Fundamentals of redox regulation in biology
Nat Rev Mol Cell Biol. 2024 Apr 30. doi: 10.1038/s41580-024-00730-2. Online ahead of print.ABSTRACTOxidation-reduction (redox) reactions are central to the existence of life. Reactive species of oxygen, nitrogen and sulfur mediate redox control of a wide range of essential cellular processes. Yet, excessive levels of oxidants are associated with ageing and many diseases, including cardiological and neurodegenerative diseases, and cancer. Hence, maintaining the fine-tuned steady-state balance of reactive species production and removal is essential. Here, we discuss new insights into the dynamic maintenance of redox homeosta...
Source: Mol Biol Cell - April 30, 2024 Category: Molecular Biology Authors: Helmut Sies Ryan J Mailloux Ursula Jakob Source Type: research
Advancing phytomining: Harnessing plant potential for sustainable rare earth element extraction
Bioresour Technol. 2024 Apr 27:130751. doi: 10.1016/j.biortech.2024.130751. Online ahead of print.ABSTRACTRare earth elements (REEs) are pivotal for advanced technologies, driving a surge in global demand. Import dependency on clean ene rgy minerals raises concerns about supply chain vulnerabilities and geopolitical risks. Conventional EE manufacturing is resource-intensive and environmentally harmful, necessitating a sustainable supply approach. Phytomining (agromining) utilizes plants for eco-friendly REE extraction, contributing to the circular economy and exploiting untapped metal resources in enriched soils. Critical ...
Source: Bioresource Technology - April 30, 2024 Category: Biotechnology Authors: Mohsen Rabbani Mohammad Taqi Rabbani Frida Muthoni Ying Sun Ehsan Vahidi Source Type: research
Molding the future: Optimization of bioleaching of rare earth elements from electronic waste by Penicillium expansum and insights into its mechanism
Bioresour Technol. 2024 Apr 27:130750. doi: 10.1016/j.biortech.2024.130750. Online ahead of print.ABSTRACTThe recovery of rare earth elements (REE) from electronic waste is crucial for ensuring future demand security, as there is a high supply risk for this group of elements, and mitigating the environmental impacts of conventional mining. This research focuses on extracting REE from waste printed circuit boards through bioleaching, addressing the limited attention given to this source. A strain of Penicillium expansum demonstrated efficient bioleaching under optimal conditions of 7.5 initial pH, 0.1 mM phosphate concentra...
Source: Bioresource Technology - April 30, 2024 Category: Biotechnology Authors: Alejandra Gonzalez Baez Leonardo Pantoja Mu ñoz Martijn Timmermans Hemda Garelick Diane Purchase Source Type: research
Resveratrol alleviates inorganic arsenic-induced ferroptosis in chicken brain via activation of the Nrf2 signaling pathway
Pestic Biochem Physiol. 2024 May;201:105885. doi: 10.1016/j.pestbp.2024.105885. Epub 2024 Mar 26.ABSTRACTInorganic arsenic (iAs) is a well-recognized environmental pollutant that induces severe brain injury in humans and animals. The antioxidant, anti-inflammatory, and anti-ferroptotic effects of resveratrol (Res) were demonstrated in multiple animal experiments. In order to investigate the protective effect of Res on iAs-induced chicken brain injury, the 40 chickens (19-d-old, female) brain injury model was established by oral administration of iAs (30 mg/L NaAsO2) for 6 weeks. All chickens had free access to both food an...
Source: Physiological Research - April 30, 2024 Category: Physiology Authors: Shan Pang Biqi Han Pengfei Wu Xu Yang Yunfeng Liu Jiayi Li Zhanjun Lv Zhigang Zhang Source Type: research
Bacterial synthase-dependent exopolysaccharide secretion: a focus on cellulose
Curr Opin Microbiol. 2024 Apr 29;79:102476. doi: 10.1016/j.mib.2024.102476. Online ahead of print.ABSTRACTBacterial biofilms are a prevalent multicellular life form in which individual members can undergo significant functional differentiation and are typically embedded in a complex extracellular matrix of proteinaceous fimbriae, extracellular DNA, and exopolysaccharides (EPS). Bacteria have evolved at least four major mechanisms for EPS biosynthesis, of which the synthase-dependent systems for bacterial cellulose secretion (Bcs) represent not only key biofilm determinants in a wide array of environmental and host-associat...
