Upper Respiratory Tract OC43 Infection Model for Investigating Airway Immune-modifying Therapies
Am J Respir Cell Mol Biol. 2023 Aug 21. doi: 10.1165/rcmb.2023-0202MA. Online ahead of print.ABSTRACTRespiratory virus infections initiate and transmit from the upper respiratory tract (URT). Coronaviruses, including OC43, are a major cause of respiratory infection and disease. Failure to mount an effective anti-viral immune response in the nasal mucosa increases the risk of severe disease and person to person transmission highlighting the need for URT infection models to support development of nasal treatments that improve coronavirus anti-viral immunity. We aimed to determine if OC43 productively infected the mouse URT a...
Source: American Journal of Respiratory Cell and Molecular Biology - August 21, 2023 Category: Molecular Biology Authors: Jason L N Girkin Nathan E Bryant Su-Ling Loo Alan Hsu Amama Kanwal Teresa C Williams Steven Maltby Stuart G Turville Peter A B Wark Nathan W Bartlett Source Type: research

Upper Respiratory Tract OC43 Infection Model for Investigating Airway Immune-modifying Therapies
Am J Respir Cell Mol Biol. 2023 Aug 21. doi: 10.1165/rcmb.2023-0202MA. Online ahead of print.ABSTRACTRespiratory virus infections initiate and transmit from the upper respiratory tract (URT). Coronaviruses, including OC43, are a major cause of respiratory infection and disease. Failure to mount an effective anti-viral immune response in the nasal mucosa increases the risk of severe disease and person to person transmission highlighting the need for URT infection models to support development of nasal treatments that improve coronavirus anti-viral immunity. We aimed to determine if OC43 productively infected the mouse URT a...
Source: Am J Respir Cell Mol... - August 21, 2023 Category: Respiratory Medicine Authors: Jason L N Girkin Nathan E Bryant Su-Ling Loo Alan Hsu Amama Kanwal Teresa C Williams Steven Maltby Stuart G Turville Peter A B Wark Nathan W Bartlett Source Type: research

Upper Respiratory Tract OC43 Infection Model for Investigating Airway Immune-modifying Therapies
Am J Respir Cell Mol Biol. 2023 Aug 21. doi: 10.1165/rcmb.2023-0202MA. Online ahead of print.ABSTRACTRespiratory virus infections initiate and transmit from the upper respiratory tract (URT). Coronaviruses, including OC43, are a major cause of respiratory infection and disease. Failure to mount an effective anti-viral immune response in the nasal mucosa increases the risk of severe disease and person to person transmission highlighting the need for URT infection models to support development of nasal treatments that improve coronavirus anti-viral immunity. We aimed to determine if OC43 productively infected the mouse URT a...
Source: Mol Biol Cell - August 21, 2023 Category: Molecular Biology Authors: Jason L N Girkin Nathan E Bryant Su-Ling Loo Alan Hsu Amama Kanwal Teresa C Williams Steven Maltby Stuart G Turville Peter A B Wark Nathan W Bartlett Source Type: research

Upper Respiratory Tract OC43 Infection Model for Investigating Airway Immune-modifying Therapies
Am J Respir Cell Mol Biol. 2023 Aug 21. doi: 10.1165/rcmb.2023-0202MA. Online ahead of print.ABSTRACTRespiratory virus infections initiate and transmit from the upper respiratory tract (URT). Coronaviruses, including OC43, are a major cause of respiratory infection and disease. Failure to mount an effective anti-viral immune response in the nasal mucosa increases the risk of severe disease and person to person transmission highlighting the need for URT infection models to support development of nasal treatments that improve coronavirus anti-viral immunity. We aimed to determine if OC43 productively infected the mouse URT a...
Source: American Journal of Respiratory Cell and Molecular Biology - August 21, 2023 Category: Molecular Biology Authors: Jason L N Girkin Nathan E Bryant Su-Ling Loo Alan Hsu Amama Kanwal Teresa C Williams Steven Maltby Stuart G Turville Peter A B Wark Nathan W Bartlett Source Type: research

Mortality risk reduction with budesonide/glycopyrrolate/formoterol fumarate versus fluticasone furoate/umeclidinium/vilanterol in COPD: a matching-adjusted indirect comparison based on ETHOS and IMPACT
CONCLUSION: In this MAIC, which adjusted for population heterogeneity between ETHOS and IMPACT, ACM was significantly reduced with BGF versus FF/UMEC/VI in patients with moderate-to-very severe COPD.PMID:37583267 | DOI:10.1080/03007995.2023.2247969 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - August 16, 2023 Category: Research Authors: Daiana Stolz Erik Hermansson Mario Ouwens Barinder Singh Akanksha Sharma Dan Jackson Patrick Darken Jonathan Marshall Karin Bowen Hana M üllerová Bernardino Alc ázar Navarrete Richard Russell MeiLan K Han Deniz Tansey-Dwyer Source Type: research

