Quantification of fluticasone propionate in human plasma by LC-MS/MS and its application in the pharmacokinetic study of nasal spray at clinical doses
Drug Metab Pharmacokinet. 2023 Dec 11;54:100541. doi: 10.1016/j.dmpk.2023.100541. Online ahead of print.ABSTRACTWe developed a method for quantifying fluticasone propionate (FP) using general-purpose liquid chromatography-tandem mass spectrometry equipment to measure the plasma concentration of FP for the pharmacokinetic study of FP following the administration of a prescribed nasal spray dose (100 μg). Using ammonium acetate (0.01 M)-formic acid (pH 2.9; 499:1, v/v) and methanol as the mobile phase, 3 pg/mL of FP was quantified. The relative error and standard deviation of the lower limit of quantification were <3.1%....
Source: Drug Metabolism and Pharmacokinetics - December 27, 2023 Category: Drugs & Pharmacology Authors: Aya Yamagata Rena Adachi Akitomo Yokokawa Tomomi Furihata Hiromi Shibasaki Source Type: research
Quantification of fluticasone propionate in human plasma by LC-MS/MS and its application in the pharmacokinetic study of nasal spray at clinical doses
Drug Metab Pharmacokinet. 2024 Feb;54:100541. doi: 10.1016/j.dmpk.2023.100541. Epub 2023 Dec 11.ABSTRACTWe developed a method for quantifying fluticasone propionate (FP) using general-purpose liquid chromatography-tandem mass spectrometry equipment to measure the plasma concentration of FP for the pharmacokinetic study of FP following the administration of a prescribed nasal spray dose (100 μg). Using ammonium acetate (0.01 M)-formic acid (pH 2.9; 499:1, v/v) and methanol as the mobile phase, 3 pg/mL of FP was quantified. The relative error and standard deviation of the lower limit of quantification were <3.1%. The int...
Source: Drug Metabolism and Pharmacokinetics - December 27, 2023 Category: Drugs & Pharmacology Authors: Aya Yamagata Rena Adachi Akitomo Yokokawa Tomomi Furihata Hiromi Shibasaki Source Type: research
Topical and oral steroids for otitis media with effusion (OME) in children
CONCLUSIONS: Overall, oral steroids may have little effect in the treatment of OME, with little improvement in the number of children with normal hearing and no effect on quality of life. There may be a reduction in the proportion of children with persistent disease after 12 months. However, this benefit may be small and must be weighed against the potential for adverse effects associated with oral steroid use. The evidence for nasal steroids was all low- or very low-certainty. It is therefore less clear if nasal steroids have any impact on hearing, quality of life or persistence of OME. Evidence on adverse effects was ver...
Source: Cochrane Database of Systematic Reviews - December 13, 2023 Category: General Medicine Authors: Caroline A Mulvaney Kevin Galbraith Katie E Webster Mridul Rana Rachel Connolly Ben Tudor-Green Tal Marom Mat Daniel Roderick P Venekamp Anne Gm Schilder Samuel MacKeith Source Type: research