Source: Current Opinion in Microbiology - April 30, 2024 Category: Microbiology Authors: Petya V Krasteva Source Type: research
Genomic mining of Geobacillus stearothermophilus GF16 for xylose production from hemicellulose-rich biomasses using secreted enzymes
N Biotechnol. 2024 Apr 28:S1871-6784(24)00013-X. doi: 10.1016/j.nbt.2024.04.002. Online ahead of print.ABSTRACTThe valorization of lignocellulosic biomass, derived from various bio-waste materials, has received considerable attention as a sustainable approach to improve production chains while reducing environmental impact. Microbial enzymes have emerged as key players in the degradation of polysaccharides, offering versatile applications in biotechnology and industry. Among these enzymes, glycoside hydrolases (GHs) play a central role. Xylanases, in particular, are used in a wide range of applications and are essential fo...
Source: New Biotechnology - April 30, 2024 Category: Biotechnology Authors: Miriam Carbonaro Martina Aulitto Scott Mazurkewich Alessia Di Fraia Patrizia Contursi Danila Limauro Johan Larsbrink Gabriella Fiorentino Source Type: research
Deciphering and predicting changes in antibiotic resistance genes during pig manure aerobic composting via machine learning model
In this study, the effects of process parameters on ARGs during aerobic composting of pig manure were explored through data mining based on 191 valid data collected from literature. Machine learning (ML) models (XGBoost and Random Forest) were utilized to predict the rate of ARGs changes during pig manure composting. The model evaluation index of the XGBoost model (R2 = 0.651) was higher than that of the Random Forest (R2 = 0.490), indicating that XGBoost had better prediction performance. Feature importance was further calculated for the XGBoost model, and the XGBoost black box model was interpreted by Shapley additive ex...
Source: Environmental Science and Pollution Research International - April 30, 2024 Category: Environmental Health Authors: Xiaohui Yu Yang Lv Qing Wang Wenhao Wang Zhiqiang Wang Nan Wu Xinyuan Liu Xiaobo Wang Xiaoyan Xu Source Type: research
Von-Hippel Lindau protein amyloid formation. The role of GST-tag
Biochem Biophys Res Commun. 2024 Apr 25;715:150008. doi: 10.1016/j.bbrc.2024.150008. Online ahead of print.ABSTRACTIn the last decade, much attention was given to the study of physiological amyloid fibrils. These structures include A-bodies, which are the nucleolar fibrillar formations that appear in the response to acidosis and heat shock, and disassemble after the end of stress. One of the proteins involved in the biogenesis of A-bodies, regardless of the type of stress, is Von-Hippel Lindau protein (VHL). Known also as a tumor suppressor, VHL is capable to form amyloid fibrils both in vitro and in vivo in response to th...
Source: Biochemical and Biophysical Research communications - April 30, 2024 Category: Biochemistry Authors: Natalia V Kuzmina Anastasia A Gavrilova Anna S Fefilova Anna E Romanovich Irina M Kuznetsova Konstantin K Turoverov Alexander V Fonin Source Type: research
Boosting treatment outcomes via the patient-practitioner relationship, treatment-beliefs or therapeutic setting. A systematic review with meta-analysis of contextual effects in chronic musculoskeletal pain
CONCLUSION: Whilst evidence gaps exist, per current evidence it may not be possible to achieve meaningful benefit for patients with chronic musculoskeletal pain by manipulating the context of non-pharmacological and non-surgical treatments. TRIAL REGISTRATION: This systematic review was prospectively registered in PROSPERO (registration number: CRD42023391601).PMID:38687160 | DOI:10.2519/jospt.2024.12259 (Source: Health Physics)
Source: Health Physics - April 30, 2024 Category: Physics Authors: Tobias Saueressig Patrick J Owen Hugo Pedder Nitin Kumar Arora Marieke Simons Svenja Kaczorowski Clint T Miller Lars Donath Daniel L Belavy Source Type: research
Single-cell transcriptomics: background, technologies, applications, and challenges
Mol Biol Rep. 2024 Apr 30;51(1):600. doi: 10.1007/s11033-024-09553-y.ABSTRACTSingle-cell sequencing was developed as a high-throughput tool to elucidate unusual and transient cell states that are barely visible in the bulk. This technology reveals the evolutionary status of cells and differences between populations, helps to identify unique cell subtypes and states, reveals regulatory relationships between genes, targets and molecular mechanisms in disease processes, tumor heterogeneity, the state of the immune environment, etc. However, the high cost and technical limitations of single-cell sequencing initially prevented ...
