Comparative efficacy and acceptability of licensed dose intranasal corticosteroids for moderate-to-severe allergic rhinitis: a systematic review and network meta-analysis
No evidence shows that one intranasal corticosteroid (INCS) is better than another for treating moderate-to-severe allergic rhinitis (AR). This network meta-analysis assessed the comparative efficacy and acceptability of licensed dose aqueous INCSs. PubMed/MEDLINE, Scopus, EMBASE, and the Cochrane Central Register of Controlled Trials were searched until 31 March 2022. Eligible studies included randomized controlled trials comparing INCSs with placebo or other types of INCSs in patients with moderate-to-severe allergic rhinitis. Two reviewers independently screened and extracted data following the Preferred Reporting Items...
Source: Frontiers in Pharmacology - May 23, 2023 Category: Drugs & Pharmacology Source Type: research

Fluticasone Propionate with Azelastine Versus Standalone Fluticasone Propionate as Nasal Spray in Allergic Rhinitis: A Prospective Comparative Study in a Rural Population of Northern India
Conclusions: According to results obtained from the current study, while both fluticasone propionate with azelastine nasal spray and standalone fluticasone propionate nasal spray are widely used for control of symptoms in PER, the former offers better results with significant reduction of symptoms when compared to the latter. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - May 6, 2023 Category: ENT & OMF Source Type: research

The Rising Cost of Rhinologic Medications
CONCLUSION: The rising cost of highly utilized medications contribute to increased patient acquisition costs and may pose barriers of drug adherence to particularly vulnerable populations.PMID:37098404 | DOI:10.1016/j.anai.2023.04.013 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 25, 2023 Category: Allergy & Immunology Authors: Milind Vasudev Sina J Torabi Lauren Michelle Leo L T Meller Jack L Birkenbeuel Kelsey M Roman Theodore V Nguyen Edward C Kuan Source Type: research

The Rising Cost of Rhinologic Medications
CONCLUSION: The rising cost of highly utilized medications contribute to increased patient acquisition costs and may pose barriers of drug adherence to particularly vulnerable populations.PMID:37098404 | DOI:10.1016/j.anai.2023.04.013 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 25, 2023 Category: Allergy & Immunology Authors: Milind Vasudev Sina J Torabi Lauren Michelle Leo L T Meller Jack L Birkenbeuel Kelsey M Roman Theodore V Nguyen Edward C Kuan Source Type: research

Real-world effects of once-daily inhaled steroid (fluticasone furoate) combined with long-acting beta-2 agonist (vilanterol) and long-acting muscarinic antagonist (umeclidinium) on lung function tests of asthma patients in Japan
Conclusion: Once-daily FF/UMEC/VI 200/62.5/25 μg was effective against asthma without serious adverse events. This is the first report that demonstrated FF/UMEC/VI dilated peripheral airways using lung function tests. This evidence on drug effects may improve our understanding of pulmonary physiology and the pathophysiology of asthma. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - April 21, 2023 Category: Physiology Source Type: research

Central and peripheral lung deposition of fluticasone propionate dry powder inhaler formulations in humans characterized by population pharmacokinetics
This study aimed to gain an in-depth understanding of the pulmonary fate of three experimental fluticasone propionate (FP) dry powder inhaler formulations which differed in mass median aerodynamic diameters (MMAD; A-4.5  µm, B-3.8 µm and C-3.7 µm; total single dose: 500 µg). Systemic disposition parameter estimates were obtained from published pharmacokinetic data after intravenous dosing to improve robustness. A biphasic pulmonary absorption model, with mucociliary clearance from the slower absorption comp artment, and three systemic disposition compartments was most suitable. Rapid absorption, presumably from per...
Source: Pharmaceutical Research - April 20, 2023 Category: Drugs & Pharmacology Source Type: research

Tezepelumab treatment for allergic bronchopulmonary aspergillosis
The patient with allergic bronchopulmonary aspergillosis (ABPA) underwent treatment with tezepelumab; the mucus plugs and pulmonary opacities diminished gradually parallel to the improvement in the control of asthmatic symptoms. Tezepelumab might provide a novel steroid-sparing strategy for the management of ABPA. AbstractAn 82-year-old man had been diagnosed with asthma. He experienced repeated exacerbations requiring treatment with a systemic corticosteroid despite being treated with medications including high-dose fluticasone furoate/umeclidinium/vilanterol, montelukast sodium, and theophylline; treatment with mepolizum...
Source: Respirology Case Reports - April 18, 2023 Category: Respiratory Medicine Authors: Hiroaki Ogata, Kachi Sha, Yasuaki Kotetsu, Aimi Enokizu ‐Ogawa, Katsuyuki Katahira, Akiko Ishimatsu, Kazuhito Taguchi, Atsushi Moriwaki, Makoto Yoshida Tags: CASE REPORT Source Type: research

Drug-induced tooth discoloration: An analysis of the US food and drug administration adverse event reporting system
Conclusion: This study revealed that certain drugs are significantly associated with tooth discoloration. Caution should be exercised when using these drugs, especially during pregnancy and early childhood. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 13, 2023 Category: Drugs & Pharmacology Source Type: research

