Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research

Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research

Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research

Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research

Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research

Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research

Formulation Studies and Application of Their Experimental Techniques to Drug Discoveries
Yakugaku Zasshi. 2023;143(7):581-598. doi: 10.1248/yakushi.23-00014.ABSTRACTIn my first experience as a researcher, I isolated and performed structural predictions of the novel compounds, cis- and trans-palythenic acids, from Noctiluca milialis. I then worked for a pharmaceutical company in a research laboratory of pharmaceutics. I examined an inclusion complex of cinnarizine with β-cyclodextrin, and found that the inclusion complex did not improve the oral bioavailability of cinnarizine. However, the bioavailability of the inclusion complex after its oral administration was improved by a competing agent. This was the fir...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2023 Category: Drugs & Pharmacology Authors: Tadakazu Tokumura Source Type: research

Acitretin/fluticasone-propionate/sars-cov-2-vaccine-inactivated-sinovac-biotech
(Source: Reactions Weekly)
Source: Reactions Weekly - July 1, 2023 Category: Drugs & Pharmacology Source Type: research

The Comparative Bioavailability of Fluticasone and Azelastine Delivered as a Single Fixed Dose Combination (MP-AzeFlu) in Comparison to Two Different Formulations of Azelastine and Fluticasone Propionate Following Intranasal Administration in Healthy Chinese Volunteers
(Source: Journal of Asthma and Allergy)
Source: Journal of Asthma and Allergy - June 30, 2023 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research

DElaying Disease Progression In COPD with Early Initiation of Dual Bronchodilator or Triple Inhaled PharmacoTherapy (DEPICT): A Predictive Modelling Approach
CONCLUSIONS: This modelling study suggests that earlier initiation of LAMA/LABA or triple therapy may have positive benefits in slowing disease progression in patients with COPD. Greater benefits were demonstrated with early initiation therapy with triple versus LAMA/LABA.PMID:37382864 | DOI:10.1007/s12325-023-02583-1 (Source: Adv Data)
Source: Adv Data - June 29, 2023 Category: Epidemiology Authors: Dave Singh Diego Litewka Rafael P áramo Adrian Rendon Abdullah Sayiner Suzana E Tanni Sudeep Acharya Bhumika Aggarwal Afisi S Ismaila Raj Sharma Peter Daley-Yates Source Type: research

Clinic versus home spirometry for monitoring lung function in patients with asthma
Chest. 2023 Jun 27:S0012-3692(23)00935-2. doi: 10.1016/j.chest.2023.06.029. Online ahead of print.ABSTRACTBACKGROUND: Studies examining agreement between home and clinic spirometry in patients with asthma are limited, with conflicting results. Understanding the strengths and limitations of telehealth and home spirometry is particularly important considering the SARS-CoV-2 pandemic.RESEARCH QUESTION: How well do home and clinic measurements of trough forced expiratory volume in 1 second (FEV1) agree in patients with uncontrolled asthma?STUDY DESIGN AND METHODS: This post hoc analysis used trough FEV1 data from the randomise...
Source: Chest - June 29, 2023 Category: Respiratory Medicine Authors: John Oppenheimer Nicola A Hanania Rekha Chaudhuri Hironori Sagara Zelie Bailes Andrew Fowler Guy Peachey Emilio Pizzichini David Slade Source Type: research

DElaying Disease Progression In COPD with Early Initiation of Dual Bronchodilator or Triple Inhaled PharmacoTherapy (DEPICT): A Predictive Modelling Approach
CONCLUSIONS: This modelling study suggests that earlier initiation of LAMA/LABA or triple therapy may have positive benefits in slowing disease progression in patients with COPD. Greater benefits were demonstrated with early initiation therapy with triple versus LAMA/LABA.PMID:37382864 | DOI:10.1007/s12325-023-02583-1 (Source: Adv Data)
Source: Adv Data - June 29, 2023 Category: Epidemiology Authors: Dave Singh Diego Litewka Rafael P áramo Adrian Rendon Abdullah Sayiner Suzana E Tanni Sudeep Acharya Bhumika Aggarwal Afisi S Ismaila Raj Sharma Peter Daley-Yates Source Type: research

Clinic versus home spirometry for monitoring lung function in patients with asthma
Chest. 2023 Jun 27:S0012-3692(23)00935-2. doi: 10.1016/j.chest.2023.06.029. Online ahead of print.ABSTRACTBACKGROUND: Studies examining agreement between home and clinic spirometry in patients with asthma are limited, with conflicting results. Understanding the strengths and limitations of telehealth and home spirometry is particularly important considering the SARS-CoV-2 pandemic.RESEARCH QUESTION: How well do home and clinic measurements of trough forced expiratory volume in 1 second (FEV1) agree in patients with uncontrolled asthma?STUDY DESIGN AND METHODS: This post hoc analysis used trough FEV1 data from the randomise...
Source: Chest - June 29, 2023 Category: Respiratory Medicine Authors: John Oppenheimer Nicola A Hanania Rekha Chaudhuri Hironori Sagara Zelie Bailes Andrew Fowler Guy Peachey Emilio Pizzichini David Slade Source Type: research

Experimental drugs in clinical trials for COPD: Artificial Intelligence via Machine Learning approach to predict the successful advance from early-stage development to approval
Expert Opin Investig Drugs. 2023 Jun 26. doi: 10.1080/13543784.2023.2230138. Online ahead of print.ABSTRACTINTRODUCTION: Therapeutic advances in drug therapy of chronic obstructive pulmonary disease (COPD) really effective in suppressing the pathological processes underlying the disease deterioration are still needed. Artificial Intelligence (AI) via Machine Learning (ML) may represent an effective tool to predict clinical development of investigational agents.AREAL COVERED: Experimental drugs in Phase I and II development for COPD from early 2014 to late 2022 were identified in the ClinicalTrials.gov database. Different M...
Source: Expert Opinion on Investigational Drugs - June 26, 2023 Category: Drugs & Pharmacology Authors: Luigino Calzetta Elena Pistocchini Alfredo Chetta Paola Rogliani Mario Cazzola Source Type: research