Anti-Acanthamoeba metallopharmaceuticals: Amoebicidal activity and synergistic effect of copper(II) coordination compound
This study evaluates the amoebicidal activity of copper(II) coordination compounds in combination with chlorhexidine and the cytotoxicity to topical ocular application. These copper(II) coordination compounds were screened against Acanthamoeba castellanii trophozoites (ATCC 50492). The cytotoxicity on rabbit corneal cell line (ATCC-CCL 60) was performed. The compounds showed high amoebicidal potential, with inhibition of trophozoite viability above 80%. The Cp12 and Cp13 compounds showed Minimal Inhibitory Amoebicidal Concentration (MIAC) at 200 µM and mean inhibitory concentration (IC50) values lower than 10 µM. Against...
Source: Biometals - April 22, 2024 Category: Biochemistry Authors: Jaqueline da Silveira Ana Paula Cardoso Christiane Fernandes Adolfo Horn Junior Gabriella da Rosa Monte Machado Karin Silva Caumo Source Type: research
Clinical Outcomes of A New Hydrophobic Trifocal Intraocular Lens with Hydroxyethyl Methacrylate in Cataract Surgery: A Prospective Multicenter Study
CONCLUSIONS: The Clareon PanOptix IOL has shown positive clinical outcomes, providing a viable option for cataract surgery. These lenses effectively address patients' visual needs, especially in intermediate and near distance tasks, reducing dependence on glasses.PMID:38644651 | DOI:10.3341/kjo.2023.0140 (Source: Korean Journal of Ophthalmology : KJO)
Source: Korean Journal of Ophthalmology : KJO - April 22, 2024 Category: Opthalmology Authors: Eunhui Jo Bokyung Kim Tae-Im Kim Mee Kum Kim Chul Young Choi Source Type: research
A PAX3 insertion in the Celestial breed and certain feline breeding lines with dominant blue eyes
Anim Genet. 2024 Apr 22. doi: 10.1111/age.13433. Online ahead of print.ABSTRACTDuring the last 60 years many inherited traits in domestic outbred cats were selected and retained giving birth to new breeds characterised by singular coat or morphological phenotypes. Among them, minimal white spotting associated with blue eyes was selected by feline breeders to create the Altai, Topaz, and Celestial breeds. Various established breeds also introduced this trait in their lineages. The trait, that was confirmed as autosomal dominant by breeding data, was first described in domestic cats from Kazakhstan and Russia, in British sho...
Source: Animal Genetics - April 22, 2024 Category: Genetics & Stem Cells Authors: Marie Abitbol Alice Couronn é Caroline Dufaure de Citres Vincent Gache Source Type: research
Characterization of central-involved diabetic macular edema using OCT and OCTA
CONCLUSIONS: CI-DME and CSME appear to represent different entities. Eyes with CI-DME show increases in abnormal retinal fluid associated with increased retinal vascular perfusion in the DCP. Eyes with CSME are apparently associated with decreased retinal vascular perfusion in the DCP and abnormal fluid in the outer retina.PMID:38644796 | DOI:10.1177/11206721241248478 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - April 22, 2024 Category: Opthalmology Authors: D ébora Reste-Ferreira Torcato Santos In ês Pereira Marques Maria Lu ísa Ribeiro Ana Rita Santos Ant ónio Cunha-Vaz Martinho Concei ção Lobo Jos é Cunha-Vaz Source Type: research
Atypical case of choroidal osteoma associated to polypoidal choroidal vasculopathy and preretinal neovascular membrane
CONCLUSION: Our case report represents an exceptional and atypical association between pre-retinal neovascularization, PCV and choroidal osteoma. While the mechanisms underlying the development of PCV and pre-retinal neovascularization in the setting of CO are not well understood, it is imperative for ophthalmologists to recognize this association as a potential cause of sudden vision loss in patients with CO, and to consider appropriate diagnostic and management strategies.PMID:38644785 | DOI:10.1177/11206721241249218 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - April 22, 2024 Category: Opthalmology Authors: Mohamed Ben Brahem Khaled El Matri Yousra Fafloul Amel Chebbi Olfa Fekih Leila Nacef Leila El Matri Source Type: research
Anterior transposition of the inferior oblique and anti-elevation syndrome - how far to go?