Budesonide/formoterol maintenance and reliever therapy versus fluticasone/salmeterol fixed-dose treatment in patients with COPD
Conclusions This first study of MART in COPD found that budesonide/formoterol MART might be similarly effective to fluticasone/salmeterol fixed-dose therapy in moderate to severe patients with COPD, at a lower daily ICS dosage. Further evidence is needed about long-term safety. (Source: Thorax)
Source: Thorax - April 13, 2023 Category: Respiratory Medicine Authors: Muiser, S., Imkamp, K., Seigers, D., Halbersma, N. J., Vonk, J. M., Luijk, B. H. D., Braunstahl, G.-J., van den Berg, J.-W., Kroesen, B.-J., Kocks, J. W. H., Heijink, I. H., Reddel, H. K., Kerstjens, H. A. M., van den Berge, M. Tags: Thorax Chronic obstructive pulmonary disease Source Type: research

Use of digital measurement of medication adherence and lung function to guide the management of uncontrolled asthma (INCA Sun): a multicentre, single-blinded, randomised clinical trial
Lancet Respir Med. 2023 Mar 21:S2213-2600(22)00534-3. doi: 10.1016/S2213-2600(22)00534-3. Online ahead of print.ABSTRACTBACKGROUND: The clinical value of using digital tools to assess adherence and lung function in uncontrolled asthma is not known. We aimed to compare treatment decisions guided by digitally acquired data on adherence, inhaler technique, and peak flow with existing methods.METHODS: A 32-week prospective, multicentre, single-blinded, parallel, randomly controlled trial was done in ten severe asthma clinics across Ireland, Northern Ireland, and England. Participants were 18 years or older, had uncontrolled as...
Source: Respiratory Care - March 24, 2023 Category: Respiratory Medicine Authors: Elaine Mac Hale Garrett Greene Christopher Mulvey Matshediso C Mokoka Job F M van Boven Breda Cushen Imran Sulaiman Vincent Brennan Patrick J Kerr Richard B Reilly Cian Hughes Brian D Kent David J Jackson Marcus Butler Ian Counihan James Hayes John Faul M Source Type: research

Enhanced Optimal Parameter-Based Nebulizer Design for Flow Analysis of Fluticasone Propionate
AAPS PharmSciTech. 2023 Mar 22;24(4):85. doi: 10.1208/s12249-023-02548-1.ABSTRACTA jet nebulizer sprays a fine mist or aerosol directly into the lungs to reduce inflammation, expand airways, and make breathing easier for respiratory patients. Asthma, COPD, emphysema, and cystic fibrosis are treated with jet nebulizers. They are chosen over other nebulizers for their shorter treatment time and wider medication compatibility. For mechanically ventilated patients, jet nebulizers humidify oxygen to provide bronchodilators, antibiotics, and other respiratory medications. Additionally, they treat pneumonia, bronchitis, and other...
Source: AAPS PharmSciTech - March 23, 2023 Category: Drugs & Pharmacology Authors: Vinoth N Bhaskara Rao Lokavarapu Source Type: research

Enhanced Optimal Parameter-Based Nebulizer Design for Flow Analysis of Fluticasone Propionate
AAPS PharmSciTech. 2023 Mar 22;24(4):85. doi: 10.1208/s12249-023-02548-1.ABSTRACTA jet nebulizer sprays a fine mist or aerosol directly into the lungs to reduce inflammation, expand airways, and make breathing easier for respiratory patients. Asthma, COPD, emphysema, and cystic fibrosis are treated with jet nebulizers. They are chosen over other nebulizers for their shorter treatment time and wider medication compatibility. For mechanically ventilated patients, jet nebulizers humidify oxygen to provide bronchodilators, antibiotics, and other respiratory medications. Additionally, they treat pneumonia, bronchitis, and other...
Source: AAPS PharmSciTech - March 23, 2023 Category: Drugs & Pharmacology Authors: Vinoth N Bhaskara Rao Lokavarapu Source Type: research

The clinical efficacy of fluticasone propionate combined with ACEI/ARB in the treatment of immunoglobulin A nephropathy
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulopathy worldwide, and lacks the effective treatment. The study was aimed to investigate the clinical efficacy of fluticasone propionate ae... (Source: BMC Nephrology)
Source: BMC Nephrology - March 22, 2023 Category: Urology & Nephrology Authors: Liping Sun, Xinyi Zi, Zhen Wang and Xinzhou Zhang Tags: Research Source Type: research

Therapeutic effect of modified Xiaoqinglong Decoction on cough-variant asthma and immunological functioning in children
CONCLUSION: The modified Xiaoqinglong Decoction has a conspicuous effect on children with CVA. It helps to reduce cough symptoms, improve pulmonary function, reduce inflammatory response and improve immunological functioning of children.PMID:36915768 | PMC:PMC10006781 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - March 14, 2023 Category: Research Authors: Jun Li Ying Han Source Type: research