Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multi-country analysis
CONCLUSIONS: Morphometric analysis of duodenal biopsy slides across geographies identified morphologic features of EED, specifically short villi, elongated crypts, and a smaller V:C ratio relative to NPA slides; although not as severe as in celiac slides. Morphometry did not explain other EED features, suggesting that EED histopathologic processes may be operating independently of morphology. While acknowledging the challenges with obtaining relevant tissue, these data form the basis for further assessments of the role of morphometry in EED.PMID:38685382 | DOI:10.1016/j.ajcnut.2024.04.027 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - April 30, 2024 Category: Nutrition Authors: Lubaina Ehsan David Coomes Paul Kelly Adam R Greene S Asad Ali Chola Mulenga Donna M Denno Kelley VanBuskirk Muhammad Faraz Raghib Mustafa Mahfuz Sean R Moore M Shabab Hossain Tahmeed Ahmed Peter B Sullivan Christopher A Moskaluk Sana Syed EEDBI Consortiu Source Type: research
Sources of Sound Exposure in Pediatric Critical Care
CONCLUSIONS: Clinicians should partner with families to limit nighttime PICU noise pollution. Large-scale studies using this reliable coding scheme are needed to understand the PICU sound environment.PMID:38688851 | DOI:10.4037/ajcc2024688 (Source: American Journal of Critical Care)
Source: American Journal of Critical Care - April 30, 2024 Category: Nursing Authors: Laura Beth Kalvas Tondi M Harrison Source Type: research
Psychometric Evaluation of the Family Willingness for Caregiving Scale
CONCLUSIONS: Further testing of the FWCS is needed. After refinement, the FWCS could be used to evaluate factors contributing to caregiving willingness of family members of ICU patients and advance the science related to family engagement in the ICU. Additionally, it could be used as a practical tool to suggest family caregiving activities in the ICU.PMID:38688853 | DOI:10.4037/ajcc2024809 (Source: American Journal of Critical Care)
Source: American Journal of Critical Care - April 30, 2024 Category: Nursing Authors: Cindy Wilk Amy Petrinec Source Type: research
Exposure Assessment and Monitoring of Antiblastic Drugs Preparation in Health Care Settings: A Systematic Review
Med Lav. 2024 Apr 24;115(2):e2024012. doi: 10.23749/mdl.v115i2.15609.ABSTRACTSeveral antiblastic drugs (ADs) are classified as carcinogenic, mutagenic, and/or toxic for reproduction. Despite established guidelines and safe handling technologies, ADs contamination of the work environments could occur in healthcare settings, leading to potential exposure of healthcare staff. This systematic review aims to investigate the main techniques and practices for assessing ADs occupational exposure in healthcare settings. The reviewed studies unveil that workplace contamination by ADs appears to be a still-topical problem in healthca...
Source: Medicina del Lavoro - April 30, 2024 Category: Occupational Health Authors: Francesca Borghi Carolina Zellino Arianna Zago Giovanni De Vito Rocco Loris Del Vecchio Andrea Cattaneo Andrea Spinazz è Domenico Maria Cavallo Source Type: research
Oviposition site selection and subsequent offspring performance of Aedes aegypti in short- and long-term detritus accumulation conditions
Acta Trop. 2024 Apr 27:107222. doi: 10.1016/j.actatropica.2024.107222. Online ahead of print.ABSTRACTThe "oviposition preference-offspring performance" hypothesis proposes that females lay their eggs in habitats that maximize the fitness of their offspring. The aim of this study was to assess the oviposition site selection by Aedes aegypti females and the success of their larvae in habitats with different detritus accumulation times, under conditions representative of the natural spatial variability of detritus quality and quantity in the Metropolitan Area of Buenos Aires, Argentina. Two experiments were performed, one ass...
