Study to Evaluate the Safety and Tolerability of PRO-190 Ophthalmic Solution Compared to Systane Ultra ® on the Ocular Surface.
Conditions: Dry Eye; Dry Eyes Chronic; Dry Eye Syndromes Interventions: Drug: PRO-190; Drug: Systane Ultra ® Sponsors: Laboratorios Sophia S.A de C.V. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 23, 2024 Category: Research Source Type: clinical trials
Photocoagulation or sham laser in addition to conventional anti-VEGF therapy in macular edema associated with TelCaps due to diabetic macular edema or retinal vein occlusion (TalaDME): a study protocol for a multicentric, French, two-group, non-commercial, active-control, observer-masked, non-inferiority, randomized controlled clinical trial
DiscussionThe best management of ME associated with TelCaps is debated, and there have been no randomized study designed to answer this question. Given the fact that TelCaps may affect 30 to 60% of patients with chronic ME due to DR or RVO, a large number of patients could benefit from a specific management of TelCaps. TalaDME aims to establish the clinical and medico-economic benefits of additional targeted laser. The results of TalaDME may raise new recommendations for managing ME and impact healthcare costs.Trial registrationEudraCT: 2018-A00800-55/ NCT03751501. Registration date: Nov. 23, 2018. (Source: Trials)
Source: Trials - April 22, 2024 Category: Research Source Type: clinical trials
Single-Blind Study Assessing the Use of a Topical Antioxidant With A Series of Laser Procedures to Reduce Sebum Production
Conditions: Acne Interventions: Drug: Topical Antioxidant Serum; Device: AviClear Laser Sponsors: Austin Institute for Clinical Research; SkinCeuticals Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 19, 2024 Category: Research Source Type: clinical trials
Study of Non-inferiority Between Manzanilla Sophia ® and Meticel Ofteno® 0.5% for Providing a Soothing Sensation to the Eyes.
Conditions: Eye Strain; Eye Strain of Both Eyes Interventions: Drug: Manzanilla Sophia ®; Drug: Meticel Ofteno® Sponsors: Laboratorios Sophia S.A de C.V. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 18, 2024 Category: Research Source Type: clinical trials
A Prospective, Multi-center, Randomized, Single-blind, Non-inferiority Confirmatory Study Designed to Compare and Evaluate the Efficacy and Safety Between TS-RF System and BRK Transseptal Needles Used for Transseptal Puncture for Left Atrial Access.
Conditions: Arrhythmias, Cardiac; Atrial Fibrillation; Heart Diseases Interventions: Device: TS-RF Transseptal Needle; Device: BRK Transseptal Needle Sponsors: Starmed; Helptrial Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 10, 2024 Category: Research Source Type: clinical trials
Understanding Visual Processing After Occipital Stroke
Conditions: Vision Loss Partial; Vision; Loss, Both Eyes; Hemianopia, Homonymous; Hemianopia; Quadrantanopia; Stroke, Ischemic; Stroke - Occipital Infarction; Cortical Blindness; Occipital Lobe Infarct; Peripheral Visual Field Defect of Both Eyes Sponsors: University of Rochester Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 8, 2024 Category: Research Source Type: clinical trials
Safety and Efficacy of 0.75% Phentolamine Ophthalmic Solution in Subjects With Post-refractive Surgery Visual Disturbances
Conditions: Mesopic Vision; Night Vision Loss Interventions: Drug: phentolamine ophthalmic solution 0.75%, a non-selective alpha-1 and alpha-2 adrenergic antagonist; Drug: Placebo Sponsors: Ocuphire Pharma, Inc.; Viatris Inc. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 5, 2024 Category: Research Source Type: clinical trials
5-EPIFAT trial protocol: a multi-center, randomized, placebo-controlled trial of the efficacy of pharmacotherapy for fatigue using methylphenidate, bupropion, ginseng, and amantadine in advanced cancer patients on active treatment
DiscussionThe findings of the 5-EPIFAT trial could be helpful to guide clinical decision-making, personalization treatment approach, design of future trials, as well as the development of CRF management guidelines.Trial registrationIRCT.ir IRCT20150302021307N6. Registered on 13 May 2023. (Source: Trials)
Source: Trials - April 3, 2024 Category: Research Source Type: clinical trials
Follow up of High Myopic Eyes
Conditions: Pathologic Myopia Interventions: Diagnostic Test: no drugs used for this study Sponsors: Istituto Auxologico Italiano Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 21, 2024 Category: Research Source Type: clinical trials
Inflammation-Reducing Drug Minocycline Shows No Benefit For Dry Age-Related Macular Degeneration in NIH Trial
March 20, 2024 -- The drug minocycline, an antibiotic that also decreases inflammation, failed to slow vision loss or expansion of geographic atrophy in people with dry age-related macular degeneration (AMD), according to a phase II clinical study... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - March 20, 2024 Category: Pharmaceuticals Source Type: clinical trials
Outcomes After Vitrectomy in Eyes With Tractional Diabetic Macular Edema
Conditions: Diabetic Macular Edema Interventions: Procedure: vitrectomy Sponsors: Rehab Azzam Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 18, 2024 Category: Research Source Type: clinical trials
Flexor Injury Rehabilitation Splint Trial (FIRST): protocol for a pragmatic randomised controlled trial comparing three splints for finger flexor tendon repairs
DiscussionFIRST will compare the three splints with respect to clinical efficacy, complications, quality of life and cost-effectiveness. FIRST is a pragmatic trial which will recruit from 26 NHS sites to allow findings to be generalisable to current clinical practice in the UK. It will also provide significant insights into patient experiences of splint wear and how adherence to splinting may impact outcomes.Trial registrationISRCTN: 10236011 (Source: Trials)
Source: Trials - March 16, 2024 Category: Research Source Type: clinical trials
Lung Cancer Screening by Artificial Intelligence Device
Conditions: Lung Cancer Interventions: Device: Lung-SIGHT Sponsors: Chinese University of Hong Kong Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 6, 2024 Category: Research Source Type: clinical trials
UV light-mediated corneal crosslinking as (lymph)angioregressive pretreatment to promote graft survival after subsequent high-risk corneal transplantation (CrossCornealVision): protocol for a multicenter, randomized controlled trial
DiscussionBased on preclinical and early pilot clinical evidence, we want to test the novel concept of temporary (lymph)angioregressive pretreatment of high-risk eyes by CXL to promote subsequent corneal graft survival. So far, there is no evidence-based approach to reliably improve graft survival in the high-risk corneal transplantation setting available in clinical routine. If successful, this approach will be the first to promote graft survival in high-risk transplants. It will significantly improve vision and quality of life in patients suffering from corneal blindness.Trial registrationClinicalTrials.gov NCT05870566. ...
Source: Trials - March 6, 2024 Category: Research Source Type: clinical trials
Effects of Acupoint Massage Around Eyes on Ocular Biological Indexes
Conditions: Investigating the Effects of Periocular Acupressure on Ocular Biological Indicators Interventions: Other: acupressure Sponsors: Zhongnan Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 5, 2024 Category: Research Source Type: clinical trials