Source: Mol Biol Cell - April 30, 2024 Category: Molecular Biology Authors: Lucky Duhan Deepika Kumari Mohammad Naime Virinder S Parmar Anil K Chhillar Mehak Dangi Ritu Pasrija Source Type: research
Boosting treatment outcomes via the patient-practitioner relationship, treatment-beliefs or therapeutic setting. A systematic review with meta-analysis of contextual effects in chronic musculoskeletal pain
CONCLUSION: Whilst evidence gaps exist, per current evidence it may not be possible to achieve meaningful benefit for patients with chronic musculoskeletal pain by manipulating the context of non-pharmacological and non-surgical treatments. TRIAL REGISTRATION: This systematic review was prospectively registered in PROSPERO (registration number: CRD42023391601).PMID:38687160 | DOI:10.2519/jospt.2024.12259 (Source: Physical Therapy)
Source: Physical Therapy - April 30, 2024 Category: Physiotherapy Authors: Tobias Saueressig Patrick J Owen Hugo Pedder Nitin Kumar Arora Marieke Simons Svenja Kaczorowski Clint T Miller Lars Donath Daniel L Belavy Source Type: research
Impact of sub-chronic polystyrene nanoplastics exposure on hematology, histology, and endoplasmic reticulum stress-related protein expression in Nile tilapia (Oreochromis niloticus)
Comp Biochem Physiol B Biochem Mol Biol. 2024 Apr 28:110982. doi: 10.1016/j.cbpb.2024.110982. Online ahead of print.ABSTRACTNanoplastics (NPs) are one of the most hazardous marine litters, having the potential to cause far-reaching impacts on the environment and humankind. The effect of NPs on fish health has been studied, but their impact on the subcellular organelles remains unexplored. The present investigation studied the possible implications of polystyrene-nanoplastics (PS-NPs) on the hematology, tissue organization, and endoplasmic reticulum (ER) stress-related proteins in Nile tilapia (Oreochromis niloticus). Fish ...
Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology. - April 30, 2024 Category: Biochemistry Authors: Vadavanath Prabhakaran Vineetha Kummari Suresh Devika Pillai Source Type: research
Single-cell transcriptomics: background, technologies, applications, and challenges
Mol Biol Rep. 2024 Apr 30;51(1):600. doi: 10.1007/s11033-024-09553-y.ABSTRACTSingle-cell sequencing was developed as a high-throughput tool to elucidate unusual and transient cell states that are barely visible in the bulk. This technology reveals the evolutionary status of cells and differences between populations, helps to identify unique cell subtypes and states, reveals regulatory relationships between genes, targets and molecular mechanisms in disease processes, tumor heterogeneity, the state of the immune environment, etc. However, the high cost and technical limitations of single-cell sequencing initially prevented ...
Source: Molecular Biology Reports - April 30, 2024 Category: Molecular Biology Authors: Lucky Duhan Deepika Kumari Mohammad Naime Virinder S Parmar Anil K Chhillar Mehak Dangi Ritu Pasrija Source Type: research
The effect of carbonized zeolitic imidazolate framework-67 (ZIF-67) support on the reactivity and selectivity of bimetal-catalytic aqueous NO < sub > 3 < /sub > < sup > - < /sup > reduction
Chemosphere. 2024 Apr 27:142161. doi: 10.1016/j.chemosphere.2024.142161. Online ahead of print.ABSTRACTA metallic catalyst, Cobalt N-doped Carbon (Co@NC), was obtained from Zeolitic-Imidazolate Framework-67 (ZIF-67) for efficient aqueous nitrate (NO3-) removal. This advanced catalyst indicated remarkable efficiency by generating valuable ammonium (NH3/NH4+) via an environmentally friendly production technique during the nitrate treatment. Among various metals (Cu, Pt, Pd, Sn, Ru, and Ni), 3.6%Pt-Co@NC exhibited an exceptional nitrate removal, demonstrating a complete removal of 60 mg/L NO3--N (265 mg/L NO3-) in 30 min with...
Source: Chemosphere - April 30, 2024 Category: Chemistry Authors: Miriam Absalyamova Meiirzhan Nurmyrza Nurbek Nurlan Sungjun Bae Woojin Lee Source Type: research
Activation of sawdust biochar with water and wastewater treatment residuals for sorption of perfluorooctanesulfonic acid in water
Chemosphere. 2024 Apr 27:142160. doi: 10.1016/j.chemosphere.2024.142160. Online ahead of print.ABSTRACTRecent research has found biochar to be a cost-effective adsorbent for removal of perfluoroalkyl substances in water. To promote cleaner production and sustainable waste management, this study explored the potential to produce activated biochars by co-pyrolyzing sawdust with iron-rich biosolids and polyaluminum sludge. The maximum capacity to adsorb perfluorooctanesulfonic acid (PFOS) reached 27.2 mg g-1 with biosolids-activated biochar and 19.2 mg g-1 with aluminum sludge-activated biochar, compared to 6.2 mg g-1 with sa...
Source: Chemosphere - April 30, 2024 Category: Chemistry Authors: Kalyani Mer Pubudu Arachchilage Wendong Tao Nosa O Egiebor Source Type: research