Source: Acta Tropica - April 30, 2024 Category: Infectious Diseases Authors: Pedro Montini Sylvia Fischer Source Type: research
TROP2 promotes PINK1-mediated mitophagy and apoptosis to accelerate the progression of senile chronic obstructive pulmonary disease by up-regulating DRP1 expression
In conclusion, TROP2 can be used as a new reference for COPD treatment.PMID:38685507 | DOI:10.1016/j.exger.2024.112441 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 30, 2024 Category: Geriatrics Authors: Yipu Zhao Zhengjie Wu Source Type: research
Down-regulating the stress axis: Living in the present while preparing for the future
Gen Comp Endocrinol. 2024 Apr 27:114541. doi: 10.1016/j.ygcen.2024.114541. Online ahead of print.ABSTRACTThe measurement of glucocorticoid (GC) hormones provides us with a window into the stress physiology of vertebrates and the adaptative responses they use to cope with predictable and unpredictable changes in the environment. Baseline GCs inform us about the metabolic demands they are subject to at that point in their yearly life-history stage, whereas GC changes (often increases) in response to acute challenges inform us on their capacity to cope with more immediate environmental challenges. However, baseline GC levels ...
Source: General and Comparative Endocrinology - April 30, 2024 Category: Endocrinology Authors: Vincent A Viblanc Sylvia Pardonnet Anouch Tamian Laura K McCaw F Stephen Dobson Rudy Boonstra Source Type: research
Artificial Intelligence and Occupational Health and Safety, Benefits and Drawbacks
Med Lav. 2024 Apr 24;115(2):e2024014. doi: 10.23749/mdl.v115i2.15835.ABSTRACTThis paper discusses the impact of artificial intelligence (AI) on occupational health and safety. Although the integration of AI into the field of occupational health and safety is still in its early stages, it has numerous applications in the workplace. Some of these applications offer numerous benefits for the health and safety of workers, such as continuous monitoring of workers' health and safety and the workplace environment through wearable devices and sensors. However, AI might have negative impacts in the workplace, such as ethical worrie...
Source: Medicina del Lavoro - April 30, 2024 Category: Occupational Health Authors: Mohamed El-Helaly Source Type: research
Dorsal dentate gyrus mediated enriched environment-induced anxiolytic and antidepressant effects in cortical infarcted mice
This study aimed to explore the effectiveness of EE on emotional disorders after cerebral ischemia and its underling mechanism. In this study, sensorimotor cortical infarction was induced by photothrombosis with stable infarct location and volume, resulting in motor dysfunction, anxiety and depression-like behaviors in mice, with decreased ALFF and ReHo values and decreased c-fos expression in the infarction area and adjacent regions. Seven days' EE treatment significantly improved motor function of contralateral forelimb and exhibited anxiolytic and antidepressant effects in infarcted mice. Compared to the mice housing in...
Source: Experimental Neurology - April 30, 2024 Category: Neurology Authors: Dan Huang Yunhui Fan Jingjun Zhang Qianfeng Wang Ming Ding Ruiqing Hou Kewei Yu Xiao Xiao Yi Wu Junfa Wu Source Type: research
Preparing Future Military Medical Officers to Conduct Emergency Fresh Whole Blood Transfusions in Austere Environments: A Novel Training Curriculum
CONCLUSIONS: Our results suggest that the implementation of streamlined EFWBT training into the undergraduate medical education of future military medical officers offers an efficient way to improve their baseline proficiency in EFWBTs. Future research is needed to assess the impact of this training on real-world applications in forward-deployed environments.PMID:38687599 | DOI:10.1093/milmed/usae162 (Source: Military Medicine)
Source: Military Medicine - April 30, 2024 Category: International Medicine & Public Health Authors: Kevin J Matthews Samuel Walther Zachery L Brown Joshua P Cuestas Jonathan T Shumaker Durwood W Moore Rebekah Cole Source Type: research
HEBE project: Healthy aging versus inflamm-aging: The role of physical exercise in modulating the biomarkers of age-associated and environmentally determined chronic diseases, study protocol
PLoS One. 2024 Apr 30;19(4):e0300011. doi: 10.1371/journal.pone.0300011. eCollection 2024.ABSTRACTInflamm-aging refers to the chronic low-grade inflammation that occurs with aging and cellular senescence, and it is linked to various diseases. Understanding the markers involved in inflammation and aging, as well as their interaction with environmental factors and bodily control mechanisms, can provide crucial tools for assessing the resilience (i.e. the ability to adapt and improve) of the human body, particularly in the presence of chronic degenerative conditions or vulnerable life stages, that place the individual and the...
