Analysis of gut target microbiota and species difference in patients with obstructive sleep apnea based on 16S rRNA sequencing
CONCLUSION: OSA patients have obvious gut microbiota disturbances, and Pseudomonas may affect the development of OSA by participating in substance metabolism to serve as the potential target gut bacteria for OSA treatment.PMID:38293986 | PMC:PMC10878889 | DOI:10.12122/j.issn.1673-4254.2024.01.17 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - January 31, 2024 Category: Universities & Medical Training Authors: J Zhu M Lu Q Jiao Y Sun L Liu H Ding Y Yu L Pan Source Type: research
Analysis of gut target microbiota and species difference in patients with obstructive sleep apnea based on 16S rRNA sequencing
CONCLUSION: OSA patients have obvious gut microbiota disturbances, and Pseudomonas may affect the development of OSA by participating in substance metabolism to serve as the potential target gut bacteria for OSA treatment.PMID:38293986 | PMC:PMC10878889 | DOI:10.12122/j.issn.1673-4254.2024.01.17 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - January 31, 2024 Category: Universities & Medical Training Authors: J Zhu M Lu Q Jiao Y Sun L Liu H Ding Y Yu L Pan Source Type: research
Analysis of gut target microbiota and species difference in patients with obstructive sleep apnea based on 16S rRNA sequencing
CONCLUSION: OSA patients have obvious gut microbiota disturbances, and Pseudomonas may affect the development of OSA by participating in substance metabolism to serve as the potential target gut bacteria for OSA treatment.PMID:38293986 | PMC:PMC10878889 | DOI:10.12122/j.issn.1673-4254.2024.01.17 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - January 31, 2024 Category: Universities & Medical Training Authors: J Zhu M Lu Q Jiao Y Sun L Liu H Ding Y Yu L Pan Source Type: research
Analysis of gut target microbiota and species difference in patients with obstructive sleep apnea based on 16S rRNA sequencing
CONCLUSION: OSA patients have obvious gut microbiota disturbances, and Pseudomonas may affect the development of OSA by participating in substance metabolism to serve as the potential target gut bacteria for OSA treatment.PMID:38293986 | PMC:PMC10878889 | DOI:10.12122/j.issn.1673-4254.2024.01.17 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - January 31, 2024 Category: Universities & Medical Training Authors: J Zhu M Lu Q Jiao Y Sun L Liu H Ding Y Yu L Pan Source Type: research
Analysis of gut target microbiota and species difference in patients with obstructive sleep apnea based on 16S rRNA sequencing
CONCLUSION: OSA patients have obvious gut microbiota disturbances, and Pseudomonas may affect the development of OSA by participating in substance metabolism to serve as the potential target gut bacteria for OSA treatment.PMID:38293986 | PMC:PMC10878889 | DOI:10.12122/j.issn.1673-4254.2024.01.17 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - January 31, 2024 Category: Universities & Medical Training Authors: J Zhu M Lu Q Jiao Y Sun L Liu H Ding Y Yu L Pan Source Type: research
Analysis of gut target microbiota and species difference in patients with obstructive sleep apnea based on 16S rRNA sequencing
CONCLUSION: OSA patients have obvious gut microbiota disturbances, and Pseudomonas may affect the development of OSA by participating in substance metabolism to serve as the potential target gut bacteria for OSA treatment.PMID:38293986 | PMC:PMC10878889 | DOI:10.12122/j.issn.1673-4254.2024.01.17 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - January 31, 2024 Category: Universities & Medical Training Authors: J Zhu M Lu Q Jiao Y Sun L Liu H Ding Y Yu L Pan Source Type: research
Analysis of gut target microbiota and species difference in patients with obstructive sleep apnea based on 16S rRNA sequencing
CONCLUSION: OSA patients have obvious gut microbiota disturbances, and Pseudomonas may affect the development of OSA by participating in substance metabolism to serve as the potential target gut bacteria for OSA treatment.PMID:38293986 | PMC:PMC10878889 | DOI:10.12122/j.issn.1673-4254.2024.01.17 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - January 31, 2024 Category: Universities & Medical Training Authors: J Zhu M Lu Q Jiao Y Sun L Liu H Ding Y Yu L Pan Source Type: research
Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance
Cancer Biol Ther. 2024 Dec 31;25(1):2306676. doi: 10.1080/15384047.2024.2306676. Epub 2024 Jan 30.ABSTRACTFusobacterium nucleatum, an anaerobic Gram-negative bacterium primarily residing in the oral cavity, has garnered significant attention for its emerging role in cancer progression and prognosis. While extensive research has revealed mechanistic links between Fusobacterium nucleatum and colorectal cancer, a comprehensive review spanning its presence and metastatic implications in cancers beyond colorectal origin is conspicuously absent. This paper broadens our perspective from colorectal cancer to various malignancies a...
