following the example of the brain-gut axis, the concept of the gum-gut axis has now been put forward. The aim of the review is to assess the literature confirming the existence of the recently proposed gum-gut axis and the resulting relationships between non-specific ...
Source: Annals of Agricultural and Environmental Medicine : AAEM - March 29, 2024 Category: Environmental Health Authors: Ma łgorzata Goździewska Aleksandra Łyszczarz Monika Kaczoruk Emilia Kolarzyk Source Type: research