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Francesca Bianchi Elia Mario Biganzoli Valentina Bollati Mario Clerici Daniela Lucini Chiara Mand ò Federica Rota HEBE Consortium Source Type: research
Cervicovaginal metabolome and tumor characteristics for endometrial cancer detection and risk stratification
CONCLUSIONS: Our findings provide insights into understanding the endometrial cancer metabolic landscape and improvement into diagnosis. The metabolic dysregulation described in this paper linked specific metabolites and pathophysiological mechanisms including cellular proliferation, energy supply, and invasion of neighbouring tissues. Furthermore, cervicovaginal metabolite levels related to tumor characteristics, which are used for risk stratification. Overall, development of non-invasive diagnostic can improve both the acceptability and accessibility of diagnosis.PMID:38687603 | DOI:10.1158/1078-0432.CCR-23-2934 (Source:...
Source: Clinical Cancer Research - April 30, 2024 Category: Cancer & Oncology Authors: Georgia M Lorentzen Pawel Laniewski Haiyan Cui Nichole D Mahnert Jamal Mourad Matthew P Borst Lyndsay Willmott Dana M Chase Denise J Roe Melissa M Herbst-Kralovetz Source Type: research
ERS International Congress 2023: highlights from the Basic and Translational Sciences Assembly
ERJ Open Res. 2024 Apr 29;10(2):00875-2023. doi: 10.1183/23120541.00875-2023. eCollection 2024 Mar.ABSTRACTEarly career members of Assembly 3 (Basic and Translational Sciences) of the European Respiratory Society (ERS) summarise the key messages discussed during six selected sessions that took place at the ERS International Congress 2023 in Milan, Italy. Aligned with the theme of the congress, the first session covered is "Micro- and macro-environments and respiratory health", which is followed by a summary of the "Scientific year in review" session. Next, recent advances in experimental methodologies and new technologies ...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Karosham Diren Reddy Nikoleta Bizymi Anja Schweikert Sachin Ananth Clarice X Lim Katharine M Lodge Audrey Joannes Niki Ubags Anne M van der Does Suzanne M Cloonan Arnaud Mailleux Nahal Mansouri Niki L Reynaert Irene H Heijink Sara Cuevas-Oca ña Source Type: research
Von-Hippel Lindau protein amyloid formation. The role of GST-tag
Biochem Biophys Res Commun. 2024 Apr 25;715:150008. doi: 10.1016/j.bbrc.2024.150008. Online ahead of print.ABSTRACTIn the last decade, much attention was given to the study of physiological amyloid fibrils. These structures include A-bodies, which are the nucleolar fibrillar formations that appear in the response to acidosis and heat shock, and disassemble after the end of stress. One of the proteins involved in the biogenesis of A-bodies, regardless of the type of stress, is Von-Hippel Lindau protein (VHL). Known also as a tumor suppressor, VHL is capable to form amyloid fibrils both in vitro and in vivo in response to th...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Natalia V Kuzmina Anastasia A Gavrilova Anna S Fefilova Anna E Romanovich Irina M Kuznetsova Konstantin K Turoverov Alexander V Fonin Source Type: research
Effect of Pressure on the Conformational Landscape of Human γD-Crystallin from Replica Exchange Molecular Dynamics Simulations
J Phys Chem B. 2024 Apr 29. doi: 10.1021/acs.jpcb.4c00178. Online ahead of print.ABSTRACTHuman γD-crystallin belongs to a crucial family of proteins known as crystallins located in the fiber cells of the human lens. Since crystallins do not undergo any turnover after birth, they need to possess remarkable thermodynamic stability. However, their sporadic misfolding and aggregation, triggered by environmental perturbations or genetic mutations, constitute the molecular basis of cataracts, which is the primary cause of blindness in the globe according to the World Health Organization. Here, we investigate the impact of high ...
Source: Health Physics - April 30, 2024 Category: Physics Authors: Arlind Kacirani Bet ül Uralcan Tiago S Domingues Amir Haji-Akbari Source Type: research
