Cervicovaginal metabolome and tumor characteristics for endometrial cancer detection and risk stratification

CONCLUSIONS: Our findings provide insights into understanding the endometrial cancer metabolic landscape and improvement into diagnosis. The metabolic dysregulation described in this paper linked specific metabolites and pathophysiological mechanisms including cellular proliferation, energy supply, and invasion of neighbouring tissues. Furthermore, cervicovaginal metabolite levels related to tumor characteristics, which are used for risk stratification. Overall, development of non-invasive diagnostic can improve both the acceptability and accessibility of diagnosis.PMID:38687603 | DOI:10.1158/1078-0432.CCR-23-2934

Source: Clinical Cancer Research - April 30, 2024 Category: Cancer & Oncology Authors: Georgia M Lorentzen Pawel Laniewski Haiyan Cui Nichole D Mahnert Jamal Mourad Matthew P Borst Lyndsay Willmott Dana M Chase Denise J Roe Melissa M Herbst-Kralovetz Source Type: research