An efficacy and safety evaluation of montelukast + fluticasone propionate vs. fluticasone propionate in the treatment of cough variant asthma in children: a meta-analysis
This study aimed to evaluate the efficacy and safety of montelukast (Mon) + fluticasone propionate (Flu) versus Flu in the treatment of cough variant asthma (CVA) in children. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - December 5, 2023 Category: Respiratory Medicine Authors: Zhengbo Wei and Sheng Li Tags: Research Source Type: research

Real-World Study of Single-Inhaler Triple Therapy with Fluticasone Furoate/Umeclidinium/Vilanterol on Asthma Control in the US
(Source: Journal of Asthma and Allergy)
Source: Journal of Asthma and Allergy - December 1, 2023 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research

EE604 Cost-Effectiveness Analysis of Single-Inhaler Triple Therapy (FF/UMEC/VI) in COPD Using the Impact Trial: China Medical Insurance System Perspective
To assess the cost-effectiveness of single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) versus UMEC/VI for patients with symptomatic COPD and a history of exacerbations from a China medical insurance system perspective based on data from the IMPACT trial (NCT02164513). (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: X. Wang, A. Martin, R. Cai, Z. Tang, D. Bointon, S.G. Noorduyn, A. Sun, A. Ismaila Source Type: research

EE558 The Cost-Effectiveness of Budesonide/Formoterol Maintenance and Reliever Therapy Versus Salmeterol/Fluticasone Plus As-Needed Salbutamol Among Asthma Patients ≥12 Years in China
To evaluate the cost-effectiveness of budesonide/formoterol combination therapy plus as need compared with salmeterol/fluticasone plus salbutamol as reliever therapy for asthma patients ≥12 years from the societal perspective. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: K. Zhou, X. Xie, C. Zuo, Y. Jiang, J. Xuan Source Type: research

EE103 Cost-Effectiveness Analysis of Single-Inhaler Triple Therapy (FF/UMEC/VI) in COPD Using the Fulfil Trial: China Medical Insurance System Perspective
To assess the cost-effectiveness of single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) versus budesonide/formoterol (BUD/FOR) for patients with symptomatic COPD and a history of exacerbations from a China medical insurance system perspective based on data from the FULFIL trial (NCT02345161). (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: S.G. Noorduyn, X. Wang, A. Martin, R. Cai, Z. Tang, D. Bointon, A. Sun, A. Ismaila Source Type: research

Chronic Obstructive Pulmonary Disease Adverse Event Signals Associated with Potential Inhibitors of Glutathione Peroxidase 1: A Sequence Symmetry Analysis
ConclusionADE signals were generated for several potential GPx1 inhibitors; however, further validation of signals is required in large well-controlled observational studies. (Source: Drug Safety)
Source: Drug Safety - November 23, 2023 Category: Drugs & Pharmacology Source Type: research

Journal club
Does a brand-name inhaler provide better efficacy compared with its generic counterpart? The clinical equivalence between generic and brand-name inhalers has yet to be determined. Moreover, there is a lack of comprehensive studies on specific populations affected by these products. To bridge this knowledge gap, Feldman et al1 conducted a cohort study focusing on adults aged 40 and above diagnosed with chronic obstructive pulmonary disease (COPD). The research aimed to compare the effectiveness and safety of fluticasone-salmeterol inhalers (a combination therapy consisting of inhaled corticosteroids and long acting bronchod...
Source: Thorax - November 20, 2023 Category: Respiratory Medicine Authors: Ee, W. W. Tags: Thorax Journal club Source Type: research

Greenness assessment of two chromatographic methods developed for the determination of Mupirocin in two binary mixtures along with its impurity
Two simple, accurate and precise chromatographic methods have been developed and validated for estimating Mupirocin (MUP) in two binary mixtures. Mixture (1); with Fluticasone propionate (FLU) together with tw... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - October 27, 2023 Category: Chemistry Authors: Maha M. Galal, Shaaban A. Abdullah, Ola Y. Mohamed and Azza A. Moustafa Tags: Research Source Type: research

