B- and T-cell lymphocytes and other immune cell infiltration in the duodenal and rectal mucosa of severe asthmatic horses
The objectives of this study were to quantify lymphocytes and eosinophils in the mucosa of the duodenum and rectum in asthmatic horses.ANIMALS: 8 healthy and 10 asthmatic horses.PROCEDURES: Asthmatic horses were evaluated in a symptomatic (after 6 weeks of exposure to moldy hay) and asymptomatic status (3 and 7 months after being fed alfalfa pellets [n = 4] or treated with inhaled fluticasone [6]). Duodenal and rectal biopsies were endoscopically (n = 4 to 6) taken in each horse. Eosinophils were counted on slides stained with hematoxylin, eosin, phloxine, and saffron, and immunohistochemistry was used to evaluate T and B ...
Source: Cell Research - August 2, 2023 Category: Cytology Authors: C éline Loubière Peggy Moreau Rullier Marine Pierre H élie Daniel Jean Source Type: research
B- and T-cell lymphocytes and other immune cell infiltration in the duodenal and rectal mucosa of severe asthmatic horses
The objectives of this study were to quantify lymphocytes and eosinophils in the mucosa of the duodenum and rectum in asthmatic horses.ANIMALS: 8 healthy and 10 asthmatic horses.PROCEDURES: Asthmatic horses were evaluated in a symptomatic (after 6 weeks of exposure to moldy hay) and asymptomatic status (3 and 7 months after being fed alfalfa pellets [n = 4] or treated with inhaled fluticasone [6]). Duodenal and rectal biopsies were endoscopically (n = 4 to 6) taken in each horse. Eosinophils were counted on slides stained with hematoxylin, eosin, phloxine, and saffron, and immunohistochemistry was used to evaluate T and B ...
Source: American Journal of Veterinary Research - August 2, 2023 Category: Veterinary Research Authors: C éline Loubière Peggy Moreau Rullier Marine Pierre H élie Daniel Jean Source Type: research
LABA/LAMA versus LABA/ICS fixed-dose combinations in the prevention of COPD exacerbations: a modeling analysis of literature aggregate data
ConclusionsThis study showed that not all LABA/LAMA FDCs were superior to LABA/ICS FDCs in safety and in preventing moderate or severe exacerbations in patients with stable COPD, providing important quantitative information for COPD-related guidelines. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - July 29, 2023 Category: Drugs & Pharmacology Source Type: research
Budget Impact Analysis of Single-Inhaler Fluticasone Furoate/Umeclidinium/Vilanterol in Patients with Asthma in the Dubai Academic Healthcare Corporation
(Source: ClinicoEconomics and Outcomes Research)
Source: ClinicoEconomics and Outcomes Research - July 13, 2023 Category: Health Management Tags: ClinicoEconomics and Outcomes Research Source Type: research
A steroid ‐resistant cockroach allergen model is associated with lung and cecal microbiome changes
AbstractThe pathogenesis of asthma has been partially linked to lung and gut microbiome. We utilized a steroid-resistant chronic model of cockroach antigen-induced (CRA) asthma with corticosteroid (fluticasone) treatment to examine lung and gut microbiome during disease. The pathophysiology assessment demonstrated that mucus and airway hyperresponsiveness were increased in the chronic CRA with no alteration in the fluticasone (Flut)-treated group, demonstrating steroid resistance. Analysis of mRNA from lungs showed no decrease of MUC5AC or Gob5 in the Flut-treated group. Furthermore, flow-cytometry in lung tissue showed eo...
Source: Physiological Reports - July 5, 2023 Category: Physiology Authors: Nobuhiro Asai,
Alexander D. Ethridge,
Wendy Fonseca,
Kazuma Yagi,
Andrew J. Rasky,
Susan B. Morris,
Nicole R. Falkowski,
Yvonne J. Huang,
Gary B. Huffnagle,
Nicholas W. Lukacs Tags: ORIGINAL ARTICLE Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research