A comparative study of human and zebrafish glucocorticoid receptor activities of natural and pharmaceutical steroids
IntroductionThe action of environmental steroids on the human glucocorticoid receptor (hGR) has been pointed out with the risk to impair physiological immune and metabolic processes regulated by this nuclear receptor. However, there is still a lack of mechanistic information regarding their ability to interact with GR in aquatic species.MethodsTo investigate ligand activation differences between hGR and zebrafish GR (zfGR), we tested several natural and synthetic steroids using reporter cell lines expressing hGR or zfGR.Results and discussionAlmost all the glucocorticoids tested (dexamethasone, cortisol, bimedrazol, medrol...
Source: Frontiers in Endocrinology - August 15, 2023 Category: Endocrinology Source Type: research

The Effect of Warm Acupuncture on EOS, IgE, Inflammatory Factors, and T Lymphocyte Subsets in Patients with Allergic Rhinitis of Lung Qi Deficiency and Cold-Type
CONCLUSION: Warming needle therapy can effectively improve the clinical symptoms of patients with lung qi deficiency and cold-type AR, reduce inflammation, and enhance immune function.PMID:37573600 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - August 13, 2023 Category: Complementary Medicine Authors: Dunpo Sun Mingxiao Jiang Meng Lu Xiaomin Ma Guochao Shang Yisong Wang Source Type: research

The Effect of Warm Acupuncture on EOS, IgE, Inflammatory Factors, and T Lymphocyte Subsets in Patients with Allergic Rhinitis of Lung Qi Deficiency and Cold-Type
CONCLUSION: Warming needle therapy can effectively improve the clinical symptoms of patients with lung qi deficiency and cold-type AR, reduce inflammation, and enhance immune function.PMID:37573600 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - August 13, 2023 Category: Complementary Medicine Authors: Dunpo Sun Mingxiao Jiang Meng Lu Xiaomin Ma Guochao Shang Yisong Wang Source Type: research

The Effect of Warm Acupuncture on EOS, IgE, Inflammatory Factors, and T Lymphocyte Subsets in Patients with Allergic Rhinitis of Lung Qi Deficiency and Cold-Type
CONCLUSION: Warming needle therapy can effectively improve the clinical symptoms of patients with lung qi deficiency and cold-type AR, reduce inflammation, and enhance immune function.PMID:37573600 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - August 13, 2023 Category: Complementary Medicine Authors: Dunpo Sun Mingxiao Jiang Meng Lu Xiaomin Ma Guochao Shang Yisong Wang Source Type: research

The Effect of Warm Acupuncture on EOS, IgE, Inflammatory Factors, and T Lymphocyte Subsets in Patients with Allergic Rhinitis of Lung Qi Deficiency and Cold-Type
CONCLUSION: Warming needle therapy can effectively improve the clinical symptoms of patients with lung qi deficiency and cold-type AR, reduce inflammation, and enhance immune function.PMID:37573600 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - August 13, 2023 Category: Complementary Medicine Authors: Dunpo Sun Mingxiao Jiang Meng Lu Xiaomin Ma Guochao Shang Yisong Wang Source Type: research

The Effect of Warm Acupuncture on EOS, IgE, Inflammatory Factors, and T Lymphocyte Subsets in Patients with Allergic Rhinitis of Lung Qi Deficiency and Cold-Type
CONCLUSION: Warming needle therapy can effectively improve the clinical symptoms of patients with lung qi deficiency and cold-type AR, reduce inflammation, and enhance immune function.PMID:37573600 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - August 13, 2023 Category: Complementary Medicine Authors: Dunpo Sun Mingxiao Jiang Meng Lu Xiaomin Ma Guochao Shang Yisong Wang Source Type: research

The Effect of Warm Acupuncture on EOS, IgE, Inflammatory Factors, and T Lymphocyte Subsets in Patients with Allergic Rhinitis of Lung Qi Deficiency and Cold-Type
CONCLUSION: Warming needle therapy can effectively improve the clinical symptoms of patients with lung qi deficiency and cold-type AR, reduce inflammation, and enhance immune function.PMID:37573600 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - August 13, 2023 Category: Complementary Medicine Authors: Dunpo Sun Mingxiao Jiang Meng Lu Xiaomin Ma Guochao Shang Yisong Wang Source Type: research

The Effect of Warm Acupuncture on EOS, IgE, Inflammatory Factors, and T Lymphocyte Subsets in Patients with Allergic Rhinitis of Lung Qi Deficiency and Cold-Type
CONCLUSION: Warming needle therapy can effectively improve the clinical symptoms of patients with lung qi deficiency and cold-type AR, reduce inflammation, and enhance immune function.PMID:37573600 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - August 13, 2023 Category: Complementary Medicine Authors: Dunpo Sun Mingxiao Jiang Meng Lu Xiaomin Ma Guochao Shang Yisong Wang Source Type: research

The Effect of Warm Acupuncture on EOS, IgE, Inflammatory Factors, and T Lymphocyte Subsets in Patients with Allergic Rhinitis of Lung Qi Deficiency and Cold-Type
CONCLUSION: Warming needle therapy can effectively improve the clinical symptoms of patients with lung qi deficiency and cold-type AR, reduce inflammation, and enhance immune function.PMID:37573600 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - August 13, 2023 Category: Complementary Medicine Authors: Dunpo Sun Mingxiao Jiang Meng Lu Xiaomin Ma Guochao Shang Yisong Wang Source Type: research