Conclusions: The anterior transposition of the inferior oblique with "J" deformity increases the risk of anti-elevation syndrome. Additionally, placing the sutures more anteriorly than 2 mm posterior to the inferior rectus insertion increases the incidence of this finding.PMID:38647121 | DOI:10.1080/09273972.2024.2338790 (Source: Strabismus)
Source: Strabismus - April 22, 2024 Category: Research Authors: Ana Let ícia Fornazieri Darcie Iara Debert Rachel Oliveira de Assis Bernardes Mariana Akemi Matsura Misawa Jo ão Fellipe Bertocco Mariza Polati Source Type: research
Biomimetic Multifunctional Graphene ‐Based Coating for Thermal Management, Solar De‐Icing, and Fire Safety: Inspired from the Antireflection Nanostructure of Compound Eyes
Herein, inspired from the compound eyes to enhance the photo-thermal capability of graphene based on the Fresnel equation. An equilibrium temperature of ≈77 °C and rapid de-icing within ≈65 s are achieved. The synergetic flame retardant mechanism results in 58% and 28% decreases in heat release rate and total heat release. AbstractDue to the ubiquitous and inexhaustible solar source, photothermal materials have gained considerable attention for their potential in heating and de-icing. Nevertheless, traditional photothermal materials, exemplified by graphene, frequently encounter challenges emanating from their elevat...
Source: Small - April 22, 2024 Category: Nanotechnology Authors: Tianyang Cui,
Yapeng Zheng,
Mengdi Hu,
Bicheng Lin,
Jingwen Wang,
Wei Cai,
Bin Fei,
Jixin Zhu,
Yuan Hu Tags: Research Article Source Type: research
Management of macula-on giant retinal tear detachments – outcome of pars-plana-vitrectomy with silicone oil versus gas tamponade
To compare the outcome of eyes with a macula-on giant retinal tear (GRT) detachment treated with pars-plana-vitrectomy (PPV) depending on the used endotamponade. (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - April 22, 2024 Category: Opthalmology Authors: Teresa Barth, Viola Radeck, Maria-Andreea Gamulescu, Horst Helbig and David M ärker Tags: Research Source Type: research
Extended depth of focus IOL in eyes with different axial myopia and targeted refraction
To evaluate the objective visual outcomes following implantation of extended depth of focus intraocular lens (EDOF IOL) in individuals with varying axial lengths (AL) and targeted refraction. (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - April 22, 2024 Category: Opthalmology Authors: Xiaohui Wang, Sinan Liu, Yinqi Chen, Jinping Gong, Nuozhou Wu and Yihua Yao Tags: Research Source Type: research
Repeatability assessment of anterior segment measurements in myopic patients using an anterior segment OCT with placido corneal topography and agreement with a swept-source OCT
The precision of anterior segment biometric measurements in eyes has become increasingly important in refractive surgery. The purpose of this study is to assess the repeatability of the automatic measurements ... (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - April 22, 2024 Category: Opthalmology Authors: Hao Wang, Li-Shuang Zhu, Chen-Jiu Pang and Qi Fan Tags: Research Source Type: research
Scleral lens induced short term corneal changes in eyes with Pellucid Marginal Degeneration
To investigate the short-term effect of scleral lens (SL) on corneal curvature and corneal oedema in Pellucid Marginal Degeneration (PMD) eyes. (Source: Contact Lens and Anterior Eye)
Source: Contact Lens and Anterior Eye - April 22, 2024 Category: Opthalmology Authors: Ronit Dutta, Geetha Iyer, Bhaskar Srinivasan, Asif Iqbal Source Type: research
Efficacy of electroacupuncture therapy in patients with functional anorectal pain: study protocol for a multicenter randomized controlled trial
DiscussionResults of this trial will be contributed to further clarify the value of electroacupuncture at Baliao acupoint as a treatment for FAP in the clinic.Trial registrationThis trial has been registered in Chinese Clinical Trial Registry https://www.chictr.org.cn/ (ChiCTR2300069757) on March 24, 2023. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 22, 2024 Category: Gastroenterology Source Type: research
Hypercapnic hypoxia as a rehabilitation method for patients after ischemic stroke
CONCLUSION: Respiratory training with hypercapnic hypoxia improves the functional state of the nervous system in patients with ischemic stroke. After conducting further clarifying studies, hypercapnic hypoxia can be considered as an effective method of neurorehabilitation, which can be used as early as 48-72 hours after the onset of stroke.PMID:38643375 | DOI:10.1080/01616412.2024.2343510 (Source: Neurological Research)
Source: Neurological Research - April 21, 2024 Category: Neurology Authors: Tatiana M Alekseeva Maria P Topuzova Vladimir P Kulikov Pavel D Kovzelev Mark G Kosenko Pavel P Tregub Source Type: research
Tear Protein Markers for Diabetic Retinopathy and Diabetic Macular Edema - Towards an Early Diagnosis and Better Prognosis
CONCLUSIONS: The review highlights major studies and their lacunae in the field of biomarkers discovery for DR and DME.PMID:38643349 | DOI:10.1080/08820538.2024.2342266 (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - April 21, 2024 Category: Opthalmology Authors: Sarmeela Sharma Akash Belenje Brijesh Takkar Ritesh Narula Varsha M Rathi Mudit Tyagi Padmaja Kumari Rani Raja Narayanan Inderjeet Kaur Source Type: research