Source: Cancer Biology and Therapy - January 30, 2024 Category: Cancer & Oncology Authors: Chun Ye Xiao Liu Zilun Liu Chuxuan Pan Xiaowei Zhang Zhanyi Zhao Haitao Sun Source Type: research
Prognostic impact of oral microbiome on survival of malignancies: a systematic review and meta-analysis
ConclusionsOur meta-analysis suggests that the composition of the oral microbiome may play a significant role in predicting survival outcomes for cancer patients. (Source: Systematic Reviews)
Source: Systematic Reviews - January 25, 2024 Category: International Medicine & Public Health Source Type: research
Cancers, Vol. 16, Pages 499: The Use of Fecal Microbiota Transplant in Overcoming and Modulating Resistance to Anti-PD-1 Therapy in Patients with Skin Cancer
n Manne
While immune checkpoint inhibitors have evolved into the standard of care for advanced melanoma, 40–50% of melanoma cases progress while on therapies. The relationship between bacterium and carcinogenesis is well founded, such as in H. pylori in gastric cancers, and Fusobacterium in colorectal cancers. This interplay between dysbiosis and carcinogenesis questions whether changes in the microbiome could affect treatment. Thus, FMT may find utility in modifying the efficacy of anti-PD-1. This review aims to examine the use of FMT in treatment-resistant melanoma. A literature search was performed usi...
Source: Cancers - January 24, 2024 Category: Cancer & Oncology Authors: Tahne Vongsavath Rodd Rahmani Kyaw Min Tun Vignan Manne Tags: Systematic Review Source Type: research
The protective effect of teprenone in TNBS-induced ulcerative colitis rats by modulating the gut microbiota and reducing inflammatory response
CONCLUSION: Based on our results, the protective effects of teprenone for UC may be related to its ability to modulate the gut microbiota and reduce the inflammatory response.PMID:38252282 | DOI:10.1080/08923973.2024.2308252 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - January 22, 2024 Category: Allergy & Immunology Authors: Jianfeng Yao Tao Sun Songbai Zheng Jianxia Ma Qinglian Zeng Kangwei Liu Wei Zhang Yang Yu Source Type: research
Tumor-associated microbiome features of metastatic colorectal cancer and clinical implications
ConclusionTumor microbiome features may be useful prognostic biomarkers for metastatic CRC. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 18, 2024 Category: Cancer & Oncology Source Type: research
Genome-wide association with footrot in hair and wool sheep
Ovine footrot is an infectious disease with important contributions from Dichelobacter nodosus and Fusobacterium necrophorum. Footrot is characterized by separation of the hoof from underlying tissue, and this causes severe lameness that negatively impacts animal wellbeing, growth, and profitability. Large economic losses result from lost production as well as treatment costs, and improved genetic tools to address footrot are a valuable long-term goal. Prior genetic studies had examined European wool sheep, but hair sheep breeds such as Katahdin and Blackbelly have been reported to have increased resistance to footrot, as ...
Source: Frontiers in Genetics - January 15, 2024 Category: Genetics & Stem Cells Source Type: research
Intratumoral presence of the genotoxic gut bacteria pks+ E. coli, Enterotoxigenic Bacteroides fragilis, and Fusobacterium nucleatum and their association with clinicopathological and molecular features of colorectal cancer
British Journal of Cancer, Published online: 10 January 2024; doi:10.1038/s41416-023-02554-xIntratumoral presence of the genotoxic gut bacteria pks+ E. coli, Enterotoxigenic Bacteroides fragilis, and Fusobacterium nucleatum and their association with clinicopathological and molecular features of colorectal cancer (Source: British Journal of Cancer)
Source: British Journal of Cancer - January 10, 2024 Category: Cancer & Oncology Authors: Jihoon E. Joo Yen Lin Chu Peter Georgeson Romy Walker Khalid Mahmood Mark Clendenning Aaron L. Meyers Julia Como Sharelle Joseland Susan G. Preston Natalie Diepenhorst Julie Toner Danielle J. Ingle Norelle L. Sherry Andrew Metz Brigid M. Lynch Roger L. Mi Source Type: research
Use of CRISPR interference for efficient and rapid gene inactivation in < em > Fusobacterium nucleatum < /em >
Appl Environ Microbiol. 2024 Jan 8:e0166523. doi: 10.1128/aem.01665-23. Online ahead of print.ABSTRACTHow can we effectively investigate the gene functions in Fusobacterium nucleatum, given the dual challenges of gene inactivation and the inherent genetic resistance of many strains? Traditional methods have been cumbersome and often inadequate. Addressing this, our work introduces a novel inducible CRISPR interference (CRISPRi) system in which dCas9 expression is controlled at the translation level by a theophylline-responsive riboswitch unit, and single-guide RNA expression is driven by the robust, constitutive rpsJ promo...
Source: Applied and Environmental Microbiology - January 8, 2024 Category: Microbiology Authors: Peng Zhou Bibek G C Flynn Stolte Chenggang Wu Source Type: research
