Genetic association of lipid-lowering drug target genes with erectile dysfunction and male reproductive health
ConclusionAfter performing drug-targeted MR analysis, we found that that there was a causal relationship between lipid-lowering drug targets and ED. APOC3, APOB, LDLR and LPL may be new candidate drug targets for the treatment of ED. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 8, 2024 Category: Endocrinology Source Type: research
Soluble guanylate cyclase stimulators and activators: new horizons in the treatment of priapism associated with sickle cell disease
Priapism, defined as a prolonged and often painful penile erection occurring without sexual stimulation or desire, is a common complication in sickle cell disease (SCD), affecting up to 48% of male patients. This condition presents significant clinical challenges and can lead to erectile dysfunction if not properly managed. Current pharmacological treatments for SCD-related priapism are primarily reactive rather than preventative, highlighting a gap in effective medical intervention strategies. A critical factor in developing priapism is the reduced basal bioavailability of nitric oxide (NO) and cyclic guanosine monophosph...
Source: Frontiers in Pharmacology - February 7, 2024 Category: Drugs & Pharmacology Source Type: research
Artificial cavernosa-like tissue based on multibubble Matrigel and a human corpus cavernous fibroblast scaffold
This study describes a preparation method for human artificial CC-like tissue that may provide an improved experimental platform for exploring the function and structure of the CC and conducting drug screening for erectile dysfunction therapy.PMID:38319194 | DOI:10.4103/aja202374 (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - February 6, 2024 Category: Urology & Nephrology Authors: Yu-Zhuo Chen Yi-Hong Zhou Min-Bo Yan Ming Xiao Biao Liu Ying-Hao Yin Xiao-Li Tan Yong-Quan Huang Yu-Hong Lin Ting Xie Jia-Li Tian Qi Wang Jian-Ying Li Zi-Zhou Meng Zheng Li Emily Xing Yu-Xin Tang Ya-Wei Li Zhong-Zhen Su Liang-Yu Zhao Source Type: research
Role of Nutraceuticals in Treating Erectile Dysfunction via Inhibition of Phosphodiesterase-5 Enzyme: A Mini Review
Curr Pharm Biotechnol. 2024 Jan 16. doi: 10.2174/0113892010256035231119071714. Online ahead of print.ABSTRACTDrug repurposing is an ongoing and clever strategy that is being developed to eradicate tuberculosis amid challenges, of which one of the major challenges is the resistance developed towards antibiotics used in standard directly observed treatment, short-course regimen. Surpassing the challenges in developing anti-tuberculous drugs, some novel host-directed therapies, repurposed drugs, and drugs with novel targets are being studied, and few are being approved too. After almost 4 decades since the approval of rifampi...
Source: Current Pharmaceutical Biotechnology - February 4, 2024 Category: Biotechnology Authors: Rashi Kulshrestha Neelam Singla Obaid Afzal Ahsas Goyal Mahendra Saini Abdulmalik Saleh Alfawaz Altamimi Waleed Hassan Almalki Imran Kazmi Fahad Al-Abbasi Sami I Alzarea Gaurav Gupta Source Type: research
Tadalafil versus tamsulosin as combination therapy with 5-alpha reductase inhibitors in benign prostatic hyperplasia, urinary and sexual outcomes
ConclusionWithin three months, both combinations are comparably effective in improving BPH related LUTS. Tamsulosin/finasteride provided significantly better Qmax only at 4th week. Tadalafil/finasteride had the advantage of improving sexual performance over the other combination. (Source: World Journal of Urology)
Source: World Journal of Urology - February 3, 2024 Category: Urology & Nephrology Source Type: research
Relationship between dietary niacin intake and erectile dysfunction: a population-based study
This study suggests an inverse association between dietary niacin intake and the risk of ED. However, establishing a cause-and-effect relationship remains elusive, and defining the safe threshold of niacin intake to prevent ED requires further investigation.PMID:38305697 | DOI:10.4103/aja202378 (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - February 2, 2024 Category: Urology & Nephrology Authors: Wei-Long Lin Cheng Zheng Hao-Xu Wang Wei Zhang Ming-En Lin Source Type: research
Investigating the prevalence of erectile dysfunction among men exposed to organophosphate insecticides
ConclusionsThe results of our study suggest a potential role for chlorpyrifos and other OPs the pathogenesis of ED. Future studies are warranted to validate these findings, determine clinical significance, and to investigate potential mechanisms underlying these associations. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 1, 2024 Category: Endocrinology Source Type: research
Interventions, Barriers, and Facilitators to Address the Sexual Problems of Gay, Bisexual and Other Men Who Have Sex with Men Living with HIV: A Rapid Scoping Review
AbstractSexual problems are common among gay, bisexual, and other men who have sex with men (GBM) after diagnosis with HIV. However, these are often overlooked in care and research, where sexual risk reduction and biomedical aspects of sexual health tend to dominate. We conducted a rapid scoping review to investigate which sexual problems of GBM living with HIV are addressed by interventions, and the barriers and facilitators to their implementation. Literature from high-income countries published in English since 2010 was reviewed. Medline, Embase, PsycInfo, and Scopus databases were searched on July 4, 2022. Targeted sex...
Source: AIDS and Behavior - January 31, 2024 Category: Infectious Diseases Source Type: research
A New Strategy for Obesity Treatment: Revealing the Frontiers of Anti-obesity Medications
Curr Mol Med. 2024 Jan 4. doi: 10.2174/0115665240270426231123155924. Online ahead of print.ABSTRACTObesity dramatically increases the risk of type 2 diabetes, fatty liver, hypertension, cardiovascular disease, and cancer, causing both declines in quality of life and life expectancy, which is a serious worldwide epidemic. At present, more and more patients with obesity are choosing drug therapy. However, given the high failure rate, high cost, and long design and testing process for discovering and developing new anti-obesity drugs, drug repurposing could be an innovative method and opportunity to broaden and improve pharma...
