Greenness assessment of two chromatographic methods developed for the determination of Mupirocin in two binary mixtures along with its impurity
Two simple, accurate and precise chromatographic methods have been developed and validated for estimating Mupirocin (MUP) in two binary mixtures. Mixture (1); with Fluticasone propionate (FLU) together with tw... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - October 27, 2023 Category: Chemistry Authors: Maha M. Galal, Shaaban A. Abdullah, Ola Y. Mohamed and Azza A. Moustafa Tags: Research Source Type: research
The efficiency of azelastine hydrochloride and fluticasone propionate nasal spray to improve PAP adherence in patients with obstructive sleep apnea
Conclusion: The preliminary findings of this study evaluating the effectiveness of azelastine hydrochloride and fluticasone propionate nasal spray in enhancing PAP adherence indicate that this combination may improve PAP usage and reduce CPAP-induced rhinitis symptoms. Further recruitment is underway to confirm these results (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Wongchan, R., Tepwimonpetkun, C., Kitsongsermthon, J., Sapankaew, T., Yotsombut, K., Chittiwan, W. Tags: Clinical and epidemiological respiratory sleep medicine Source Type: research
Inflammatory phenotype categorized by proximal and distal airway in patients with stable asthma
Conclusions: The classification categorized by proximal and distal airway inflammation may reflect distinct clinical features in patients with adult stable asthma. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Fukumitsu, K., Kanemitsu, Y., Ito, K., Nishiyama, H., Tajiri, T., Mori, Y., Fukuda, S., Uemura, T., Ohkubo, H., Maeno, K., Ito, Y., Oguri, T., Takemura, M., Niimi, A. Tags: Monitoring airway disease Source Type: research
The ERS CRC Severe Paediatric Asthma Collaborative in Europe: asthma control in Children on Biologics
Conclusions: Most children with severe asthma obtain good asthma control and quality of life on biologics, although some remain uncontrolled and may need other or new biologics. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Liu, N. M., Pijnenburg, M. W. H., Deschildre, A., Carraro, S., Fenu, G., Ferraro, V., Fleming, L. L., Hanssens, L., Licardi, A., Lombardi, E., Valverde Molina, J., Vierhout, A., De Mir, I., Rusconi, F. Tags: Paediatric asthma and allergy Source Type: research
Adherence to single and multiple inhaler triple therapies among patients with COPD in the real world in Japan
Conclusions: Patients with COPD in Japan newly initiating SITT have statistically significantly better adherence compared with patients initiating MITT.Funding: GSK (217615) (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Joksaite, S., Wood, R. P., Mizukami, A., Camidge, L. J., Czira, A., Jennison, T., Ishii, T., Massey, O., Hashimoto, K., Siddiqui, R., Yarita, M., Compton, C., Sharma, R., Ismaila, A. S., Rothnie, K. J. Tags: Airway pharmacology and treatment Source Type: research
Characteristics and treatment pathways of COPD patients initiating single-inhaler dual or triple therapy in England
Conclusions: New users of FF/UMEC/VI were more breathless, had worse lung function and more prior exacerbations at therapy initiation than new users of single-inhaler dual therapies in England. ICS/LABA and LAMA/LABA single-inhaler new users mostly stepped up from ICS and LAMA monotherapy, respectively, or were initial maintenance therapy users, whilst most FF/UMEC/VI new users switched from prior MITT use.Funding: GSK 2145933 (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Noorduyn, S. G., Wood, R. P., Rothnie, K. J., Rai, K. K., Seif, M., Massey, L., Compton, C., Ismaila, A. S. Tags: Airway pharmacology and treatment Source Type: research
The effect of different inhaled corticosteroids on airway bacterial load and the microbiome in COPD: a randomized controlled trial
Conclusion: Patients randomized to fluticasone/salmeterol at licensed doses had an increased bacterial load in sputum over time compared to budesonide/formoterol. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Richardson, H., Keir, H. R., Clarke, C., Alferes De Lima, D., Veluchamy, A., Rauchhaus, P., Pembridge, T., Crichton, M., Pollock, J., Finch, S., Dicker, A. J., Billingham, P., Hussain, F., Band, M., Smith, A., Patel, M., Paracha, M., Choudhury, G., Dhasma Tags: Airway pharmacology and treatment Source Type: research
Effect of inhalation formulation on symptoms and impulse oscillometry indices in teen-aged asthmatics
Conclusion: In asthmatic patients with mild symptoms despite of the chronic bronchial obstruction the intervention with the ICS/LABA did not improve small airways indices significantly. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Tanninen, T., Pelkonen, A., Malmberg, P., Mäkelä, M. Tags: Paediatric asthma and allergy Source Type: research
Relating Type 2 status to steroid exposure, cytokine expression and symptoms
T2 low asthma remains poorly understood even though it may account for up to 50% of patients.We aimed to characterise the inflammatory signature and symptom burden in T2 low patients and relate T2 status to corticosteroid exposure.We evaluated 200 patients’ T2 status from the INCA-SUN RCT over 6 visits. Four groups were identified based on frequency of T2 inflammation: Consistently T2 low (n=40), Usually T2 low (n=48), Usually T2 high (n=64) and Consistently T2 high (n=48). Inhaled (ICS) and oral corticosteroid burden (OCS) were measured by digital inhaler monitors and pharmacy records. Multiplex assays of inflammato...
