Extracellular vesicles from Fusobacterium nucleatum: roles in the malignant phenotypes of gastric cancer
Volume 23, Issue 3, February 2024, Page 294-307 . (Source: Cell Cycle)
Source: Cell Cycle - March 6, 2024 Category: Cytology Authors: Xiangkun MengGang MaXu ZhangHua YinYu MiaoFang Hea Department of Gastroenterology, General Hospital of Ningxia Medical University, Yinchuan, Chinab Department of Anesthesiology, General Hospital of Ningxia Medical University, Yinchuan, China Source Type: research
Explainable artificial intelligence for microbiome data analysis in colorectal cancer biomarker identification
DISCUSSION: These findings emphasizes the potential of leveraging gut microbiota data within an explainable AI framework for CRC classification. The significant association observed aligns with existing knowledge. The precision exhibited by the RF algorithm reinforces its suitability for such classification tasks. The SHAP analysis not only enhanced interpretability but identified specific bacteria crucial in CRC determination. This approach opens avenues for targeted interventions based on microbial signatures. Further exploration is warranted to deepen our understanding of the intricate interplay between microbiota and h...
Source: Cancer Control - March 1, 2024 Category: Cancer & Oncology Authors: Pierfrancesco Novielli Donato Romano Michele Magarelli Pierpaolo Di Bitonto Domenico Diacono Annalisa Chiatante Giuseppe Lopalco Daniele Sabella Vincenzo Venerito Pasquale Filannino Roberto Bellotti Maria De Angelis Florenzo Iannone Sabina Tangaro Source Type: research
Possible roles of short-chain fatty acids produced by oral bacteria in the development of alveolar osteitis
CONCLUSION: These data suggest that SCFAs produced by P. gingivalis and F. nucleatum may reduce the inflammatory response and mildly induce mineralization of the alveolar walls. These results may contribute to the understanding of alveolar osteitis.PMID:38417878 | DOI:10.2334/josnusd.23-0410 (Source: Journal of oral science)
Source: Journal of oral science - February 28, 2024 Category: Dentistry Authors: Takayuki Asayama Ayaka Takada Yoshikazu Mikami Hirofumi Yamaguchi Muneaki Tamura Kunihito Matsumoto Kiwa Miyake Yoshiyuki Yonehara Hiromasa Tsuda Source Type: research
An Overview of the Dichotomous Role of Microbiota in Cancer Progression and Management
Curr Cancer Drug Targets. 2024 Feb 21. doi: 10.2174/0115680096282503240124104029. Online ahead of print.ABSTRACTIt is a well-known fact that cancer is considered the second leading cause of mortality across the globe. Although the human oral cavity and intestine are the natural habitat of thousands of microbes, dysbiosis results in malignancies, such as oral squamous cell carcinoma and colorectal cancer. Amongst the intestinal microbes, H. pylori is a deadly carcinogen. Also, causative pathogens for the development of pancreatic and colorectal cancer are found in the oral cavity, such as Fusobacterium nucleatum and Porphyr...
Source: Current Cancer Drug Targets - February 27, 2024 Category: Cancer & Oncology Authors: Pooja Jain Sradhanjali Mohapatra Uzma Farooq Nazia Hassan Mohd Aamir Mirza Zeenat Iqbal Source Type: research
An Overview of the Dichotomous Role of Microbiota in Cancer Progression and Management
Curr Cancer Drug Targets. 2024 Feb 21. doi: 10.2174/0115680096282503240124104029. Online ahead of print.ABSTRACTIt is a well-known fact that cancer is considered the second leading cause of mortality across the globe. Although the human oral cavity and intestine are the natural habitat of thousands of microbes, dysbiosis results in malignancies, such as oral squamous cell carcinoma and colorectal cancer. Amongst the intestinal microbes, H. pylori is a deadly carcinogen. Also, causative pathogens for the development of pancreatic and colorectal cancer are found in the oral cavity, such as Fusobacterium nucleatum and Porphyr...