Source: Current Molecular Medicine - January 30, 2024 Category: Molecular Biology Authors: Pan-Feng Huang Qi-Yu Wang Rong-Bin Chen Ya-Di Wang Yuan-Yuan Wang Jiang-Hua Liu Xin-Hua Xiao Zhe-Zhen Liao Source Type: research
A prospective evaluation of quality of life, psychosocial distress, and functional outcomes two years after radical cystectomy and urinary diversion in 842 German bladder cancer patients
ConclusionGlobal HRQoL two years after RC is comparable to the general German population. Female patients should be informed about worse continence rates. Conversely, men should be educated about erectile dysfunction. Aftercare should include psycho-oncologic counseling, especially for patients at risk.Implications for cancer survivorsPatients should be counseled on long-term functional outcomes and persistent psychosocial distress after RC. Closer cooperation between urologists and psycho-oncologists is needed. (Source: Journal of Cancer Survivorship)
Source: Journal of Cancer Survivorship - January 30, 2024 Category: Cancer & Oncology Source Type: research
Long-term tadalafil once daily in Chinese men with erectile dysfunction: a 2-year final analysis of a post-marketing, multicenter, randomized, open-label trial
Asian J Androl. 2024 Jan 26. doi: 10.4103/aja202370. Online ahead of print.ABSTRACTThe long-term safety and effectiveness of once-daily tadalafil is crucial, but limited data are available in Chinese patients with erectile dysfunction (ED). In this post-marketing, multicenter, randomized, open-label trial with 2-year follow-up, 635 ED cases were randomized to receive daily oral tadalafil 2.5 mg or 5 mg for 3 months, of whom 580 continued once-daily tadalafil 5 mg for 21 months. Treatment-emergent adverse events in the 12-month and 24-month period were similar, with the most common being viral upper respiratory tract infect...
Source: Asian Journal of Andrology - January 29, 2024 Category: Urology & Nephrology Authors: Hui Jiang Lian-Ming Zhao Su Yan Ji-Hong Liu Zhao-Hui Zhu Jin-Dan Luo Yu-Tian Dai Fu-Biao Li Hao-Cheng Lin Zhi-Chao Zhang Source Type: research
3 ‐Hydroxy‐3‐methylglutaryl‐CoA synthase 2 facilitates erectile dysfunction via inhibiting autophagy by enhancing the mammalian target of rapamycin pathway in type 1 diabetic mellitus rats
Discussion and conclusionHMGCS2 upregulation in T1DM rats inhibited autophagy and eNOS activity by activating the mTOR pathway and led to a decrease in the erectile function. (Source: Andrology)
Source: Andrology - January 26, 2024 Category: Urology & Nephrology Authors: Zhiqiang Dai,
Yang Zeng,
Xiao Tan,
Tao Zhou,
Xiong Li,
Qingfu Deng Tags: ORIGINAL ARTICLE Source Type: research
Efficacy of low-intensity shockwave therapy with different tadalafil regimens in patients with PDE5 inhibitor-resistant erectile dysfunction: a retrospective cohort study
In this study, a cohort of 105 patients with PDE5i-resistant ED was recruited and divided into three groups labeled as A (only LI-SWT), B (LI-SWT plus 5 mg tadalafil daily), and C (LI-SWT plus 20 mg tadalafil alternate-day), comprising 27, 42, and 36 patients, respectively. The patients' International Index of Erectile Function-5 (IIEF-5) scores and the Erection Hardness Score (EHS) were evaluated at the baseline, three months and six months foll owing the treatment.ResultsAfter three months post-treatment, the IIEF-5 scores in group A, B, and C increased by 4.1 ± 0.6, 7.3 ± 0.6, and 8.2 ± 0.6, respectiv...
Source: International Urology and Nephrology - January 25, 2024 Category: Urology & Nephrology Source Type: research
Causal effects of gut microbiota on the risk of erectile dysfunction: a Mendelian randomization study
International Journal of Impotence Research, Published online: 25 January 2024; doi:10.1038/s41443-024-00824-7Causal effects of gut microbiota on the risk of erectile dysfunction: a Mendelian randomization study (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - January 25, 2024 Category: Urology & Nephrology Authors: Ran Xu Shuo Liu Lu-Yi Li Ying Zhang Bo-Qin Fang Guang-Cheng Luo Xin-Jun Wang Source Type: research
Grafts in Peyronie's surgery without the use of prostheses: a systematic review and meta-analysis
The objective of this review was to evaluate the available literature and identify the most effective graft material for penile curvature correction in PD. A literature search was conducted using electronic databases, including PubMed, Scopus, and the Cochrane Library. The patients, intervention, comparison, and outcome (PICO) approach was used to define the eligibility of studies. Two authors independently selected studies, evaluated them, and extracted data. Random-effect models using the DerSimonian-Laird method were used. Most studies were single-arm studies and had a high risk of bias. Buccal mucosa grafts (BMG) were ...
Source: Asian Journal of Andrology - January 24, 2024 Category: Urology & Nephrology Authors: Anastasios Natsos Vasileios Tatanis Stavros Kontogiannis Sharon Waisbrod Kristiana Gkeka Mohamed Obaidad Angelis Peteinaris Konstantinos Pagonis Costas Papadopoulos Panagiotis Kallidonis Evangelos Liatsikos Petros Drettas Source Type: research