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Brennan, V., Mulvey, C., Lombard, L., Mac Hale, E., Kerr, P., Greene, G., Costello, R. Tags: Airway cell biology and immunopathology Source Type: research
Recognizing asthma risk scenarios: individualized inhaler usage and inhalation parameter profiles from an electronic inhaler with integrated sensors
Conclusions: Objective data from the DS offer opportunities to identify individual asthma patients with elevated risk of adverse asthma outcomes. Real-time identification of these high-risk patterns may allow clinicians and patients to intervene early and prevent future asthma exacerbations. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Levy, M. L., Hoyte, F., Mosnaim, G., Wechsler, M., Safioti, G., Magnus, N., Sagalovich, K., Bosnic-Anticevich, S., Kocks, J. Tags: Monitoring airway disease Source Type: research
Characteristics of patients with asthma using single inhaler triple therapy (SITT) in the USA
Conclusions: Differences in baseline clinical characteristics were noted between TT100/200 groups, with older and more severe patients initiating high dose FF/UMEC/VI.Funding: GSK (217417) (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Noorduyn, S. G., Kahle-Wrobleski, K., Paczkowski, R., Lee, L., Veeranki, P., Johnson, M., Ismaila, A. S., Igboekwe, E., Nack, J., Gronroos, N. N. Tags: Airway pharmacology and treatment Source Type: research
Heterogeneous treatment effect estimation of LABA/LAMA/ICS on COPD exacerbation risk in the IMPACT trial
We aimed to identify heterogeneity in the treatment effect of triple therapy (LABA/LAMA/ICS) compared to dual therapy (LABA/LAMA) for COPD exacerbation risk.We used data from subjects in the fluticasone furoate/umeclidinium/vilanterol (FF/U/V, n=3989) and U/V (n=2001) arms in the IMPACT trial (NCT02164513). Subjects were split (70:30) in a training (n=4193) and independent test set (n=1797). We applied survival analysis on time-to-first exacerbation and compared Cox proportional hazards model (CPH, one model for both arms) with machine learning model Random Survival Forest (RSF, one model for each arm). The models were tra...
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Verstraete, K., Gyselinck, I., Huts, H., De Vos, M., Janssens, W. Tags: Airway pharmacology and treatment Source Type: research
Economic benefit of fluticasone furoate (FF)/umeclidinium (UMEC)/vilanterol (VI) by baseline blood eosinophil (EOS) count in COPD in the UK - The IMPACT trial
Conclusions: FF/UMEC/VI is expected to be a cost-effective treatment option for COPD patients in the UK, irrespective of baseline blood EOS count.Funding: GSK 206973 (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Ismaila, A. S., Shah, D., Martin, A., Kendall, R., Noorduyn, S. G., Dasari, P., Risebrough, N. A., Compton, C., Noorduyn, S. G. Tags: Airway pharmacology and treatment Source Type: research
Characteristics of COPD patients initiating budesonide/glycopyrronium/formoterol (BGF) and other triple therapy in Japan: a health-care claims-based real-world database study (MITOS program)
Conclusions: The proportion of asthma+COPD patients was high among those initiating TT, especially MITT. Patients using BGF in the first 12 months after market approval had a higher history of exacerbations. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Takahashi, K., Makita, N., Castaneda, J., Argoubi, R., Nowacki, G., Issa, S., Matsumoto, I., Yoshida, Y., Mullerova, H. Tags: Airway pharmacology and treatment Source Type: research
Serum inhaled corticosteroid levels in patients with severe asthma.
There are no robust methods of assessing compliance to inhaled corticosteroid (ICS) therapy. Medication possession ratio calculated based on dispensed prescriptions is often used but does not account for whether the medication was taken, and if so correctly. We explored the feasibility of measuring serum ICS levels in patients with severe asthma on biologics.Patients with severe asthma approved for mepolizumab were invited. Patients were instructed to withhold their ICS on the morning of the first visit for spirometry, but to continue their prescribed ICS for the remainder of the study. Serum was taken approximately four h...
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Pang, Y. L., Ali, M., Fowler, S. J., Keevil, B., Mckeever, T., Sayers, I., Shaw, D. E. Tags: Airway pharmacology and treatment Source Type: research