The efficiency of azelastine hydrochloride and fluticasone propionate nasal spray to improve PAP adherence in patients with obstructive sleep apnea
Conclusion: The preliminary findings of this study evaluating the effectiveness of azelastine hydrochloride and fluticasone propionate nasal spray in enhancing PAP adherence indicate that this combination may improve PAP usage and reduce CPAP-induced rhinitis symptoms. Further recruitment is underway to confirm these results (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Wongchan, R., Tepwimonpetkun, C., Kitsongsermthon, J., Sapankaew, T., Yotsombut, K., Chittiwan, W. Tags: Clinical and epidemiological respiratory sleep medicine Source Type: research

Inflammatory phenotype categorized by proximal and distal airway in patients with stable asthma
Conclusions: The classification categorized by proximal and distal airway inflammation may reflect distinct clinical features in patients with adult stable asthma. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Fukumitsu, K., Kanemitsu, Y., Ito, K., Nishiyama, H., Tajiri, T., Mori, Y., Fukuda, S., Uemura, T., Ohkubo, H., Maeno, K., Ito, Y., Oguri, T., Takemura, M., Niimi, A. Tags: Monitoring airway disease Source Type: research

The ERS CRC Severe Paediatric Asthma Collaborative in Europe: asthma control in Children on Biologics
Conclusions: Most children with severe asthma obtain good asthma control and quality of life on biologics, although some remain uncontrolled and may need other or new biologics. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Liu, N. M., Pijnenburg, M. W. H., Deschildre, A., Carraro, S., Fenu, G., Ferraro, V., Fleming, L. L., Hanssens, L., Licardi, A., Lombardi, E., Valverde Molina, J., Vierhout, A., De Mir, I., Rusconi, F. Tags: Paediatric asthma and allergy Source Type: research

Adherence to single and multiple inhaler triple therapies among patients with COPD in the real world in Japan
Conclusions: Patients with COPD in Japan newly initiating SITT have statistically significantly better adherence compared with patients initiating MITT.Funding: GSK (217615) (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Joksaite, S., Wood, R. P., Mizukami, A., Camidge, L. J., Czira, A., Jennison, T., Ishii, T., Massey, O., Hashimoto, K., Siddiqui, R., Yarita, M., Compton, C., Sharma, R., Ismaila, A. S., Rothnie, K. J. Tags: Airway pharmacology and treatment Source Type: research

Characteristics and treatment pathways of COPD patients initiating single-inhaler dual or triple therapy in England
Conclusions: New users of FF/UMEC/VI were more breathless, had worse lung function and more prior exacerbations at therapy initiation than new users of single-inhaler dual therapies in England. ICS/LABA and LAMA/LABA single-inhaler new users mostly stepped up from ICS and LAMA monotherapy, respectively, or were initial maintenance therapy users, whilst most FF/UMEC/VI new users switched from prior MITT use.Funding: GSK 2145933 (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Noorduyn, S. G., Wood, R. P., Rothnie, K. J., Rai, K. K., Seif, M., Massey, L., Compton, C., Ismaila, A. S. Tags: Airway pharmacology and treatment Source Type: research

The effect of different inhaled corticosteroids on airway bacterial load and the microbiome in COPD: a randomized controlled trial
Conclusion: Patients randomized to fluticasone/salmeterol at licensed doses had an increased bacterial load in sputum over time compared to budesonide/formoterol. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Richardson, H., Keir, H. R., Clarke, C., Alferes De Lima, D., Veluchamy, A., Rauchhaus, P., Pembridge, T., Crichton, M., Pollock, J., Finch, S., Dicker, A. J., Billingham, P., Hussain, F., Band, M., Smith, A., Patel, M., Paracha, M., Choudhury, G., Dhasma Tags: Airway pharmacology and treatment Source Type: research