Source: Current Cancer Drug Targets - February 27, 2024 Category: Cancer & Oncology Authors: Pooja Jain Sradhanjali Mohapatra Uzma Farooq Nazia Hassan Mohd Aamir Mirza Zeenat Iqbal Source Type: research
Microbiota changes: the unseen players in cervical cancer progression
In conclusion, a more profound understanding of the microbial landscape could elucidate the pathogenesis of cervical diseases and inform future strategies for diagnosis, prevention, and treatment.PMID:38389527 | PMC:PMC10881787 | DOI:10.3389/fmicb.2024.1352778 (Source: Cancer Control)
Source: Cancer Control - February 23, 2024 Category: Cancer & Oncology Authors: W M Fong Amaris Paulo Pimentel de Assump ção Leonardo Jacomo Valadares Fabiano Cordeiro Moreira Source Type: research
Oral microbiota –host interaction: the chief culprit of alveolar bone resorption
There exists a bidirectional relationship between oral health and general well-being, with an imbalance in oral symbiotic flora posing a threat to overall human health. Disruptions in the commensal flora can lead to oral diseases, while systemic illnesses can also impact the oral cavity, resulting in the development of oral diseases and disorders. Porphyromonas gingivalis and Fusobacterium nucleatum, known as pathogenic bacteria associated with periodontitis, play a crucial role in linking periodontitis to accompanying systemic diseases. In periodontal tissues, these bacteria, along with their virulence factors, can excess...
Source: Frontiers in Immunology - February 22, 2024 Category: Allergy & Immunology Source Type: research
Electro-antibacterial therapy (EAT) to enhance intracellular bacteria clearance in pancreatic cancer cells
In this study, we investigate the use of electroporation in combination with metronidazole to enhance the clearance of intracellular Fusobacterium nucleatum within pancreatic cancer cells. We explore various parameters, including electric field strength, pulse width, and pulse number to assess the permeability of pancreatic cancer cells infected with F. nucleatum, compared to non-infected cells of the same type. We subsequently quantify the clearance of intracellular bacteria when these pulsing schemes are applied to a suspension of infected pancreatic cancer cells in the presence of metronidazole. Our results reveal disti...
Source: Bioelectrochemistry - February 20, 2024 Category: Biochemistry Authors: Josie L Duncan Raffae N Ahmad Hunter Danesi Daniel J Slade Rafael V Davalos Scott S Verbridge Source Type: research
Fusobacterium nucleatum bacteremia complicated with intracranial Porphyromonas gingivalis and HSV-1 infection: a case report and literature review
CONCLUSION: To our knowledge, this is the first report of intracranial P. gingivalis and HSV-1 infection combined with F. nucleatum bacteremia.PMID:38378498 | PMC:PMC10877767 | DOI:10.1186/s12879-024-09078-6 (Source: Herpes)
Source: Herpes - February 20, 2024 Category: Infectious Diseases Authors: Sumei Wang Yaqiong Tian Yujing Wu Zhen Yu Jinjuan Zhang Jiandong Zhang Shuye Liu Source Type: research
Electro-antibacterial therapy (EAT) to enhance intracellular bacteria clearance in pancreatic cancer cells
In this study, we investigate the use of electroporation in combination with metronidazole to enhance the clearance of intracellular Fusobacterium nucleatum within pancreatic cancer cells. We explore various parameters, including electric field strength, pulse width, and pulse number to assess the permeability of pancreatic cancer cells infected with F. nucleatum, compared to non-infected cells of the same type. We subsequently quantify the clearance of intracellular bacteria when these pulsing schemes are applied to a suspension of infected pancreatic cancer cells in the presence of metronidazole. Our results reveal disti...
Source: Bioelectrochemistry - February 20, 2024 Category: Biochemistry Authors: Josie L Duncan Raffae N Ahmad Hunter Danesi Daniel J Slade Rafael V Davalos Scott S Verbridge Source Type: research
